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Insulin receptor substrate 1 (IRS-1) (pp185)

 IRS1_RAT                Reviewed;        1235 AA.
P35570;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
16-JAN-2019, entry version 160.
RecName: Full=Insulin receptor substrate 1;
Short=IRS-1;
AltName: Full=pp185;
Name=Irs1; Synonyms=Irs-1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
STRAIN=Sprague-Dawley; TISSUE=Liver;
PubMed=1648180; DOI=10.1038/352073a0;
Sun X.-J., Rothenberg P.L., Kahn C.R., Backer J.M., Araki E.,
Wilden P.A., Cahill D.A., Goldstein B.J., White M.F.;
"Structure of the insulin receptor substrate IRS-1 defines a unique
signal transduction protein.";
Nature 352:73-77(1991).
[2]
PROTEIN SEQUENCE OF 44-51; 173-178; 223-243; 489-506; 635-646; 932-947
AND 1098-1106.
PubMed=2022647;
Rothenberg P.L., Lane W.S., Karasik A., Backer J.M., White M.F.,
Kahn C.R.;
"Purification and partial sequence analysis of pp185, the major
cellular substrate of the insulin receptor tyrosine kinase.";
J. Biol. Chem. 266:8302-8311(1991).
[3]
FUNCTION, PHOSPHORYLATION, AND INTERACTION WITH PIK3R1.
PubMed=1380456;
Backer J.M., Myers M.G. Jr., Shoelson S.E., Chin D.J., Sun X.-J.,
Miralpeix M., Hu P., Margolis B., Skolnik E.Y., Schlessinger J.,
White M.F.;
"Phosphatidylinositol 3'-kinase is activated by association with IRS-1
during insulin stimulation.";
EMBO J. 11:3469-3479(1992).
[4]
INTERACTION WITH GRB2.
PubMed=8491186;
Skolnik E.Y., Lee C.-H., Batzer A.G., Vicentini L.M., Zhou M.,
Daly R.J., Myers M.J. Jr., Backer J.M., Ullrich A., White M.F.,
Schlessinger J.;
"The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-
phosphorylated IRS1 and Shc: implications for insulin control of ras
signalling.";
EMBO J. 12:1929-1936(1993).
[5]
PHOSPHORYLATION AT TYR-460; TYR-608; TYR-628; TYR-895; TYR-939;
TYR-987; TYR-1172 AND TYR-1222.
PubMed=7504175; DOI=10.1128/MCB.13.12.7418;
Sun X.-J., Crimmins D.L., Myers M.G. Jr., Miralpeix M., White M.F.;
"Pleiotropic insulin signals are engaged by multisite phosphorylation
of IRS-1.";
Mol. Cell. Biol. 13:7418-7428(1993).
[6]
PHOSPHORYLATION AT SER-99 AND THR-502.
PubMed=8349691;
Tanasijevic M.J., Myers M.G. Jr., Thoma R.S., Crimmins D.L.,
White M.F., Sacks D.B.;
"Phosphorylation of the insulin receptor substrate IRS-1 by casein
kinase II.";
J. Biol. Chem. 268:18157-18166(1993).
[7]
INTERACTION WITH PHIP, AND MUTAGENESIS OF TRP-106.
PubMed=11018022; DOI=10.1074/jbc.C000611200;
Farhang-Fallah J., Yin X., Trentin G., Cheng A.M., Rozakis-Adcock M.;
"Cloning and characterization of PHIP, a novel insulin receptor
substrate-1 pleckstrin homology domain interacting protein.";
J. Biol. Chem. 275:40492-40497(2000).
[8]
PHOSPHORYLATION AT SER-307.
PubMed=11606564; DOI=10.1074/jbc.M101521200;
Aguirre V., Werner E.D., Giraud J., Lee Y.H., Shoelson S.E.,
White M.F.;
"Phosphorylation of Ser307 in insulin receptor substrate-1 blocks
interactions with the insulin receptor and inhibits insulin action.";
J. Biol. Chem. 277:1531-1537(2002).
[9]
PHOSPHORYLATION AT SER-789.
PubMed=12006586; DOI=10.1074/jbc.M201494200;
Qiao L.Y., Zhande R., Jetton T.L., Zhou G., Sun X.-J.;
"In vivo phosphorylation of insulin receptor substrate 1 at serine 789
by a novel serine kinase in insulin-resistant rodents.";
J. Biol. Chem. 277:26530-26539(2002).
[10]
INTERACTION WITH ROCK1, AND PHOSPHORYLATION.
PubMed=11739394; DOI=10.1074/jbc.M110508200;
Begum N., Sandu O.A., Ito M., Lohmann S.M., Smolenski A.;
"Active Rho kinase (ROK-alpha) associates with insulin receptor
substrate-1 and inhibits insulin signaling in vascular smooth muscle
cells.";
J. Biol. Chem. 277:6214-6222(2002).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; SER-343; THR-441;
THR-448 AND SER-891, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE
SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
[12]
INTERACTION WITH GKAP1.
PubMed=25586176; DOI=10.1074/jbc.M114.624759;
Ando Y., Shinozawa Y., Iijima Y., Yu B.C., Sone M., Ooi Y.,
Watanaka Y., Chida K., Hakuno F., Takahashi S.;
"Tumor necrosis factor (TNF)-alpha-induced repression of GKAP42
protein levels through cGMP-dependent kinase (cGK)-Ialpha causes
insulin resistance in 3T3-L1 adipocytes.";
J. Biol. Chem. 290:5881-5892(2015).
[13]
INTERACTION WITH DGKZ.
PubMed=27739494; DOI=10.1038/srep35438;
Liu T., Yu B., Kakino M., Fujimoto H., Ando Y., Hakuno F.,
Takahashi S.I.;
"A novel IRS-1-associated protein, DGKzeta regulates GLUT4
translocation in 3T3-L1 adipocytes.";
Sci. Rep. 6:35438-35438(2016).
-!- FUNCTION: May mediate the control of various cellular processes by
insulin. When phosphorylated by the insulin receptor binds
specifically to various cellular proteins containing SH2 domains
such as phosphatidylinositol 3-kinase p85 subunit or GRB2.
Activates phosphatidylinositol 3-kinase when bound to the
regulatory p85 subunit. {ECO:0000269|PubMed:1380456}.
-!- SUBUNIT: Interacts with SOCS7 (By similarity). Interacts (via IRS-
type PTB domain) with IGF1R and INSR (via the tyrosine-
phosphorylated NPXY motif) (By similarity). Interacts with UBTF,
FER and PIK3CA (By similarity). Interacts (via phosphorylated YXXM
motifs) with PIK3R1 (PubMed:1380456). Interacts with ROCK1
(PubMed:11739394). Interacts (via PH domain) with PHIP
(PubMed:11018022). Interacts with GRB2 (PubMed:8491186). Interacts
with ALK (By similarity). Interacts with EIF2AK2/PKR (By
similarity). Interacts with GKAP1 (PubMed:25586176). Interacts
with DGKZ in the absence of insulin; insulin stimulation decreases
this interaction (PubMed:27739494). Found in a ternary complex
with DGKZ and PIP5K1A in the absence of insulin stimulation (By
similarity). {ECO:0000250|UniProtKB:P35568,
ECO:0000250|UniProtKB:P35569, ECO:0000269|PubMed:11018022,
ECO:0000269|PubMed:11739394, ECO:0000269|PubMed:1380456,
ECO:0000269|PubMed:25586176, ECO:0000269|PubMed:27739494,
ECO:0000269|PubMed:8491186}.
-!- INTERACTION:
P39688:Fyn (xeno); NbExp=4; IntAct=EBI-520230, EBI-524514;
P62993:GRB2 (xeno); NbExp=5; IntAct=EBI-520230, EBI-401755;
P06213:INSR (xeno); NbExp=5; IntAct=EBI-520230, EBI-475899;
Q9EPH8:Pabpc1; NbExp=2; IntAct=EBI-520230, EBI-919825;
Q8VDD9:Phip (xeno); NbExp=2; IntAct=EBI-520230, EBI-1369766;
P27986:PIK3R1 (xeno); NbExp=2; IntAct=EBI-520230, EBI-79464;
Q63787:Pik3r1; NbExp=3; IntAct=EBI-520230, EBI-518443;
Q04759:PRKCQ (xeno); NbExp=2; IntAct=EBI-520230, EBI-374762;
P18031:PTPN1 (xeno); NbExp=3; IntAct=EBI-520230, EBI-968788;
Q06124:PTPN11 (xeno); NbExp=3; IntAct=EBI-520230, EBI-297779;
Q13625-2:TP53BP2 (xeno); NbExp=4; IntAct=EBI-520230, EBI-287091;
-!- PTM: Serine phosphorylation of IRS1 is a mechanism for insulin
resistance. Ser-307 phosphorylation inhibits insulin action
through disruption of IRS1 interaction with the insulin receptor,
and Ser-789 phosphorylation is increased in the liver of insulin-
resistant rats (PubMed:11606564, PubMed:12006586, PubMed:7504175).
Phosphorylation of Tyr-895 is required for GRB2-binding.
Phosphorylated by ALK. Phosphorylated at Ser-265, Ser-302, Ser-632
and Ser-1100 by RPS6KB1; phosphorylation induces accelerated
degradation of IRS1 (By similarity). Phosphorylated on tyrosine
residues in response to insulin (By similarity).
{ECO:0000250|UniProtKB:P35568, ECO:0000250|UniProtKB:P35569,
ECO:0000269|PubMed:11606564, ECO:0000269|PubMed:12006586,
ECO:0000269|PubMed:7504175}.
-!- PTM: Ubiquitinated by the Cul7-RING(FBXW8) complex in a mTOR-
dependent manner, leading to its degradation: the Cul7-RING(FBXW8)
complex recognizes and binds IRS1 previously phosphorylated by S6
kinase (RPS6KB1 or RPS6KB2). {ECO:0000250}.
-----------------------------------------------------------------------
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EMBL; X58375; CAA41264.1; -; mRNA.
PIR; S16948; S16948.
RefSeq; NP_037101.1; NM_012969.1.
UniGene; Rn.10476; -.
PDB; 5WRK; X-ray; 2.62 A; P=607-614.
PDB; 5WRL; X-ray; 3.10 A; P=627-634.
PDB; 5WRM; X-ray; 2.60 A; P=657-664.
PDBsum; 5WRK; -.
PDBsum; 5WRL; -.
PDBsum; 5WRM; -.
ProteinModelPortal; P35570; -.
SMR; P35570; -.
BioGrid; 247500; 13.
CORUM; P35570; -.
DIP; DIP-664N; -.
ELM; P35570; -.
IntAct; P35570; 21.
MINT; P35570; -.
STRING; 10116.ENSRNOP00000019579; -.
BindingDB; P35570; -.
ChEMBL; CHEMBL1163110; -.
iPTMnet; P35570; -.
PhosphoSitePlus; P35570; -.
PaxDb; P35570; -.
PRIDE; P35570; -.
GeneID; 25467; -.
KEGG; rno:25467; -.
UCSC; RGD:2922; rat.
CTD; 3667; -.
RGD; 2922; Irs1.
eggNOG; ENOG410IXEK; Eukaryota.
eggNOG; ENOG410Z9EP; LUCA.
HOGENOM; HOG000113103; -.
HOVERGEN; HBG000542; -.
InParanoid; P35570; -.
KO; K16172; -.
OrthoDB; 298675at2759; -.
PhylomeDB; P35570; -.
PRO; PR:P35570; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0005899; C:insulin receptor complex; IMP:BHF-UCL.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0005158; F:insulin receptor binding; IMP:RGD.
GO; GO:0005159; F:insulin-like growth factor receptor binding; IPI:RGD.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IDA:UniProtKB.
GO; GO:0019904; F:protein domain specific binding; IPI:RGD.
GO; GO:0019901; F:protein kinase binding; IPI:RGD.
GO; GO:0005080; F:protein kinase C binding; IPI:BHF-UCL.
GO; GO:0042169; F:SH2 domain binding; IPI:UniProtKB.
GO; GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; IMP:BHF-UCL.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:1904385; P:cellular response to angiotensin; IDA:RGD.
GO; GO:1990416; P:cellular response to brain-derived neurotrophic factor stimulus; IEP:RGD.
GO; GO:0071478; P:cellular response to radiation; IEP:RGD.
GO; GO:0008286; P:insulin receptor signaling pathway; IDA:BHF-UCL.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:BHF-UCL.
GO; GO:0046676; P:negative regulation of insulin secretion; IMP:BHF-UCL.
GO; GO:0090275; P:negative regulation of somatostatin secretion; IMP:BHF-UCL.
GO; GO:0070094; P:positive regulation of glucagon secretion; IMP:BHF-UCL.
GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IMP:BHF-UCL.
GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO; GO:0042327; P:positive regulation of phosphorylation; IDA:BHF-UCL.
GO; GO:0051291; P:protein heterooligomerization; IDA:RGD.
GO; GO:0014823; P:response to activity; IEP:RGD.
GO; GO:0031000; P:response to caffeine; IDA:RGD.
GO; GO:0043434; P:response to peptide hormone; IDA:UniProtKB.
CDD; cd01204; PTB_IRS; 1.
Gene3D; 2.30.29.30; -; 2.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
Pfam; PF00169; PH; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00233; PH; 1.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Direct protein sequencing;
Phosphoprotein; Reference proteome; Repeat; Transducer;
Ubl conjugation.
CHAIN 1 1235 Insulin receptor substrate 1.
/FTId=PRO_0000084238.
DOMAIN 12 115 PH. {ECO:0000255|PROSITE-
ProRule:PRU00145}.
DOMAIN 155 259 IRS-type PTB. {ECO:0000255|PROSITE-
ProRule:PRU00389}.
REGION 3 133 Mediates interaction with PHIP.
{ECO:0000269|PubMed:11018022}.
REGION 895 897 GRB2-binding.
MOTIF 460 463 YXXM motif 1.
MOTIF 546 549 YXXM motif 2.
MOTIF 608 611 YXXM motif 3.
MOTIF 628 631 YXXM motif 4.
MOTIF 658 661 YXXM motif 5.
MOTIF 727 730 YXXM motif 6.
MOTIF 939 942 YXXM motif 7.
MOTIF 987 990 YXXM motif 8.
MOTIF 1010 1013 YXXM motif 9.
COMPBIAS 872 881 Poly-Gln.
COMPBIAS 1196 1200 Poly-Pro.
MOD_RES 3 3 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 99 99 Phosphoserine; by CK2.
{ECO:0000269|PubMed:8349691}.
MOD_RES 265 265 Phosphoserine; by RPS6KB1.
{ECO:0000250|UniProtKB:P35568}.
MOD_RES 302 302 Phosphoserine; by RPS6KB1.
{ECO:0000250|UniProtKB:P35568}.
MOD_RES 307 307 Phosphoserine; by IKKB, MAPK8 and
RPS6KB1. {ECO:0000250|UniProtKB:P35568}.
MOD_RES 318 318 Phosphoserine.
{ECO:0000250|UniProtKB:P35568}.
MOD_RES 325 325 Phosphoserine.
{ECO:0000250|UniProtKB:P35569}.
MOD_RES 340 340 Phosphoserine.
{ECO:0000250|UniProtKB:P35569}.
MOD_RES 343 343 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 414 414 Phosphoserine.
{ECO:0000250|UniProtKB:P35569}.
MOD_RES 441 441 Phosphothreonine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 448 448 Phosphothreonine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 460 460 Phosphotyrosine; by INSR.
{ECO:0000269|PubMed:7504175}.
MOD_RES 502 502 Phosphothreonine; by CK2.
{ECO:0000269|PubMed:8349691}.
MOD_RES 522 522 Phosphoserine; by RPS6KB1.
{ECO:0000250|UniProtKB:P35568}.
MOD_RES 608 608 Phosphotyrosine; by INSR.
{ECO:0000269|PubMed:7504175}.
MOD_RES 628 628 Phosphotyrosine; by INSR.
{ECO:0000269|PubMed:7504175}.
MOD_RES 632 632 Phosphoserine; by RPS6KB1 and ROCK2.
{ECO:0000250|UniProtKB:P35569}.
MOD_RES 658 658 Phosphotyrosine.
{ECO:0000250|UniProtKB:P35568}.
MOD_RES 789 789 Phosphoserine; by AMPK and SIK2.
{ECO:0000269|PubMed:12006586}.
MOD_RES 891 891 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 895 895 Phosphotyrosine; by INSR.
{ECO:0000269|PubMed:7504175}.
MOD_RES 939 939 Phosphotyrosine; by INSR.
{ECO:0000269|PubMed:7504175}.
MOD_RES 987 987 Phosphotyrosine; by INSR.
{ECO:0000269|PubMed:7504175}.
MOD_RES 1099 1099 Phosphoserine.
{ECO:0000250|UniProtKB:P35569}.
MOD_RES 1100 1100 Phosphoserine; by RPS6KB1.
{ECO:0000250|UniProtKB:P35568}.
MOD_RES 1172 1172 Phosphotyrosine; by INSR.
{ECO:0000269|PubMed:7504175}.
MOD_RES 1222 1222 Phosphotyrosine; by INSR.
{ECO:0000269|PubMed:7504175}.
MUTAGEN 106 106 W->A: Loss of interaction with PHIP.
{ECO:0000269|PubMed:11018022}.
CONFLICT 1098 1098 H -> L (in Ref. 2; AA sequence).
{ECO:0000305}.
SEQUENCE 1235 AA; 131178 MW; A274BC7540CA85C5 CRC64;
MASPPDTDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP
KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKAH
HDGAGGGCGG SCSGSSGVGE AGEDLSYDTG PGPAFKEVWQ VILKPKGLGQ TKNLIGIYRL
CLTSKTISFV KLNSEAAAVV LQLMNIRRCG HSENFFFIEV GRSAVTGPGE FWMQVDDSVV
AQNMHETILE AMRAMSDEFR PRTKSQSSSS CSNPISVPLR RHHLNNPPPS QVGLTRRSRT
ESITATSPAS MVGGKPGSFR VRASSDGEGT MSRPASVDGS PVSPSTNRTH AHRHRGSSRL
HPPLNHSRSI PMPSSRCSPS ATSPVSLSSS STSGHGSTSD CLFPRRSSAS VSGSPSDGGF
ISSDEYGSSP CDFRSSFRSV TPDSLGHTPP ARGEEELSNY ICMGGKGAST LTAPNGHYIL
SRGGNGHRYI PGATMGTSPA LTGDEAAGAA DLDNRFRKRT HSAGTSPTIS HQKTPSQSSV
VSIEEYTEMM PAAYPPGGGS GGRLPGYRHS AFVPTHSYPE EGLEMHHLER RGGHHRPDSS
NLHTDDGYMP MSPGVAPVPS NRKGNGDYMP MSPKSVSAPQ QIINPIRRHP QRVDPNGYMM
MSPSGSCSPD IGGGSCSSSS ISAAPSGSSY GKPWTNGVGG HHTHALPHAK PPVESGGGKL
LPCTGDYMNM SPVGDSNTSS PSECYYGPED PQHKPVLSYY SLPRSFKHTQ RPGEPEEGAR
HQHLRLSSSS GRLRYTATAE DSSSSTSSDS LGGGYCGARP ESSVTHPHHH ALQPHLPRKV
DTAAQTNSRL ARPTRLSLGD PKASTLPRVR EQQQQQQQQQ QSSLHPPEPK SPGEYVNIEF
GSGQPGYLAG PATSRSSPSV RCLPQLHPAP REETGSEEYM NMDLGPGRRA TWQESGGVEL
GRVGPAPPGA ASICRPTRSV PNSRGDYMTM QIGCPRQSYV DTSPVAPVSY ADMRTGIAAE
KVSLPRTTGA APPPSSTASA SASVTPQGAA EQAAHSSLLG GPQGPGGMSA FTRVNLSPNH
NQSAKVIRAD TQGCRRRHSS ETFSAPTRAA NTVSFGAGAA GGGSGGGSED VKRHSSASFE
NVWLRPGDLG GASKESAPGC GAAGGLEKSL NYIDLDLVKD VKQHPQDCPS QQQSLPPPPP
HQPLGSNEGS SPRRSSEDLS TYASINFQKQ PEDRQ


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Pathways :
WP1913: Signaling by Insulin receptor
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1025: B Cell Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1067: Toll-like receptor signaling pathway
WP1077: cytochrome P450
WP1085: Insulin Signaling
WP1112: EPO Receptor Signaling
WP1121: Kit Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1133: Androgen receptor signaling pathway
WP1144: B Cell Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1183: Toll-like receptor signaling pathway
WP1194: cytochrome P450
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1219: cytochrome P450
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1249: EPO Receptor Signaling
WP1271: Toll-like receptor signaling pathway
WP1274: cytochrome P450

Related Genes :
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[IRS1] Insulin receptor substrate 1 (IRS-1)
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
[IRS4] Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[InR dinr Dir-a Inr-a CG18402] Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
[Irs4] Insulin receptor substrate 4 (IRS-4) (Phosphoprotein of 160 kDa) (pp160)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC 2.7.10.1) (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[irs1-a] Insulin receptor substrate 1-A (IRS1-A) (xIRS-1-A) (XIRS-L)
[DOK5 C20orf180] Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)
[KRT71 K6IRS1 KB34 KRT6IRS1] Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34)
[DOK4] Docking protein 4 (Downstream of tyrosine kinase 4) (Insulin receptor substrate 5) (IRS-5) (IRS5)
[Sirpa Bit Mfr Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (Macrophage membrane protein MFP150) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (CD antigen CD172a)
[Krt71 K6irs1 Kb34 Krt2-6g Krt6g] Keratin, type II cytoskeletal 71 (Cytokeratin-6G) (CK-6G) (Cytokeratin-71) (CK-71) (Keratin-6G) (K6G) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (mK6irs) (mK6irs1/Krt2-6g) (Type-II keratin Kb34)
[NISCH IRAS KIAA0975] Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] (Fragment)
[SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
[INS] Insulin [Cleaved into: Insulin B chain; Insulin A chain]
[PTPN11 PTP2C SHPTP2] Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
[rseA mclA yfiJ b2572 JW2556] Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA) (Sigma-E factor negative regulatory protein)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)

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[9496432] Tissue-specific regulation of IRS-1 in unilaterally nephrectomized rats.
[9267983] Fatty acid induced insulin resistance in rat-1 fibroblasts overexpressing human insulin receptors: impaired insulin-stimulated mitogen-activated protein kinase activity.