Insulin receptor substrate 2

 F1Q219_CANLF            Unreviewed;      1382 AA.
 F1Q219;
 03-MAY-2011, integrated into UniProtKB/TrEMBL.
 11-DEC-2019, sequence version 2.
 12-AUG-2020, entry version 64.
 SubName: Full=Insulin receptor substrate 2 {ECO:0000313|Ensembl:ENSCAFP00000009098};
 Name=IRS2 {ECO:0000313|VGNC:VGNC:42099};
 Canis lupus familiaris (Dog) (Canis familiaris).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
 NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000009098, ECO:0000313|Proteomes:UP000002254};
 [1] {ECO:0000313|Ensembl:ENSCAFP00000009098, ECO:0000313|Proteomes:UP000002254}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000009098,
 ECO:0000313|Proteomes:UP000002254};
 PubMed=16341006; DOI=10.1038/nature04338;
 Broad Sequencing Platform;
 Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
 Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E.,
 Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F.,
 Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W.,
 Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S.,
 Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A.,
 Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P.,
 Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
 Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
 Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P.,
 Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B.,
 Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A.,
 Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M.,
 Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S.,
 Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L.,
 Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
 Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C.,
 Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G.,
 Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
 Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A.,
 Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A.,
 Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M.,
 Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L.,
 LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A.,
 Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S.,
 Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T.,
 Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A.,
 Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
 Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S.,
 Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M.,
 Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F.,
 Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T.,
 Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C.,
 Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C.,
 Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D.,
 Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H.,
 Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
 Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J.,
 Zembek L., Zimmer A., Lander E.S.;
 "Genome sequence, comparative analysis and haplotype structure of the
 domestic dog.";
 Nature 438:803-819(2005).
 [2] {ECO:0000313|Ensembl:ENSCAFP00000009098}
 IDENTIFICATION.
 STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000009098};
 Ensembl;
 Submitted (JUL-2011) to UniProtKB.
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 EMBL; AAEX03013379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 STRING; 9612.ENSCAFP00000009098; -.
 PaxDb; F1Q219; -.
 Ensembl; ENSCAFT00000009800; ENSCAFP00000009098; ENSCAFG00000006058.
 VGNC; VGNC:42099; IRS2.
 eggNOG; ENOG502QUNU; Eukaryota.
 GeneTree; ENSGT00940000161407; -.
 HOGENOM; CLU_004902_1_0_1; -.
 InParanoid; F1Q219; -.
 TreeFam; TF325994; -.
 Reactome; R-CFA-109704; PI3K Cascade.
 Reactome; R-CFA-112399; IRS-mediated signalling.
 Reactome; R-CFA-112412; SOS-mediated signalling.
 Reactome; R-CFA-1257604; PIP3 activates AKT signaling.
 Reactome; R-CFA-1266695; Interleukin-7 signaling.
 Reactome; R-CFA-198203; PI3K/AKT activation.
 Reactome; R-CFA-2428928; IRS-related events triggered by IGF1R.
 Reactome; R-CFA-5673001; RAF/MAP kinase cascade.
 Reactome; R-CFA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
 Reactome; R-CFA-74713; IRS activation.
 Reactome; R-CFA-74749; Signal attenuation.
 Reactome; R-CFA-8853659; RET signaling.
 Reactome; R-CFA-9027276; Erythropoietin activates Phosphoinositide-3-kinase (PI3K).
 Reactome; R-CFA-9027284; Erythropoietin activates RAS.
 Proteomes; UP000002254; Chromosome 22.
 Bgee; ENSCAFG00000006058; Expressed in brain and 51 other tissues.
 GO; GO:0005829; C:cytosol; IBA:GO_Central.
 GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
 GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
 GO; GO:0005158; F:insulin receptor binding; IBA:GO_Central.
 GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IBA:GO_Central.
 GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
 GO; GO:0007420; P:brain development; IEA:Ensembl.
 GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
 GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
 GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
 GO; GO:0033673; P:negative regulation of kinase activity; IEA:Ensembl.
 GO; GO:0010748; P:negative regulation of long-chain fatty acid import across plasma membrane; IEA:Ensembl.
 GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
 GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
 GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
 GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
 GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
 GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
 GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
 GO; GO:0009749; P:response to glucose; IEA:Ensembl.
 CDD; cd01204; PTB_IRS; 1.
 Gene3D; 2.30.29.30; -; 2.
 InterPro; IPR039011; IRS.
 InterPro; IPR002404; IRS_PTB.
 InterPro; IPR011993; PH-like_dom_sf.
 InterPro; IPR001849; PH_domain.
 PANTHER; PTHR10614; PTHR10614; 1.
 Pfam; PF02174; IRS; 1.
 Pfam; PF00169; PH; 1.
 PRINTS; PR00628; INSULINRSI.
 SMART; SM00233; PH; 1.
 SMART; SM00310; PTBI; 1.
 PROSITE; PS51064; IRS_PTB; 1.
 PROSITE; PS50003; PH_DOMAIN; 1.
 4: Predicted;
 Reference proteome {ECO:0000313|Proteomes:UP000002254}.
 DOMAIN          29..142
                 /note="PH"
                 /evidence="ECO:0000259|PROSITE:PS50003"
 DOMAIN          193..297
                 /note="IRS-type PTB"
                 /evidence="ECO:0000259|PROSITE:PS51064"
 REGION          1..30
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          301..350
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          362..552
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          702..722
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          847..935
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          964..1301
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        302..317
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        453..468
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        487..505
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        964..1005
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        1025..1058
                 /note="Pro-rich"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        1066..1080
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        1143..1157
                 /note="Polyampholyte"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        1158..1199
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 SEQUENCE   1382 AA;  142931 MW;  C6405F8DE23B218B CRC64;
 XXXXXXXXXX XXXXXXGPNL NNNNNNNHSV RKCGYLRKQK HGHKRFFVLR GPGDEAAATA
 GGVPAPQPPR LEYYESEKKW RSKAGAPKRV IALDCCLNIN KRADAKHKYL IALYTRDEYF
 AVAAENEQEQ EGWYRALTDL LSEGRAGDAP PAPAPANAAA SCSASLPGAL GGSAGAAAAD
 DSYGLVAPAT AAYREVWQVN LKPKGLGQSK NLTGVYRLCL SARTIGFVKL NCEQPSVTLQ
 LMNIRRCGHS DSFFFIEVGR SAVTGPGELW MQADDSVVAQ NIHETILEAM KALKELFEFR
 PRSKSQSSGS SSTHPISVPG ARRHHHLVNL PPSQTGLVRR SRTDSLAATP PAAKCSSCRV
 RTASEGDGGA GAGAAGAGAG VGAGAGAGAG GRPVSVAGSP LSPGPVRAPL SRSHTLSGGC
 GGRASKVAPA PAGGALQHSR SMSMPVAHSP PAATSPGSLS SSSGHGSGSY PPPPGPHPPL
 QHPLHHAASQ RPSSGSASAS GSPSDPGFMS LDEYGSSPGD LRAFCSHRSN TPESIAETPP
 ARDGGGGELY GYMTMDRPLS HCGRPYRRVS GDGAQDLDRG LRKRTYSLTT PARQRPVPQP
 SSASLDEYTL MRATFSGSSG RLCPSCPASS PKVAYNPYPE DYGDVEIGSH RSSSSNLGAD
 DGYMPMTPGV ALMGGGGGSC KSDDYMPMSP TSVSAPKQIL QPRASAAALP PTGAAVPAPA
 PSAGRAFAAS GSGVSYKASS PAESSPEDSG YMRMWCGSKL SMESADSKLL PNGDYLNMSP
 SDAGTSGTPP DFFSAALHGS GEMLRGVPGY CYSSLPRSYK APYTCNGDNN DQYVLMSSPV
 GRILEEERLE PPASPGPTAG GAFAGAGGHT QPPHPAVPSP GRPGGSSAGR PDGFLTQRCR
 AVRPTRLSLE GLQTLPSMHE YPLPPEPKSP GEYINIDFGE AGARLSPPAP PLLASAASSC
 SLLSASSPAS SLGSGTPGTS SDSRQRSPLS DYMNLDFSSP KSPKPGAQSG DPVGSLDALL
 SPEAASPYPP LPPRPAAPAA SLQLQPPPPP PPGELYRLPP AAPSQGPGAA SSSSSEPGDN
 GDYTEMAFGV AATPPQPIAA PPKPEGARVT SPTSGVKRLS LMDQVSGVEA FLQASQPPDP
 HRGAKVIRAD PQGGRRRHSS ETFASTTTVT PVSPSFAHNP KRHNSASVEN VSLRKSSEGG
 SSGVLGAGDD RPMSPRQLQP PHPQQARPWG PGQPGGLVGC PGGSGAPMRR ETSAGFQNGL
 NYIAIDVRDE PGLSPAPQQH PHPQPGDKSA WGRTRSLGGL ITAVGSSGGG GVCGGPSPGA
 LPPANTYASI DFLSHHLKEA TIVKGEAFGP CEGWEDRWED GWKHRWENRW ESGGLLFFAT
 WT

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