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Insulin receptor substrate 1

 Q543V3_MOUSE            Unreviewed;      1231 AA.
Q543V3;
24-MAY-2005, integrated into UniProtKB/TrEMBL.
24-MAY-2005, sequence version 1.
17-JUN-2020, entry version 142.
SubName: Full=Insulin receptor substrate 1 {ECO:0000313|Ensembl:ENSMUSP00000063795};
Name=Irs1 {ECO:0000313|Ensembl:ENSMUSP00000063795,
ECO:0000313|MGI:MGI:99454};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC32308.1};
[1] {ECO:0000313|EMBL:BAC32308.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC32308.1};
TISSUE=Heart {ECO:0000313|EMBL:BAE24991.1}, and
Parthenogenote {ECO:0000313|EMBL:BAC32308.1};
PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
Carninci P., Hayashizaki Y.;
"High-efficiency full-length cDNA cloning.";
Methods Enzymol. 303:19-44(1999).
[2] {ECO:0000313|EMBL:BAC32308.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC32308.1};
TISSUE=Heart {ECO:0000313|EMBL:BAE24991.1}, and
Parthenogenote {ECO:0000313|EMBL:BAC32308.1};
PubMed=11042159; DOI=10.1101/gr.145100;
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
"Normalization and subtraction of cap-trapper-selected cDNAs to prepare
full-length cDNA libraries for rapid discovery of new genes.";
Genome Res. 10:1617-1630(2000).
[3] {ECO:0000313|EMBL:BAC32308.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC32308.1};
TISSUE=Heart {ECO:0000313|EMBL:BAE24991.1}, and
Parthenogenote {ECO:0000313|EMBL:BAC32308.1};
PubMed=11076861; DOI=10.1101/gr.152600;
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
"RIKEN integrated sequence analysis (RISA) system--384-format sequencing
pipeline with 384 multicapillary sequencer.";
Genome Res. 10:1757-1771(2000).
[4] {ECO:0000313|EMBL:BAC32308.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC32308.1};
TISSUE=Heart {ECO:0000313|EMBL:BAE24991.1}, and
Parthenogenote {ECO:0000313|EMBL:BAC32308.1};
PubMed=11217851; DOI=10.1038/35055500;
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
"Functional annotation of a full-length mouse cDNA collection.";
Nature 409:685-690(2001).
[5] {ECO:0000313|EMBL:BAC32308.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC32308.1};
TISSUE=Parthenogenote {ECO:0000313|EMBL:BAC32308.1};
Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
Hayashizaki Y.;
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000313|EMBL:BAC32308.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC32308.1};
TISSUE=Heart {ECO:0000313|EMBL:BAE24991.1}, and
Parthenogenote {ECO:0000313|EMBL:BAC32308.1};
PubMed=12466851; DOI=10.1038/nature01266;
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
"Analysis of the mouse transcriptome based on functional annotation of
60,770 full-length cDNAs.";
Nature 420:563-573(2002).
[7] {ECO:0000313|EMBL:BAE24991.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24991.1};
TISSUE=Heart {ECO:0000313|EMBL:BAE24991.1};
Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:BAC32308.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC32308.1};
TISSUE=Heart {ECO:0000313|EMBL:BAE24991.1}, and
Parthenogenote {ECO:0000313|EMBL:BAC32308.1};
The FANTOM Consortium;
Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
"The Transcriptional Landscape of the Mammalian Genome.";
Science 309:1559-1563(2005).
[9] {ECO:0000313|EMBL:BAC32308.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC32308.1};
TISSUE=Heart {ECO:0000313|EMBL:BAE24991.1}, and
Parthenogenote {ECO:0000313|EMBL:BAC32308.1};
PubMed=16141073; DOI=10.1126/science.1112009;
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
"Antisense Transcription in the Mammalian Transcriptome.";
Science 309:1564-1566(2005).
[10] {ECO:0000213|PubMed:17242355}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[11] {ECO:0000313|Ensembl:ENSMUSP00000063795, ECO:0000313|Proteomes:UP000000589}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000063795,
ECO:0000313|Proteomes:UP000000589};
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[12] {ECO:0000213|PubMed:21183079}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[13] {ECO:0000313|Ensembl:ENSMUSP00000063795}
IDENTIFICATION.
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000063795};
Ensembl;
Submitted (JUN-2011) to UniProtKB.
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EMBL; AC123690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC137845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AK045317; BAC32308.1; -; mRNA.
EMBL; AK142242; BAE24991.1; -; mRNA.
RefSeq; NP_034700.2; NM_010570.4.
Antibodypedia; 3935; 2451 antibodies.
Ensembl; ENSMUST00000069799; ENSMUSP00000063795; ENSMUSG00000055980.
GeneID; 16367; -.
KEGG; mmu:16367; -.
UCSC; uc007brp.2; mouse.
CTD; 3667; -.
MGI; MGI:99454; Irs1.
eggNOG; ENOG410IXEK; Eukaryota.
eggNOG; ENOG410Z9EP; LUCA.
GeneTree; ENSGT00940000161579; -.
HOGENOM; CLU_004902_2_0_1; -.
KO; K16172; -.
OMA; YGKLWTN; -.
OrthoDB; 298675at2759; -.
TreeFam; TF325994; -.
BioGRID-ORCS; 16367; 4 hits in 12 CRISPR screens.
ChiTaRS; Irs1; mouse.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000055980; Expressed in pineal body and 269 other tissues.
GO; GO:0005901; C:caveola; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:Ensembl.
CDD; cd01204; PTB_IRS; 1.
Gene3D; 2.30.29.30; -; 2.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
Pfam; PF00169; PH; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00233; PH; 1.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
1: Evidence at protein level;
Proteomics identification {ECO:0000213|MaxQB:Q543V3,
ECO:0000213|PeptideAtlas:Q543V3};
Reference proteome {ECO:0000313|Proteomes:UP000000589}.
DOMAIN 12..115
/note="PH"
/evidence="ECO:0000259|PROSITE:PS50003"
DOMAIN 155..259
/note="IRS-type PTB"
/evidence="ECO:0000259|PROSITE:PS51064"
REGION 257..425
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 651..720
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 766..985
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1015..1135
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1174..1231
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 261..276
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 288..311
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 362..425
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 668..693
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 769..783
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 784..812
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 867..883
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1029..1054
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1065..1083
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1202..1225
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 1231 AA; 130584 MW; FC4388974D9B561A CRC64;
MASPPDTDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP
KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKAH
HDGAGGGCGG SCSGSSGVGE AGEDLSYDTG PGPAFKEVWQ VILKPKGLGQ TKNLIGIYRL
CLTSKTISFV KLNSEAAAVV LQLMNIRRCG HSENFFFIEV GRSAVTGPGE FWMQVDDSVV
AQNMHETILE AMRAMSDEFR PRSKSQSSSS CSNPISVPLR RHHLNNPPPS QVGLTRRSRT
ESITATSPAS MVGGKPGSFR VRASSDGEGT MSRPASVDGS PVSPSTNRTH AHRHRGSSRL
HPPLNHSRSI PMPSSRCSPS ATSPVSLSSS STSGHGSTSD CLFPRRSSAS VSGSPSDGGF
ISSDEYGSSP CDFRSSFRSV TPDSLGHTPP ARGEEELSNY ICMGGKGAST LAAPNGHYIL
SRGGNGHRYI PGANLGTSPA LPGDEAAGAA DLDNRFRKRT HSAGTSPTIS HQKTPSQSSV
ASIEEYTEMM PAAYPPGGGS GGRLPGYRHS AFVPTHSYPE EGLEMHHLER RGGHHRPDTS
NLHTDDGYMP MSPGVAPVPS NRKGNGDYMP MSPKSVSAPQ QIINPIRRHP QRVDPNGYMM
MSPSGSCSPD IGGGSSSSSS ISAAPSGSSY GKPWTNGVGG HHTHALPHAK PPVESGGGKL
LPCTGDYMNM SPVGDSNTSS PSECYYGPED PQHKPVLSYY SLPRSFKHTQ RPGEPEEGAR
HQHLRLSSSS GRLRYTATAE DSSSSTSSDS LGGGYCGARP ESSLTHPHHH VLQPHLPRKV
DTAAQTNSRL ARPTRLSLGD PKASTLPRVR EQQQQQQSSL HPPEPKSPGE YVNIEFGSGQ
PGYLAGPATS RSSPSVRCPP QLHPAPREET GSEEYMNMDL GPGRRATWQE SGGVELGRIG
PAPPGSATVC RPTRSVPNSR GDYMTMQIGC PRQSYVDTSP VAPVSYADMR TGIAAEKASL
PRPTGAAPPP SSTASSSVTP QGATAEQATH SSLLGGPQGP GGMSAFTRVN LSPNHNQSAK
VIRADTQGCR RRHSSETFSA PTRAGNTVPF GAGAAVGGSG GGGGGGSEDV KRHSSASFEN
VWLRPGDLGG VSKESAPVCG AAGGLEKSLN YIDLDLAKER SQDCPSQQQS LPPPPPHQPL
GSNEGNSPRR SSEDLSNYAS ISFQKQPEDR Q


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Pathways :
WP1913: Signaling by Insulin receptor
WP1449: Regulation of toll-like receptor signaling pathway
WP1354: B Cell Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP17: daf-2 or insulin signaling pathway
WP1313: Insulin Signaling
WP1345: T Cell Receptor Signaling Pathway
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP1350: Type II interferon signaling (IFNG)
WP1183: Toll-like receptor signaling pathway
WP481: Insulin Signaling
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1337: MAPK signaling pathway
WP403: Wnt Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP1355: One Carbon Metabolism
WP2328: Allograft rejection
WP774: Kit Receptor Signaling Pathway
WP1411: Cell Division: First embryonic mitosis
WP710: DNA damage response (only ATM dependent)
WP1025: B Cell Receptor Signaling Pathway
WP1384: Toll-like receptor signaling pathway
WP258: TGF-beta Receptor Signaling Pathway
WP794: B Cell Receptor Signaling Pathway

Related Genes :
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IRS1] Insulin receptor substrate 1 (IRS-1)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[chico IRS CG5686] Insulin receptor substrate 1 (dIRS) (Protein chico)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[BAIAP2L1 IRTKS] Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[InR dinr Dir-a Inr-a CG18402] Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[igf1r] Insulin-like growth factor 1 receptor (xIGF-1R) (xIGFR) (EC 2.7.10.1) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IRS4] Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
[Insrr Irr] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[insr] Insulin receptor (IR) (EC 2.7.10.1) (XTK-1b) (Xe-InsR) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[IRS2] Insulin receptor substrate 2 (IRS-2)
[INSRR IRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Irs2] Insulin receptor substrate 2 (IRS-2) (4PS)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) (Fragments)
[chico GF14127] Insulin receptor substrate 1 (Protein chico)
[chico GG23965] Insulin receptor substrate 1 (Protein chico)
[chico GM11923] Insulin receptor substrate 1 (Protein chico)
[INSRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC 2.7.10.1) (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[Insrr] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor)

Bibliography :
[32603046] A 3'-untranslated region variant (rs2289046) of insulin receptor substrate 2 gene is associated with susceptibility to nonalcoholic fatty liver disease.
[32597148] Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells.
[32588693] DPP-4 inhibition resembles exercise in preventing type 2 diabetes development by inhibiting hepatic protein kinase C expression in a mouse model of hyperinsulinemia.
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