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IRF tryptophan pentad repeat domain-containing protein

 A0A2K5JJF6_COLAP        Unreviewed;       503 AA.
A0A2K5JJF6;
28-MAR-2018, integrated into UniProtKB/TrEMBL.
28-MAR-2018, sequence version 1.
11-DEC-2019, entry version 14.
SubName: Full=Interferon regulatory factor 7 {ECO:0000313|Ensembl:ENSCANP00000029008};
Name=IRF7 {ECO:0000313|Ensembl:ENSCANP00000029008};
Colobus angolensis palliatus (Peters' Angolan colobus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Colobinae; Colobus.
NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000029008, ECO:0000313|Proteomes:UP000233080};
[1] {ECO:0000313|Ensembl:ENSCANP00000029008, ECO:0000313|Proteomes:UP000233080}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Hughes D.S., Murali S., Raveendran M., Korchina V., Bandaranaike D.,
Bellair M., Blankenburg K., Chao H., Dahdouli M., Dinh H., Doddapaneni H.,
Gnanaolivu R., Gross S., Jayaseelan J., Jones J., Khan Z., Kovar C.,
Kurapati P., Le B., Lee S., Mathew T., Narasimhan A., Okwuonu G.,
Ongeri F., Osuji N., Qu C., Quiroz J., Rajbhandari K., Reid J.G.,
Santibanez J., Skinner E., Wang Y., Xin Y., Han Y., Muzny D.M.,
Richards S., Worley K.C., Rogers J., Gibbs R.A.;
"Black and white colobus reference genome project.";
Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSCANP00000029008}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
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RefSeq; XP_011785391.1; XM_011930001.1.
Ensembl; ENSCANT00000052124; ENSCANP00000029008; ENSCANG00000038035.
GeneID; 105503197; -.
CTD; 3665; -.
GeneTree; ENSGT00940000160931; -.
OrthoDB; 648909at2759; -.
Proteomes; UP000233080; Whole Genome Shotgun Assembly.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0001158; F:enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000987; F:proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0016064; P:immunoglobulin mediated immune response; IEA:Ensembl.
GO; GO:0032607; P:interferon-alpha production; IEA:Ensembl.
GO; GO:0032608; P:interferon-beta production; IEA:Ensembl.
GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002819; P:regulation of adaptive immune response; IEA:Ensembl.
GO; GO:0034124; P:regulation of MyD88-dependent toll-like receptor signaling pathway; IEA:Ensembl.
GO; GO:0034127; P:regulation of MyD88-independent toll-like receptor signaling pathway; IEA:Ensembl.
GO; GO:0045351; P:type I interferon biosynthetic process; IEA:Ensembl.
GO; GO:0060337; P:type I interferon signaling pathway; IEA:Ensembl.
CDD; cd00103; IRF; 1.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 2.60.200.10; -; 1.
InterPro; IPR019817; Interferon_reg_fac_CS.
InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
InterPro; IPR019471; Interferon_reg_factor-3.
InterPro; IPR017855; SMAD-like_dom_sf.
InterPro; IPR008984; SMAD_FHA_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
PANTHER; PTHR11949; PTHR11949; 1.
Pfam; PF00605; IRF; 1.
Pfam; PF10401; IRF-3; 1.
PRINTS; PR00267; INTFRNREGFCT.
SMART; SM00348; IRF; 1.
SMART; SM01243; IRF-3; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF49879; SSF49879; 1.
PROSITE; PS00601; IRF_1; 1.
PROSITE; PS51507; IRF_2; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000233080}.
DOMAIN 11..127
/note="IRF tryptophan pentad repeat"
/evidence="ECO:0000259|PROSITE:PS51507"
REGION 69..90
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 130..179
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 503 AA; 54354 MW; A7C923172529FD10 CRC64;
MALAPERAAP RVLFGEWLLG EISSGCYEGL QWLDEARTCF RVPWKHFARK DLSEADARIF
KAWAVARGRW PPSSRGGDPP PPEAEAAERA GWKTNFRCAL RSTRRFVMLR DNSGDPADPH
KVYALSPEPC WRGPGTDQTE AEAPAAVRPP QGRPPGPFLA HGDAGLQAPG PLPAPAGDKG
DLLLQAVQQS CLADHLLTAS WGADPVPAQA PGEGQEGLPL TGACAGGPGF PAGELCAWSV
EATPSPGPQP AALMTGEGTA PEPPHQAEPY LAPSPSACTA VQEPSPGALD VTIMYKGRTV
LQKVVGPPSC MFLYGPPDPA VRATDPQQVA FPSPAELPDQ KQLRYTEELL RHVAPGLQLE
LRGPQLWARR MGKCKVYWEV GGPPGSASPS TPACLLPRNC DTPIFDFRVF FRELVEFRAR
QRRGSPCYTI YLGFGQDLSA RRPKEKSLVL VKLEPWLCRV HLEGTQREGV SSLDSSSLSL
CLSSTNSLYD DIECLLMELE QPV


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