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Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Hydroxylaminopurine sensitivity protein 1) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)

 ITPA_YEAST              Reviewed;         197 AA.
P47119; D6VWP0;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
13-FEB-2019, entry version 148.
RecName: Full=Inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
Short=ITPase {ECO:0000255|HAMAP-Rule:MF_03148};
Short=Inosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
EC=3.6.1.9 {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528};
AltName: Full=Hydroxylaminopurine sensitivity protein 1;
AltName: Full=Non-canonical purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
AltName: Full=Non-standard purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
AltName: Full=Nucleoside-triphosphate diphosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
AltName: Full=Nucleoside-triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
Short=NTPase {ECO:0000255|HAMAP-Rule:MF_03148};
Name=HAM1 {ECO:0000255|HAMAP-Rule:MF_03148};
OrderedLocusNames=YJR069C; ORFNames=J1811;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8789257;
DOI=10.1002/(SICI)1097-0061(199601)12:1<17::AID-YEA875>3.0.CO;2-I;
Noskov V.N., Staak K., Shcherbakova P.V., Kozmin S.G., Negishi K.,
Ono B.-C., Hayatsu H., Pavlov Y.I.;
"HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and
mutagenesis in the yeast Saccharomyces cerevisiae.";
Yeast 12:17-29(1996).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=8840504;
DOI=10.1002/(SICI)1097-0061(199607)12:9<869::AID-YEA964>3.0.CO;2-1;
Huang M.-E., Manus V., Chuat J.-C., Galibert F.;
"Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open
reading frames and a gene cluster with a counterpart on chromosome
XI.";
Yeast 12:869-875(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=8641269;
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N.,
Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H.,
Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A.,
Hennemann A., Herbert C.J., Heumann K., Hilger F., Hollenberg C.P.,
Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L.,
Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V.,
Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M.,
Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W.,
Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M.,
Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A.,
Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M.,
Zollner A., Karpfinger-Hartl L.;
"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
X.";
EMBO J. 15:2031-2049(1996).
[4]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=17322287; DOI=10.1101/gr.6037607;
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-
encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[6]
FUNCTION.
PubMed=9918490;
Kozmin S.G., Leroy P., Pavlov Y.I.;
"Overexpression of the yeast HAM1 gene prevents 6-N-
hydroxylaminopurine mutagenesis in Escherichia coli.";
Acta Biochim. Pol. 45:645-652(1998).
[7]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[8]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[9]
FUNCTION.
PubMed=17899088; DOI=10.1007/s00294-007-0152-z;
Takayama S., Fujii M., Kurosawa A., Adachi N., Ayusawa D.;
"Overexpression of HAM1 gene detoxifies 5-bromodeoxyuridine in the
yeast Saccharomyces cerevisiae.";
Curr. Genet. 52:203-211(2007).
[10]
SUBSTRATE SPECIFICITY, FUNCTION, CATALYTIC ACTIVITY, AND
BIOPHYSICOCHEMICAL PROPERTIES.
PubMed=17090528; DOI=10.1074/jbc.M608708200;
Burgis N.E., Cunningham R.P.;
"Substrate specificity of RdgB protein, a deoxyribonucleoside
triphosphate pyrophosphohydrolase.";
J. Biol. Chem. 282:3531-3538(2007).
-!- FUNCTION: Pyrophosphatase that hydrolyzes the non-canonical purine
nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate
(dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate
(dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their
respective monophosphate derivatives. Xanthosine 5'-triphosphate
(XTP) is also a potential substrate. The enzyme does not
distinguish between the deoxy- and ribose forms. Probably excludes
non-canonical purines from RNA and DNA precursor pools, thus
preventing their incorporation into RNA and DNA and avoiding
chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148,
ECO:0000269|PubMed:17090528, ECO:0000269|PubMed:17899088,
ECO:0000269|PubMed:9918490}.
-!- CATALYTIC ACTIVITY:
Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside
5'-phosphate + diphosphate + H(+); Xref=Rhea:RHEA:23996,
ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.9;
Evidence={ECO:0000255|HAMAP-Rule:MF_03148,
ECO:0000269|PubMed:17090528};
-!- CATALYTIC ACTIVITY:
Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
deoxyribonucleoside 5'-phosphate + diphosphate + H(+);
Xref=Rhea:RHEA:44644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:65317;
EC=3.6.1.9; Evidence={ECO:0000255|HAMAP-Rule:MF_03148,
ECO:0000269|PubMed:17090528};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000255|HAMAP-Rule:MF_03148};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000255|HAMAP-Rule:MF_03148};
Note=Binds 1 divalent metal cation per subunit; can use either
Mg(2+) or Mn(2+). {ECO:0000255|HAMAP-Rule:MF_03148};
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=13.4 uM for dITP {ECO:0000269|PubMed:17090528};
KM=26.9 uM for dHAPTP {ECO:0000269|PubMed:17090528};
KM=722 uM for dGTP {ECO:0000269|PubMed:17090528};
Note=Vmax values are similar for dITP, dHAPTP and dGTP.;
-!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_03148}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148,
ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000255|HAMAP-
Rule:MF_03148, ECO:0000269|PubMed:14562095}.
-!- MISCELLANEOUS: Present with 3490 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the HAM1 NTPase family. {ECO:0000255|HAMAP-
Rule:MF_03148}.
-----------------------------------------------------------------------
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EMBL; Z49569; CAA89597.1; -; Genomic_DNA.
EMBL; L47993; AAB39295.1; -; Genomic_DNA.
EMBL; AY557897; AAS56223.1; -; Genomic_DNA.
EMBL; BK006943; DAA08856.1; -; Genomic_DNA.
PIR; S57088; S57088.
RefSeq; NP_012603.1; NM_001181727.1.
ProteinModelPortal; P47119; -.
SMR; P47119; -.
BioGrid; 33826; 56.
DIP; DIP-5491N; -.
IntAct; P47119; 5.
MINT; P47119; -.
STRING; 4932.YJR069C; -.
iPTMnet; P47119; -.
MaxQB; P47119; -.
PaxDb; P47119; -.
PRIDE; P47119; -.
EnsemblFungi; YJR069C_mRNA; YJR069C_mRNA; YJR069C.
GeneID; 853532; -.
KEGG; sce:YJR069C; -.
EuPathDB; FungiDB:YJR069C; -.
SGD; S000003830; HAM1.
GeneTree; ENSGT00390000015399; -.
HOGENOM; HOG000293320; -.
InParanoid; P47119; -.
KO; K01519; -.
OMA; YDPIFQP; -.
BioCyc; YEAST:G3O-31702-MONOMER; -.
Reactome; R-SCE-74259; Purine catabolism.
PRO; PR:P47119; -.
Proteomes; UP000002311; Chromosome X.
GO; GO:0005737; C:cytoplasm; HDA:SGD.
GO; GO:0005634; C:nucleus; HDA:SGD.
GO; GO:0008828; F:dATP pyrophosphohydrolase activity; IDA:SGD.
GO; GO:0047840; F:dCTP diphosphatase activity; IDA:SGD.
GO; GO:0036217; F:dGTP diphosphatase activity; IDA:SGD.
GO; GO:0035870; F:dITP diphosphatase activity; IDA:SGD.
GO; GO:0036218; F:dTTP diphosphatase activity; IDA:SGD.
GO; GO:0004170; F:dUTP diphosphatase activity; IDA:SGD.
GO; GO:0036219; F:GTP diphosphatase activity; IDA:SGD.
GO; GO:0036220; F:ITP diphosphatase activity; IDA:SGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0035529; F:NADH pyrophosphatase activity; IEA:UniProtKB-EC.
GO; GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IBA:GO_Central.
GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO; GO:0036221; F:UTP diphosphatase activity; IDA:SGD.
GO; GO:0036222; F:XTP diphosphatase activity; IDA:SGD.
GO; GO:0009143; P:nucleoside triphosphate catabolic process; IBA:GO_Central.
GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
GO; GO:0009217; P:purine deoxyribonucleoside triphosphate catabolic process; IDA:SGD.
GO; GO:0009213; P:pyrimidine deoxyribonucleoside triphosphate catabolic process; IDA:SGD.
CDD; cd00515; HAM1; 1.
Gene3D; 3.90.950.10; -; 1.
HAMAP; MF_03148; HAM1_NTPase; 1.
InterPro; IPR002637; Ham1p-like.
InterPro; IPR027502; ITPase.
InterPro; IPR029001; ITPase-like_fam.
PANTHER; PTHR11067; PTHR11067; 1.
Pfam; PF01725; Ham1p_like; 1.
SUPFAM; SSF52972; SSF52972; 1.
TIGRFAMs; TIGR00042; TIGR00042; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese;
Metal-binding; Nucleotide metabolism; Nucleotide-binding; Nucleus;
Reference proteome.
CHAIN 1 197 Inosine triphosphate pyrophosphatase.
/FTId=PRO_0000178279.
REGION 10 15 Substrate binding. {ECO:0000255|HAMAP-
Rule:MF_03148}.
REGION 76 77 Substrate binding. {ECO:0000255|HAMAP-
Rule:MF_03148}.
REGION 151 154 Substrate binding. {ECO:0000255|HAMAP-
Rule:MF_03148}.
REGION 180 181 Substrate binding. {ECO:0000255|HAMAP-
Rule:MF_03148}.
METAL 45 45 Magnesium or manganese.
{ECO:0000255|HAMAP-Rule:MF_03148}.
METAL 76 76 Magnesium or manganese.
{ECO:0000255|HAMAP-Rule:MF_03148}.
BINDING 58 58 Substrate. {ECO:0000255|HAMAP-
Rule:MF_03148}.
BINDING 175 175 Substrate. {ECO:0000255|HAMAP-
Rule:MF_03148}.
SEQUENCE 197 AA; 22093 MW; 1C7AA19465467C07 CRC64;
MSNNEIVFVT GNANKLKEVQ SILTQEVDNN NKTIHLINEA LDLEELQDTD LNAIALAKGK
QAVAALGKGK PVFVEDTALR FDEFNGLPGA YIKWFLKSMG LEKIVKMLEP FENKNAEAVT
TICFADSRGE YHFFQGITRG KIVPSRGPTT FGWDSIFEPF DSHGLTYAEM SKDAKNAISH
RGKAFAQFKE YLYQNDF


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Pathways :
WP1709: Thiamine metabolism
WP1694: Pyrimidine metabolism
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1693: Purine metabolism
WP203: De Novo Biosynthesis of Purine Nucleotides
WP2184: Purine metabolism
WP2185: Purine metabolism
WP416: Superpathway of Histidine, Purine, and Pyrimidine
WP463: Purine Fermentation
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation

Related Genes :
[HAM1 YJR069C J1811] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Hydroxylaminopurine sensitivity protein 1) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[Itpa] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[rdgB yggV b2954 JW2921] dITP/XTP pyrophosphatase (EC 3.6.1.66) (Deoxyribonucleoside triphosphate pyrophosphohydrolase) (Inosine triphosphate pyrophosphatase) (ITPase) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[MJ0226] dITP/XTP pyrophosphatase (EC 3.6.1.66) (Hypoxanthine/xanthine dNTP pyrophosphatase) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (Nucleotide triphosphatase)
[BN1708_014415] Multifunctional fusion protein [Includes: Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase); Adenylate kinase isoenzyme 6 homolog (AK6) (EC 2.7.4.3) (Dual activity adenylate kinase/ATPase) (AK/ATPase)]
[HAM1 CAGL0F00429g] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[Itpa] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[NCAS0G03460 HAM1 NCAS_0G03460] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[NDAI0D01490 HAM1 NDAI_0D01490] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[TDEL0F00410 HAM1 TDEL_0F00410] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[YJR069C HAM1 SKUD_191604] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[CDV55_101637] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[HAM1 SU7_1858] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[HAM1 WICANDRAFT_32318] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[HAM1 NADFUDRAFT_40215] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[HAM1 BN7_879] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[KAFR0E00280 HAM1 KAFR_0E00280] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[TBLA0A08640 HAM1 TBLA_0A08640] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[VFPPC_16490] Multifunctional fusion protein [Includes: Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase); Adenylate kinase isoenzyme 6 homolog (AK6) (EC 2.7.4.3) (Dual activity adenylate kinase/ATPase) (AK/ATPase)]
[HAM1 DI49_3082] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[HAM1 KO01_02827] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[ZPAR0E00390_A HAM1 BZL39_E00390] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[HAM1 Kpol_1018p180] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[SPCC830.10] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[HAM1 ZYRO0G02068g] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[HAM1 BN860_15984g] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[HAM1 CANCADRAFT_28874] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[HAM1 LIPSTDRAFT_73351] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[BN1708_007575] Multifunctional fusion protein [Includes: Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase); Adenylate kinase isoenzyme 6 homolog (AK6) (EC 2.7.4.3) (Dual activity adenylate kinase/ATPase) (AK/ATPase)]
[HAM1 BN1211_4750] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)

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