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Insulin receptor substrate 1

 F1MYE0_BOVIN            Unreviewed;      1160 AA.
F1MYE0;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
10-APR-2019, sequence version 3.
26-FEB-2020, entry version 69.
SubName: Full=Insulin receptor substrate 1 {ECO:0000313|Ensembl:ENSBTAP00000028392};
Name=IRS1 {ECO:0000313|VGNC:VGNC:30283};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000028392, ECO:0000313|Proteomes:UP000009136};
[1] {ECO:0000313|Ensembl:ENSBTAP00000028392}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028392};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
[2] {ECO:0000313|Ensembl:ENSBTAP00000028392, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028392,
ECO:0000313|Proteomes:UP000009136};
Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
"ARS-UCD1.2.";
Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
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STRING; 9913.ENSBTAP00000028392; -.
PaxDb; F1MYE0; -.
Ensembl; ENSBTAT00000028392; ENSBTAP00000028392; ENSBTAG00000021308.
VGNC; VGNC:30283; IRS1.
eggNOG; ENOG410IXEK; Eukaryota.
eggNOG; ENOG410Z9EP; LUCA.
GeneTree; ENSGT00940000161579; -.
HOGENOM; CLU_004902_2_0_1; -.
InParanoid; F1MYE0; -.
OrthoDB; 298675at2759; -.
TreeFam; TF325994; -.
Reactome; R-BTA-109704; PI3K Cascade.
Reactome; R-BTA-112399; IRS-mediated signalling.
Reactome; R-BTA-112412; SOS-mediated signalling.
Reactome; R-BTA-1257604; PIP3 activates AKT signaling.
Reactome; R-BTA-1266695; Interleukin-7 signaling.
Reactome; R-BTA-198203; PI3K/AKT activation.
Reactome; R-BTA-5673001; RAF/MAP kinase cascade.
Reactome; R-BTA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-BTA-74749; Signal attenuation.
Proteomes; UP000009136; Chromosome 2.
Bgee; ENSBTAG00000021308; Expressed in skeletal muscle tissue and 8 other tissues.
GO; GO:0005901; C:caveola; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005158; F:insulin receptor binding; IBA:GO_Central.
GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IBA:GO_Central.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:Ensembl.
CDD; cd01204; PTB_IRS; 1.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000009136}.
DOMAIN 83..187
/note="IRS-type PTB"
/evidence="ECO:0000259|PROSITE:PS51064"
REGION 42..62
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 185..353
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 448..468
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 516..539
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 578..616
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 696..753
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 774..813
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 833..853
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 952..1066
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1106..1160
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 189..204
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 216..241
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 251..275
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 290..353
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 449..468
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 596..616
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 697..712
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 715..740
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 798..812
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 833..847
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 952..970
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 990..1004
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1016..1031
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1112..1127
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1128..1160
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 1160 AA; 121758 MW; 70ACF3BC6E45D531 CRC64;
MAGGVRMASQ GPLGLRDIKV TWEKQAVQEH QALLQLHNRA KGHHDGAAAP GAGGGGGSCS
GSSGLGEAGE DLSYGDVPPG PAFKEVWQVI LKPKGLGQTK NLIGIYRLCL TSKTISFVKL
NSEAAAVVLQ LMNIRRCGHS ENFFFIEVGR SAVTGPGEFW MQVDDSVVAQ NMHETILEAM
RAMSDEFRPR SKSQSSSNCS NPISVPLRRH HLNNPPPSQV GLTRRSRTES ITATSPASLV
GGKQGSFRVR ASSDGEGTMS RPASVDGSPV SPSTNRTHAH RHRGSSRLHP PLNHSRSIPM
PSSRCSPSAT SPVSLSSSST SGHGSTSDCL FPRRSSASVS GSPSDGGFIS SDEYGSSPCD
FRSSFRSVTP DSLGHTPPAR GEEELSNYIC MGGKGASTLT APNGHYILPR GGNGHRYVPA
AGLGTSPALP GEEAAGAADL DNRFRKRTHS AGTSPTISHQ KTPSQSSVAS IEEYTEMMPA
YPPGGGSGGR VPSYRHSAFV PTHSYPEEGL EMHPLERRGG HHRPDTSSLH TDDGYMPMSP
GVAPVPGSRK GSGDYMPMSP KSVSAPQQII NPIRRHPQRV DPNGYMMMSP SGSCSPDIGG
GPSSGGSSSG AAPSGSSYGK LWTNGVGGHH SHALPHPKLP VESGSGKLLS CTGDYMNMSP
VGDSNTSSPS DCYYGPEDPQ HKPVLSYYSL PRSFKHTQRP GELEEPRHHQ HLRLSSSSGR
LLYTAAAEDS SSSTSSDSLG GGYCGARPEP GLPHLHHQVL QAHLPRKVDT AAQTNNRLAR
PTRLSLGDPK ASTLPRAREQ QPPPPLLLPP EPKSPGEYVN IEFGSDQPGY LSGPVASHSS
PSIRCPSQLQ PAPREEDTGA EEYMNMDLGP GRRATWQKSV GVQPGRVGPA PPGAASVCRP
TRAVPSSCGD YMTMQMGGPR QSYVDTSPVA PISYADMRTG VVVEDASLPR ATAAAPSSSS
TASVSSTAPP PGTGELAARS ALLGGPSAFT RVNLSPNRNQ SAKVIRADPQ GCRRRHSSET
FSSTPSATRV GNTMPFGAGA AVGGSGGGSS SSAEDVKRHS SASFENVWLR PGELGGAPKE
LAQVCGAAGG LENGLNYIDL DLVKDFKQRP QECPPQPQPP PLPAPHQPLA SSQSGPTSRS
SEDLSAYASI TFQKQPEDLQ


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Pathways :
WP1913: Signaling by Insulin receptor
WP1449: Regulation of toll-like receptor signaling pathway
WP1354: B Cell Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP17: daf-2 or insulin signaling pathway
WP1313: Insulin Signaling
WP1345: T Cell Receptor Signaling Pathway
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP1350: Type II interferon signaling (IFNG)
WP1183: Toll-like receptor signaling pathway
WP481: Insulin Signaling
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1337: MAPK signaling pathway
WP403: Wnt Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP1355: One Carbon Metabolism
WP2328: Allograft rejection
WP774: Kit Receptor Signaling Pathway
WP1411: Cell Division: First embryonic mitosis
WP710: DNA damage response (only ATM dependent)
WP1025: B Cell Receptor Signaling Pathway
WP1384: Toll-like receptor signaling pathway
WP258: TGF-beta Receptor Signaling Pathway
WP794: B Cell Receptor Signaling Pathway

Related Genes :
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IRS1] Insulin receptor substrate 1 (IRS-1)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[chico IRS CG5686] Insulin receptor substrate 1 (dIRS) (Protein chico)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[BAIAP2L1 IRTKS] Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[InR dinr Dir-a Inr-a CG18402] Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[igf1r] Insulin-like growth factor 1 receptor (xIGF-1R) (xIGFR) (EC 2.7.10.1) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IRS4] Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
[Insrr Irr] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[insr] Insulin receptor (IR) (EC 2.7.10.1) (XTK-1b) (Xe-InsR) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[IRS2] Insulin receptor substrate 2 (IRS-2)
[INSRR IRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Irs2] Insulin receptor substrate 2 (IRS-2) (4PS)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) (Fragments)
[chico GF14127] Insulin receptor substrate 1 (Protein chico)
[chico GG23965] Insulin receptor substrate 1 (Protein chico)
[chico GM11923] Insulin receptor substrate 1 (Protein chico)
[INSRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC 2.7.10.1) (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[Insrr] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor)

Bibliography :
[32603046] A 3'-untranslated region variant (rs2289046) of insulin receptor substrate 2 gene is associated with susceptibility to nonalcoholic fatty liver disease.
[32597148] Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells.
[32588693] DPP-4 inhibition resembles exercise in preventing type 2 diabetes development by inhibiting hepatic protein kinase C expression in a mouse model of hyperinsulinemia.
[32564738] Interleukin-4 Restores Insulin Sensitivity in Insulin-Resistant Osteoblasts by Increasing the Expression of Insulin Receptor Substrate 1.
[32554797] The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint.
[32536688] Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance.
[32497958] Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: roles of FGF21 and bile acids.
[32469087] HMGB1-induced aberrant autophagy contributes to insulin resistance in granulosa cells in PCOS.
[32458968] Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats.
[32455838] Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms-A Narrative Review.