Insulin receptor substrate 2

 H2Q7S8_PANTR            Unreviewed;      1340 AA.
 H2Q7S8;
 21-MAR-2012, integrated into UniProtKB/TrEMBL.
 28-FEB-2018, sequence version 2.
 02-DEC-2020, entry version 47.
 SubName: Full=Insulin receptor substrate 2 {ECO:0000313|Ensembl:ENSPTRP00000010246};
 Name=IRS2 {ECO:0000313|Ensembl:ENSPTRP00000010246,
 ECO:0000313|VGNC:VGNC:13119};
 Pan troglodytes (Chimpanzee).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
 Pan.
 NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000010246, ECO:0000313|Proteomes:UP000002277};
 [1] {ECO:0000313|Ensembl:ENSPTRP00000010246, ECO:0000313|Proteomes:UP000002277}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 PubMed=16136131; DOI=10.1038/nature04072;
 Chimpanzee sequencing and analysis consortium;
 "Initial sequence of the chimpanzee genome and comparison with the human
 genome.";
 Nature 437:69-87(2005).
 [2] {ECO:0000313|Ensembl:ENSPTRP00000010246}
 IDENTIFICATION.
 Ensembl;
 Submitted (FEB-2012) to UniProtKB.
 ---------------------------------------------------------------------------
 Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
 Distributed under the Creative Commons Attribution (CC BY 4.0) License
 ---------------------------------------------------------------------------
 EMBL; AACZ04072733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 EMBL; AACZ04072734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 RefSeq; XP_016781015.1; XM_016925526.1.
 STRING; 9598.ENSPTRP00000010246; -.
 PaxDb; H2Q7S8; -.
 Ensembl; ENSPTRT00000011069; ENSPTRP00000010246; ENSPTRG00000006030.
 GeneID; 452657; -.
 KEGG; ptr:452657; -.
 CTD; 8660; -.
 VGNC; VGNC:13119; IRS2.
 eggNOG; ENOG502QUNU; Eukaryota.
 GeneTree; ENSGT00940000161407; -.
 HOGENOM; CLU_004902_1_0_1; -.
 InParanoid; H2Q7S8; -.
 OMA; YKAPYTC; -.
 OrthoDB; 298675at2759; -.
 TreeFam; TF325994; -.
 Proteomes; UP000002277; Chromosome 13.
 Bgee; ENSPTRG00000006030; Expressed in heart and 7 other tissues.
 GO; GO:0005829; C:cytosol; IBA:GO_Central.
 GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
 GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
 GO; GO:0005158; F:insulin receptor binding; IBA:GO_Central.
 GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IBA:GO_Central.
 GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
 GO; GO:0007420; P:brain development; IEA:Ensembl.
 GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
 GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
 GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
 GO; GO:0033673; P:negative regulation of kinase activity; IEA:Ensembl.
 GO; GO:0010748; P:negative regulation of long-chain fatty acid import across plasma membrane; IEA:Ensembl.
 GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
 GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
 GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
 GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
 GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
 GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
 GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
 GO; GO:0009749; P:response to glucose; IEA:Ensembl.
 CDD; cd01204; PTB_IRS; 1.
 Gene3D; 2.30.29.30; -; 2.
 InterPro; IPR039011; IRS.
 InterPro; IPR002404; IRS_PTB.
 InterPro; IPR011993; PH-like_dom_sf.
 InterPro; IPR001849; PH_domain.
 PANTHER; PTHR10614; PTHR10614; 1.
 Pfam; PF02174; IRS; 1.
 Pfam; PF00169; PH; 1.
 PRINTS; PR00628; INSULINRSI.
 SMART; SM00233; PH; 1.
 SMART; SM00310; PTBI; 1.
 PROSITE; PS51064; IRS_PTB; 1.
 PROSITE; PS50003; PH_DOMAIN; 1.
 4: Predicted;
 Reference proteome {ECO:0000313|Proteomes:UP000002277}.
 DOMAIN          30..144
                 /note="PH"
                 /evidence="ECO:0000259|PROSITE:PS50003"
 DOMAIN          194..298
                 /note="IRS-type PTB"
                 /evidence="ECO:0000259|PROSITE:PS51064"
 REGION          1..31
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          51..72
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          303..411
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          428..537
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          701..737
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          838..1105
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          1121..1293
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        16..31
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        442..457
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        458..475
                 /note="Pro-rich"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        480..494
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        941..985
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        1013..1045
                 /note="Pro-rich"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        1056..1072
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        1134..1148
                 /note="Polyampholyte"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        1149..1185
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        1206..1221
                 /note="Pro-rich"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        1265..1281
                 /note="Pro-rich"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 SEQUENCE   1340 AA;  137550 MW;  D990CF0825421075 CRC64;
 MASPPRQGPP GPASGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL RGPGAGGDEA
 TAGGGSAPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK YLIALYTKDE
 YFAVAAENEQ EQEGWYRALT DLVSEGRAAA GDAPPTAAPA ASCSASLPGA LGGSAGAAGA
 EDSYGLVAPA TAAYREVWQV NLKPKGLGQS KNLTGVYRLC LSARTIGFVK LNCEQPSVTL
 QLMNIRRCGH SDSFFFIEVG RSAVTGPGEL WMQADDSVVA QNIHETILEA MKALKELFEF
 RPRSKSQSSG SSATHPISVP GARRHHHLVN LPPSQTGLVR RSRTDSLAAT PPAAKCSSCR
 VRTASEGDGG AAAGAAAAGA RPVSVAGSPL SPGPVRAPLS RSHTLSGGCG GRGSKVALLP
 AGGALQHSRS MSMPVAHSPP AATSPGSLSS SSGHGSGSYP PPPGPHPPLP HPLHHGPGQR
 PSSGSASASG SPSDPGFMSL DEYGSSPGDL RAFCSHRSNT PESIAETPPA RDGGGGGEFY
 GYMTMDRPLS HCGRPYRRVS GDAAQDLDRG LRKRTYSLTT PARQRPVPQP SSASLDEYTL
 MRATFSGSAG RLCPSCPASS PKVAYHPYPE DYGDIEIGSH RSSSSNLGAD DGYMPMTPGA
 ALAGSGSGSC RSDDYMPMSP ASVSAPKQIL QPRAAAAAAV PSAGPAGPAP TSAAGRTFPA
 SGGGYKASSP AESSPEDSGY MRMWCGSKLS MEHADGKLLP NGDYLNVSPS DAVTTGTPPD
 FFSAALHPGG EPLRGVPGCC YSSLPRSYKA PYTCGGDSDQ YVLMSSPVGR ILEEERLEPQ
 ATPGPSQAAS AFGAGPTQPP HPVVPSPVRP SGGLGGGRPE GFLGQRGRAV RPTRLSLEGL
 PSLPSMHEYP LPPEPKSPGE YINIDFGEPG ARLSPPAPPL LASAASSSSL LSASSPASSL
 GSGTPGTSSD SRQRSPLSDY MNLDFSSPKS PKPGAPSGHP VGSLDGLLSP EASSPYPPLP
 PRPSASPSSS LQPPPPPPPP GELYRLPPAS AVATAQGPGA ASSLSSDTGD NGDYTEMAFG
 VAATPPQPIA APPKPEAARV ASPTSGVKRL SLMEQVSGVE AFLQASQPPD PHRGAKVIRA
 DPQGGRRRHS SETFSSTTTV TPVSPSFAHN PKRHNSASVE NVSLRKSSEG GVGVGPGGGD
 EPPTSPRQLQ PAPPLAPQGR PWTPGQPGGL VGCPGSGGSP MRRETSAGFQ NGLNYIAIDV
 REEPGLPPQP QPQPPPLPQP GDKSSWGRTR SLGGLISAVG VGSTGGGCGG PGPGALPPAN
 TYASIDFLSH HLKEATVVKE

Related products :