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F1Q219_CANLF Unreviewed; 1382 AA.
F1Q219;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
11-DEC-2019, sequence version 2.
12-AUG-2020, entry version 64.
SubName: Full=Insulin receptor substrate 2 {ECO:0000313|Ensembl:ENSCAFP00000009098};
Name=IRS2 {ECO:0000313|VGNC:VGNC:42099};
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000009098, ECO:0000313|Proteomes:UP000002254};
[1] {ECO:0000313|Ensembl:ENSCAFP00000009098, ECO:0000313|Proteomes:UP000002254}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000009098,
ECO:0000313|Proteomes:UP000002254};
PubMed=16341006; DOI=10.1038/nature04338;
Broad Sequencing Platform;
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E.,
Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F.,
Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W.,
Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S.,
Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A.,
Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P.,
Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P.,
Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B.,
Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A.,
Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M.,
Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S.,
Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L.,
Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C.,
Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G.,
Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A.,
Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A.,
Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M.,
Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L.,
LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A.,
Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S.,
Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T.,
Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A.,
Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S.,
Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M.,
Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F.,
Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T.,
Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C.,
Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C.,
Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D.,
Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H.,
Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J.,
Zembek L., Zimmer A., Lander E.S.;
"Genome sequence, comparative analysis and haplotype structure of the
domestic dog.";
Nature 438:803-819(2005).
[2] {ECO:0000313|Ensembl:ENSCAFP00000009098}
IDENTIFICATION.
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000009098};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
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EMBL; AAEX03013379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9612.ENSCAFP00000009098; -.
PaxDb; F1Q219; -.
Ensembl; ENSCAFT00000009800; ENSCAFP00000009098; ENSCAFG00000006058.
VGNC; VGNC:42099; IRS2.
eggNOG; ENOG502QUNU; Eukaryota.
GeneTree; ENSGT00940000161407; -.
HOGENOM; CLU_004902_1_0_1; -.
InParanoid; F1Q219; -.
TreeFam; TF325994; -.
Reactome; R-CFA-109704; PI3K Cascade.
Reactome; R-CFA-112399; IRS-mediated signalling.
Reactome; R-CFA-112412; SOS-mediated signalling.
Reactome; R-CFA-1257604; PIP3 activates AKT signaling.
Reactome; R-CFA-1266695; Interleukin-7 signaling.
Reactome; R-CFA-198203; PI3K/AKT activation.
Reactome; R-CFA-2428928; IRS-related events triggered by IGF1R.
Reactome; R-CFA-5673001; RAF/MAP kinase cascade.
Reactome; R-CFA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-CFA-74713; IRS activation.
Reactome; R-CFA-74749; Signal attenuation.
Reactome; R-CFA-8853659; RET signaling.
Reactome; R-CFA-9027276; Erythropoietin activates Phosphoinositide-3-kinase (PI3K).
Reactome; R-CFA-9027284; Erythropoietin activates RAS.
Proteomes; UP000002254; Chromosome 22.
Bgee; ENSCAFG00000006058; Expressed in brain and 51 other tissues.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0005158; F:insulin receptor binding; IBA:GO_Central.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IBA:GO_Central.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0007420; P:brain development; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
GO; GO:0033673; P:negative regulation of kinase activity; IEA:Ensembl.
GO; GO:0010748; P:negative regulation of long-chain fatty acid import across plasma membrane; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
CDD; cd01204; PTB_IRS; 1.
Gene3D; 2.30.29.30; -; 2.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
Pfam; PF00169; PH; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00233; PH; 1.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000002254}.
DOMAIN 29..142
/note="PH"
/evidence="ECO:0000259|PROSITE:PS50003"
DOMAIN 193..297
/note="IRS-type PTB"
/evidence="ECO:0000259|PROSITE:PS51064"
REGION 1..30
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 301..350
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 362..552
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 702..722
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 847..935
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 964..1301
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 302..317
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 453..468
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 487..505
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 964..1005
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1025..1058
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1066..1080
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1143..1157
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1158..1199
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 1382 AA; 142931 MW; C6405F8DE23B218B CRC64;
XXXXXXXXXX XXXXXXGPNL NNNNNNNHSV RKCGYLRKQK HGHKRFFVLR GPGDEAAATA
GGVPAPQPPR LEYYESEKKW RSKAGAPKRV IALDCCLNIN KRADAKHKYL IALYTRDEYF
AVAAENEQEQ EGWYRALTDL LSEGRAGDAP PAPAPANAAA SCSASLPGAL GGSAGAAAAD
DSYGLVAPAT AAYREVWQVN LKPKGLGQSK NLTGVYRLCL SARTIGFVKL NCEQPSVTLQ
LMNIRRCGHS DSFFFIEVGR SAVTGPGELW MQADDSVVAQ NIHETILEAM KALKELFEFR
PRSKSQSSGS SSTHPISVPG ARRHHHLVNL PPSQTGLVRR SRTDSLAATP PAAKCSSCRV
RTASEGDGGA GAGAAGAGAG VGAGAGAGAG GRPVSVAGSP LSPGPVRAPL SRSHTLSGGC
GGRASKVAPA PAGGALQHSR SMSMPVAHSP PAATSPGSLS SSSGHGSGSY PPPPGPHPPL
QHPLHHAASQ RPSSGSASAS GSPSDPGFMS LDEYGSSPGD LRAFCSHRSN TPESIAETPP
ARDGGGGELY GYMTMDRPLS HCGRPYRRVS GDGAQDLDRG LRKRTYSLTT PARQRPVPQP
SSASLDEYTL MRATFSGSSG RLCPSCPASS PKVAYNPYPE DYGDVEIGSH RSSSSNLGAD
DGYMPMTPGV ALMGGGGGSC KSDDYMPMSP TSVSAPKQIL QPRASAAALP PTGAAVPAPA
PSAGRAFAAS GSGVSYKASS PAESSPEDSG YMRMWCGSKL SMESADSKLL PNGDYLNMSP
SDAGTSGTPP DFFSAALHGS GEMLRGVPGY CYSSLPRSYK APYTCNGDNN DQYVLMSSPV
GRILEEERLE PPASPGPTAG GAFAGAGGHT QPPHPAVPSP GRPGGSSAGR PDGFLTQRCR
AVRPTRLSLE GLQTLPSMHE YPLPPEPKSP GEYINIDFGE AGARLSPPAP PLLASAASSC
SLLSASSPAS SLGSGTPGTS SDSRQRSPLS DYMNLDFSSP KSPKPGAQSG DPVGSLDALL
SPEAASPYPP LPPRPAAPAA SLQLQPPPPP PPGELYRLPP AAPSQGPGAA SSSSSEPGDN
GDYTEMAFGV AATPPQPIAA PPKPEGARVT SPTSGVKRLS LMDQVSGVEA FLQASQPPDP
HRGAKVIRAD PQGGRRRHSS ETFASTTTVT PVSPSFAHNP KRHNSASVEN VSLRKSSEGG
SSGVLGAGDD RPMSPRQLQP PHPQQARPWG PGQPGGLVGC PGGSGAPMRR ETSAGFQNGL
NYIAIDVRDE PGLSPAPQQH PHPQPGDKSA WGRTRSLGGL ITAVGSSGGG GVCGGPSPGA
LPPANTYASI DFLSHHLKEA TIVKGEAFGP CEGWEDRWED GWKHRWENRW ESGGLLFFAT
WT