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Insulin receptor substrate 1

 A0A1D5QB09_MACMU        Unreviewed;      1253 AA.
A0A1D5QB09;
30-NOV-2016, integrated into UniProtKB/TrEMBL.
30-NOV-2016, sequence version 1.
26-FEB-2020, entry version 24.
SubName: Full=Insulin receptor substrate 1 {ECO:0000313|Ensembl:ENSMMUP00000045227};
Name=IRS1 {ECO:0000313|Ensembl:ENSMMUP00000045227,
ECO:0000313|VGNC:VGNC:73766};
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000045227, ECO:0000313|Proteomes:UP000006718};
[1] {ECO:0000313|Ensembl:ENSMMUP00000045227, ECO:0000313|Proteomes:UP000006718}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000045227,
ECO:0000313|Proteomes:UP000006718};
PubMed=17431167; DOI=10.1126/science.1139247;
Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
Kuhn R.M., Smith K.E., Zwieg A.S.;
"Evolutionary and biomedical insights from the rhesus macaque genome.";
Science 316:222-234(2007).
[2] {ECO:0000313|Ensembl:ENSMMUP00000045227}
IDENTIFICATION.
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000045227};
Ensembl;
Submitted (OCT-2016) to UniProtKB.
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RefSeq; XP_014966672.1; XM_015111186.1.
RefSeq; XP_014966673.1; XM_015111187.1.
STRING; 9544.ENSMMUP00000037491; -.
Ensembl; ENSMMUT00000055849; ENSMMUP00000045227; ENSMMUG00000019467.
GeneID; 707870; -.
KEGG; mcc:707870; -.
CTD; 3667; -.
VGNC; VGNC:73766; IRS1.
GeneTree; ENSGT00940000161579; -.
KO; K16172; -.
OrthoDB; 298675at2759; -.
Proteomes; UP000006718; Chromosome 12.
GO; GO:0005901; C:caveola; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005158; F:insulin receptor binding; IBA:GO_Central.
GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IBA:GO_Central.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:Ensembl.
CDD; cd01204; PTB_IRS; 1.
Gene3D; 2.30.29.30; -; 2.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
Pfam; PF00169; PH; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00233; PH; 1.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000006718}.
DOMAIN 12..115
/note="PH"
/evidence="ECO:0000259|PROSITE:PS50003"
DOMAIN 160..264
/note="IRS-type PTB"
/evidence="ECO:0000259|PROSITE:PS51064"
REGION 262..430
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 494..513
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 594..616
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 669..691
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 802..947
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1067..1182
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1197..1253
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 266..281
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 293..316
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 376..430
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 675..691
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 870..895
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 920..935
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1081..1097
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1109..1124
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1205..1221
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1222..1253
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 1253 AA; 133138 MW; 1EC32B39819A0DBE CRC64;
MASPPESDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP
KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKGH
HDGAAALGAG GGGGSCSGSS GVGEAGEDLS YGDVPPGPAF KEVWQVILKP KGLGQTKNLI
GIYRLCLTSK TISFVKLNSE AAAVVLQLMN IRRCGHSENF FFIEVGRSAV TGPGEFWMQV
DDSVVAQNMH ETILEAMRAM SDEFRPRSKS QSSSNCSNPI SVPLRRHHLN NPPPSQVGLT
RRSRTESITA TSPASMVGGK PGSFRVRASS DGEGTMSRPA SVDGSPVSPS TNRTHAHRHR
GSARLHPPLN HSRSIPMPAS RCSPSATSPV SLSSSSTSGH GSTSDCLFPR RSSASVSGSP
SDGGFISSDE YGSSPCDFRS SFRSVTPDSL GHTPPARGEE ELSNYICMGG KGPSTLTAPN
GHYILSRGGN GHRYTPGTGL GTSPALAGDE ASSAADLDNR FRKRTHSAGT SPTITHQKTP
SQSSVASIEE YTEMMPAYPP GGGSGGRLPG HRHSAFVPTH SYPEEGLEMH PLERRGGHHR
PDSSTLHTDD GYMPMSPGVA PVPSSRKGSG DYMPMSPKSV SAPQQIINPI RRHPQRVDPN
GYMMMSPSGG CSPDIGGGPS SSSSSAVPSG SSYGKLWTNG VGGHHSHVLP HPKPPVESSG
GKLLPCTGDY MNMSPVGDSN TSSPSDCYYG PEDPQHKPVL SYYSLPRSFK HTQRPGEPEE
GARHQHLRLS ASSGRLLYAA TVDDSSSSTS SDSLGGGYCG ARLEPSLPHP HHQVLQPHLP
RKVDTAAQTN SRLARPTRLS LGDPKASTLP RAREQQQQQQ QQQQQQQQQQ QQPLLHPPEP
KSPGEYVNIE FGSDQPGYLS GPVASRSSPS VRCPSQLQPA PREEETGTEE YMKMDLGPGR
RAAWQESTGV EMGRLGPAPP GAASICRPTR AVPSSRGDYM TMQMSCPRQS YVDTSPIAPV
SYADMRTGIA AEEVSLPRAT MAAASSSSAA SASPTGPQGA AELAAHSSLL GGPQGPGGMS
AFTRVNLSPN RNQSAKVIRA DPQGCRRRHS SETFSSTPSA TRVGNTVPFG AGAAIGGGGG
SSSSSEDVKR HSSASFENVW LRPGELGGAP KEPAQLCGAA GGLENGLNYI DLDLVKDFKQ
RPQECSPQPQ PPPPPPPHQP LGSSESSSTR RCSSEDLSAY ASISFQKQPE DLQ


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WP1913: Signaling by Insulin receptor
WP1449: Regulation of toll-like receptor signaling pathway
WP1354: B Cell Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP17: daf-2 or insulin signaling pathway
WP1313: Insulin Signaling
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1345: T Cell Receptor Signaling Pathway
WP481: Insulin Signaling
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1337: MAPK signaling pathway
WP403: Wnt Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP1355: One Carbon Metabolism
WP2328: Allograft rejection
WP774: Kit Receptor Signaling Pathway
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP1350: Type II interferon signaling (IFNG)
WP1183: Toll-like receptor signaling pathway
WP258: TGF-beta Receptor Signaling Pathway
WP794: B Cell Receptor Signaling Pathway
WP2184: Purine metabolism
WP1339: Electron Transport Chain
WP1219: cytochrome P450
WP1963: The effect of Glucocorticoids on target gene expression

Related Genes :
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IRS1] Insulin receptor substrate 1 (IRS-1)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[chico IRS CG5686] Insulin receptor substrate 1 (dIRS) (Protein chico)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[BAIAP2L1 IRTKS] Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[InR dinr Dir-a Inr-a CG18402] Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[igf1r] Insulin-like growth factor 1 receptor (xIGF-1R) (xIGFR) (EC 2.7.10.1) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IRS4] Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
[Insrr Irr] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[insr] Insulin receptor (IR) (EC 2.7.10.1) (XTK-1b) (Xe-InsR) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[IRS2] Insulin receptor substrate 2 (IRS-2)
[INSRR IRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Irs2] Insulin receptor substrate 2 (IRS-2) (4PS)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) (Fragments)
[chico GF14127] Insulin receptor substrate 1 (Protein chico)
[chico GG23965] Insulin receptor substrate 1 (Protein chico)
[chico GM11923] Insulin receptor substrate 1 (Protein chico)
[INSRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC 2.7.10.1) (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[Insrr] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor)

Bibliography :
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