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Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)

 IKKB_MOUSE              Reviewed;         757 AA.
O88351; Q9R1J6;
01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
13-FEB-2019, entry version 177.
RecName: Full=Inhibitor of nuclear factor kappa-B kinase subunit beta;
Short=I-kappa-B-kinase beta;
Short=IKK-B;
Short=IKK-beta;
Short=IkBKB;
EC=2.7.11.10;
AltName: Full=I-kappa-B kinase 2;
Short=IKK2;
AltName: Full=Nuclear factor NF-kappa-B inhibitor kinase beta;
Short=NFKBIKB;
Name=Ikbkb; Synonyms=Ikkb;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PHOSPHORYLATION BY MEKK1.
STRAIN=C57BL/6J; TISSUE=Spleen;
PubMed=9520401; DOI=10.1073/pnas.95.7.3537;
Nakano H., Shindo M., Sakon S., Nishinaka S., Mihara M., Yagita H.,
Okumura K.;
"Differential regulation of IkappaB kinase alpha and beta by two
upstream kinases, NF-kappaB-inducing kinase and mitogen-activated
protein kinase/ERK kinase kinase-1.";
Proc. Natl. Acad. Sci. U.S.A. 95:3537-3542(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Hu M.C.-T., Wang Y.-P., Mikhail A., Qiu W.R.;
"Murine IkB kinase-B, a developmentally regulated protein kinase that
constitutively phosphorylates serine residues of IkB.";
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
[3]
DISRUPTION PHENOTYPE.
PubMed=10229185; DOI=10.1016/S1074-7613(00)80042-4;
Tanaka M., Fuentes M.E., Yamaguchi K., Durnin M.H., Dalrymple S.A.,
Hardy K.L., Goeddel D.V.;
"Embryonic lethality, liver degeneration, and impaired NF-kappa B
activation in IKK-beta-deficient mice.";
Immunity 10:421-429(1999).
[4]
DEVELOPMENTAL STAGE.
PubMed=10523828; DOI=10.1038/sj.onc.1202740;
Hu M.C.-T., Wang Y.-P., Qiu W.R., Mikhail A., Meyer C.F., Tan T.-H.;
"Hematopoietic progenitor kinase-1 (HPK1) stress response signaling
pathway activates IkappaB kinases (IKK-alpha/beta) and IKK-beta is a
developmentally regulated protein kinase.";
Oncogene 18:5514-5524(1999).
[5]
IKK PHOSPHORYLATION.
PubMed=9819420; DOI=10.1128/MCB.18.12.7336;
Nemoto S., DiDonato J.A., Lin A.;
"Coordinate regulation of IkappaB kinases by mitogen-activated protein
kinase kinase kinase 1 and NF-kappaB-inducing kinase.";
Mol. Cell. Biol. 18:7336-7343(1998).
[6]
DISRUPTION PHENOTYPE.
PubMed=10195897; DOI=10.1126/science.284.5412.321;
Li Q., Van Antwerp D., Mercurio F., Lee K.F., Verma I.M.;
"Severe liver degeneration in mice lacking the IkappaB kinase 2
gene.";
Science 284:321-325(1999).
[7]
REVIEW.
PubMed=10712233;
Jobin C., Sartor R.B.;
"The I kappa B/NF-kappa B system: a key determinant of mucosal
inflammation and protection.";
Am. J. Physiol. 278:C451-C462(2000).
[8]
INTERACTION WITH EIF2AK2.
PubMed=10848580; DOI=10.1128/MCB.20.13.4532-4542.2000;
Bonnet M.C., Weil R., Dam E., Hovanessian A.G., Meurs E.F.;
"PKR stimulates NF-kappaB irrespective of its kinase function by
interacting with the IkappaB kinase complex.";
Mol. Cell. Biol. 20:4532-4542(2000).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-672, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brown adipose tissue, Kidney, Lung, Pancreas, Spleen, and
Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[10]
INTERACTION WITH TERF2IP.
PubMed=20622870; DOI=10.1038/ncb2080;
Teo H., Ghosh S., Luesch H., Ghosh A., Wong E.T., Malik N., Orth A.,
de Jesus P., Perry A.S., Oliver J.D., Tran N.L., Speiser L.J.,
Wong M., Saez E., Schultz P., Chanda S.K., Verma I.M., Tergaonkar V.;
"Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-
dependent gene expression.";
Nat. Cell Biol. 12:758-767(2010).
[11]
INTERACTION WITH ZC3H12A.
PubMed=22037600; DOI=10.1038/ni.2137;
Iwasaki H., Takeuchi O., Teraguchi S., Matsushita K., Uehata T.,
Kuniyoshi K., Satoh T., Saitoh T., Matsushita M., Standley D.M.,
Akira S.;
"The IkappaB kinase complex regulates the stability of cytokine-
encoding mRNA induced by TLR-IL-1R by controlling degradation of
regnase-1.";
Nat. Immunol. 12:1167-1175(2011).
[12]
INTERACTION WITH AKAP13, IDENTIFICATION BY MASS SPECTROMETRY, AND
TISSUE SPECIFICITY.
PubMed=23090968; DOI=10.1128/MCB.00887-12;
del Vescovo C.D., Cotecchia S., Diviani D.;
"A-kinase-anchoring protein-Lbc anchors IkappaB kinase beta to support
interleukin-6-mediated cardiomyocyte hypertrophy.";
Mol. Cell. Biol. 33:14-27(2013).
-!- FUNCTION: Serine kinase that plays an essential role in the NF-
kappa-B signaling pathway which is activated by multiple stimuli
such as inflammatory cytokines, bacterial or viral products, DNA
damages or other cellular stresses. Acts as part of the canonical
IKK complex in the conventional pathway of NF-kappa-B activation
and phosphorylates inhibitors of NF-kappa-B on 2 critical serine
residues. These modifications allow polyubiquitination of the
inhibitors and subsequent degradation by the proteasome. In turn,
free NF-kappa-B is translocated into the nucleus and activates the
transcription of hundreds of genes involved in immune response,
growth control, or protection against apoptosis. In addition to
the NF-kappa-B inhibitors, phosphorylates several other components
of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits
RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE.
IKK-related kinase phosphorylations may prevent the overproduction
of inflammatory mediators since they exert a negative regulation
on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-
dependent inactivation of this pro-apoptotic transcription factor.
Also phosphorylates other substrates including NCOA3, BCL10 and
IRS1. Within the nucleus, acts as an adapter protein for NFKBIA
degradation in UV-induced NF-kappa-B activation.
{ECO:0000250|UniProtKB:O14920}.
-!- CATALYTIC ACTIVITY:
Reaction=[I-kappa-B protein]-L-serine + ATP = [I-kappa-B protein]-
O-phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:19073,
Rhea:RHEA-COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378,
ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
ChEBI:CHEBI:456216; EC=2.7.11.10;
-!- SUBUNIT: Component of the I-kappa-B-kinase (IKK) core complex
consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-
beta/IKBKB dimers are associated with four gamma/IKBKG subunits.
The IKK core complex seems to associate with regulatory or adapter
proteins to form a IKK-signalosome holo-complex (By similarity).
The IKK complex associates with TERF2IP/RAP1, leading to promote
IKK-mediated phosphorylation of RELA/p65 (PubMed:20622870). Part
of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and
CREBBP. Part of a 70-90 kDa complex at least consisting of
CHUK/IKKA, IKBKB, NFKBIA, RELA, ELP1 and MAP3K14. Found in a
membrane raft complex, at least composed of BCL10, CARD11, DPP4
and IKBKB. Interacts with SQSTM1 through PRKCZ or PRKCI. Forms an
NGF-induced complex with IKBKB, PRKCI and TRAF6. May interact with
MAVS/IPS1. Interacts with NALP2. Interacts with TICAM1. Interacts
with FAF1; the interaction disrupts the IKK complex formation.
Interacts with ATM. Part of a ternary complex consisting of TANK,
IKBKB and IKBKG. Interacts with NIBP; the interaction is direct.
Interacts with ARRB1 and ARRB2. Interacts with TRIM21. Interacts
with NLRC5; prevents IKBKB phosphorylation and kinase activity.
Interacts with PDPK1 (By similarity). Interacts with EIF2AK2/PKR
(PubMed:10848580). The phosphorylated form interacts with PPM1A
and PPM1B. Interacts with ZNF268 isoform 2; the interaction is
further increased in a TNF-alpha-dependent manner. Interacts with
IKBKE. Interacts with NAA10, leading to NAA10 degradation.
Interacts with FOXO3 (By similarity). Interacts with ZC3H12A
(PubMed:22037600). Interacts with AKAP13 (PubMed:23090968).
Interacts with LRRC14; disrupts IKBKB-IKBKG interaction preventing
I-kappa-B-kinase (IKK) core complex formation and leading to a
decrease of IKBKB phosphorylation and NF-kappaB activation (By
similarity). {ECO:0000250|UniProtKB:O14920,
ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:20622870,
ECO:0000269|PubMed:22037600}.
-!- INTERACTION:
Q60680:Chuk; NbExp=4; IntAct=EBI-447960, EBI-646245;
O88522:Ikbkg; NbExp=7; IntAct=EBI-447960, EBI-998011;
Q14145:KEAP1 (xeno); NbExp=2; IntAct=EBI-447960, EBI-751001;
P68040:Rack1; NbExp=4; IntAct=EBI-447960, EBI-296749;
P01375:TNF (xeno); NbExp=3; IntAct=EBI-447960, EBI-359977;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O14920}.
Nucleus {ECO:0000250|UniProtKB:O14920}. Membrane raft
{ECO:0000250|UniProtKB:O14920}. Note=Colocalized with DPP4 in
membrane rafts. {ECO:0000250|UniProtKB:O14920}.
-!- TISSUE SPECIFICITY: Detected in heart (at protein level)
(PubMed:23090968). Expressed in liver, kidney and spleen.
{ECO:0000269|PubMed:23090968}.
-!- DEVELOPMENTAL STAGE: While it is expressed ubiquitously throughout
the mouse embryo, at 9.5 dpc its expression begins to be localized
to the brain, neural ganglia, neural tube, and in liver at 12.5
dpc. At 15.5 dpc, the expression is further restricted to specific
tissues of the embryo. {ECO:0000269|PubMed:10523828}.
-!- DOMAIN: The kinase domain is located in the N-terminal region. The
leucine zipper is important to allow homo- and hetero-
dimerization. At the C-terminal region is located the region
responsible for the interaction with NEMO/IKBKG (By similarity).
{ECO:0000250}.
-!- PTM: Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-
181 by MEKK1 and/or MAP3K14/NIK as well as TBK1 and PRKCZ; which
enhances activity. Once activated, autophosphorylates on the C-
terminal serine cluster; which decreases activity and prevents
prolonged activation of the inflammatory response. Phosphorylated
by the IKK-related kinases TBK1 and IKBKE, which is associated
with reduced CHUK/IKKA and IKBKB activity and NF-kappa-B-dependent
gene transcription. Dephosphorylated at Ser-177 and Ser-181 by
PPM1A and PPM1B. {ECO:0000250|UniProtKB:O14920}.
-!- PTM: Ubiquitinated. Monoubiquitination involves TRIM21 that leads
to inhibition of Tax-induced NF-kappa-B signaling. 'Ser-163' may
not serve as a monoubiquitination site. Ubiquitination on 'Ser-
163' may modulate phosphorylation on C-terminal serine residues.
{ECO:0000250|UniProtKB:O14920}.
-!- PTM: Hydroxylated by PHD1/EGLN2, loss of hydroxylation under
hypoxic conditions results in activation of NF-kappa-B.
{ECO:0000250|UniProtKB:O14920}.
-!- DISRUPTION PHENOTYPE: Mice present extensive liver damage from
apoptosis and die as embryos. They show a marked reduction in TNF-
alpha and IL1-alpha-induced NF-kappa-B activity.
{ECO:0000269|PubMed:10195897, ECO:0000269|PubMed:10229185}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
protein kinase family. I-kappa-B kinase subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00159}.
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EMBL; AF026524; AAC23557.1; -; mRNA.
EMBL; AF088910; AAD52095.1; -; mRNA.
CCDS; CCDS52522.1; -.
RefSeq; NP_034676.1; NM_010546.2.
UniGene; Mm.277886; -.
ProteinModelPortal; O88351; -.
SMR; O88351; -.
BioGrid; 200601; 25.
ComplexPortal; CPX-3270; IkappaB kinase complex.
CORUM; O88351; -.
DIP; DIP-29813N; -.
IntAct; O88351; 26.
MINT; O88351; -.
STRING; 10090.ENSMUSP00000033939; -.
BindingDB; O88351; -.
ChEMBL; CHEMBL6012; -.
iPTMnet; O88351; -.
PhosphoSitePlus; O88351; -.
EPD; O88351; -.
MaxQB; O88351; -.
PaxDb; O88351; -.
PeptideAtlas; O88351; -.
PRIDE; O88351; -.
GeneID; 16150; -.
KEGG; mmu:16150; -.
CTD; 3551; -.
MGI; MGI:1338071; Ikbkb.
eggNOG; KOG4250; Eukaryota.
eggNOG; ENOG410XRMU; LUCA.
HOGENOM; HOG000038048; -.
HOVERGEN; HBG018241; -.
InParanoid; O88351; -.
KO; K07209; -.
OrthoDB; 1013139at2759; -.
PhylomeDB; O88351; -.
BRENDA; 2.7.11.10; 3474.
PRO; PR:O88351; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0035631; C:CD40 receptor complex; IDA:BHF-UCL.
GO; GO:0005737; C:cytoplasm; TAS:MGI.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IDA:BHF-UCL.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0008385; C:IkappaB kinase complex; ISO:MGI.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; ISO:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0008384; F:IkappaB kinase activity; IDA:MGI.
GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0004672; F:protein kinase activity; IDA:MGI.
GO; GO:0019901; F:protein kinase binding; ISO:MGI.
GO; GO:0019903; F:protein phosphatase binding; IPI:ARUK-UCL.
GO; GO:0004674; F:protein serine/threonine kinase activity; ISO:MGI.
GO; GO:0097110; F:scaffold protein binding; ISO:MGI.
GO; GO:0001782; P:B cell homeostasis; IMP:MGI.
GO; GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.
GO; GO:0030866; P:cortical actin cytoskeleton organization; ISO:MGI.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; ISO:MGI.
GO; GO:0007252; P:I-kappaB phosphorylation; TAS:MGI.
GO; GO:0070498; P:interleukin-1-mediated signaling pathway; ISO:MGI.
GO; GO:1903347; P:negative regulation of bicellular tight junction assembly; ISO:MGI.
GO; GO:0035509; P:negative regulation of myosin-light-chain-phosphatase activity; ISO:MGI.
GO; GO:0031175; P:neuron projection development; ISO:MGI.
GO; GO:0018105; P:peptidyl-serine phosphorylation; ISO:MGI.
GO; GO:2001259; P:positive regulation of cation channel activity; IGI:MGI.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
GO; GO:1901216; P:positive regulation of neuron death; ISO:MGI.
GO; GO:0010976; P:positive regulation of neuron projection development; ISO:MGI.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISO:MGI.
GO; GO:0010765; P:positive regulation of sodium ion transport; IGI:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0072659; P:protein localization to plasma membrane; ISO:MGI.
GO; GO:0006468; P:protein phosphorylation; ISO:MGI.
GO; GO:1903140; P:regulation of establishment of endothelial barrier; ISO:MGI.
GO; GO:0042325; P:regulation of phosphorylation; ISO:MGI.
GO; GO:0061847; P:response to cholecystokinin; ISO:MGI.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IMP:UniProtKB.
InterPro; IPR022007; IKKbetaNEMObind.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF12179; IKKbetaNEMObind; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM01239; IKKbetaNEMObind; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; Cytoplasm; Hydroxylation;
Isopeptide bond; Kinase; Membrane; Nucleotide-binding; Nucleus;
Phosphoprotein; Reference proteome; S-nitrosylation;
Serine/threonine-protein kinase; Transferase; Ubl conjugation.
CHAIN 1 757 Inhibitor of nuclear factor kappa-B
kinase subunit beta.
/FTId=PRO_0000086014.
DOMAIN 15 300 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 21 29 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 458 479 Leucine-zipper.
REGION 737 742 NEMO-binding.
ACT_SITE 145 145 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 44 44 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 177 177 Phosphoserine; by TBK1 and PKC/PRKCZ.
{ECO:0000250|UniProtKB:O14920}.
MOD_RES 179 179 S-nitrosocysteine.
{ECO:0000250|UniProtKB:O14920}.
MOD_RES 181 181 Phosphoserine; by TBK1, PKC/PRKCZ and
PDPK1. {ECO:0000250|UniProtKB:O14920}.
MOD_RES 191 191 Hydroxyproline. {ECO:0000250}.
MOD_RES 670 670 Phosphoserine; by autocatalysis.
{ECO:0000250|UniProtKB:O14920}.
MOD_RES 672 672 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 675 675 Phosphoserine; by autocatalysis.
{ECO:0000250|UniProtKB:O14920}.
MOD_RES 682 682 Phosphoserine; by autocatalysis.
{ECO:0000250|UniProtKB:O14920}.
MOD_RES 689 689 Phosphoserine; by autocatalysis.
{ECO:0000250|UniProtKB:O14920}.
MOD_RES 692 692 Phosphoserine; by autocatalysis.
{ECO:0000250|UniProtKB:O14920}.
MOD_RES 697 697 Phosphoserine; by autocatalysis.
{ECO:0000250|UniProtKB:O14920}.
MOD_RES 705 705 Phosphoserine; by autocatalysis.
{ECO:0000250|UniProtKB:O14920}.
MOD_RES 733 733 Phosphoserine; by autocatalysis.
{ECO:0000250|UniProtKB:O14920}.
MOD_RES 740 740 Phosphoserine; by autocatalysis.
{ECO:0000250|UniProtKB:O14920}.
CROSSLNK 163 163 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000250|UniProtKB:O14920}.
CONFLICT 56 56 N -> D (in Ref. 2; AAD52095).
{ECO:0000305}.
CONFLICT 343 343 N -> D (in Ref. 2; AAD52095).
{ECO:0000305}.
CONFLICT 356 356 K -> E (in Ref. 2; AAD52095).
{ECO:0000305}.
CONFLICT 390 390 L -> F (in Ref. 2; AAD52095).
{ECO:0000305}.
CONFLICT 406 406 P -> Q (in Ref. 2; AAD52095).
{ECO:0000305}.
CONFLICT 573 573 K -> R (in Ref. 2; AAD52095).
{ECO:0000305}.
CONFLICT 736 757 TLDWSWLQMEDEERCSLEQACD -> VTA (in Ref.
2). {ECO:0000305}.
SEQUENCE 757 AA; 86690 MW; FED962F095449C5E CRC64;
MSWSPSLPTQ TCGAWEMKER LGTGGFGNVI RWHNQATGEQ IAIKQCRQEL SPKNRNRWCL
EIQIMRRLNH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRRYLNQ FENCCGLREG
AVLTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEKRL IHKIIDLGYA KELDQGSLCT
SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE
VDIVVSEDLN GAVKFSSSLP FPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPQYGPNGCF
RALDDILNLK LVHVLNMVTG TVHTYPVTED ESLQSLKTRI QENTGILETD QELLQKAGLV
LLPDKPATQC ISDSKTNEGL TLDMDLVFLL DNSKINYETQ ITPRPPPESV SCILQEPKRN
LSFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMSLLR NNSCLSKMKN AMASTAQQLK
AKLDFFKTSI QIDLEKYKEQ TEFGITSDKL LLAWREMEQA VEQCGRENDV KHLVERMMAL
QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRKLREKPRD QRTEGDSQEM VRLLLQAIQS
FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE RTVVRLQEKR QKELWNLLKI
ACSKVRGPVS GSPDSMNVSR LSHPGQLMSQ PSSACDSLPE SDKKSEELVA EAHALCSRLE
SALQDTVKEQ DRSFTTLDWS WLQMEDEERC SLEQACD


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E1953m ELISA I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,Mouse,Mus musculus,NFKBIKB,Nuclear factor NF-kappa-B inhibit 96T
E1953h ELISA kit Homo sapiens,Human,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKKB,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B in 96T
U1953b CLIA Bos taurus,Bovine,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kina 96T
E1953b ELISA kit Bos taurus,Bovine,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibito 96T
E1953m ELISA kit I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,Mouse,Mus musculus,NFKBIKB,Nuclear factor NF-kappa-B in 96T
U1953m CLIA kit I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,Mouse,Mus musculus,NFKBIKB,Nuclear factor NF-kappa-B inh 96T
U1953b CLIA kit Bos taurus,Bovine,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor 96T
E1953b ELISA Bos taurus,Bovine,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kin 96T
E1953r ELISA kit I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kinase beta 96T
E1953r ELISA I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kinase beta,Rat, 96T
U1953r CLIA I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kinase beta,Rat,R 96T
U1953r CLIA kit I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kinase beta, 96T
15-288-21171 Inhibitor of nuclear factor kappa B kinase subunit beta - EC 2.7.11.10; I-kappa-B-kinase beta; IkBKB; IKK-beta; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIK 0.1 mg
18-661-15057 Inhibitor of nuclear factor kappa B kinase subunit beta - EC 2.7.11.10; I-kappa-B-kinase beta; IkBKB; IKK-beta; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIK 0.1 mg
15-288-21171 Inhibitor of nuclear factor kappa B kinase subunit beta - EC 2.7.11.10; I-kappa-B-kinase beta; IkBKB; IKK-beta; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIK 0.05 mg
CSB-EL011572RA Rat Inhibitor of nuclear factor kappa-B kinase subunit beta(IKBKB) ELISA kit 96T
CSB-EL011572RA Rat Inhibitor of nuclear factor kappa-B kinase subunit beta(IKBKB) ELISA kit SpeciesRat 96T
CSB-EL011572MO Mouse Inhibitor of nuclear factor kappa-B kinase subunit beta(IKBKB) ELISA kit 96T
CSB-EL011572BO Bovine Inhibitor of nuclear factor kappa-B kinase subunit beta(IKBKB) ELISA kit 96T
CSB-EL011572MO Mouse Inhibitor of nuclear factor kappa-B kinase subunit beta(IKBKB) ELISA kit SpeciesMouse 96T
CSB-EL011572BO Bovine Inhibitor of nuclear factor kappa-B kinase subunit beta(IKBKB) ELISA kit SpeciesBovine 96T

Kits Elisa; taq POLYMERASE

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Gentaur; yes we can

Pathways :
WP1224: EBV LMP1 signaling
WP1571: EBV LMP1 signaling
WP262: EBV LMP1 signaling
WP32: Translation Factors
WP1102: EBV LMP1 signaling
WP1209: EBV LMP1 signaling
WP1243: EBV LMP1 signaling
WP1278: EBV LMP1 signaling
WP1328: EBV LMP1 signaling
WP1566: Citrate cycle (TCA cycle)
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP758: EBV LMP1 signaling
WP866: EBV LMP1 signaling
WP1045: TGF-beta Receptor Signaling Pathway
WP1048: TGF Beta Signaling Pathway
WP105: Fatty Acid Beta Oxidation 2
WP1058: Senescence and Autophagy
WP1061: Fatty Acid Beta Oxidation
WP1106: Keap1-Nrf2
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP113: TGF Beta Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1164: TGF Beta Signaling Pathway
WP1177: Fatty Acid Beta Oxidation

Related Genes :
[IKBKB IKKB] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[Ikbkb Ikkb] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[Ikbkb Ikkb] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[IKBKB] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[CHUK IKKA TCF16] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
[Chuk Ikka] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[CHUK IKKA] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (EC 2.7.11.10) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[IKBKG FIP3 NEMO] NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[IKBKE IKKE IKKI KIAA0151] Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
[Ikbke Ikke Ikki] Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
[Ikbkg Nemo] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[Ikbkg Nemo] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[IKBKG NEMO] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[IKBKG] NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[TBK1 NAK] Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[NFKB2 LYT10] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[RELA NFKB3] Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
[Rel CG11992] Nuclear factor NF-kappa-B p110 subunit (Rel-p110) (Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit (Rel-p68); Nuclear factor NF-kappa-B p49 subunit (Rel-p49)]
[IKBIP IKIP] Inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase-interacting protein) (IKBKB-interacting protein) (IKK-interacting protein)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] (Fragment)
[Nfkb2] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[Rela Nfkb3] Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
[TONSL IKBR NFKBIL2] Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)
[TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6] Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[NFKBIA IKBA MAD3 NFKBI] NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
[NFKBIB IKBB TRIP9] NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
[TICAM1 PRVTIRB TRIF] TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)

Bibliography :