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Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (EC 2.7.11.10) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)

 IKKA_BOVIN              Reviewed;         740 AA.
Q95KV1; A7YWD1;
12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
10-APR-2019, entry version 124.
RecName: Full=Inhibitor of nuclear factor kappa-B kinase subunit alpha;
Short=I-kappa-B kinase alpha;
Short=IKK-A;
Short=IKK-alpha;
Short=IkBKA;
EC=2.7.11.10;
AltName: Full=I-kappa-B kinase 1;
Short=IKK1;
AltName: Full=Nuclear factor NF-kappa-B inhibitor kinase alpha;
Short=NFKBIKA;
Name=CHUK; Synonyms=IKKA;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH IKBKB AND IKBKG.
PubMed=12459277; DOI=10.1016/S0378-1119(02)01011-9;
Rottenberg S., Schmuckli-Maurer J., Grimm S., Heussler V.T.,
Dobbelaere D.A.E.;
"Characterization of the bovine IkappaB kinases (IKK)alpha and
IKKbeta, the regulatory subunit NEMO and their substrate
IkappaBalpha.";
Gene 299:293-300(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Ascending colon;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Serine kinase that plays an essential role in the NF-
kappa-B signaling pathway which is activated by multiple stimuli
such as inflammatory cytokines, bacterial or viral products, DNA
damages or other cellular stresses. Acts as part of the canonical
IKK complex in the conventional pathway of NF-kappa-B activation
and phosphorylates inhibitors of NF-kappa-B on serine residues.
These modifications allow polyubiquitination of the inhibitors and
subsequent degradation by the proteasome. In turn, free NF-kappa-B
is translocated into the nucleus and activates the transcription
of hundreds of genes involved in immune response, growth control,
or protection against apoptosis. Negatively regulates the pathway
by phosphorylating the scaffold protein TAXBP1 and thus promoting
the assembly of the A20/TNFAIP3 ubiquitin-editing complex
(composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and
RNF11). Therefore, CHUK plays a key role in the negative feedback
of NF-kappa-B canonical signaling to limit inflammatory gene
activation. As part of the non-canonical pathway of NF-kappa-B
activation, the MAP3K14-activated CHUK/IKKA homodimer
phosphorylates NFKB2/p100 associated with RelB, inducing its
proteolytic processing to NFKB2/p52 and the formation of NF-kappa-
B RelB-p52 complexes. In turn, these complexes regulate genes
encoding molecules involved in B-cell survival and lymphoid
organogenesis. Participates also in the negative feedback of the
non-canonical NF-kappa-B signaling pathway by phosphorylating and
destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates
CREBBP and consequently increases both its transcriptional and
histone acetyltransferase activities. Modulates chromatin
accessibility at NF-kappa-B-responsive promoters by
phosphorylating histones H3 at 'Ser-10' that are subsequently
acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the
CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and
may regulate this pro-apoptotic transcription factor.
{ECO:0000250|UniProtKB:O15111}.
-!- CATALYTIC ACTIVITY:
Reaction=[I-kappa-B protein]-L-serine + ATP = [I-kappa-B protein]-
O-phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:19073,
Rhea:RHEA-COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378,
ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
ChEBI:CHEBI:456216; EC=2.7.11.10;
-!- ACTIVITY REGULATION: Activated when phosphorylated and inactivated
when dephosphorylated.
-!- SUBUNIT: Component of the I-kappa-B-kinase (IKK) core complex
consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-
beta/IKBKB dimers are associated with four gamma/IKBKG subunits.
The IKK core complex seems to associate with regulatory or adapter
proteins to form a IKK-signalosome holo-complex (PubMed:12459277).
The IKK complex associates with TERF2IP/RAP1, leading to promote
IKK-mediated phosphorylation of RELA/p65. Part of a complex
composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part
of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB,
NFKBIA, RELA, ELP1 and MAP3K14. Directly interacts with TRPC4AP.
May interact with TRAF2. Interacts with NALP2. May interact with
MAVS/IPS1. Interacts with ARRB1 and ARRB2. Interacts with NLRC5;
prevents CHUK phosphorylation and kinase activity. Interacts with
PIAS1; this interaction induces PIAS1 phosphorylation. Interacts
with ZNF268 isoform 2; the interaction is further increased in a
TNF-alpha-dependent manner (By similarity). Interacts with IFIT5;
the interaction synergizes the recruitment of IKK to MAP3K7 and
enhances IKK phosphorylation (By similarity). Interacts with
LRRC14 (By similarity). {ECO:0000250|UniProtKB:O15111,
ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12459277}.
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between
the cytoplasm and the nucleus. {ECO:0000250}.
-!- DOMAIN: The kinase domain is located in the N-terminal region. The
leucine zipper is important to allow homo- and hetero-
dimerization. At the C-terminal region is located the region
responsible for the interaction with NEMO/IKBKG (By similarity).
{ECO:0000250}.
-!- PTM: Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by
MEKK1, and dephosphorylated by PP2A. Autophosphorylated (By
similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
protein kinase family. I-kappa-B kinase subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00159}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AJ414555; CAC93686.1; -; mRNA.
EMBL; BC134510; AAI34511.1; -; mRNA.
RefSeq; NP_776446.1; NM_174021.2.
UniGene; Bt.63925; -.
ProteinModelPortal; Q95KV1; -.
SMR; Q95KV1; -.
BioGrid; 158442; 2.
DIP; DIP-44031N; -.
IntAct; Q95KV1; 2.
STRING; 9913.ENSBTAP00000009985; -.
PaxDb; Q95KV1; -.
PRIDE; Q95KV1; -.
Ensembl; ENSBTAT00000009985; ENSBTAP00000009985; ENSBTAG00000007591.
GeneID; 281073; -.
KEGG; bta:281073; -.
CTD; 1147; -.
VGNC; VGNC:27354; CHUK.
eggNOG; KOG4250; Eukaryota.
eggNOG; ENOG410XRMU; LUCA.
GeneTree; ENSGT00950000182937; -.
HOGENOM; HOG000038048; -.
HOVERGEN; HBG018241; -.
InParanoid; Q95KV1; -.
KO; K04467; -.
OMA; TPQASAW; -.
OrthoDB; 1013139at2759; -.
TreeFam; TF324269; -.
Reactome; R-BTA-1169091; Activation of NF-kappaB in B cells.
Reactome; R-BTA-168638; NOD1/2 Signaling Pathway.
Reactome; R-BTA-1810476; RIP-mediated NFkB activation via ZBP1.
Reactome; R-BTA-198323; AKT phosphorylates targets in the cytosol.
Reactome; R-BTA-202424; Downstream TCR signaling.
Reactome; R-BTA-2871837; FCERI mediated NF-kB activation.
Reactome; R-BTA-445989; TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
Reactome; R-BTA-5357905; Regulation of TNFR1 signaling.
Reactome; R-BTA-5357956; TNFR1-induced NFkappaB signaling pathway.
Reactome; R-BTA-5607761; Dectin-1 mediated noncanonical NF-kB signaling.
Reactome; R-BTA-5607764; CLEC7A (Dectin-1) signaling.
Reactome; R-BTA-5676590; NIK-->noncanonical NF-kB signaling.
Reactome; R-BTA-5684264; MAP3K8 (TPL2)-dependent MAPK1/3 activation.
Reactome; R-BTA-9020702; Interleukin-1 signaling.
Reactome; R-BTA-933542; TRAF6 mediated NF-kB activation.
Reactome; R-BTA-937039; IRAK1 recruits IKK complex.
Reactome; R-BTA-937041; IKK complex recruitment mediated by RIP1.
Reactome; R-BTA-975144; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
Proteomes; UP000009136; Chromosome 26.
Bgee; ENSBTAG00000007591; Expressed in 10 organ(s), highest expression level in spleen.
GO; GO:0008385; C:IkappaB kinase complex; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008384; F:IkappaB kinase activity; IEA:UniProtKB-EC.
GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0004672; F:protein kinase activity; ISS:UniProtKB.
GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IBA:GO_Central.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IBA:GO_Central.
InterPro; IPR022007; IKKbetaNEMObind.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF12179; IKKbetaNEMObind; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM01239; IKKbetaNEMObind; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
Nucleus; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1 740 Inhibitor of nuclear factor kappa-B
kinase subunit alpha.
/FTId=PRO_0000268159.
DOMAIN 15 302 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 21 29 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 455 476 Leucine-zipper.
REGION 733 738 NEMO-binding. {ECO:0000250}.
ACT_SITE 144 144 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 44 44 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 23 23 Phosphothreonine; by PKB/AKT1.
{ECO:0000250|UniProtKB:O15111}.
MOD_RES 176 176 Phosphoserine; by MAP3K14.
{ECO:0000250|UniProtKB:O15111}.
MOD_RES 180 180 Phosphoserine.
{ECO:0000250|UniProtKB:O15111}.
SEQUENCE 740 AA; 84344 MW; 01903BE11F44D176 CRC64;
MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDLK IAIKSCRLEL STKNRERWCH
EIQIMKKLNH ANVVKACDVP EELNFLINDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ
ILSLLSDIGS GIRYLHENKI IHRDLKPENI VLQDVGGKIM HKIIDLGYAK DVDQGSLCTS
FVGTLQYLAP ELFENKPYTA TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK
CIFACEEMTG EVRFSSHLPQ PNSLCSLIVE PMENWLQLML NWDPQQRGGP VDLTLKQPRC
FVLMDHILNL KIVHILNMTS AKIISFLLPP DESLHSLQSR IERETGINTG SQELLSEMGI
SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS RSLSDCVNYI VQDSKIQLPI
IQLRKVWAEA VHYVSGLKED YSRLFQGQRA AMLSLLRYNT NLTKMKNTLI SASQQLKAKL
EFFHKSIQLD LERYSEQMTY GISSEKMLKA WKEMEEKAIH YAEVGVIGYL EDQIMSLHTE
IMELQKSPYG RRQGDLMESL EQRAIDLYKQ LKHRPSDHSY SDSTEMVKII VHTVQSQDRV
LKELFGHLSK LLGCKQKIID LLPKVEMALS NIKEADSTVM FMQGKRQKEI WHLLKIACTQ
SSARSLVGSS LEGVTPQLPP TSAEREHPLS CVVTPQDGET LAQMIEENLN CLGHLSTIIH
EANEKQGNNM MSLDWSWLTE


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Pathways :
WP1209: EBV LMP1 signaling
WP1224: EBV LMP1 signaling
WP1571: EBV LMP1 signaling
WP262: EBV LMP1 signaling
WP32: Translation Factors
WP1566: Citrate cycle (TCA cycle)
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP1003: Ovarian Infertility Genes
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1102: EBV LMP1 signaling
WP1120: Ovarian Infertility Genes
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1225: estrogen signalling
WP1243: EBV LMP1 signaling
WP1278: EBV LMP1 signaling
WP1328: EBV LMP1 signaling
WP1340: Ovarian Infertility Genes
WP1369: TNF-alpha NF-kB Signaling Pathway
WP1434: Osteopontin Signaling
WP1487: TNF-alpha and mucus production in lung epythelium
WP1493: Carbon assimilation C4 pathway
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Related Genes :
[CHUK IKKA TCF16] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
[Chuk Ikka] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[CHUK IKKA] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (EC 2.7.11.10) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[IKBKB IKKB] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[Ikbkb Ikkb] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[Ikbkb Ikkb] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[IKBKG FIP3 NEMO] NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[IKBKB] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[IKBKE IKKE IKKI KIAA0151] Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
[Ikbke Ikke Ikki] Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
[Ikbkg Nemo] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[Ikbkg Nemo] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[IKBKG NEMO] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[IKBKG] NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[NFKB2 LYT10] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[Rel CG11992] Nuclear factor NF-kappa-B p110 subunit (Rel-p110) (Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit (Rel-p68); Nuclear factor NF-kappa-B p49 subunit (Rel-p49)]
[RELA NFKB3] Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
[NFKBIA IKBA MAD3 NFKBI] NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
[TBK1 NAK] Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] (Fragment)
[IKBIP IKIP] Inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase-interacting protein) (IKBKB-interacting protein) (IKK-interacting protein)
[Nfkb2] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[Rela Nfkb3] Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
[TONSL IKBR NFKBIL2] Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)
[TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6] Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)
[NFKBIA IKBA] NF-kappa-B inhibitor alpha (ECI-6) (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha)
[Nfkbia Ikba] NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha)

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