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Homologous-pairing protein 2 homolog (Nuclear receptor coactivator GT198) (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein)

 HOP2_RAT                Reviewed;         217 AA.
Q91ZY6;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
29-SEP-2021, entry version 104.
RecName: Full=Homologous-pairing protein 2 homolog;
AltName: Full=Nuclear receptor coactivator GT198;
AltName: Full=PSMC3-interacting protein;
AltName: Full=Proteasome 26S ATPase subunit 3-interacting protein;
Name=Psmc3ip;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH NR3C1; ESR2; THRB AND RXRA,
REGION, PHOSPHORYLATION, AND FUNCTION.
TISSUE=Pituitary;
PubMed=11739747; DOI=10.1128/mcb.22.1.357-369.2002;
Ko L., Cardona G.R., Henrion-Caude A., Chin W.W.;
"Identification and characterization of a tissue-specific coactivator,
GT198, that interacts with the DNA-binding domains of nuclear receptors.";
Mol. Cell. Biol. 22:357-369(2002).
-!- FUNCTION: Plays an important role in meiotic recombination. Stimulates
DMC1-mediated strand exchange required for pairing homologous
chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA,
stimulates the recombinase activity of DMC1 as well as DMC1 D-loop
formation from double-strand DNA. This complex stabilizes presynaptic
RAD51 and DMC1 filaments formed on single strand DNA to capture double-
strand DNA. This complex stimulates both synaptic and presynaptic
critical steps in RAD51 and DMC1-promoted homologous pairing. May
inhibit HIV-1 viral protein TAT activity and modulate the activity of
proteasomes through association with PSMC3 (By similarity). Plays a
role as a coactivator in nuclear receptor-mediated transcription.
{ECO:0000250, ECO:0000269|PubMed:11739747}.
-!- SUBUNIT: Forms a stable heterodimer with MND1. Interacts with
PSMC3/TBP1 (By similarity). Interacts with the DNA-binding domain of
the nuclear receptors NR3C1/GR, ESR2/ER-beta, THRB and RXRA.
{ECO:0000250, ECO:0000269|PubMed:11739747}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- PTM: Phosphorylated by PKA, PKC and MAPK.
{ECO:0000269|PubMed:11739747}.
-!- SIMILARITY: Belongs to the HOP2 family. {ECO:0000305}.
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EMBL; AF352812; AAL23906.1; -; mRNA.
RefSeq; NP_604453.2; NM_134458.2.
SMR; Q91ZY6; -.
BioGRID; 250872; 1.
CORUM; Q91ZY6; -.
STRING; 10116.ENSRNOP00000027159; -.
iPTMnet; Q91ZY6; -.
PhosphoSitePlus; Q91ZY6; -.
PaxDb; Q91ZY6; -.
GeneID; 140938; -.
KEGG; rno:140938; -.
UCSC; RGD:621885; rat.
CTD; 29893; -.
RGD; 621885; Psmc3ip.
eggNOG; KOG4603; Eukaryota.
InParanoid; Q91ZY6; -.
OrthoDB; 1498024at2759; -.
PhylomeDB; Q91ZY6; -.
PRO; PR:Q91ZY6; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0050681; F:androgen receptor binding; IDA:RGD.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0050692; F:DNA binding domain binding; IDA:RGD.
GO; GO:0030331; F:estrogen receptor binding; IDA:RGD.
GO; GO:0035259; F:glucocorticoid receptor binding; IDA:RGD.
GO; GO:0030374; F:nuclear receptor coactivator activity; IDA:RGD.
GO; GO:0044877; F:protein-containing complex binding; IMP:RGD.
GO; GO:0046966; F:thyroid hormone receptor binding; IDA:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:RGD.
GO; GO:0065003; P:protein-containing complex assembly; TAS:RGD.
GO; GO:0007131; P:reciprocal meiotic recombination; IEA:InterPro.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR040461; Hop2.
InterPro; IPR010776; Hop2_WH_dom.
InterPro; IPR040661; LZ3wCH.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
PANTHER; PTHR15938; PTHR15938; 1.
Pfam; PF18517; LZ3wCH; 1.
Pfam; PF07106; TBPIP; 1.
SUPFAM; SSF46785; SSF46785; 1.
1: Evidence at protein level;
Coiled coil; DNA recombination; DNA-binding; Meiosis; Nucleus;
Reference proteome.
CHAIN 1..217
/note="Homologous-pairing protein 2 homolog"
/id="PRO_0000314137"
REGION 89..117
/note="Interaction with NR3C1, homodimerization and
transcriptional activation almost abolished when missing"
/evidence="ECO:0000269|PubMed:11739747"
REGION 118..182
/note="DNA binding"
/evidence="ECO:0000250"
REGION 118..182
/note="Interaction with NR3C1 decreased when missing"
COILED 93..153
/evidence="ECO:0000255"
SEQUENCE 217 AA; 24768 MW; 422C1F1ED22EAD63 CRC64;
MSKSRAEAAA GAPGIVLRYL QEQNRPYSAQ DVFGNLQKEH GLGKAAVVKA LDQLAQQGKI
KEKTYGKQKI YFADQDQFDT VSDADLHSLD ASIMALTAKV QGLQQSCRHM EAELKELTSA
LTTPEMQTEI QELKKECARY TERLKNIKAA TNHVTPEEKE KVYRERQKYC KEWRKRKRMT
TELCDAILEG YPKSKKQFFE EVGIETDEDH NVTLPNP


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Bibliography :