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Insulin receptor substrate 2

 H2Q7S8_PANTR            Unreviewed;      1340 AA.
H2Q7S8;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 2.
02-DEC-2020, entry version 47.
SubName: Full=Insulin receptor substrate 2 {ECO:0000313|Ensembl:ENSPTRP00000010246};
Name=IRS2 {ECO:0000313|Ensembl:ENSPTRP00000010246,
ECO:0000313|VGNC:VGNC:13119};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000010246, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000010246, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the human
genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000010246}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
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EMBL; AACZ04072733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ04072734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_016781015.1; XM_016925526.1.
STRING; 9598.ENSPTRP00000010246; -.
PaxDb; H2Q7S8; -.
Ensembl; ENSPTRT00000011069; ENSPTRP00000010246; ENSPTRG00000006030.
GeneID; 452657; -.
KEGG; ptr:452657; -.
CTD; 8660; -.
VGNC; VGNC:13119; IRS2.
eggNOG; ENOG502QUNU; Eukaryota.
GeneTree; ENSGT00940000161407; -.
HOGENOM; CLU_004902_1_0_1; -.
InParanoid; H2Q7S8; -.
OMA; YKAPYTC; -.
OrthoDB; 298675at2759; -.
TreeFam; TF325994; -.
Proteomes; UP000002277; Chromosome 13.
Bgee; ENSPTRG00000006030; Expressed in heart and 7 other tissues.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0005158; F:insulin receptor binding; IBA:GO_Central.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IBA:GO_Central.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0007420; P:brain development; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
GO; GO:0033673; P:negative regulation of kinase activity; IEA:Ensembl.
GO; GO:0010748; P:negative regulation of long-chain fatty acid import across plasma membrane; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
CDD; cd01204; PTB_IRS; 1.
Gene3D; 2.30.29.30; -; 2.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
Pfam; PF00169; PH; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00233; PH; 1.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000002277}.
DOMAIN 30..144
/note="PH"
/evidence="ECO:0000259|PROSITE:PS50003"
DOMAIN 194..298
/note="IRS-type PTB"
/evidence="ECO:0000259|PROSITE:PS51064"
REGION 1..31
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 51..72
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 303..411
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 428..537
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 701..737
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 838..1105
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1121..1293
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 16..31
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 442..457
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 458..475
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 480..494
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 941..985
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1013..1045
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1056..1072
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1134..1148
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1149..1185
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1206..1221
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1265..1281
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 1340 AA; 137550 MW; D990CF0825421075 CRC64;
MASPPRQGPP GPASGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL RGPGAGGDEA
TAGGGSAPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK YLIALYTKDE
YFAVAAENEQ EQEGWYRALT DLVSEGRAAA GDAPPTAAPA ASCSASLPGA LGGSAGAAGA
EDSYGLVAPA TAAYREVWQV NLKPKGLGQS KNLTGVYRLC LSARTIGFVK LNCEQPSVTL
QLMNIRRCGH SDSFFFIEVG RSAVTGPGEL WMQADDSVVA QNIHETILEA MKALKELFEF
RPRSKSQSSG SSATHPISVP GARRHHHLVN LPPSQTGLVR RSRTDSLAAT PPAAKCSSCR
VRTASEGDGG AAAGAAAAGA RPVSVAGSPL SPGPVRAPLS RSHTLSGGCG GRGSKVALLP
AGGALQHSRS MSMPVAHSPP AATSPGSLSS SSGHGSGSYP PPPGPHPPLP HPLHHGPGQR
PSSGSASASG SPSDPGFMSL DEYGSSPGDL RAFCSHRSNT PESIAETPPA RDGGGGGEFY
GYMTMDRPLS HCGRPYRRVS GDAAQDLDRG LRKRTYSLTT PARQRPVPQP SSASLDEYTL
MRATFSGSAG RLCPSCPASS PKVAYHPYPE DYGDIEIGSH RSSSSNLGAD DGYMPMTPGA
ALAGSGSGSC RSDDYMPMSP ASVSAPKQIL QPRAAAAAAV PSAGPAGPAP TSAAGRTFPA
SGGGYKASSP AESSPEDSGY MRMWCGSKLS MEHADGKLLP NGDYLNVSPS DAVTTGTPPD
FFSAALHPGG EPLRGVPGCC YSSLPRSYKA PYTCGGDSDQ YVLMSSPVGR ILEEERLEPQ
ATPGPSQAAS AFGAGPTQPP HPVVPSPVRP SGGLGGGRPE GFLGQRGRAV RPTRLSLEGL
PSLPSMHEYP LPPEPKSPGE YINIDFGEPG ARLSPPAPPL LASAASSSSL LSASSPASSL
GSGTPGTSSD SRQRSPLSDY MNLDFSSPKS PKPGAPSGHP VGSLDGLLSP EASSPYPPLP
PRPSASPSSS LQPPPPPPPP GELYRLPPAS AVATAQGPGA ASSLSSDTGD NGDYTEMAFG
VAATPPQPIA APPKPEAARV ASPTSGVKRL SLMEQVSGVE AFLQASQPPD PHRGAKVIRA
DPQGGRRRHS SETFSSTTTV TPVSPSFAHN PKRHNSASVE NVSLRKSSEG GVGVGPGGGD
EPPTSPRQLQ PAPPLAPQGR PWTPGQPGGL VGCPGSGGSP MRRETSAGFQ NGLNYIAIDV
REEPGLPPQP QPQPPPLPQP GDKSSWGRTR SLGGLISAVG VGSTGGGCGG PGPGALPPAN
TYASIDFLSH HLKEATVVKE


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WP1354: B Cell Receptor Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway
WP17: daf-2 or insulin signaling pathway
WP1313: Insulin Signaling
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WP1333: Hypothetical Network for Drug Addiction
WP794: B Cell Receptor Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP2355: Corticotropin-releasing hormone
WP774: Kit Receptor Signaling Pathway
WP1380: Regulation of Actin Cytoskeleton
WP1025: B Cell Receptor Signaling Pathway
WP1390: cytochrome P450
WP26: Signal Transduction of S1P Receptor
WP79: Tryptophan metabolism
WP1355: One Carbon Metabolism
WP1219: cytochrome P450
WP2075: Alzheimers Disease
WP57: Signal Transduction of S1P Receptor

Related Genes :
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC 2.7.10.1) (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[chico IRS CG5686] Insulin receptor substrate 1 (dIRS) (Protein chico)
[IRS2] Insulin receptor substrate 2 (IRS-2)
[Irs2] Insulin receptor substrate 2 (IRS-2) (4PS)
[BAIAP2L1 IRTKS] Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[InR dinr Dir-a Inr-a CG18402] Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[IRS1] Insulin receptor substrate 1 (IRS-1)
[Insrr Irr] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[IRS4] Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[INSRR IRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[insr] Insulin receptor (IR) (EC 2.7.10.1) (XTK-1b) (Xe-InsR) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[igf1r] Insulin-like growth factor 1 receptor (xIGF-1R) (xIGFR) (EC 2.7.10.1) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[INSRR] Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
[IGF2R MPRI] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[Igf2r] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[chico GF14127] Insulin receptor substrate 1 (Protein chico)
[chico GG23965] Insulin receptor substrate 1 (Protein chico)
[IGF2R M6P] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (CD antigen CD222)

Bibliography :
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