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Insulin receptor substrate 2

 F7DE94_MACMU            Unreviewed;      1394 AA.
F7DE94;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
11-DEC-2019, sequence version 3.
26-FEB-2020, entry version 50.
SubName: Full=Insulin receptor substrate 2 {ECO:0000313|Ensembl:ENSMMUP00000028694};
Name=IRS2 {ECO:0000313|Ensembl:ENSMMUP00000028694,
ECO:0000313|VGNC:VGNC:82164};
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000028694, ECO:0000313|Proteomes:UP000006718};
[1] {ECO:0000313|Ensembl:ENSMMUP00000028694, ECO:0000313|Proteomes:UP000006718}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000028694,
ECO:0000313|Proteomes:UP000006718};
PubMed=17431167; DOI=10.1126/science.1139247;
Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
Kuhn R.M., Smith K.E., Zwieg A.S.;
"Evolutionary and biomedical insights from the rhesus macaque genome.";
Science 316:222-234(2007).
[2] {ECO:0000313|Ensembl:ENSMMUP00000028694}
IDENTIFICATION.
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000028694};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
---------------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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STRING; 9544.ENSMMUP00000028694; -.
Ensembl; ENSMMUT00000030659; ENSMMUP00000028694; ENSMMUG00000021790.
VGNC; VGNC:82164; IRS2.
eggNOG; ENOG410IXEK; Eukaryota.
eggNOG; ENOG410Z9EP; LUCA.
GeneTree; ENSGT00940000161407; -.
HOGENOM; CLU_004902_1_0_1; -.
InParanoid; F7DE94; -.
TreeFam; TF325994; -.
Proteomes; UP000006718; Chromosome 17.
Bgee; ENSMMUG00000021790; Expressed in prefrontal cortex and 12 other tissues.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0005158; F:insulin receptor binding; IBA:GO_Central.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IBA:GO_Central.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0007420; P:brain development; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
GO; GO:0033673; P:negative regulation of kinase activity; IEA:Ensembl.
GO; GO:0010748; P:negative regulation of long-chain fatty acid import across plasma membrane; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
CDD; cd01204; PTB_IRS; 1.
Gene3D; 2.30.29.30; -; 2.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
Pfam; PF00169; PH; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00233; PH; 1.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000006718}.
DOMAIN 30..144
/note="PH"
/evidence="ECO:0000259|PROSITE:PS50003"
DOMAIN 191..295
/note="IRS-type PTB"
/evidence="ECO:0000259|PROSITE:PS51064"
REGION 1..31
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 48..72
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 300..408
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 425..534
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 698..736
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 837..1095
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1117..1239
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1255..1284
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 16..31
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 439..454
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 455..472
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 477..491
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 936..980
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1008..1040
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1050..1065
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1127..1141
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1142..1178
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1199..1214
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1258..1272
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 1394 AA; 144340 MW; F7F54B0B86EE061A CRC64;
MASPPRHGPP GPASGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL RGPGTGGDEA
TAGGGSAPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK YLIALYTKDE
YFAVAAENEQ EQEGWYRALT DLVSEGRAAA ADAPPTAAPA ASCSASLPGA LGGSAGAEDT
YGLVAPATAA YREVWQVNLK PKGLGQSKNL TGVYRLCLSA RTIGFVKLNC EQPSVTLQLM
NIRRCGHSDS FFFIEVGRSA VTGPGELWMQ ADDSVVAQNI HETILEAMKA LKELFEFRPR
SKSQSSGSSA THPISVPGAR RHHHLVNLPP SQTGLVRRSR TDSLAATPPA AKCSSCRVRT
ASEGDGGAAA GAAAAGARPV SVAGSPLSPG PVRAPLSRSH TLSGGCGGRG SKVALLPAGG
ALQHSRSMSM PVAHSPPAAT SPGSLSSSSG HGSGSYPPPP GPHPPLPHPL HHGPGQRPSS
GSASASGSPS DPGFMSLDEY GSSPGDLRAF CSHRSNTPES IAETPPARDG SGGGEFYGYM
TMDRPLSHCG RPYRRVSGDA AQDLDRGLRK RTYSLTTPAR QRPVPQPSSA SLDEYTLMRA
TFSGSAGRLC PSCPASSPKV AYHPYPEDYG DIEIGSHRSS SSNLGADDGY MPMTPGAALA
GSGSGSCRSD DYMPMSPASV SAPKQILQPR AAAAAAATVP PAGPAGPAPT SAAGRTFPAS
GGGYKASSPA ESSPEDSGYM RMWCGSKLSM EHADGKLLLN GDYLNVSPSD AVTTGTPPDF
FSAALHAGGE PLRGVPGCCY SSLPRSYKAP YTCGGDSDQY VLMSSPVGRI LEEERLEPQA
TPGPSQAASA FGTGPTQPPH PVVPSPVRPS GGRPEGLLGQ RGRAVRPTRL SLEGLPSLPS
MHEYPLPPEP KSPGEYINID FGEPGARLSP PAPPLLASAA SSSSLLSASS PASSLGSGTP
GTSSDSRQRS PLSDYMNLDF SSPKSPKPGA RSGHPVGSLD ALLSPEASSP YPPLPPRPSA
SPSSSLQPPP PPPPPGELYR LPPASATATV QGPGAASSSD TGDNGDYTEM AFGVAATPPQ
PIAAPSKPEA VRVASPTSGV KRLSLMEQVS GVEAFLQASQ PPDPHRGAKV IRADPQGGRR
RHSSETFSST TTVTPVSPSF AHNPKRHNSA SVENVSLRKS SEGGVGGVPG GGDEPPTSPR
QLQPAPPLAP QGRPWTPGQP GGLVGCPGSG GSPMRRETSA GFQNGLNYIA IDVREEPGLP
PQPQPQPQSP LPQPGDKNSW GRTRSLGGLI SAVGVGSTGG GCGGPGPGAL PPANTYASID
FLSHHLKEAT IVKGHQVSVQ RDPVDRCPKN KPTIMEFLMT LPTRGMEAAF PGHPYTQNNE
SWLLFTPLDF ISKW


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WP1354: B Cell Receptor Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway
WP17: daf-2 or insulin signaling pathway
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WP1913: Signaling by Insulin receptor
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WP480: T Cell Receptor Signaling Pathway
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WP794: B Cell Receptor Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP2355: Corticotropin-releasing hormone
WP774: Kit Receptor Signaling Pathway
WP1380: Regulation of Actin Cytoskeleton
WP966: Insulin Signaling
WP1183: Toll-like receptor signaling pathway
WP1390: cytochrome P450
WP26: Signal Transduction of S1P Receptor
WP79: Tryptophan metabolism
WP1355: One Carbon Metabolism
WP1219: cytochrome P450
WP2075: Alzheimers Disease
WP57: Signal Transduction of S1P Receptor
WP216: Striated Muscle Contraction

Related Genes :
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)
[chico IRS CG5686] Insulin receptor substrate 1 (dIRS) (Protein chico)
[IRS2] Insulin receptor substrate 2 (IRS-2)
[Irs2] Insulin receptor substrate 2 (IRS-2) (4PS)
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC 2.7.10.1) (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[BAIAP2L1 IRTKS] Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[InR dinr Dir-a Inr-a CG18402] Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insrr Irr] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[IRS1] Insulin receptor substrate 1 (IRS-1)
[IRS4] Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[INSRR IRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[insr] Insulin receptor (IR) (EC 2.7.10.1) (XTK-1b) (Xe-InsR) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[igf1r] Insulin-like growth factor 1 receptor (xIGF-1R) (xIGFR) (EC 2.7.10.1) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) (Fragments)
[INSRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[IGF2R MPRI] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[Igf2r] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[IGF2R M6P] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (CD antigen CD222)
[chico GF14127] Insulin receptor substrate 1 (Protein chico)

Bibliography :
[32631952] Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats.
[32603046] A 3'-untranslated region variant (rs2289046) of insulin receptor substrate 2 gene is associated with susceptibility to nonalcoholic fatty liver disease.
[32597148] Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells.
[32564738] Interleukin-4 Restores Insulin Sensitivity in Insulin-Resistant Osteoblasts by Increasing the Expression of Insulin Receptor Substrate 1.
[32554797] The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint.
[32458968] Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats.
[32455838] Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms-A Narrative Review.
[32454173] An unbiased lipidomics approach identifies key lipid molecules as potential therapeutic targets of Dohongsamul-tang against non-alcoholic fatty liver diseases in a mouse model of obesity.
[32397873] Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport.
[32385144] MHC-restricted phosphopeptide antigens: preclinical validation and first-in-humans clinical trial in participants with high-risk melanoma.