GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Insulin receptor substrate 2

 F1MJE0_BOVIN            Unreviewed;      1384 AA.
F1MJE0;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
10-APR-2019, sequence version 3.
10-FEB-2021, entry version 68.
SubName: Full=Insulin receptor substrate 2 {ECO:0000313|Ensembl:ENSBTAP00000049448};
Name=IRS2 {ECO:0000313|VGNC:VGNC:30284};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000049448, ECO:0000313|Proteomes:UP000009136};
[1] {ECO:0000313|Ensembl:ENSBTAP00000049448}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000049448};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
[2] {ECO:0000313|Ensembl:ENSBTAP00000049448, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000049448,
ECO:0000313|Proteomes:UP000009136};
Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
"ARS-UCD1.2.";
Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
STRING; 9913.ENSBTAP00000049448; -.
PaxDb; F1MJE0; -.
PRIDE; F1MJE0; -.
Ensembl; ENSBTAT00000015938; ENSBTAP00000049448; ENSBTAG00000012019.
VGNC; VGNC:30284; IRS2.
eggNOG; ENOG502QUNU; Eukaryota.
GeneTree; ENSGT00940000161407; -.
HOGENOM; CLU_004902_1_0_1; -.
InParanoid; F1MJE0; -.
TreeFam; TF325994; -.
Reactome; R-BTA-109704; PI3K Cascade.
Reactome; R-BTA-112399; IRS-mediated signalling.
Reactome; R-BTA-112412; SOS-mediated signalling.
Reactome; R-BTA-1257604; PIP3 activates AKT signaling.
Reactome; R-BTA-198203; PI3K/AKT activation.
Reactome; R-BTA-5673001; RAF/MAP kinase cascade.
Reactome; R-BTA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-BTA-74749; Signal attenuation.
Reactome; R-BTA-8853659; RET signaling.
Reactome; R-BTA-9027276; Erythropoietin activates Phosphoinositide-3-kinase (PI3K).
Proteomes; UP000009136; Chromosome 12.
Bgee; ENSBTAG00000012019; Expressed in heart and 17 other tissues.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0005158; F:insulin receptor binding; IBA:GO_Central.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IBA:GO_Central.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0007420; P:brain development; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
GO; GO:0033673; P:negative regulation of kinase activity; IEA:Ensembl.
GO; GO:0010748; P:negative regulation of long-chain fatty acid import across plasma membrane; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
CDD; cd01204; PTB_IRS; 1.
Gene3D; 2.30.29.30; -; 2.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
Pfam; PF00169; PH; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00233; PH; 1.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000009136}.
DOMAIN 30..144
/note="PH"
/evidence="ECO:0000259|PROSITE:PS50003"
DOMAIN 195..299
/note="IRS-type PTB"
/evidence="ECO:0000259|PROSITE:PS51064"
REGION 1..35
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 51..71
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 304..359
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 383..526
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 696..731
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 823..873
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 942..1089
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1110..1233
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 17..33
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 439..454
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 455..469
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 472..488
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 942..984
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1004..1034
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1043..1059
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1120..1134
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1135..1163
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1192..1206
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 1384 AA; 142218 MW; F5BDF3B378B0C869 CRC64;
MASPPEHGPP GPAGGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL RGPGAGGDEA
GAGGGPAPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK YLIALYTKDE
YFAVAAENEQ EQEGWYRALT DLVSEGRAGA GDAPPAAAAT SGSCSASLPG ALGGSAGAAA
ADDSYGLVAP ATAAYREVWQ VNLKPKGLGQ SKNLTGVYRL CLSARTIGFV KLNCEQPSVT
LQLMSIRRCG HSDSFFFIEV GRSAVTGPGE LWMQADDSVV AQNIHETILE AMKALKELFE
FRPRSKSQSS GSSATHPISV PGARRHHHLV NLPPSQTGLV RRSRTDSLAA TPPAAKCSAC
RVRTASEGDG GAAAAAAAGA GAGAAAGSPL SPGPVRAPLS RSHTLSGGRA GKAALAPAGG
GLQHSRSMSM PVAHSPPAAT SPGSLSSSSG HGSGSYPPPP GPHPHLQHPL HPQRPSSGSA
SASGSPSDPG FMSLDEYGSS PGDLRVYCGH RSNTPESIAE TPPARDGSAG ELYGYMTMER
PLSHCGGRAY RRVSGDGAPD LDRGLRKRTY SLTTPARQRP VPQPSSASLD EYTLMRATFS
GSSGRLCPSC PASSPKVAYH PYPEDYGDIE IGSHRSSSSN LGTDDGYVPM TPGVALLGTG
SGSCKSDDYM PMSPTSVSAP KQILQPRPVP AALPPAGATV PTPASAAGRA FPGTAGSYKT
GSPAESSPED SGYMRMWCGS KLSMESADSK LLPNGDYLNM SPSDAGTAGT PPDFFSAAGE
TLRCVPGYCY SSLPRSYKAP HACHGDSDQY VLMSSPVGRV LEEEQLEPPP GPAQPASAFP
AAAAGSGHPQ PLHPVVPSSG RPGGGGGSRP DGFLAQRCRA VRPTRLSLEG LPALPRMHEY
PLPPEPRSPG EYINIDFGEA GARLSPPAPP LLASAASSSS LLSASSPASS LGSGTPGTSG
DSRQRSPLSD YMNLDFSSPK SPQPGAQGRD PVGSLDALLS PEASVYPPLP PRPAAPSSAL
QPPPPPPPPG ELYRLPAAPA SQGPGAASSS SSDTGDNSDY TEMAFGVAAT PPQPIAAPPK
PDGARVSSPV SGLKRLSLMD QVSGVEAFLQ AGQPPDPHRG AKVIRADPQG GRRRHSSETF
SSTTTVTPVS PSFAHTPKRH NSASVENVCL RKGSEGGGAG GSVLGGGDEP PSSPRQLPPP
TPQQARAWTP AQPGGGLVGC PGGSSSPMRR ETSAGFQNGL NYIAIDVRDE PGLSPPLQQH
PHAQMGDRSA WGRTRSLGGL ISAVGAGSPA GVCGGPGPGA LPAANAYASI DFLTHHLKEA
TVVKGEGLGR GGARACGVLE AASLRGYRDL SARVLAQGSR FVLPLSQCKS FPRDLARALK
SPLS


Related products :

Catalog number Product name Quantity
orb70494 RR-SRC, Insulin Receptor Tyrosine Kinase Substrate peptide This is RR-SRC, Insulin Receptor Tyrosine Kinase Substrate peptide. For research use only. 1 mg
E02I0406 Rat Insulin receptor substrate 2 96 Tests/kit
E0919Ra Rat Insulin receptor substrate 1,IRS-1 ELISA Kit 48T
E0919Ra Rat Insulin receptor substrate 1,IRS-1 ELISA Kit 96T
E02I0403 Rat Insulin receptor substrate 1 ELISA 96T/kit
E02I0403 Rat Insulin receptor substrate 1 ELISA, IRS-1 96 Tests/kit
E01I0406 Human Insulin receptor substrate 2 96 Tests/kit
E02I0406 Rat Insulin receptor substrate 2 ELISA 96T/kit
201-20-7104 IRS P53{Insulin receptor substrate P53}rabbit.pAb 0.2ml
E0918Ra Rat Insulin receptor substrate 1,IRS-1 ELISA Kit 48T
YHB0581Ra Rat Insulin receptor substrate 1,IRS-1 ELISA Kit 48T
E05I0406 Guinea Insulin receptor substrate 2 96 Tests/kit
E03I0406 Mouse Insulin receptor substrate 2 96 Tests/kit
CSB-E14318r Rat insulin receptor substrate-1(IRS-1) ELISA Kit 96T
E02I0406 Rat Insulin receptor substrate 2 ELISA, IRS-2 96 Tests/kit
EH822 Insulin receptor substrate 2 Elisa Kit 96T
E08I0406 Canine Insulin receptor substrate 2 96 Tests/kit
3521P IRS-1 _ Insulin receptor substrate-1 Peptide 0.05 mg
E11I0406 Bovine Insulin receptor substrate 2 96 Tests/kit
YHB0581Ra Rat Insulin receptor substrate 1,IRS-1 ELISA Kit 96T
E02I0406 Rat Insulin receptor substrate 2 ELISA, IRS-2
E02I0406 Rat anti-Insulin receptor substrate 2 96 Tests/kit
ER577 Insulin receptor substrate 1 Elisa Kit 96T
E04I0406 Rabbit Insulin receptor substrate 2 96 Tests/kit
E13I0406 Anserine Insulin receptor substrate 2 96 Tests/kit
Pathways :
WP1354: B Cell Receptor Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway
WP17: daf-2 or insulin signaling pathway
WP1313: Insulin Signaling
WP1345: T Cell Receptor Signaling Pathway
WP1913: Signaling by Insulin receptor
WP966: Insulin Signaling
WP1183: Toll-like receptor signaling pathway
WP1963: The effect of Glucocorticoids on target gene expression
WP480: T Cell Receptor Signaling Pathway
WP1333: Hypothetical Network for Drug Addiction
WP794: B Cell Receptor Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP2355: Corticotropin-releasing hormone
WP774: Kit Receptor Signaling Pathway
WP1380: Regulation of Actin Cytoskeleton
WP1025: B Cell Receptor Signaling Pathway
WP1390: cytochrome P450
WP26: Signal Transduction of S1P Receptor
WP79: Tryptophan metabolism
WP1355: One Carbon Metabolism
WP1219: cytochrome P450
WP2075: Alzheimers Disease
WP57: Signal Transduction of S1P Receptor

Related Genes :
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC 2.7.10.1) (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[chico IRS CG5686] Insulin receptor substrate 1 (dIRS) (Protein chico)
[IRS2] Insulin receptor substrate 2 (IRS-2)
[Irs2] Insulin receptor substrate 2 (IRS-2) (4PS)
[BAIAP2L1 IRTKS] Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[InR dinr Dir-a Inr-a CG18402] Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[IRS1] Insulin receptor substrate 1 (IRS-1)
[Insrr Irr] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[IRS4] Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[INSRR IRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[insr] Insulin receptor (IR) (EC 2.7.10.1) (XTK-1b) (Xe-InsR) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[igf1r] Insulin-like growth factor 1 receptor (xIGF-1R) (xIGFR) (EC 2.7.10.1) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[INSRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[IGF2R MPRI] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[Igf2r] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[chico GF14127] Insulin receptor substrate 1 (Protein chico)
[chico GG23965] Insulin receptor substrate 1 (Protein chico)
[IGF2R M6P] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (CD antigen CD222)

Bibliography :
No related Items