Insulin receptor substrate 2

 A0A287B726_PIG          Unreviewed;      1092 AA.
 A0A287B726;
 22-NOV-2017, integrated into UniProtKB/TrEMBL.
 11-DEC-2019, sequence version 2.
 02-DEC-2020, entry version 21.
 SubName: Full=Insulin receptor substrate 2 {ECO:0000313|Ensembl:ENSSSCP00000052323};
 Name=IRS2 {ECO:0000313|Ensembl:ENSSSCP00000052323,
 ECO:0000313|VGNC:VGNC:89214};
 Sus scrofa (Pig).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
 NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000052323, ECO:0000313|Proteomes:UP000008227};
 [1] {ECO:0000313|Ensembl:ENSSSCP00000052323, ECO:0000313|Proteomes:UP000008227}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000052323,
 ECO:0000313|Proteomes:UP000008227};
 Porcine genome sequencing project;
 Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
 [2] {ECO:0000313|Ensembl:ENSSSCP00000052323}
 IDENTIFICATION.
 Ensembl;
 Submitted (OCT-2017) to UniProtKB.
 ---------------------------------------------------------------------------
 Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
 Distributed under the Creative Commons Attribution (CC BY 4.0) License
 ---------------------------------------------------------------------------
 EMBL; AEMK02000079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 Ensembl; ENSSSCT00000043241; ENSSSCP00000052323; ENSSSCG00000034763.
 VGNC; VGNC:89214; IRS2.
 GeneTree; ENSGT00940000161407; -.
 Reactome; R-SSC-109704; PI3K Cascade.
 Reactome; R-SSC-112399; IRS-mediated signalling.
 Reactome; R-SSC-112412; SOS-mediated signalling.
 Reactome; R-SSC-1257604; PIP3 activates AKT signaling.
 Reactome; R-SSC-1266695; Interleukin-7 signaling.
 Reactome; R-SSC-198203; PI3K/AKT activation.
 Reactome; R-SSC-5673001; RAF/MAP kinase cascade.
 Reactome; R-SSC-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
 Reactome; R-SSC-74749; Signal attenuation.
 Reactome; R-SSC-8853659; RET signaling.
 Reactome; R-SSC-9027276; Erythropoietin activates Phosphoinositide-3-kinase (PI3K).
 Reactome; R-SSC-9027284; Erythropoietin activates RAS.
 Proteomes; UP000008227; Chromosome 11.
 GO; GO:0005829; C:cytosol; IBA:GO_Central.
 GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
 GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
 GO; GO:0005158; F:insulin receptor binding; IBA:GO_Central.
 GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IBA:GO_Central.
 GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
 GO; GO:0007420; P:brain development; IEA:Ensembl.
 GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
 GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
 GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
 GO; GO:0033673; P:negative regulation of kinase activity; IEA:Ensembl.
 GO; GO:0010748; P:negative regulation of long-chain fatty acid import across plasma membrane; IEA:Ensembl.
 GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
 GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
 GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
 GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
 GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
 GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
 GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
 GO; GO:0009749; P:response to glucose; IEA:Ensembl.
 Gene3D; 2.30.29.30; -; 1.
 InterPro; IPR039011; IRS.
 InterPro; IPR002404; IRS_PTB.
 InterPro; IPR011993; PH-like_dom_sf.
 PANTHER; PTHR10614; PTHR10614; 1.
 Pfam; PF02174; IRS; 1.
 PRINTS; PR00628; INSULINRSI.
 SMART; SM00310; PTBI; 1.
 PROSITE; PS51064; IRS_PTB; 1.
 4: Predicted;
 Reference proteome {ECO:0000313|Proteomes:UP000008227}.
 DOMAIN          1..56
                 /note="IRS-type PTB"
                 /evidence="ECO:0000259|PROSITE:PS51064"
 REGION          60..289
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          454..492
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          591..642
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          659..684
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          712..828
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          880..1000
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          1016..1039
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        200..215
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        216..230
                 /note="Pro-rich"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        233..249
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        461..489
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        712..753
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        774..813
                 /note="Pro-rich"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        814..828
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        890..904
                 /note="Polyampholyte"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        905..944
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 SEQUENCE   1092 AA;  111913 MW;  AAA5297C295A278E CRC64;
 MNIRRCGHSD SFFFIEVGRS AVTGPGELWM QADDSVVAQN IHETILEAMK ALKELFEFRP
 RSKSQSSGSS ATHPISVPGA RRHHHLVNLP PSQTGLVRRS RTDSLAATPP AAKCSSCRVR
 TASEGDGGAA AGAGAAGGRP VSVSGSPLSP GPVRAPLSRS HTLSGGCGGR ASKVTLAPAG
 GALQHSRSMS MPVAHSPPAA TSPGSLSSSS GHGSGSYPPP PGPHPHLQHP LHPQRPSSGS
 ASASGSPSDP GFMSLDEYGS SPGDLRAFCS HRSNTPESIA ETPPARDVSG GELYGYMTMD
 RPLSHCGRPY RRVSGDGAQD LDRGLRKRTY SLTTPARQRP VPQPSSASLD EYTLMRATFS
 GSSGRLCPSC PVSSPKVAYH PYPEDYGDIE IGSHRSSSSN LGTDDGYMPM TPGVALMGGG
 SGSCKSDDYM PMSPTSVSAP KQILQPRATA AAVPPTGAAV PTPTSAASRA FPGSGGSSYK
 ASSPAESSPE DSGYMRMWCG SKLSMENADG KLLSNGDYLN MSPSDVGAPG TPPDFFAAAL
 HGGGEMLRGV PGYCYSSLPR SYKAPYTCNG DNDQYVLMSS PVGRILEEER LEPPAGPGST
 GSTQLDGAFG AAAGGGGHTQ PPHPSVPSPG RPSGVGSGRP EGFLSQRCRA VRPTRLSLEG
 LQTLPSTHEY PLPPEPKSPG EYINIDFGEA GARLSPPAPP LLASAASSSS LLSASSPASS
 LGSGTPGTSG DSRQRSPLSD YMNLDFSSPK SPQPGPQGGH PVGSLDALLS PEASAYPPLP
 PRPAAPSSAL QPVPPPPPPG ELYRLPPAPT PQGPSAASAS SSETAENGDY TEMAFGVAAT
 PPQPIAAPPK PEGARVTSPV SGLKRLSLMD QVSGVEAFLQ ASQPPDPHRG AKVIRADPQG
 GRRRHSSETF SSTTTVTPVS PSFAHNPKRH NSASVENVSL RKSSEGGSGG VLGGGDEPPT
 SPRQLQPPLP HQARPWTSGQ PGGLVGCPGG SGSPMRRETS AGFQNGLNYI AIDVRDEPGL
 SPAPPQHPHP QAGDKSAWGR TRSLGGLISA VGGGSTGGVC GGPSPGTLSS ANTYASIDFL
 THHLKEATAV KE

Related products :