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INHB (Inhibin beta A subunit)

 F8SXW5_CAPHI            Unreviewed;       425 AA.
F8SXW5;
21-SEP-2011, integrated into UniProtKB/TrEMBL.
21-SEP-2011, sequence version 1.
13-FEB-2019, entry version 43.
SubName: Full=INHB {ECO:0000313|EMBL:AEP40508.1};
SubName: Full=Inhibin beta A subunit {ECO:0000313|EMBL:AEJ07667.1};
Name=INHBA {ECO:0000313|EMBL:AEJ07667.1};
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925 {ECO:0000313|EMBL:AEJ07667.1};
[1] {ECO:0000313|EMBL:AEJ07667.1}
NUCLEOTIDE SEQUENCE.
Quan Z.H.;
"Cloning and sequencing of inhibin beta A subunit (INHBA) mRNA in Dazu
black goat.";
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:AEP40508.1}
NUCLEOTIDE SEQUENCE.
PubMed=22128068; DOI=10.1002/mrd.22001;
Zi X.D., Xu H.W., Wang Y.;
"Variation in sequences and mRNA expression levels of inhibin subunits
? (INHA) and ?A (INHBA) genes between prolific and nonprolific goat
breeds.";
Mol. Reprod. Dev. 79:238-238(2012).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
-!- SIMILARITY: Belongs to the TGF-beta family.
{ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
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EMBL; HQ699621; AEJ07667.1; -; mRNA.
EMBL; JN620336; AEP40508.1; -; mRNA.
RefSeq; NP_001272510.1; NM_001285581.1.
RefSeq; XP_013818788.1; XM_013963334.2.
UniGene; Chi.33311; -.
SMR; F8SXW5; -.
GeneID; 100860960; -.
KEGG; chx:100860960; -.
CTD; 3624; -.
KO; K04667; -.
OrthoDB; 1385831at2759; -.
GO; GO:0043509; C:activin A complex; IEA:Ensembl.
GO; GO:0043512; C:inhibin A complex; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005179; F:hormone activity; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
GO; GO:0070699; F:type II activin receptor binding; IEA:Ensembl.
GO; GO:0032924; P:activin receptor signaling pathway; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0035987; P:endodermal cell differentiation; IEA:Ensembl.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0061029; P:eyelid development in camera-type eye; IEA:Ensembl.
GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0097154; P:GABAergic neuron differentiation; IEA:Ensembl.
GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO; GO:0042541; P:hemoglobin biosynthetic process; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0048333; P:mesodermal cell differentiation; IEA:Ensembl.
GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0051799; P:negative regulation of hair follicle development; IEA:Ensembl.
GO; GO:0042476; P:odontogenesis; IEA:Ensembl.
GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0060279; P:positive regulation of ovulation; IEA:Ensembl.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0042701; P:progesterone secretion; IEA:Ensembl.
GO; GO:0046880; P:regulation of follicle-stimulating hormone secretion; IEA:Ensembl.
GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
GO; GO:0021773; P:striatal medium spiny neuron differentiation; IEA:Ensembl.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR000491; Inhibin_betaA.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
PRINTS; PR00670; INHIBINBA.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
Growth factor {ECO:0000256|RuleBase:RU000354,
ECO:0000256|SAAS:SAAS00516085};
Secreted {ECO:0000256|SAAS:SAAS00516087};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 425 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5007658882.
DOMAIN 305 425 TGF_BETA_2.
{ECO:0000259|PROSITE:PS51362}.
SEQUENCE 425 AA; 47565 MW; DAA8C5F0D2B1FD68 CRC64;
MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL ATLPKDVPNS QPEMVEAVKK
HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT
SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEIWLFLK VPKANRTRSK VTIRLFQQQK
HLQGSLDAGE EAEEVGLKGE KSEMLISEKV VDARKSTWHI FPVSSCIQRL LDQGKSSLDI
RIACEQCQET GASLVLLGKK KRKEEEGEGK KRDGEGGAGG DEEKEQSHRP FLMLQARQSE
DHPHRRRRRG LECDGKVNIC CKKQFYVSFK DIGWNDWIIA PSGYHANYCE GECPSHIAGT
SGSSLSFHST VINHYRMRGH SPFANLKSCC VPTKLRPMSM LYYDDGQNII KKDIQNMIVE
ECGCS


Related products :

Catalog number Product name Quantity
DL-INHB-Hu Human Inhibin B (INHB) ELISA Kit 96T
DL-INHB-b Bovine Inhibin B (INHB) ELISA Kit 96T
DL-INHB-Ra Rat Inhibin B (INHB) ELISA Kit 96T
32-181 INHA(A-inhibin subunit precursor, inhibin alpha subunit ),also called inhibin(alpha) ,which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion 0.1 mg
E90760Hu ELISA Kit for Inhibin B (INHB) 96T/Kit
E-EL-R1027 Rat INHB (Inhibin B) ELISA Kit 96T
E90760Ra ELISA Kit for Rat Inhibin B(INHB) 96T
E90760Ra ELISA Kit for Inhibin B (INHB) 96T/Kit
E90760Po ELISA Kit for Inhibin B (INHB) 96T/Kit
E-EL-H0313 Human INHB (Inhibin B) ELISA Kit 96T
E-EL-M0698 Mouse INHB (Inhibin B) ELISA Kit 96T
E90760Po ELISA Kit for Porcine Inhibin B(INHB) 96T
SEA760Ra ELISA Kit for Inhibin B (INHB) Rattus norvegicus (Rat) 96T
SEA760Bo ELISA Kit for Inhibin B (INHB) Bos taurus; Bovine (Cattle) 96T
SEA760Hu ELISA Kit for Inhibin B (INHB) Homo sapiens (Human) 96T
E90760Po ELISA Kit for Inhibin B (INHB) Organism: Sus scrofa; Porcine (Pig) 96T
E90760Po ELISA Kit for Inhibin B (INHB) Organism Sus scrofa (Porcine; Pig) 96T
E90760Ra ELISA Kit for Inhibin B (INHB) Organism: Rattus norvegicus (Rat) 96T
E90760Ra ELISA Kit for Inhibin B (INHB) Organism Rattus norvegicus (Rat) 96T
E90760Hu ELISA Kit for Inhibin B (INHB) Organism Homo sapiens (Human) 96T
E90760Bo ELISA Kit for Inhibin B (INHB) Organism: Bos taurus; Bovine (Cattle) 96T
E90760Hu ELISA Kit for Inhibin B (INHB) Organism: Homo sapiens (Human) 96T
26-810 INHA joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppress 0.05 mg
30-895 INHA joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppress 0.05 mg
PNb-014-I Activin-B (inactive) Human Host: Nicotiana benthamiana INHBBActivin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2 10

Kits Elisa; taq POLYMERASE

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Pathways :
WP1566: Citrate cycle (TCA cycle)
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP1045: TGF-beta Receptor Signaling Pathway
WP1048: TGF Beta Signaling Pathway
WP105: Fatty Acid Beta Oxidation 2
WP1058: Senescence and Autophagy
WP1061: Fatty Acid Beta Oxidation
WP1106: Keap1-Nrf2
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP113: TGF Beta Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1164: TGF Beta Signaling Pathway
WP1177: Fatty Acid Beta Oxidation
WP1207: Fatty Acid Beta Oxidation
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP1226: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1237: Fatty Acid Beta Oxidation
WP126: Fatty Acid Beta Oxidation 1
WP1269: Fatty Acid Beta Oxidation
WP1307: Fatty Acid Beta Oxidation
WP1367: TGF-beta Receptor Signaling Pathway
WP1370: TGF Beta Signaling Pathway
WP143: Fatty Acid Beta Oxidation

Related Genes :
[INHBA] Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF)
[INHBA] Inhibin beta A chain (Activin beta-A chain)
[INHBA] Inhibin beta A chain (Activin beta-A chain)
[Inhba] Inhibin beta A chain (Activin beta-A chain)
[INHBA] Inhibin beta A chain (Activin beta-A chain)
[INHBA] Inhibin beta A chain (Activin beta-A chain)
[INHBA] Inhibin beta A chain (Activin beta-A chain)
[Inhba] Inhibin beta A chain (Activin beta-A chain)
[INHBA] Inhibin beta A chain (Activin beta-A chain)
[Inhbb] Inhibin beta B chain (Activin beta-B chain)
[INHBB] Inhibin beta B chain (Activin beta-B chain)
[Inhbb] Inhibin beta B chain (Activin beta-B chain)
[INHBB] Inhibin beta B chain (Activin beta-B chain)
[INHBB] Inhibin beta B chain (Activin beta-B chain)
[MSMB PRSP] Beta-microseminoprotein (Immunoglobulin-binding factor) (IGBF) (PN44) (Prostate secreted seminal plasma protein) (Prostate secretory protein of 94 amino acids) (PSP-94) (PSP94) (Seminal plasma beta-inhibin)
[Actbeta activin-beta CG11062] Inhibin beta chain (Activin beta chain) (dAct) (dActivin)
[INHA] Inhibin alpha chain
[Inha] Inhibin alpha chain
[Inha] Inhibin alpha chain
[al-2 B22I21.230 NCU00585] Bifunctional lycopene cyclase/phytoene synthase (Protein albino-2) [Includes: Lycopene beta-cyclase (EC 5.5.1.19) (Carotene cyclase) (Lycopene cyclase); Phytoene synthase (EC 2.5.1.32)]
[SEMG1 SEMG] Semenogelin-1 (Cancer/testis antigen 103) (Semenogelin I) (SGI) [Cleaved into: Alpha-inhibin-92; Alpha-inhibin-31; Seminal basic protein]
[INHBB] Inhibin beta B chain (Activin beta-B chain)
[INHA] Inhibin alpha chain
[pep NCU02549] Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (Ubiquinol-cytochrome-c reductase complex core protein I)
[IGSF1 IGDC1 KIAA0364 PGSF2] Immunoglobulin superfamily member 1 (IgSF1) (Immunoglobulin-like domain-containing protein 1) (Inhibin-binding protein) (InhBP) (Pituitary gland-specific factor 2) (p120)
[B4GALT1 GGTB2] Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1]
[B4GALT1 GALT GGTB2] Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1]
[B4galt1 Ggtb Ggtb2] Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1]
[INHA] Inhibin alpha chain
[Ppp2r2b] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform BRB) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta)

Bibliography :
[28197932] Effect of GnRHa ovulation trigger dose on follicular fluid characteristics and granulosa cell gene expression profiles.
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