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Insulin receptor substrate 2

 A0A287B726_PIG          Unreviewed;      1092 AA.
A0A287B726;
22-NOV-2017, integrated into UniProtKB/TrEMBL.
11-DEC-2019, sequence version 2.
02-DEC-2020, entry version 21.
SubName: Full=Insulin receptor substrate 2 {ECO:0000313|Ensembl:ENSSSCP00000052323};
Name=IRS2 {ECO:0000313|Ensembl:ENSSSCP00000052323,
ECO:0000313|VGNC:VGNC:89214};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000052323, ECO:0000313|Proteomes:UP000008227};
[1] {ECO:0000313|Ensembl:ENSSSCP00000052323, ECO:0000313|Proteomes:UP000008227}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000052323,
ECO:0000313|Proteomes:UP000008227};
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSSCP00000052323}
IDENTIFICATION.
Ensembl;
Submitted (OCT-2017) to UniProtKB.
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EMBL; AEMK02000079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSSSCT00000043241; ENSSSCP00000052323; ENSSSCG00000034763.
VGNC; VGNC:89214; IRS2.
GeneTree; ENSGT00940000161407; -.
Reactome; R-SSC-109704; PI3K Cascade.
Reactome; R-SSC-112399; IRS-mediated signalling.
Reactome; R-SSC-112412; SOS-mediated signalling.
Reactome; R-SSC-1257604; PIP3 activates AKT signaling.
Reactome; R-SSC-1266695; Interleukin-7 signaling.
Reactome; R-SSC-198203; PI3K/AKT activation.
Reactome; R-SSC-5673001; RAF/MAP kinase cascade.
Reactome; R-SSC-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-SSC-74749; Signal attenuation.
Reactome; R-SSC-8853659; RET signaling.
Reactome; R-SSC-9027276; Erythropoietin activates Phosphoinositide-3-kinase (PI3K).
Reactome; R-SSC-9027284; Erythropoietin activates RAS.
Proteomes; UP000008227; Chromosome 11.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0005158; F:insulin receptor binding; IBA:GO_Central.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IBA:GO_Central.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0007420; P:brain development; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
GO; GO:0033673; P:negative regulation of kinase activity; IEA:Ensembl.
GO; GO:0010748; P:negative regulation of long-chain fatty acid import across plasma membrane; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000008227}.
DOMAIN 1..56
/note="IRS-type PTB"
/evidence="ECO:0000259|PROSITE:PS51064"
REGION 60..289
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 454..492
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 591..642
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 659..684
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 712..828
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 880..1000
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1016..1039
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 200..215
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 216..230
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 233..249
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 461..489
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 712..753
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 774..813
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 814..828
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 890..904
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 905..944
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 1092 AA; 111913 MW; AAA5297C295A278E CRC64;
MNIRRCGHSD SFFFIEVGRS AVTGPGELWM QADDSVVAQN IHETILEAMK ALKELFEFRP
RSKSQSSGSS ATHPISVPGA RRHHHLVNLP PSQTGLVRRS RTDSLAATPP AAKCSSCRVR
TASEGDGGAA AGAGAAGGRP VSVSGSPLSP GPVRAPLSRS HTLSGGCGGR ASKVTLAPAG
GALQHSRSMS MPVAHSPPAA TSPGSLSSSS GHGSGSYPPP PGPHPHLQHP LHPQRPSSGS
ASASGSPSDP GFMSLDEYGS SPGDLRAFCS HRSNTPESIA ETPPARDVSG GELYGYMTMD
RPLSHCGRPY RRVSGDGAQD LDRGLRKRTY SLTTPARQRP VPQPSSASLD EYTLMRATFS
GSSGRLCPSC PVSSPKVAYH PYPEDYGDIE IGSHRSSSSN LGTDDGYMPM TPGVALMGGG
SGSCKSDDYM PMSPTSVSAP KQILQPRATA AAVPPTGAAV PTPTSAASRA FPGSGGSSYK
ASSPAESSPE DSGYMRMWCG SKLSMENADG KLLSNGDYLN MSPSDVGAPG TPPDFFAAAL
HGGGEMLRGV PGYCYSSLPR SYKAPYTCNG DNDQYVLMSS PVGRILEEER LEPPAGPGST
GSTQLDGAFG AAAGGGGHTQ PPHPSVPSPG RPSGVGSGRP EGFLSQRCRA VRPTRLSLEG
LQTLPSTHEY PLPPEPKSPG EYINIDFGEA GARLSPPAPP LLASAASSSS LLSASSPASS
LGSGTPGTSG DSRQRSPLSD YMNLDFSSPK SPQPGPQGGH PVGSLDALLS PEASAYPPLP
PRPAAPSSAL QPVPPPPPPG ELYRLPPAPT PQGPSAASAS SSETAENGDY TEMAFGVAAT
PPQPIAAPPK PEGARVTSPV SGLKRLSLMD QVSGVEAFLQ ASQPPDPHRG AKVIRADPQG
GRRRHSSETF SSTTTVTPVS PSFAHNPKRH NSASVENVSL RKSSEGGSGG VLGGGDEPPT
SPRQLQPPLP HQARPWTSGQ PGGLVGCPGG SGSPMRRETS AGFQNGLNYI AIDVRDEPGL
SPAPPQHPHP QAGDKSAWGR TRSLGGLISA VGGGSTGGVC GGPSPGTLSS ANTYASIDFL
THHLKEATAV KE


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WP1348: Androgen Receptor Signaling Pathway
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WP1333: Hypothetical Network for Drug Addiction
WP794: B Cell Receptor Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP2355: Corticotropin-releasing hormone
WP774: Kit Receptor Signaling Pathway
WP1380: Regulation of Actin Cytoskeleton
WP1025: B Cell Receptor Signaling Pathway
WP1390: cytochrome P450
WP26: Signal Transduction of S1P Receptor
WP79: Tryptophan metabolism
WP1355: One Carbon Metabolism
WP1219: cytochrome P450
WP2075: Alzheimers Disease
WP57: Signal Transduction of S1P Receptor

Related Genes :
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC 2.7.10.1) (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[chico IRS CG5686] Insulin receptor substrate 1 (dIRS) (Protein chico)
[IRS2] Insulin receptor substrate 2 (IRS-2)
[Irs2] Insulin receptor substrate 2 (IRS-2) (4PS)
[BAIAP2L1 IRTKS] Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[InR dinr Dir-a Inr-a CG18402] Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[IRS1] Insulin receptor substrate 1 (IRS-1)
[Insrr Irr] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[IRS4] Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[INSRR IRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[insr] Insulin receptor (IR) (EC 2.7.10.1) (XTK-1b) (Xe-InsR) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[igf1r] Insulin-like growth factor 1 receptor (xIGF-1R) (xIGFR) (EC 2.7.10.1) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[INSRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[IGF2R MPRI] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[Igf2r] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[chico GF14127] Insulin receptor substrate 1 (Protein chico)
[chico GG23965] Insulin receptor substrate 1 (Protein chico)
[IGF2R M6P] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (CD antigen CD222)

Bibliography :
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