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Insulin receptor substrate 2

 F1Q219_CANLF            Unreviewed;      1382 AA.
F1Q219;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
11-DEC-2019, sequence version 2.
17-JUN-2020, entry version 63.
SubName: Full=Insulin receptor substrate 2 {ECO:0000313|Ensembl:ENSCAFP00000009098};
Name=IRS2 {ECO:0000313|VGNC:VGNC:42099};
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000009098, ECO:0000313|Proteomes:UP000002254};
[1] {ECO:0000313|Ensembl:ENSCAFP00000009098, ECO:0000313|Proteomes:UP000002254}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000009098,
ECO:0000313|Proteomes:UP000002254};
PubMed=16341006; DOI=10.1038/nature04338;
Broad Sequencing Platform;
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E.,
Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F.,
Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W.,
Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S.,
Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A.,
Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P.,
Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P.,
Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B.,
Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A.,
Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M.,
Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S.,
Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L.,
Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C.,
Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G.,
Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A.,
Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A.,
Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M.,
Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L.,
LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A.,
Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S.,
Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T.,
Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A.,
Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S.,
Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M.,
Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F.,
Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T.,
Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C.,
Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C.,
Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D.,
Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H.,
Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J.,
Zembek L., Zimmer A., Lander E.S.;
"Genome sequence, comparative analysis and haplotype structure of the
domestic dog.";
Nature 438:803-819(2005).
[2] {ECO:0000313|Ensembl:ENSCAFP00000009098}
IDENTIFICATION.
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000009098};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
---------------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AAEX03013379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9612.ENSCAFP00000009098; -.
PaxDb; F1Q219; -.
Ensembl; ENSCAFT00000009800; ENSCAFP00000009098; ENSCAFG00000006058.
VGNC; VGNC:42099; IRS2.
eggNOG; ENOG410IXEK; Eukaryota.
eggNOG; ENOG410Z9EP; LUCA.
GeneTree; ENSGT00940000161407; -.
HOGENOM; CLU_004902_1_0_1; -.
InParanoid; F1Q219; -.
TreeFam; TF325994; -.
Reactome; R-CFA-109704; PI3K Cascade.
Reactome; R-CFA-112399; IRS-mediated signalling.
Reactome; R-CFA-112412; SOS-mediated signalling.
Reactome; R-CFA-1257604; PIP3 activates AKT signaling.
Reactome; R-CFA-1266695; Interleukin-7 signaling.
Reactome; R-CFA-198203; PI3K/AKT activation.
Reactome; R-CFA-2428928; IRS-related events triggered by IGF1R.
Reactome; R-CFA-5673001; RAF/MAP kinase cascade.
Reactome; R-CFA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-CFA-74713; IRS activation.
Reactome; R-CFA-74749; Signal attenuation.
Reactome; R-CFA-8853659; RET signaling.
Reactome; R-CFA-9027276; Erythropoietin activates Phosphoinositide-3-kinase (PI3K).
Reactome; R-CFA-9027284; Erythropoietin activates RAS.
Proteomes; UP000002254; Chromosome 22.
Bgee; ENSCAFG00000006058; Expressed in liver and 2 other tissues.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0005158; F:insulin receptor binding; IBA:GO_Central.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IBA:GO_Central.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0007420; P:brain development; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
GO; GO:0033673; P:negative regulation of kinase activity; IEA:Ensembl.
GO; GO:0010748; P:negative regulation of long-chain fatty acid import across plasma membrane; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
CDD; cd01204; PTB_IRS; 1.
Gene3D; 2.30.29.30; -; 2.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
Pfam; PF00169; PH; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00233; PH; 1.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000002254}.
DOMAIN 29..142
/note="PH"
/evidence="ECO:0000259|PROSITE:PS50003"
DOMAIN 193..297
/note="IRS-type PTB"
/evidence="ECO:0000259|PROSITE:PS51064"
REGION 1..30
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 301..350
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 362..552
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 702..722
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 847..935
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 964..1301
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 302..317
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 453..468
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 487..505
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 964..1005
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1025..1058
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1066..1080
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1143..1157
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1158..1199
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 1382 AA; 142931 MW; C6405F8DE23B218B CRC64;
XXXXXXXXXX XXXXXXGPNL NNNNNNNHSV RKCGYLRKQK HGHKRFFVLR GPGDEAAATA
GGVPAPQPPR LEYYESEKKW RSKAGAPKRV IALDCCLNIN KRADAKHKYL IALYTRDEYF
AVAAENEQEQ EGWYRALTDL LSEGRAGDAP PAPAPANAAA SCSASLPGAL GGSAGAAAAD
DSYGLVAPAT AAYREVWQVN LKPKGLGQSK NLTGVYRLCL SARTIGFVKL NCEQPSVTLQ
LMNIRRCGHS DSFFFIEVGR SAVTGPGELW MQADDSVVAQ NIHETILEAM KALKELFEFR
PRSKSQSSGS SSTHPISVPG ARRHHHLVNL PPSQTGLVRR SRTDSLAATP PAAKCSSCRV
RTASEGDGGA GAGAAGAGAG VGAGAGAGAG GRPVSVAGSP LSPGPVRAPL SRSHTLSGGC
GGRASKVAPA PAGGALQHSR SMSMPVAHSP PAATSPGSLS SSSGHGSGSY PPPPGPHPPL
QHPLHHAASQ RPSSGSASAS GSPSDPGFMS LDEYGSSPGD LRAFCSHRSN TPESIAETPP
ARDGGGGELY GYMTMDRPLS HCGRPYRRVS GDGAQDLDRG LRKRTYSLTT PARQRPVPQP
SSASLDEYTL MRATFSGSSG RLCPSCPASS PKVAYNPYPE DYGDVEIGSH RSSSSNLGAD
DGYMPMTPGV ALMGGGGGSC KSDDYMPMSP TSVSAPKQIL QPRASAAALP PTGAAVPAPA
PSAGRAFAAS GSGVSYKASS PAESSPEDSG YMRMWCGSKL SMESADSKLL PNGDYLNMSP
SDAGTSGTPP DFFSAALHGS GEMLRGVPGY CYSSLPRSYK APYTCNGDNN DQYVLMSSPV
GRILEEERLE PPASPGPTAG GAFAGAGGHT QPPHPAVPSP GRPGGSSAGR PDGFLTQRCR
AVRPTRLSLE GLQTLPSMHE YPLPPEPKSP GEYINIDFGE AGARLSPPAP PLLASAASSC
SLLSASSPAS SLGSGTPGTS SDSRQRSPLS DYMNLDFSSP KSPKPGAQSG DPVGSLDALL
SPEAASPYPP LPPRPAAPAA SLQLQPPPPP PPGELYRLPP AAPSQGPGAA SSSSSEPGDN
GDYTEMAFGV AATPPQPIAA PPKPEGARVT SPTSGVKRLS LMDQVSGVEA FLQASQPPDP
HRGAKVIRAD PQGGRRRHSS ETFASTTTVT PVSPSFAHNP KRHNSASVEN VSLRKSSEGG
SSGVLGAGDD RPMSPRQLQP PHPQQARPWG PGQPGGLVGC PGGSGAPMRR ETSAGFQNGL
NYIAIDVRDE PGLSPAPQQH PHPQPGDKSA WGRTRSLGGL ITAVGSSGGG GVCGGPSPGA
LPPANTYASI DFLSHHLKEA TIVKGEAFGP CEGWEDRWED GWKHRWENRW ESGGLLFFAT
WT


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WP1354: B Cell Receptor Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway
WP17: daf-2 or insulin signaling pathway
WP1313: Insulin Signaling
WP1345: T Cell Receptor Signaling Pathway
WP1913: Signaling by Insulin receptor
WP1963: The effect of Glucocorticoids on target gene expression
WP480: T Cell Receptor Signaling Pathway
WP1333: Hypothetical Network for Drug Addiction
WP794: B Cell Receptor Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP2355: Corticotropin-releasing hormone
WP774: Kit Receptor Signaling Pathway
WP1380: Regulation of Actin Cytoskeleton
WP966: Insulin Signaling
WP1183: Toll-like receptor signaling pathway
WP1390: cytochrome P450
WP26: Signal Transduction of S1P Receptor
WP79: Tryptophan metabolism
WP1355: One Carbon Metabolism
WP1219: cytochrome P450
WP2075: Alzheimers Disease
WP57: Signal Transduction of S1P Receptor
WP216: Striated Muscle Contraction

Related Genes :
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)
[chico IRS CG5686] Insulin receptor substrate 1 (dIRS) (Protein chico)
[IRS2] Insulin receptor substrate 2 (IRS-2)
[Irs2] Insulin receptor substrate 2 (IRS-2) (4PS)
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC 2.7.10.1) (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[BAIAP2L1 IRTKS] Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[InR dinr Dir-a Inr-a CG18402] Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insrr Irr] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[IRS1] Insulin receptor substrate 1 (IRS-1)
[IRS4] Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[INSRR IRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[insr] Insulin receptor (IR) (EC 2.7.10.1) (XTK-1b) (Xe-InsR) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[igf1r] Insulin-like growth factor 1 receptor (xIGF-1R) (xIGFR) (EC 2.7.10.1) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) (Fragments)
[INSRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[IGF2R MPRI] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[Igf2r] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[IGF2R M6P] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (CD antigen CD222)
[chico GF14127] Insulin receptor substrate 1 (Protein chico)

Bibliography :
[32631952] Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats.
[32603046] A 3'-untranslated region variant (rs2289046) of insulin receptor substrate 2 gene is associated with susceptibility to nonalcoholic fatty liver disease.
[32597148] Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells.
[32564738] Interleukin-4 Restores Insulin Sensitivity in Insulin-Resistant Osteoblasts by Increasing the Expression of Insulin Receptor Substrate 1.
[32554797] The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint.
[32458968] Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats.
[32455838] Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms-A Narrative Review.
[32454173] An unbiased lipidomics approach identifies key lipid molecules as potential therapeutic targets of Dohongsamul-tang against non-alcoholic fatty liver diseases in a mouse model of obesity.
[32397873] Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport.
[32385144] MHC-restricted phosphopeptide antigens: preclinical validation and first-in-humans clinical trial in participants with high-risk melanoma.