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Homologous recombination OB-fold protein

 HROB_HUMAN              Reviewed;         647 AA.
Q8N3J3; A8K7A9; Q9BWM9; Q9HAI1;
29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
29-SEP-2021, entry version 128.
RecName: Full=Homologous recombination OB-fold protein {ECO:0000303|PubMed:31467087};
Name=HROB {ECO:0000312|HGNC:HGNC:28460}; Synonyms=C17orf53;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
TISSUE=Embryo, and Neuroepithelioma;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Melanoma;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in the
human lineage.";
Nature 440:1045-1049(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT PRO-126.
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[7]
METHYLATION [LARGE SCALE ANALYSIS] AT ARG-285; ARG-295; ARG-329 AND
ARG-337, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Colon carcinoma;
PubMed=24129315; DOI=10.1074/mcp.o113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
[8]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH MCM8.
PubMed=31467087; DOI=10.1101/gad.329508.119;
Hustedt N., Saito Y., Zimmermann M., Alvarez-Quilon A., Setiaputra D.,
Adam S., McEwan A., Yuan J.Y., Olivieri M., Zhao Y., Kanemaki M.T.,
Jurisicova A., Durocher D.;
"Control of homologous recombination by the HROB-MCM8-MCM9 pathway.";
Genes Dev. 33:1397-1415(2019).
-!- FUNCTION: DNA-binding protein involved in homologous recombination that
acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA
damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}.
-!- SUBUNIT: Interacts with MCM8; this interaction is necessary for MCM8-
MCM9 helicase complex recruitment to DNA damage sites
(PubMed:31467087). Interacts with RPA1; this interaction associates
HROB with the RPA complex (By similarity).
{ECO:0000250|UniProtKB:Q32P12, ECO:0000269|PubMed:31467087}.
-!- INTERACTION:
Q8N3J3-3; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-11061081, EBI-726739;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31467087}. Chromosome
{ECO:0000269|PubMed:31467087}. Note=Localized to the sites of DNA
damage. {ECO:0000269|PubMed:31467087}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1;
IsoId=Q8N3J3-1; Sequence=Displayed;
Name=2;
IsoId=Q8N3J3-2; Sequence=VSP_025651, VSP_025652;
Name=3;
IsoId=Q8N3J3-3; Sequence=VSP_025653, VSP_025654, VSP_025655;
Name=4;
IsoId=Q8N3J3-4; Sequence=VSP_047077;
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EMBL; AK291924; BAF84613.1; -; mRNA.
EMBL; AK021656; BAB13867.1; -; mRNA.
EMBL; AL834295; CAD38968.1; -; mRNA.
EMBL; AC004596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC000121; AAH00121.1; -; mRNA.
CCDS; CCDS11477.1; -. [Q8N3J3-1]
CCDS; CCDS59293.1; -. [Q8N3J3-4]
CCDS; CCDS82136.1; -. [Q8N3J3-3]
RefSeq; NP_001164722.1; NM_001171251.2. [Q8N3J3-4]
RefSeq; NP_001308239.1; NM_001321310.1. [Q8N3J3-3]
RefSeq; NP_001308240.1; NM_001321311.1.
RefSeq; NP_076937.2; NM_024032.4. [Q8N3J3-1]
BioGRID; 122466; 17.
IntAct; Q8N3J3; 11.
MINT; Q8N3J3; -.
STRING; 9606.ENSP00000313500; -.
iPTMnet; Q8N3J3; -.
PhosphoSitePlus; Q8N3J3; -.
BioMuta; C17orf53; -.
DMDM; 74714855; -.
EPD; Q8N3J3; -.
jPOST; Q8N3J3; -.
MassIVE; Q8N3J3; -.
MaxQB; Q8N3J3; -.
PaxDb; Q8N3J3; -.
PeptideAtlas; Q8N3J3; -.
PRIDE; Q8N3J3; -.
ProteomicsDB; 71808; -. [Q8N3J3-1]
ProteomicsDB; 71809; -. [Q8N3J3-2]
ProteomicsDB; 71810; -. [Q8N3J3-3]
Antibodypedia; 17380; 197 antibodies.
DNASU; 78995; -.
Ensembl; ENST00000245382; ENSP00000245382; ENSG00000125319. [Q8N3J3-3]
Ensembl; ENST00000319977; ENSP00000313500; ENSG00000125319. [Q8N3J3-1]
Ensembl; ENST00000585683; ENSP00000466618; ENSG00000125319. [Q8N3J3-4]
GeneID; 78995; -.
KEGG; hsa:78995; -.
UCSC; uc002ifi.2; human. [Q8N3J3-1]
CTD; 78995; -.
DisGeNET; 78995; -.
GeneCards; HROB; -.
HGNC; HGNC:28460; HROB.
HPA; ENSG00000125319; Group enriched (bone marrow, lymphoid tissue, testis).
MIM; 618611; gene.
neXtProt; NX_Q8N3J3; -.
OpenTargets; ENSG00000125319; -.
PharmGKB; PA142672236; -.
VEuPathDB; HostDB:ENSG00000125319; -.
eggNOG; ENOG502QV5E; Eukaryota.
GeneTree; ENSGT00400000022305; -.
HOGENOM; CLU_028006_0_0_1; -.
InParanoid; Q8N3J3; -.
OMA; QQPHWEV; -.
OrthoDB; 1079551at2759; -.
PhylomeDB; Q8N3J3; -.
TreeFam; TF331108; -.
PathwayCommons; Q8N3J3; -.
BioGRID-ORCS; 78995; 40 hits in 996 CRISPR screens.
ChiTaRS; C17orf53; human.
GenomeRNAi; 78995; -.
Pharos; Q8N3J3; Tdark.
PRO; PR:Q8N3J3; -.
Proteomes; UP000005640; Chromosome 17.
RNAct; Q8N3J3; protein.
Bgee; ENSG00000125319; Expressed in lower esophagus muscularis layer and 124 other tissues.
Genevisible; Q8N3J3; HS.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0090734; C:site of DNA damage; IMP:UniProtKB.
GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:UniProtKB.
GO; GO:0000731; P:DNA synthesis involved in DNA repair; IMP:UniProtKB.
GO; GO:0007292; P:female gamete generation; ISS:UniProtKB.
GO; GO:0036297; P:interstrand cross-link repair; IMP:UniProtKB.
GO; GO:0048232; P:male gamete generation; ISS:UniProtKB.
GO; GO:0000725; P:recombinational repair; IEA:InterPro.
InterPro; IPR028045; HROB.
PANTHER; PTHR14523; PTHR14523; 1.
Pfam; PF15072; DUF4539; 1.
1: Evidence at protein level;
Alternative splicing; Chromosome; DNA damage; DNA recombination;
DNA repair; DNA synthesis; DNA-binding; Methylation; Nucleus;
Phosphoprotein; Reference proteome.
CHAIN 1..647
/note="Homologous recombination OB-fold protein"
/id="PRO_0000288092"
REGION 284..361
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 380..399
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 581..631
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 284..309
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 316..337
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOD_RES 47
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:23186163"
MOD_RES 285
/note="Asymmetric dimethylarginine"
/evidence="ECO:0007744|PubMed:24129315"
MOD_RES 295
/note="Asymmetric dimethylarginine"
/evidence="ECO:0007744|PubMed:24129315"
MOD_RES 329
/note="Asymmetric dimethylarginine"
/evidence="ECO:0007744|PubMed:24129315"
MOD_RES 337
/note="Asymmetric dimethylarginine"
/evidence="ECO:0007744|PubMed:24129315"
VAR_SEQ 108..137
/note="SSWIGNQRRVTVTEVLRETARPQSSALHPL -> NCLNSSHSATPLGSLSAT
LHCSSTSASPSC (in isoform 2)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_025651"
VAR_SEQ 138..647
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_025652"
VAR_SEQ 409..484
/note="Missing (in isoform 3)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_025653"
VAR_SEQ 484
/note="Missing (in isoform 4)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_047077"
VAR_SEQ 592..597
/note="DSGSFQ -> MTWMDS (in isoform 3)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_025654"
VAR_SEQ 598..647
/note="Missing (in isoform 3)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_025655"
VARIANT 126
/note="T -> P (in dbSNP:rs227584)"
/evidence="ECO:0000269|PubMed:15489334"
/id="VAR_032393"
SEQUENCE 647 AA; 69771 MW; 087F0413951BCD43 CRC64;
MACSLQKLFA VEEEFEDEDF LSAVEDAENR FTGSLPVNAG RLRPVSSRPQ ETVQAQSSRL
LLLHPTAPSE ALGLPDLDLC LPASSTPSAD SRPSCIGAAP LRPVSTSSSW IGNQRRVTVT
EVLRETARPQ SSALHPLLTF ESQQQQVGGF EGPEQDEFDK VLASMELEEP GMELECGVSS
EAIPILPAQQ REGSVLAKKA RVVDLSGSCQ KGPVPAIHKA GIMSAQDESL DPVIQCRTPR
PPLRPGAVGH LPVPTALTVP TQQLHWEVCP QRSPVQALQP LQAARGTIQS SPQNRFPCQP
FQSPSSWLSG KAHLPRPRTP NSSCSTPSRT SSGLFPRIPL QPQAPVSSIG SPVGTPKGPQ
GALQTPIVTN HLVQLVTAAS RTPQQPTHPS TRAKTRRFPG PAGILPHQQS GRSLEDIMVS
APQTPTHGAL AKFQTEIVAS SQASVEEDFG RGPWLTMKST LGLDERDPSC FLCTYSIVMV
LRKQAALKQL PRNKVPNMAV MIKSLTRSTM DASVVFKDPT GEMQGTVHRL LLETCQNELK
PGSVLLLKQI GVFSPSLRNH YLNVTPNNLV HIYSPDSGDG SFLKPSQPFP KDSGSFQHDV
AAKPEEGFRT AQNLEAEASP EEELPEADDL DGLLSELPED FFCGTSS


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WP861: Non-homologous end joining
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WP1493: Carbon assimilation C4 pathway
WP1714: Tyrosine metabolism
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Related Genes :
[HROB C17orf53] Homologous recombination OB-fold protein
[Hrob] Homologous recombination OB-fold protein
[mbnA MettrDRAFT_4473] Methanobactin mb-OB3b (Copper-binding compound) (CBC) (Hydrogen peroxide reductase) (EC 1.11.1.-) (Superoxide dismutase) (EC 1.15.1.1)
[MHR1 XTC1 YDR296W] Mitochondrial homologous recombination protein 1 (Cross-linked transcription component 1) (Mitochondrial large ribosomal subunit protein mL67)
[Meiob] Meiosis-specific with OB domain-containing protein (EC 3.1.-.-) (Protein expressed in male leptotene and zygotene spermatocytes 675) (MLZ-675)
[ligD MSMEG_5570 MSMEI_5419] Multifunctional non-homologous end joining protein LigD (NHEJ DNA polymerase) [Includes: DNA repair polymerase (Pol) (Polymerase/primase); 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase) (PE); DNA ligase (Lig) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])]
[ligD PA2138] Multifunctional non-homologous end joining protein LigD (NHEJ DNA polymerase) [Includes: 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase); DNA ligase D (LigD) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]); DNA repair polymerase (Pol) (Polymerase/primase)]
[ligD Rv0938 MTCY08D9.01c MTCY10D7.36c] Multifunctional non-homologous end joining DNA repair protein LigD (NHEJ DNA repair protein D) (Mt-Lig) (NHEJ DNA polymerase) [Includes: DNA repair polymerase (Pol) (Polymerase/primase); 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase) (PE); DNA ligase (Lig) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])]
[Hrob] Homologous recombination OB-fold protein
[MEIOB C16orf73] Meiosis-specific with OB domain-containing protein (EC 3.1.-.-)
[NABP2 OBFC2B SSB1 LP3587] SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1)
[NABP1 OBFC2A SSB2] SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2)
[Nabp1 Obfc2a Ssb2] SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2)
[zhp-3 K02B12.8] Zip homologous protein 3 (Zip3-homologous protein)
[NHEJ1 XLF] Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)
[Psmc3ip Hop2 Tbpip] Homologous-pairing protein 2 homolog (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) (Tat-binding protein 1-interacting protein) (TBP-1-interacting protein)
[Nhej1 Xlf] Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)
[PSMC3IP HOP2 TBPIP] Homologous-pairing protein 2 homolog (Nuclear receptor coactivator GT198) (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) (Tat-binding protein 1-interacting protein) (TBP-1-interacting protein)
[Psmc3ip] Homologous-pairing protein 2 homolog (Nuclear receptor coactivator GT198) (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein)
[NEJ1 LIF2 YLR265C] Non-homologous end-joining protein 1
[Nabp2 Obfc2b Ssb1] SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1)
[RAD54L RAD54A] DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54)
[CYREN C7orf49 MRI] Cell cycle regulator of non-homologous end joining (Cell cycle regulator of NHEJ) (Modulator of retrovirus infection homolog)
[ligD BQ2027_MB0963] Multifunctional non-homologous end joining protein LigD (NHEJ DNA polymerase) [Includes: DNA repair polymerase (Pol) (Polymerase/primase); 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase) (PE); DNA ligase (Lig) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])]
[Ddit3 Chop Chop10 Gadd153] DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153)
[DDIT3 CHOP CHOP10 GADD153] DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)
[PAIR2 ASY1 Os09g0506800 LOC_Os09g32930 OSNPB_090506800] Meiosis-specific protein PAIR2 (OsASY1) (Protein HOMOLOGOUS PAIRING ABERRATION IN RICE MEIOSIS 2)
[MRE11 HNGS1 MRE11A] Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
[ligD MT0965] Multifunctional non-homologous end joining DNA repair protein LigD (NHEJ DNA repair protein D) (Mt-Lig) (NHEJ DNA polymerase) [Includes: DNA repair polymerase (Pol) (Polymerase/primase); 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase) (PE); DNA ligase (Lig) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])]
[Hivep3 KBP1 Kiaa1555 Krc Rc shn3 Zas3] Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3 homolog) (KB-binding and recognition component) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Recombinant component) (Schnurri-3) (Zinc finger protein ZAS3)

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[34354233] ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection.
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[31467087] Control of homologous recombination by the HROB-MCM8-MCM9 pathway.
[30254264] An OB-fold complex controls the repair pathways for DNA double-strand breaks.
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