GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Insulin receptor substrate 1-A (IRS1-A) (xIRS-1-A) (XIRS-L)

 IRS1A_XENLA             Reviewed;         885 AA.
Q91615;
21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
11-DEC-2019, entry version 93.
RecName: Full=Insulin receptor substrate 1-A;
Short=IRS1-A;
Short=xIRS-1-A;
AltName: Full=XIRS-L;
Name=irs1-a;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
NCBI_TaxID=8355;
[1] {ECO:0000305, ECO:0000312|EMBL:AAA73572.1}
NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, PHOSPHORYLATION, AND
INTERACTION WITH PIK3R1.
TISSUE=Ovary {ECO:0000269|PubMed:7791763};
PubMed=7791763; DOI=10.1128/mcb.15.7.3563;
Liu X.J., Sorisky A., Zhu L., Pawson T.;
"Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA
and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus
oocyte maturation.";
Mol. Cell. Biol. 15:3563-3570(1995).
-!- FUNCTION: May mediate the control of various cellular processes by
insulin. When phosphorylated by the insulin receptor binds specifically
to various cellular proteins containing SH2 domains such as
phosphatidylinositol 3-kinase p85 subunit or grb2. Activates
phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated igf1r
and insr via the PTB domain (By similarity). Binds to
phosphatidylinositol 3-kinase p85 subunit at a low level in vitro prior
to phosphorylation. Binding is greatly enhanced following tyrosine
phosphorylation by insr and probably occurs via the phosphorylated YXXM
motifs. {ECO:0000250|UniProtKB:P35568, ECO:0000269|PubMed:7791763}.
-!- DEVELOPMENTAL STAGE: Expressed in stage VI primed oocytes (at protein
level). {ECO:0000269|PubMed:7791763}.
-!- PTM: Phosphorylation of Tyr-582 is required for grb2-binding.
{ECO:0000250}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; U27842; AAA73572.1; -; mRNA.
RefSeq; NP_001084092.1; NM_001090623.1.
SMR; Q91615; -.
PRIDE; Q91615; -.
GeneID; 399299; -.
KEGG; xla:399299; -.
CTD; 399299; -.
Xenbase; XB-GENE-478676; irs1.
KO; K16172; -.
OrthoDB; 298675at2759; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IDA:UniProtKB.
GO; GO:0042169; F:SH2 domain binding; ISS:UniProtKB.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
1: Evidence at protein level;
Phosphoprotein; Repeat; Transducer.
CHAIN 1..885
/note="Insulin receptor substrate 1-A"
/evidence="ECO:0000305"
/id="PRO_0000223524"
DOMAIN 1..56
/note="IRS-type PTB"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00389"
REGION 582..584
/note="GRB2-binding"
/evidence="ECO:0000250|UniProtKB:P35570"
MOTIF 257..260
/note="YXXM motif 1"
/evidence="ECO:0000255"
MOTIF 318..321
/note="YXXM motif 2"
/evidence="ECO:0000255"
MOTIF 364..367
/note="YXXM motif 3"
/evidence="ECO:0000255"
MOTIF 381..384
/note="YXXM motif 4"
/evidence="ECO:0000255"
MOTIF 409..412
/note="YXXM motif 5"
/evidence="ECO:0000255"
MOTIF 451..454
/note="YXXM motif 6"
/evidence="ECO:0000255"
MOTIF 620..623
/note="YXXM motif 7"
/evidence="ECO:0000255"
MOTIF 672..675
/note="YXXM motif 8"
/evidence="ECO:0000255"
MOTIF 706..709
/note="YXXM motif 9"
/evidence="ECO:0000255"
COMPBIAS 114..237
/note="Ser-rich"
/evidence="ECO:0000255"
COMPBIAS 517..526
/note="Poly-Ser"
/evidence="ECO:0000255"
MOD_RES 104
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P35570"
MOD_RES 257
/note="Phosphotyrosine; by INSR"
/evidence="ECO:0000250"
MOD_RES 364
/note="Phosphotyrosine; by INSR"
/evidence="ECO:0000250"
MOD_RES 381
/note="Phosphotyrosine; by INSR"
/evidence="ECO:0000250"
MOD_RES 409
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:P35568"
MOD_RES 582
/note="Phosphotyrosine; by INSR"
/evidence="ECO:0000250"
MOD_RES 620
/note="Phosphotyrosine; by INSR"
/evidence="ECO:0000250"
MOD_RES 672
/note="Phosphotyrosine; by INSR"
/evidence="ECO:0000250"
MOD_RES 834
/note="Phosphotyrosine; by INSR"
/evidence="ECO:0000250"
MOD_RES 866
/note="Phosphotyrosine; by INSR"
/evidence="ECO:0000250"
SEQUENCE 885 AA; 96146 MW; 9F1B96C64949CA7D CRC64;
MNIRRCGHSE NFFFIEVGRS AVTGAGEFWM QVDDSVVAQN MHETILEAMK ALSDEFRPRS
KSQSSSNCSN PISVPLRRHH LNHPPPSQVG LNRRARTESA TATSPAGGAA KHGSSSFRVR
ASSDGEGTMS RPASMEGSPV SPSASRTQSH RHRGSSRLHP PLNHSRSIPM PATRCSPSAT
SPVSLSSSST SGHGSTSDCM CPRRSSASIS GSPSDGGFIS SDEYGSSPCD FRSSFRSVTP
DSMGHTPPAR EEELNNYICM GKSSSHLQRG PQQRYQPSRG EELTDFDKVF RKRTHSSGTS
PPTVSHQKTP SQSSIEEYTE MMPTHPVRLT SFRHSAFVPT YSYPEECLDL HLEGSRANHK
DDGYMPMSPG VAPVSTKTND YMPMSPKSVS APQQIINPRW HSAVDSNGYM MMSPSGSCSP
DNTNYSKIWT NGTNPKLSID SIEGKLPCSD YINMSPASGS TTSTPPDSYL NSVEESTKPV
YSYFSLPRSF KHVHRKSEDG NLRISANSGH NLYTEDSSSS STSSDSLGGQ DPQQPRKGEG
CIQGKRLTRP TRLSLENSSK ASTLPRVREP ALPPEPKSPG EYVNIEFNDK VFSGGLVPSM
CSLPFVQSRV VPQRENLSEY MNMDLGVWRA KTSYASTSSY EPPNKPVNSV CPTETCSSSR
PPIRGKPISR DYMSMQLGSL CPDYSQVPPT RLSAKSITLS SSKSNYAEMS SGRVSDNIPA
IAPASNSSLS EASRSSLLGQ GSGPSAFTRV SLSPNRNPSA KVIRAGDPQG RRRHSSETFS
STPTTARVTT GPVSGEDVKR HSSASFENVW LRPGEIARRD SLQPSDHTHN GLNYIDLDLA
KDLSSLDHCN SHQSGVSHPS DDLSPYASIT FHKLEEHRSQ AETEE


Related products :

Catalog number Product name Quantity
DL-IRS1-Mu Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit 96T
201-20-2839 IRS1{insulin receptor substrate 1}rabbit.pAb 0.2ml
IRS4 IRS1 Gene insulin receptor substrate 1
MD-14-0387 Rabbit Anti-Insulin Receptor Substrate 1 (IRS1) 100
CSB-EL011829MO Mouse Insulin receptor substrate 1(IRS1) ELISA kit 96T
CSB-EL011829HU Human Insulin receptor substrate 1(IRS1) ELISA kit 96T
CSB-EL011829HU Human Insulin receptor substrate 1(IRS1) ELISA kit SpeciesHuman 96T
SEC546Mu ELISA Kit for Insulin Receptor Substrate 1 (IRS1) Mus musculus (Mouse) 96T
CSB-EL011829MO Mouse Insulin receptor substrate 1(IRS1) ELISA kit SpeciesMouse 96T
IRS1-1466H Protein Recombinant Human Insulin Receptor Substrate 1, GST-tagged 50μg
E92546Mu ELISA Kit for Insulin Receptor Substrate 1 (IRS1) Organism: Mus musculus (Mouse) 96T
E1660m ELISA Kit FOR Insulin receptor substrate 1; organism: Mouse; gene name: Irs1 96T
IRS1-1466H Protein: Recombinant Human Insulin Receptor Substrate 1, GST-tagged 50μg
GWB-9CC51F Insulin Receptor Substrate-1 (IRS1) Rabbit anti-Human Polyclonal (Internal) Antibody
CSB-EL011829MO Mouse insulin receptor substrate 1 (IRS1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL011829HU Human insulin receptor substrate 1 (IRS1) ELISA kit, Species Human, Sample Type serum, plasma 96T
orb70494 RR-SRC, Insulin Receptor Tyrosine Kinase Substrate peptide This is RR-SRC, Insulin Receptor Tyrosine Kinase Substrate peptide. For research use only. 1 mg
KN0487Ra Rat Insulin Receptor 1(IRS1)ELISA Kit 96 WELLS
E02I0406 Rat Insulin receptor substrate 2 96 Tests/kit
E02I0406 Rat Insulin receptor substrate 2 ELISA 96T/kit
E02I0403 Rat Insulin receptor substrate 1 ELISA 96T/kit
E02I0403 Rat Insulin receptor substrate 1 ELISA, IRS-1 96 Tests/kit
E0918Ra Rat Insulin receptor substrate 1,IRS-1 ELISA Kit 48T
201-20-7104 IRS P53{Insulin receptor substrate P53}rabbit.pAb 0.2ml
E13I0406 Anserine Insulin receptor substrate 2 96 Tests/kit
Pathways :
WP481: Insulin Signaling
WP847: Insulin Signaling
WP996: EPO Receptor Signaling
WP1085: Insulin Signaling
WP1913: Signaling by Insulin receptor
WP581: EPO Receptor Signaling
WP878: EPO Receptor Signaling
WP1112: EPO Receptor Signaling
WP743: Insulin Signaling
WP1249: EPO Receptor Signaling
WP1284: EPO Receptor Signaling
WP768: EPO Receptor Signaling
WP966: Insulin Signaling
WP578: Leptin Insulin Overlap
WP65: Insulin Signaling
WP439: Insulin Signaling
WP1403: AMPK signaling
WP26: Signal Transduction of S1P Receptor
WP734: Serotonin Receptor 4/6/7 and NR3C Signaling
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP10: IL-9 Signaling Pathway
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1965: VEGF-receptor Signal Transduction
WP815: Id Signaling Pathway
WP1105: Adipogenesis

Related Genes :
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[IRS1] Insulin receptor substrate 1 (IRS-1)
[irs1-a] Insulin receptor substrate 1-A (IRS1-A) (xIRS-1-A) (XIRS-L)
[irs1-b] Insulin receptor substrate 1-B (IRS1-B) (xIRS-1-B) (XIRS-L')
[InR dinr Dir-a Inr-a CG18402] Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[KRT71 K6IRS1 KB34 KRT6IRS1] Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Krt71 K6irs1 Kb34 Krt2-6g Krt6g] Keratin, type II cytoskeletal 71 (Cytokeratin-6G) (CK-6G) (Cytokeratin-71) (CK-71) (Keratin-6G) (K6G) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (mK6irs) (mK6irs1/Krt2-6g) (Type-II keratin Kb34)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Or22a AN11 DOR22A.1 dor53 Or22A.1 CG12193] Odorant receptor 22a
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) (Fragments)
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[IRS4] Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
[Or22b AN12 DOR22A.2 dor67 Or22A.2 CG4231] Odorant receptor 22b
[Sirt1 Sir2l1] NAD-dependent protein deacetylase sirtuin-1 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
[] Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); P3; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[VMA1 CLS8 TFP1 YDL185W D1286] V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (Vacuolar proton pump subunit A) [Cleaved into: Endonuclease PI-SceI (EC 3.1.-.-) (Sce VMA intein) (VMA1-derived endonuclease) (VDE)]
[EIF2AK2 PKR PRKR] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[NS] Non-structural protein 1 (NS1) (NS1A)
[Eif2ak2 Pkr Prkr Tik] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[] Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0; Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.4.13); Protein 3A (P3A); VPg (P3B) (Protein 3B); Protein 3CD (EC 3.4.22.28); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC 2.7.10.1) (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[IRS1] Insulin receptor substrate 1 (IRS-1)

Bibliography :
No related Items