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Immunoglobulin superfamily member 21 (IgSF21)

 IGS21_MOUSE             Reviewed;         468 AA.
Q7TNR6;
21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
25-MAY-2022, entry version 131.
RecName: Full=Immunoglobulin superfamily member 21;
Short=IgSF21;
Flags: Precursor;
Name=Igsf21;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, INTERACTION WITH
NRXN2, DOMAIN, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=28864826; DOI=10.1038/s41467-017-00333-w;
Tanabe Y., Naito Y., Vasuta C., Lee A.K., Soumounou Y., Linhoff M.W.,
Takahashi H.;
"IgSF21 promotes differentiation of inhibitory synapses via binding to
neurexin2alpha.";
Nat. Commun. 8:408-408(2017).
-!- FUNCTION: Involved in synaptic inhibition in the brain. Selectively
regulates inhibitory presynaptic differentiation through interacting
with presynaptic NRXN2. {ECO:0000269|PubMed:28864826}.
-!- SUBUNIT: Interacts (Ig-like 1 domain) with NRXN2 (via Laminin G-like 1
domain) in a trans-interaction manner. {ECO:0000269|PubMed:28864826}.
-!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
membrane {ECO:0000269|PubMed:28864826}; Lipid-anchor, GPI-anchor
{ECO:0000269|PubMed:28864826}.
-!- TISSUE SPECIFICITY: Expressed in brain (at protein levels)
(PubMed:28864826). Highly expressed in the pyramidal cell layer of the
dorsal and ventral hippocampal CA1 and CA3 regions, layers 5 and 6 of
the cortex, the thalamus and the pons and weakly expressed in the
cerebellum (PubMed:28864826). Expressed in neurons but not in glia
(PubMed:28864826). {ECO:0000269|PubMed:28864826}.
-!- DEVELOPMENTAL STAGE: Expressed in the brain at both embryonic and
postnatal stages including the adult stage. The period of highest
expression of the long isoform is at around two postnatal weeks,
coinciding with the peak period of synaptogenesis.
{ECO:0000269|PubMed:28864826}.
-!- DOMAIN: Ig-like 1 domain is indispensable for synaptogenic activity
whereas Ig-like 2 domain is secondarily responsible for the activity.
{ECO:0000269|PubMed:28864826}.
-!- DISRUPTION PHENOTYPE: Mutants grow normally. They show an impaired
sensorimotor gating with no effect on motor activity and coordination.
{ECO:0000269|PubMed:28864826}.
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EMBL; BC055811; AAH55811.1; -; mRNA.
CCDS; CCDS18851.1; -.
RefSeq; NP_941012.1; NM_198610.2.
AlphaFoldDB; Q7TNR6; -.
IntAct; Q7TNR6; 2.
MINT; Q7TNR6; -.
STRING; 10090.ENSMUSP00000046558; -.
GlyConnect; 2382; 6 N-Linked glycans (1 site).
GlyGen; Q7TNR6; 3 sites, 6 N-linked glycans (1 site).
PhosphoSitePlus; Q7TNR6; -.
MaxQB; Q7TNR6; -.
PaxDb; Q7TNR6; -.
PeptideAtlas; Q7TNR6; -.
PRIDE; Q7TNR6; -.
ProteomicsDB; 269544; -.
Antibodypedia; 29423; 80 antibodies from 19 providers.
DNASU; 230868; -.
Ensembl; ENSMUST00000039331; ENSMUSP00000046558; ENSMUSG00000040972.
GeneID; 230868; -.
KEGG; mmu:230868; -.
UCSC; uc008vmu.2; mouse.
CTD; 84966; -.
MGI; MGI:2681842; Igsf21.
VEuPathDB; HostDB:ENSMUSG00000040972; -.
eggNOG; ENOG502QQMY; Eukaryota.
GeneTree; ENSGT00390000002421; -.
HOGENOM; CLU_054054_0_0_1; -.
InParanoid; Q7TNR6; -.
OMA; RPYTEHP; -.
OrthoDB; 422073at2759; -.
PhylomeDB; Q7TNR6; -.
TreeFam; TF331223; -.
BioGRID-ORCS; 230868; 3 hits in 71 CRISPR screens.
ChiTaRS; Igsf21; mouse.
PRO; PR:Q7TNR6; -.
Proteomes; UP000000589; Chromosome 4.
RNAct; Q7TNR6; protein.
Bgee; ENSMUSG00000040972; Expressed in brain and 85 other tissues.
Genevisible; Q7TNR6; MM.
GO; GO:0005912; C:adherens junction; IBA:GO_Central.
GO; GO:0031362; C:anchored component of external side of plasma membrane; IDA:UniProtKB.
GO; GO:0060077; C:inhibitory synapse; IDA:UniProtKB.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0042734; C:presynaptic membrane; IDA:UniProtKB.
GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
GO; GO:0060074; P:synapse maturation; IMP:UniProtKB.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 2.
SUPFAM; SSF48726; SSF48726; 3.
PROSITE; PS50835; IG_LIKE; 2.
1: Evidence at protein level;
Cell junction; Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor;
Immunoglobulin domain; Lipoprotein; Membrane; Postsynaptic cell membrane;
Reference proteome; Repeat; Signal; Synapse.
SIGNAL 1..24
/evidence="ECO:0000255"
CHAIN 25..468
/note="Immunoglobulin superfamily member 21"
/id="PRO_0000223339"
DOMAIN 25..132
/note="Ig-like 1"
DOMAIN 344..429
/note="Ig-like 2"
CARBOHYD 82
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 165
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 407
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 46..116
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SEQUENCE 468 AA; 51937 MW; B9577B5E9B66633D CRC64;
MQAAPSLRRA SCLLLAAILD LARGYLTVNI EPLPPVVAGD AVTLKCNFKT DGRMREIVWY
RVTDGGTIKQ KIFTFDAMFS TNYSHMENYR KREDLVYQST VRLPEVRISD NGPYECHVGI
YDRATREKVV LASGNIFLNV MAPPTSIEVV AADSPAPFSR YQAQNFTLVC IVSGGKPAPM
VYFKRDGEPI DAVPLTELPA ASSGPVQDSR PFRSLLHRDV DDTKMQKSLS LLDTEYRAGR
PYTERPARSL TQDPSLFVQP TTENIPETVV SREFPRWVHS AEPVYFLRHS RTPGSDGTVE
VRALLTWTLN PQIDNEALFS CEVKHPALSM PMQAEVTLVA PKGPKIMMTP SRARVGDTVR
ILVHGFQNEV FPEPMFTWTR VGSRLLDGSA EFDGKELVLE RVPAELNGSM YRCTAQNPLG
STDTHTRLIV FENPNIPRGT EDSRGSASGP AGVRLTLVLA LTVILELT


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