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Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Nuclear body-associated kinase 3) (Nbak3)

 HIPK3_MOUSE             Reviewed;        1192 AA.
Q9ERH7; A2AQH2; O88906; Q9QZR2;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 3.
17-JUN-2020, entry version 152.
RecName: Full=Homeodomain-interacting protein kinase 3;
EC=2.7.11.1;
AltName: Full=Androgen receptor-interacting nuclear protein kinase;
Short=ANPK;
AltName: Full=Fas-interacting serine/threonine-protein kinase;
Short=FIST;
AltName: Full=Nuclear body-associated kinase 3;
Short=Nbak3;
Name=Hipk3; Synonyms=Fist3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH NKX1-2.
STRAIN=BALB/cJ;
PubMed=9748262; DOI=10.1074/jbc.273.40.25875;
Kim Y.H., Choi C.Y., Lee S.-J., Conti M.A., Kim Y.;
"Homeodomain-interacting protein kinases, a novel family of co-repressors
for homeodomain transcription factors.";
J. Biol. Chem. 273:25875-25879(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH FAS AND DAXX, IDENTIFICATION
IN A COMPLEX WITH FAS AND FADD, TISSUE SPECIFICITY, SUBCELLULAR LOCATION,
FUNCTION, AND MUTAGENESIS OF LYS-226 AND ASP-322.
STRAIN=CD-1; TISSUE=Testis;
PubMed=11034606; DOI=10.1084/jem.192.8.1165;
Rochat-Steiner V., Becker K., Micheau O., Schneider P., Burns K.,
Tschopp J.;
"FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces
FADD phosphorylation and inhibits Fas-mediated Jun NH2-terminal kinase
activation.";
J. Exp. Med. 192:1165-1174(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Sather S.L., Johnson N.L., Johnson G.L.;
"Protein kinases associated with PML/CBP nuclear bodies and filamentous
threads regulate transcription and inhibit cell growth.";
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[5]
INTERACTION WITH AR, AND SUBCELLULAR LOCATION.
PubMed=9725910; DOI=10.1091/mbc.9.9.2527;
Moilanen A.-M., Karvonen U., Poukka H., Jaenne O.A., Palvimo J.J.;
"Activation of androgen receptor function by a novel nuclear protein
kinase.";
Mol. Biol. Cell 9:2527-2543(1998).
[6]
FUNCTION AS KINASE AND IN CAMP SIGNALING PATHWAY, INTERACTION WITH
NR5A1/SF1, AND MUTAGENESIS OF LYS-226.
PubMed=17210646; DOI=10.1128/mcb.02253-06;
Lan H.-C., Li H.-J., Lin G., Lai P.-Y., Chung B.-C.;
"Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through
homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and
c-Jun phosphorylation.";
Mol. Cell. Biol. 27:2027-2036(2007).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-359, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=18034455; DOI=10.1021/pr0701254;
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
"Large-scale identification and evolution indexing of tyrosine
phosphorylation sites from murine brain.";
J. Proteome Res. 7:311-318(2008).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-359, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[9]
FUNCTION AS RUNX2 KINASE, AND INTERACTION WITH RUNX2 AND SPEN/MINT.
PubMed=20484411; DOI=10.1210/me.2010-0029;
Sierra O.L., Towler D.A.;
"Runx2 trans-activation mediated by the MSX2-interacting nuclear target
requires homeodomain interacting protein kinase-3.";
Mol. Endocrinol. 24:1478-1497(2010).
-!- FUNCTION: Serine/threonine-protein kinase involved in transcription
regulation, apoptosis and steroidogenic gene expression. Phosphorylates
JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD
phosphorylation. Enhances androgen receptor-mediated transcription. May
act as a transcriptional corepressor for NK homeodomain transcription
factors. The phosphorylation of NR5A1 activates SF1 leading to
increased steroidogenic gene expression upon cAMP signaling pathway
stimulation. In osteoblasts, supports transcription activation:
phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-
mediated activation of the osteocalcin FGF-responsive element (OCFRE).
{ECO:0000269|PubMed:11034606, ECO:0000269|PubMed:17210646,
ECO:0000269|PubMed:20484411}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1;
-!- SUBUNIT: Interacts with UBL1/SUMO-1 (By similarity). Interacts with and
stabilizes ligand-bound androgen receptor (AR). Interacts with Nkx1-2.
Interacts with FAS and DAXX. Probably part of a complex consisting of
HIPK3, FAS and FADD. Binds to NR5A1/SF1, SPEN/MINT and RUNX2.
{ECO:0000250, ECO:0000269|PubMed:11034606, ECO:0000269|PubMed:17210646,
ECO:0000269|PubMed:20484411, ECO:0000269|PubMed:9725910,
ECO:0000269|PubMed:9748262}.
-!- INTERACTION:
Q9ERH7; P25446: Fas; NbExp=3; IntAct=EBI-524356, EBI-296206;
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
-!- TISSUE SPECIFICITY: Heart, skeletal muscle, spleen, testis and lung.
{ECO:0000269|PubMed:11034606}.
-!- PTM: Autophosphorylated, but autophosphorylation is not required for
catalytic activity. {ECO:0000250}.
-!- PTM: May be sumoylated.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr
protein kinase family. HIPK subfamily. {ECO:0000305}.
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EMBL; AF077660; AAC63012.1; -; mRNA.
EMBL; AF305238; AAG25989.1; -; mRNA.
EMBL; AF170305; AAD52570.1; -; mRNA.
EMBL; AL844591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS16489.1; -.
PIR; T17089; T17089.
RefSeq; NP_034564.2; NM_010434.2.
SMR; Q9ERH7; -.
BioGRID; 200308; 1.
IntAct; Q9ERH7; 3.
STRING; 10090.ENSMUSP00000028600; -.
iPTMnet; Q9ERH7; -.
PhosphoSitePlus; Q9ERH7; -.
PaxDb; Q9ERH7; -.
PRIDE; Q9ERH7; -.
Antibodypedia; 25715; 194 antibodies.
Ensembl; ENSMUST00000028600; ENSMUSP00000028600; ENSMUSG00000027177.
Ensembl; ENSMUST00000111124; ENSMUSP00000106753; ENSMUSG00000027177.
GeneID; 15259; -.
KEGG; mmu:15259; -.
UCSC; uc008lju.2; mouse.
CTD; 10114; -.
MGI; MGI:1314882; Hipk3.
eggNOG; KOG0667; Eukaryota.
eggNOG; ENOG410XPET; LUCA.
GeneTree; ENSGT00940000155960; -.
HOGENOM; CLU_003045_2_0_1; -.
InParanoid; Q9ERH7; -.
KO; K08826; -.
OMA; VPAWQQI; -.
OrthoDB; 59821at2759; -.
TreeFam; TF105417; -.
BioGRID-ORCS; 15259; 1 hit in 14 CRISPR screens.
ChiTaRS; Hipk3; mouse.
PRO; PR:Q9ERH7; -.
Proteomes; UP000000589; Chromosome 2.
RNAct; Q9ERH7; protein.
Bgee; ENSMUSG00000027177; Expressed in aorta and 290 other tissues.
ExpressionAtlas; Q9ERH7; baseline and differential.
Genevisible; Q9ERH7; MM.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0016604; C:nuclear body; ISO:MGI.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0016605; C:PML body; IDA:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004672; F:protein kinase activity; ISS:UniProtKB.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO; GO:0004713; F:protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0009299; P:mRNA transcription; ISO:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
GO; GO:0043508; P:negative regulation of JUN kinase activity; IMP:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; IDA:UniProtKB.
GO; GO:0043388; P:positive regulation of DNA binding; ISS:UniProtKB.
GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
Apoptosis; ATP-binding; Cytoplasm; Isopeptide bond; Kinase;
Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Transcription; Transcription regulation;
Transferase; Ubl conjugation.
CHAIN 1..1192
/note="Homeodomain-interacting protein kinase 3"
/id="PRO_0000085999"
DOMAIN 197..525
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 203..211
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
REGION 767..921
/note="Interaction with AR"
/evidence="ECO:0000250"
REGION 775..868
/note="Interaction with FAS"
/evidence="ECO:0000269|PubMed:11034606"
REGION 832..988
/note="Required for localization to nuclear speckles"
/evidence="ECO:0000250"
REGION 843..895
/note="SUMO interaction motifs (SIM); required for nuclear
localization and kinase activity"
/evidence="ECO:0000250"
REGION 847..857
/note="Interaction with UBL1"
/evidence="ECO:0000250"
COMPBIAS 887..939
/note="Ser-rich"
ACT_SITE 322
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 226
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 359
/note="Phosphotyrosine"
/evidence="ECO:0000244|PubMed:18034455,
ECO:0000244|PubMed:21183079"
CROSSLNK 27
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO); alternate"
/evidence="ECO:0000250"
CROSSLNK 27
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2); alternate"
/evidence="ECO:0000250|UniProtKB:Q9H422"
CROSSLNK 1185
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO)"
/evidence="ECO:0000250"
MUTAGEN 226
/note="K->R: Loss of kinase activity and impaired
activation of SF1."
/evidence="ECO:0000269|PubMed:11034606,
ECO:0000269|PubMed:17210646"
MUTAGEN 226
/note="K->S: Impairs catalytic activity."
/evidence="ECO:0000269|PubMed:11034606,
ECO:0000269|PubMed:17210646"
MUTAGEN 322
/note="D->N: Impairs catalytic activity and abolishes
interaction with DAXX."
/evidence="ECO:0000269|PubMed:11034606"
CONFLICT 65
/note="K -> N (in Ref. 1; AAC63012)"
/evidence="ECO:0000305"
CONFLICT 405
/note="Y -> H (in Ref. 1; AAC63012)"
/evidence="ECO:0000305"
CONFLICT 813
/note="G -> R (in Ref. 1; AAC63012, 2; AAG25989 and 3;
AAD52570)"
/evidence="ECO:0000305"
CONFLICT 985
/note="D -> G (in Ref. 1; AAC63012 and 3; AAD52570)"
/evidence="ECO:0000305"
CONFLICT 1084
/note="A -> D (in Ref. 1; AAC63012)"
/evidence="ECO:0000305"
CONFLICT 1186
/note="L -> V (in Ref. 1; AAC63012)"
/evidence="ECO:0000305"
SEQUENCE 1192 AA; 130081 MW; D153322BAFB5F3F9 CRC64;
MASQVLVYPP YVYQTQSSAF CSVKKLKVEP SGCVFQERTY PQIHVNGRNF GNSHPSTKGS
AFQTKIPFTK PRGHSFSLQA GAIVVKDTAG ATKVLAAQAQ QAGVEAPRAV VWRNRLHFLE
GPQRCGLKRK SEELENHSGA MQIVDELSIL PAMLQTNMGN PVTVVTATTG SKQNCTSGEG
DYQLVQHEVL CSMKNTYEVL DFLGRGTFGQ VVKCWKRGTN EIVAIKILKN HPSYARQGQI
EVSILARLST ENADEYNFVR AYECFQHRNH TCLVFEMLEQ NLYDFLKQNK FSPLPLKVIR
PVLQQVATAL KKLKSLGLIH ADLKPENIML VDPVRQPYRV KVIDFGSASH VSKTVCSTYL
QSRYYRAPEI ILGLPFCEAI DMWSLGCVIA ELFLGWPLYP GALEYDQIRY ISQTQGLPGE
QLLNVGTKST RFFCRETDMS HSGWRLKTLE EHEAETGMKS KEARKYIFNS LDDIVHVNTV
MDLEGGDLLA EKADRREFVN LLKKMLLIDA DLRITPIETL NHPFVNMKHL LDFPHSNHVK
SCFHIMDICK SPSSCETNNH SKMSLLRPVA SNGTAALAAN FTKVGTLRSQ ALTTSAHSVV
HHGIPLQAGT AQFGCGDAFH QTLIICPPAI QGIPAAHGKP TSYSIRVDNT VPLVTQAPAV
QPLQIRPGVL SQQTWSGRTQ QMLIPAWQQV TPMAPAAATL TSEGMAGSQR LGDWGKMIPH
SNHYNSVMPP PLLTNQITLS APQPISVGIA HVVWPQPATT KKNKLCQNRS NSLQNTNIPH
SAFISPKIIS GKEVEEVSCV DTQDNHTSEG EAGTCREASV RQDSSVSDKQ RQTIIIADSP
SPAVSVITIS SDSDDEETSP RPSLRECKGS LDCEACQSTL NIDRMCSLSS PDSTLSTSSS
GQSSPSPCKR PNSMSDDEQE SGCETVDGSP TSDSSGHDSP FAENSFVEDA HQNTELGTCA
GPEAKPAVGT AVEPPVGRES GLSVDEHMAN TDSTCQPLRK GQPAPGKLHQ PPALGARQQK
PAAAFPQQHL NLSQVQHFGT GHQEWNGNFG HRRQQAYIPT SVTSNPFTLS HGSPNHTAVH
AHLAGSTHLG GQPTLLPYPS SASLSSAAPV AHLLASPCTS RPMLQHPTYN ISHPSGIVHQ
VPVGINPRLL PSPTIHQTQY KPIFPPHSYI AASPAYTGFP LSPTKLSQYP YM


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[RIPK4 ANKRD3 DIK] Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
[DAPK3 ZIPK] Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase)
[Ripk1 Rinp Rip] Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
[HIPK2] Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)
[Ripk2] Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
[CIPK7 PKS7 SnRK3.10 SR2 SRPK1 At3g23000 MXC7.3] CBL-interacting serine/threonine-protein kinase 7 (EC 2.7.11.1) (SNF1-related kinase 3.10) (SOS2-like protein kinase PKS7) (Serine/threonine-protein kinase SR2) (AtSR2) (AtSRPK1)
[hpk-1 F20B6.8] Homeodomain-interacting protein kinase 1 (EC 2.7.11.1)
[Mknk2 Mnk2] MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)
[CIPK14 PKS24 SnRK3.15 SR1 At5g01820 T20L15.90] CBL-interacting serine/threonine-protein kinase 14 (EC 2.7.11.1) (SNF1-related kinase 3.15) (SOS2-like protein kinase PKS24) (Serine/threonine-protein kinase SR1) (AtSR1)
[CIPK6 PKS4 SIP3 SnRK3.14 At4g30960 F6I18.130] CBL-interacting serine/threonine-protein kinase 6 (EC 2.7.11.1) (SNF1-related kinase 3.14) (SOS2-like protein kinase PKS4) (SOS3-interacting protein 3)
[Cit Crik] Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Rho-interacting, serine/threonine-protein kinase 21)
[CIPK24 SnRK3.11 SOS2 At5g35410 F6I13.1 K21B8.3] CBL-interacting serine/threonine-protein kinase 24 (EC 2.7.11.1) (Protein SALT OVERLY SENSITIVE 2) (SNF1-related kinase 3.11)
[RIPK2] Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
[CIPK23 LKS1 PKS17 SnRK3.23 At1g30270 F12P21.6] CBL-interacting serine/threonine-protein kinase 23 (EC 2.7.11.1) (Protein LOW-K(+)-SENSITIVE 1) (SNF1-related kinase 3.23) (SOS2-like protein kinase PKS17)
[CIPK9 PKS6 SnRK3.12 At1g01140 F6F3.28 T25K16.13] CBL-interacting serine/threonine-protein kinase 9 (EC 2.7.11.1) (SNF1-related kinase 3.12) (SOS2-like protein kinase PKS6)
[UHMK1 KIS KIST] Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (PAM COOH-terminal interactor protein 2) (P-CIP2) (U2AF homology motif kinase 1)
[Cit CRIK] Citron rho-interacting kinase (CRIK) (EC 2.7.11.1) (Rho-interacting, serine/threonine-protein kinase 21)
[mnk-1 R166.5] MAP kinase-interacting serine/threonine-protein kinase mnk-1 (EC 2.7.11.1) (MAP kinase integrating kinase-1)
[MAP4K2 GCK RAB8IP] Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)
[ZC3HC1 NIPA HSPC216] Nuclear-interacting partner of ALK (Nuclear-interacting partner of anaplastic lymphoma kinase) (hNIPA) (Zinc finger C3HC-type protein 1)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[Gsk3b] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[NCOA3 AIB1 BHLHE42 RAC3 TRAM1] Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
[TNNI3K CARK] Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase)
[MIK1 PXL2 At4g28650 T5F17.100] MDIS1-interacting receptor like kinase 1 (AtMIK1) (Leucine-rich repeat receptor-like protein kinase PXL2) (EC 2.7.11.1) (Protein PHLOEM INTERCALATED WITH XYLEM-LIKE 2)
[PKM OIP3 PK2 PK3 PKM2] Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58)
[DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P] Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496)

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