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Hsp70-Hsp90 organizing protein 1 (GmHop-1) (Heat shock protein STI) (GmSTI) (Stress-inducible protein)

 HSOP1_SOYBN             Reviewed;         572 AA.
Q43468; A0A0R0FCV3; I1MUX1;
16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
16-APR-2014, sequence version 2.
02-JUN-2021, entry version 117.
RecName: Full=Hsp70-Hsp90 organizing protein 1;
Short=GmHop-1;
AltName: Full=Heat shock protein STI;
Short=GmSTI;
AltName: Full=Stress-inducible protein;
Name=HOP1; Synonyms=STI; OrderedLocusNames=Glyma17g137700;
Glycine max (Soybean) (Glycine hispida).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
Glycine subgen. Soja.
NCBI_TaxID=3847 {ECO:0000312|EMBL:CAA56165.1};
[1] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
STRAIN=cv. Williams {ECO:0000312|EMBL:CAA56165.1};
TISSUE=Epicotyl {ECO:0000312|EMBL:CAA56165.1};
PubMed=7766904; DOI=10.1007/bf00020896;
Torres J.H., Chatellard P., Stutz E.;
"Isolation and characterization of gmsti, a stress-inducible gene from
soybean (Glycine max) coding for a protein belonging to the TPR
(tetratricopeptide repeats) family.";
Plant Mol. Biol. 27:1221-1226(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Williams 82; TISSUE=Callus;
PubMed=20075913; DOI=10.1038/nature08670;
Schmutz J., Cannon S.B., Schlueter J., Ma J., Mitros T., Nelson W.,
Hyten D.L., Song Q., Thelen J.J., Cheng J., Xu D., Hellsten U., May G.D.,
Yu Y., Sakurai T., Umezawa T., Bhattacharyya M.K., Sandhu D.,
Valliyodan B., Lindquist E., Peto M., Grant D., Shu S., Goodstein D.,
Barry K., Futrell-Griggs M., Abernathy B., Du J., Tian Z., Zhu L., Gill N.,
Joshi T., Libault M., Sethuraman A., Zhang X.-C., Shinozaki K.,
Nguyen H.T., Wing R.A., Cregan P., Specht J., Grimwood J., Rokhsar D.,
Stacey G., Shoemaker R.C., Jackson S.A.;
"Genome sequence of the palaeopolyploid soybean.";
Nature 463:178-183(2010).
[3]
FUNCTION, INTERACTION WITH HSP90, MUTAGENESIS OF 327-THR--GLN-397, TISSUE
SPECIFICITY, AND INDUCTION BY ABIOTIC STRESS.
PubMed=12586877; DOI=10.1104/pp.011940;
Zhang Z., Quick M.K., Kanelakis K.C., Gijzen M., Krishna P.;
"Characterization of a plant homolog of hop, a cochaperone of hsp90.";
Plant Physiol. 131:525-535(2003).
-!- FUNCTION: Mediates nuclear encoded chloroplast preproteins binding to
HSP90 prior to chloroplastic sorting (By similarity). Mediates the
association of the molecular chaperones HSP70 and HSP90. {ECO:0000250,
ECO:0000269|PubMed:12586877}.
-!- SUBUNIT: Co-chaperone that forms a complex with HSP70 and HSP90 and
preproteins (e.g. chloroplast preproteins) (By similarity). Interacts
with HSP90. {ECO:0000250, ECO:0000269|PubMed:12586877}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed ubiquitously, with maximal expression in
cotyledons, followed by shoots and flowers.
{ECO:0000269|PubMed:12586877}.
-!- INDUCTION: By heat shock, heat, cold shock and wounding.
{ECO:0000269|PubMed:12586877, ECO:0000269|PubMed:7766904}.
-!- DOMAIN: The tetratricopeptide repeat (TPR) domain, forming a
carboxylate clamp (CC), mediates interaction with the highly conserved
'EEVD' motif at the C-terminal ends of HSP90 and HSP70. {ECO:0000250}.
-!- PTM: Phosphorylated. {ECO:0000250}.
-!- PTM: Acetylated. {ECO:0000250}.
-!- SEQUENCE CAUTION:
Sequence=CAA56165.1; Type=Frameshift; Evidence={ECO:0000305};
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EMBL; CM000850; KRH04070.1; -; Genomic_DNA.
EMBL; X79770; CAA56165.1; ALT_FRAME; mRNA.
PIR; S56658; S56658.
RefSeq; NP_001236261.1; NM_001249332.1.
SMR; Q43468; -.
STRING; 3847.GLYMA17G14660.1; -.
PRIDE; Q43468; -.
ProMEX; Q43468; -.
EnsemblPlants; KRH04070; KRH04070; GLYMA_17G137700.
GeneID; 547932; -.
Gramene; KRH04070; KRH04070; GLYMA_17G137700.
KEGG; gmx:547932; -.
eggNOG; KOG0548; Eukaryota.
HOGENOM; CLU_000134_46_5_1; -.
InParanoid; Q43468; -.
OrthoDB; 1070087at2759; -.
Proteomes; UP000008827; Chromosome 17.
Genevisible; Q43468; GM.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0051879; F:Hsp90 protein binding; IDA:UniProtKB.
GO; GO:0070678; F:preprotein binding; ISS:UniProtKB.
GO; GO:0070417; P:cellular response to cold; IEP:UniProtKB.
GO; GO:0034605; P:cellular response to heat; IEP:UniProtKB.
GO; GO:0051131; P:chaperone-mediated protein complex assembly; IDA:UniProtKB.
GO; GO:0009408; P:response to heat; IDA:UniProtKB.
GO; GO:0006986; P:response to unfolded protein; IDA:UniProtKB.
GO; GO:0009611; P:response to wounding; IEP:UniProtKB.
Gene3D; 1.25.40.10; -; 3.
InterPro; IPR041243; STI1.
InterPro; IPR006636; STI1_HS-bd.
InterPro; IPR013026; TPR-contain_dom.
InterPro; IPR011990; TPR-like_helical_dom_sf.
InterPro; IPR001440; TPR_1.
InterPro; IPR019734; TPR_repeat.
Pfam; PF17830; STI1; 2.
Pfam; PF00515; TPR_1; 1.
SMART; SM00727; STI1; 2.
SMART; SM00028; TPR; 9.
SUPFAM; SSF48452; SSF48452; 1.
PROSITE; PS50005; TPR; 9.
PROSITE; PS50293; TPR_REGION; 2.
1: Evidence at protein level;
Acetylation; Chaperone; Cytoplasm; Nucleus; Phosphoprotein;
Reference proteome; Repeat; Stress response; TPR repeat.
CHAIN 1..572
/note="Hsp70-Hsp90 organizing protein 1"
/id="PRO_0000106328"
REPEAT 2..35
/note="TPR 1"
/evidence="ECO:0000305"
REPEAT 37..69
/note="TPR 2"
REPEAT 70..103
/note="TPR 3"
DOMAIN 142..181
/note="STI1 1"
REPEAT 244..277
/note="TPR 4"
REPEAT 279..311
/note="TPR 5"
REPEAT 319..356
/note="TPR 6"
REPEAT 383..416
/note="TPR 7"
REPEAT 417..450
/note="TPR 8"
REPEAT 451..484
/note="TPR 9"
DOMAIN 521..560
/note="STI1 2"
REGION 192..253
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOTIF 241..258
/note="Bipartite nuclear localization signal"
/evidence="ECO:0000255"
COMPBIAS 234..253
/note="Basic and acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MUTAGEN 327..397
/note="Missing: Loss of binding with HSP90."
/evidence="ECO:0000269|PubMed:12586877"
SEQUENCE 572 AA; 64178 MW; C0F7CAB4E4E0403C CRC64;
MAEEAKAKGN AAFSAGDFAA AVRHFSDAIA LSPSNHVLYS NRSAAHASLQ NYAEALADAQ
KTVDLKPDWP KAYSRLGAAH LGLRRHRDAF SAYKTGLQLD PDNAALKSGL ADAQAAASRP
PPTSPFATAF SGPDMWARLT ADPTARANLQ DPEFVKIMQD IQKDPNKFNL HLSDQRVMHA
IGVLLNVKIQ TPNHDENDHD ADDDVSEDEV VSQPEPEHEP EAAVEVAEEE EEEEKETRDR
KGQAQKEKEA GNAAYKKKDF ETAIGHYSKA LELDDEDISY LTNRAAVYLE MGKFEDCIKD
CEKAVERGKE LRSDYKMIAR ALTRKGTALA KMAKCSKDFE PAIEIFQKAL TENRNPDTLK
KLNEAEKAKK ELEQQEYFDP KLADEAREKG NELFKQQKYP EATKHYTEAI KRNPKDAKAY
SNRAACYTKL GAMPEGLKDA EKCIELDPTF SKGYTRKGAV QFSMKEYDKA LETYREGLKH
DPNNQELLDG IRRCVEQINK ASRGDFTPEE LKERQAKAMQ DPEIQSILQD PVMTQVLTDF
QENPRAAEEH VKNPMVMNKI QKLISAGIVQ MR


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Catalog number Product name Quantity
GWB-C3E55D Anti- STIP1 (stress-induced-phosphoprotein 1 (Hsp70 Hsp90-organizing protein)) Antibody
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10-782-55038 Heat-shock protein beta-1 - HspB1; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein N_A 0.05 mg
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18-785-210205 HSP27 (Phospho-Ser15) - HspB1; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein Polyclonal 0.1 mg
18-785-210207 HSP27 (Phospho-Ser82) - HspB1; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein Polyclonal 0.05 mg
18-785-210206 HSP27 (Phospho-Ser78) - HspB1; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein Polyclonal 0.05 mg
18-785-210207 HSP27 (Phospho-Ser82) - HspB1; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein Polyclonal 0.1 mg
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18-785-210208 HSP27 (Ab-15) - HspB1; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein Polyclonal 0.1 mg
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Pathways :
WP2199: Seed Development
WP1502: Mitochondrial biogenesis
WP1672: Mismatch repair
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WP731: Sterol regulatory element binding protein related
WP1613: 1,4-Dichlorobenzene degradation
WP1939: Unfolded Protein Response
WP813: G Protein Signaling Pathways
WP1676: Non-homologous end-joining
WP1689: Porphyrin and chlorophyll metabolism
WP35: G Protein Signaling Pathways
WP1625: Base excision repair
WP2032: TSH signaling pathway
WP1654: gamma-Hexachlorocyclohexane degradation
WP211: BMP signaling pathway
WP1371: G Protein Signaling Pathways
WP1693: Purine metabolism
WP1438: Influenza A virus infection
WP1713: Two-component system
WP525: Mitochondrial Unfolded-Protein Response
WP2203: TSLP Signaling Pathway
WP1665: Limonene and pinene degradation
WP2292: Chemokine signaling pathway

Related Genes :
[sti-1 R09E12.3] Stress-induced-phosphoprotein 1 (CeSTI1) (STI1) (Hsc70/Hsp90-organizing protein) (CeHop) (Hop)
[Hspa1b Hsp70-2 Hspa2] Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1)
[Hspa1a Hsp70-1 Hspa1] Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2)
[Hspa1a Hsp70-3 Hsp70A1] Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 3) (HSP70.3) (Hsp68)
[HSPA1A HSP70-1] Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70.1)
[Hsp90aa1 Hsp86 Hsp86-1 Hspca] Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Tumor-specific transplantation 86 kDa antigen) (TSTA)
[Hspa5 Grp78] Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
[HSP90AA1 HSP90A HSPC1 HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
[HSP90AB1 HSP90B HSPC2 HSPCB] Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84)
[HSPA1A HSP72 HSPA1 HSX70] Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1)
[Hspa1b Hcp70.1 Hsp70-1 Hsp70a1 Hspa1] Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 1) (HSP70.1)
[STI1 YOR027W OR26.17] Heat shock protein STI1
[HSPA1B HSP72] Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2)
[HSPA5 GRP78] Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
[Hsp90aa1 Hsp86 Hspca] Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86)
[HSP90AA1 HSP90A HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[HSP90AA1 HSP90A HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[HSP90AA1 HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[HSP90AA1 QtrA-10430] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[HSP90AA1 HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[Hsp90ab1 Hsp84 Hsp84-1 Hspcb] Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84) (Tumor-specific transplantation 84 kDa antigen) (TSTA)
[HSP90AA1 HSP90A HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[SSB1 YG101 YDL229W] Ribosome-associated molecular chaperone SSB1 (EC 3.6.4.10) (Cold-inducible protein YG101) (Heat shock protein SSB1) (Hsp70 chaperone Ssb)
[Hspa5 Grp78] Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) (Steroidogenesis-activator polypeptide)
[HSPA5 GRP78] Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
[HSPA5 GRP78] Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) (Fragment)
[HSPA5 GRP78] Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
[HSPA5 GRP78 I79_019946] Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
[HSPA1A HSPA1] Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70.1)
[hsp90a.1 hsp90 hsp90a hsp90aa1 zgc:86652] Heat shock protein HSP 90-alpha 1

Bibliography :