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Immunoglobulin-binding protein 1 (Alpha4 phosphoprotein) (CD79a-binding protein 1) (Lymphocyte signal transduction molecule alpha 4) (Protein phosphatase 2/4/6 regulatory subunit) (p52)

 IGBP1_MOUSE             Reviewed;         340 AA.
Q61249;
01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
07-APR-2021, entry version 147.
RecName: Full=Immunoglobulin-binding protein 1;
AltName: Full=Alpha4 phosphoprotein;
AltName: Full=CD79a-binding protein 1;
AltName: Full=Lymphocyte signal transduction molecule alpha 4;
AltName: Full=Protein phosphatase 2/4/6 regulatory subunit;
AltName: Full=p52;
Name=Igbp1; Synonyms=Pc52;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=NZC; TISSUE=B-cell;
PubMed=7876543;
Inui S., Kuwahara K., Mizutani J., Maeda K., Kawai T., Nakayasu H.,
Sakaguchi N.;
"Molecular cloning of a cDNA clone encoding a phosphoprotein component
related to the Ig receptor-mediated signal transduction.";
J. Immunol. 154:2714-2723(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63.
STRAIN=BALB/cJ; TISSUE=Liver;
PubMed=9573385; DOI=10.1016/s0378-1119(98)00079-1;
Maeda K., Inui S., Sanjo H., Sakaguchi N.;
"The gene structure and promoter analysis of mouse lymphocyte signal
transduction molecule alpha 4 that is related to the yeast TAP42 involved
in a rapamycin-sensitive pathway.";
Gene 210:287-295(1998).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[4]
X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1-223, AND INTERACTION WITH MID1
AND PPP2CA.
PubMed=21454489; DOI=10.1074/jbc.m111.222414;
LeNoue-Newton M., Watkins G.R., Zou P., Germane K.L., McCorvey L.R.,
Wadzinski B.E., Spiller B.W.;
"The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains
of the Alpha4 protein are both required for Alpha4 to inhibit PP2A
degradation.";
J. Biol. Chem. 286:17665-17671(2011).
-!- FUNCTION: Associated to surface IgM-receptor; may be involved in signal
transduction. Involved in regulation of the catalytic activity of the
phosphatases PP2A, PP4 and PP6 by protecting their partially folded
catalytic subunits from degradative polyubiquitination until they
associate with regulatory subunits.
-!- SUBUNIT: Interacts with PPP2CB, and with PP4 and PP6. Interacts with
MID2. Interacts with ubiquitin (By similarity). Interacts with
partially folded PPP2CA, but not with the fully active protein.
Interacts with MID1. {ECO:0000250, ECO:0000269|PubMed:21454489}.
-!- INTERACTION:
Q61249; P63330: Ppp2ca; NbExp=2; IntAct=EBI-7002233, EBI-397144;
Q61249; P67775: PPP2CA; Xeno; NbExp=3; IntAct=EBI-7002233, EBI-712311;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
-!- TISSUE SPECIFICITY: Expressed in spleen, thymus, liver and brain.
Ubiquitously expressed in B lineage cell lines.
-!- DOMAIN: The UIM domain is required for protective effect on PP2A.
-!- PTM: Phosphorylated.
-!- PTM: Monoubiquitination by MID1 triggers calpain-mediated cleavage and
switches IGBP1 activity from protective to destructive. {ECO:0000250}.
-!- SIMILARITY: Belongs to the IGBP1/TAP42 family. {ECO:0000305}.
---------------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; L31652; AAA67891.1; -; mRNA.
EMBL; AJ000633; CAA04190.1; -; Genomic_DNA.
EMBL; AJ223156; CAA11135.1; -; Genomic_DNA.
EMBL; AJ223157; CAA11135.1; JOINED; Genomic_DNA.
EMBL; AJ223158; CAA11135.1; JOINED; Genomic_DNA.
EMBL; AJ223159; CAA11135.1; JOINED; Genomic_DNA.
EMBL; AJ223160; CAA11135.1; JOINED; Genomic_DNA.
EMBL; AJ000634; CAA04191.1; -; Genomic_DNA.
CCDS; CCDS30302.1; -.
PIR; I49451; I49451.
RefSeq; NP_032810.4; NM_008784.3.
PDB; 3QC1; X-ray; 2.35 A; A=1-223.
PDBsum; 3QC1; -.
SMR; Q61249; -.
BioGRID; 202041; 28.
IntAct; Q61249; 4.
MINT; Q61249; -.
STRING; 10090.ENSMUSP00000033570; -.
iPTMnet; Q61249; -.
PhosphoSitePlus; Q61249; -.
REPRODUCTION-2DPAGE; Q61249; -.
EPD; Q61249; -.
jPOST; Q61249; -.
MaxQB; Q61249; -.
PaxDb; Q61249; -.
PeptideAtlas; Q61249; -.
PRIDE; Q61249; -.
ProteomicsDB; 269531; -.
Ensembl; ENSMUST00000033570; ENSMUSP00000033570; ENSMUSG00000031221.
GeneID; 18518; -.
KEGG; mmu:18518; -.
UCSC; uc009tvz.2; mouse.
CTD; 3476; -.
MGI; MGI:1346500; Igbp1.
eggNOG; KOG2830; Eukaryota.
GeneTree; ENSGT00390000002414; -.
HOGENOM; CLU_041824_1_0_1; -.
InParanoid; Q61249; -.
OMA; PFILTKD; -.
OrthoDB; 1348942at2759; -.
PhylomeDB; Q61249; -.
TreeFam; TF313433; -.
BioGRID-ORCS; 18518; 19 hits in 53 CRISPR screens.
ChiTaRS; Igbp1; mouse.
EvolutionaryTrace; Q61249; -.
PRO; PR:Q61249; -.
Proteomes; UP000000589; Chromosome X.
RNAct; Q61249; protein.
Bgee; ENSMUSG00000031221; Expressed in vas deferens and 315 other tissues.
Genevisible; Q61249; MM.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005874; C:microtubule; IGI:UniProtKB.
GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO; GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:UniProtKB.
GO; GO:0019904; F:protein domain specific binding; IDA:UniProtKB.
GO; GO:0051721; F:protein phosphatase 2A binding; ISO:MGI.
GO; GO:0019888; F:protein phosphatase regulator activity; ISO:MGI.
GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IMP:MGI.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
GO; GO:0035308; P:negative regulation of protein dephosphorylation; IDA:UniProtKB.
GO; GO:0032873; P:negative regulation of stress-activated MAPK cascade; ISO:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0035306; P:positive regulation of dephosphorylation; IMP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
GO; GO:0035303; P:regulation of dephosphorylation; IBA:GO_Central.
GO; GO:0060632; P:regulation of microtubule-based movement; ISO:MGI.
GO; GO:0070555; P:response to interleukin-1; ISO:MGI.
GO; GO:0034612; P:response to tumor necrosis factor; ISO:MGI.
Gene3D; 1.25.40.540; -; 1.
InterPro; IPR038511; TAP42/TAP46-like_sf.
InterPro; IPR007304; TAP46-like.
PANTHER; PTHR10933; PTHR10933; 1.
Pfam; PF04177; TAP42; 1.
1: Evidence at protein level;
3D-structure; Acetylation; B-cell activation; Chaperone; Cytoplasm;
Phosphoprotein; Reference proteome; Ubl conjugation.
CHAIN 1..340
/note="Immunoglobulin-binding protein 1"
/id="PRO_0000218619"
DOMAIN 47..61
/note="UIM"
/evidence="ECO:0000305"
REGION 99..203
/note="Interaction with PPP2CA"
/evidence="ECO:0000250"
REGION 226..291
/note="Interaction with MID1"
/evidence="ECO:0000250"
SITE 256..257
/note="Cleavage; by calpain"
/evidence="ECO:0000250"
MOD_RES 242
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:P78318"
HELIX 13..29
/evidence="ECO:0007744|PDB:3QC1"
HELIX 37..60
/evidence="ECO:0007744|PDB:3QC1"
TURN 61..63
/evidence="ECO:0007744|PDB:3QC1"
STRAND 65..67
/evidence="ECO:0007744|PDB:3QC1"
TURN 74..76
/evidence="ECO:0007744|PDB:3QC1"
HELIX 77..81
/evidence="ECO:0007744|PDB:3QC1"
HELIX 82..90
/evidence="ECO:0007744|PDB:3QC1"
HELIX 96..98
/evidence="ECO:0007744|PDB:3QC1"
HELIX 99..114
/evidence="ECO:0007744|PDB:3QC1"
HELIX 147..181
/evidence="ECO:0007744|PDB:3QC1"
HELIX 187..219
/evidence="ECO:0007744|PDB:3QC1"
SEQUENCE 340 AA; 38971 MW; 9C6BEF7C2E56BAE4 CRC64;
MAASEDELLL PRLPELFETS KKLLEDVEVA TEPTGSRTIQ DKVSKGLELL EKAAGMLSQL
DLFSRNEDLE EIASTDLKYL MVPALQGALT MKQVNPSKRL DHLQRAREHF VHFLTQCHCY
HVAEFQLPQT KTNSAENNTA SSSMAYPNLV AMASQRQAKI ERYKQKKEVE HRLSALKSAV
ESGQADDERV REYHLLHLRR WIAVSLEELE SIDQEIKILK EKDSPREETA CHSSLPEKPP
MKPFILTRNK AQAKVFGTGY PSLATMTVSD WYEQHQKYGV LPDRGIAKPA SADFQRAAQQ
QEDQEQKDEE SEEKALHRMR EWDDWKDTHP RGYGNRQNMG


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[Cd79a Iga Mb-1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[CD79A IGA MB1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[CCL3 G0S19-1 MIP1A SCYA3] C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]
[NFKB2 LYT10] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[Itga4] Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (Lymphocyte Peyer patch adhesion molecules subunit alpha) (LPAM subunit alpha) (VLA-4 subunit alpha) (CD antigen CD49d)
[gpaD DDB_G0285425] Guanine nucleotide-binding protein alpha-4 subunit (G alpha-4)
[] Genome polyprotein [Cleaved into: Leader protease (Lb(pro)) (EC 3.4.22.46); Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A) (P52); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Protein 3B-1 (P3B-1) (Genome-linked protein VPg1); Protein 3B-2 (P3B-2) (Genome-linked protein VPg2); Protein 3B-3 (P3B-3) (Genome-linked protein VPg3); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C) (Protease P20B); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48) (P56A)]
[RPS6KA4 MSK2] Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)
[Rps6ka4 Msk2] Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (RSK-like protein kinase) (RLSK)
[] Genome polyprotein [Cleaved into: Leader protease (Lpro) (EC 3.4.22.46); Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A) (P52); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Protein 3B-1 (P3B-1) (Genome-linked protein VPg1); Protein 3B-2 (P3B-2) (Genome-linked protein VPg2); Protein 3B-3 (P3B-3) (Genome-linked protein VPg3); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C) (Protease P20B); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48) (P56A)]
[] Genome polyprotein [Cleaved into: Leader protease (Lpro) (EC 3.4.22.46); Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A) (P52); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Protein 3B-1 (P3B-1) (Genome-linked protein VPg1); Protein 3B-2 (P3B-2) (Genome-linked protein VPg2); Protein 3B-3 (P3B-3) (Genome-linked protein VPg3); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C) (Protease P20B); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48) (P56A)]
[] Genome polyprotein [Cleaved into: Leader protease (Lpro) (EC 3.4.22.46); Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A) (P52); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Protein 3B-1 (P3B-1) (Genome-linked protein VPg1); Protein 3B-2 (P3B-2) (Genome-linked protein VPg2); Protein 3B-3 (P3B-3) (Genome-linked protein VPg3); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C) (Protease P20B); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48) (P56A)]
[] Genome polyprotein (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1A) (P1B) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2A) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (VP4-VP2) (Virion protein 1) (Virion protein 2) (Virion protein 3) (Virion protein 4) (protein 2B)
[] Genome polyprotein [Cleaved into: Leader protease (Lpro) (EC 3.4.22.46); Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A) (P52); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Protein 3B-1 (P3B-1) (Genome-linked protein VPg1); Protein 3B-2 (P3B-2) (Genome-linked protein VPg2); Protein 3B-3 (P3B-3) (Genome-linked protein VPg3); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C) (Protease P20B); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48) (P56A)]
[] Genome polyprotein [Cleaved into: Leader protease (Lpro) (EC 3.4.22.46); Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A) (P52); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Protein 3B-1 (P3B-1) (Genome-linked protein VPg1); Protein 3B-2 (P3B-2) (Genome-linked protein VPg2); Protein 3B-3 (P3B-3) (Genome-linked protein VPg3); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C) (Protease P20B); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48) (P56A)]
[] Genome polyprotein [Cleaved into: Leader protease (Lpro) (EC 3.4.22.46); Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A) (P52); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Protein 3B-1 (P3B-1) (Genome-linked protein VPg1); Protein 3B-2 (P3B-2) (Genome-linked protein VPg2); Protein 3B-3 (P3B-3) (Genome-linked protein VPg3); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C) (Protease P20B); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48) (P56A)]
[] Genome polyprotein [Cleaved into: Leader protease (Lpro) (EC 3.4.22.46); Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A) (P52); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Protein 3B-1 (P3B-1) (Genome-linked protein VPg1); Protein 3B-2 (P3B-2) (Genome-linked protein VPg2); Protein 3B-3 (P3B-3) (Genome-linked protein VPg3); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C) (Protease P20B); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48) (P56A)]
[] Genome polyprotein [Cleaved into: Leader protease (Lpro) (EC 3.4.22.46); Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A) (P52); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Protein 3B-1 (P3B-1) (Genome-linked protein VPg1); Protein 3B-2 (P3B-2) (Genome-linked protein VPg2); Protein 3B-3 (P3B-3) (Genome-linked protein VPg3); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C) (Protease P20B); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48) (P56A)]
[SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
[] Genome polyprotein (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1A) (P1B) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2A) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (VP4-VP2) (Virion protein 1) (Virion protein 2) (Virion protein 3) (Virion protein 4) (protein 2B)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Sirpa Bit Myd1 Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)
[Chrna4 Acra4] Neuronal acetylcholine receptor subunit alpha-4
[Nfkb2] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[] Genome polyprotein (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1A) (P1B) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2A) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (VP4-VP2) (Virion protein 1) (Virion protein 2) (Virion protein 3) (Virion protein 4) (protein 2B)
[KPNA3 QIP2] Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)
[] Genome polyprotein (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1A) (P1B) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2A) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (VP4-VP2) (Virion protein 1) (Virion protein 2) (Virion protein 3) (Virion protein 4) (protein 2B)
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]

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