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Insulin receptor substrate 2-A (IRS-2-A) (Insulin receptor substrate-undetermined designation) (Insulin receptor substrate-unique) (xIRS-u)

 IRS2A_XENLA             Reviewed;        1074 AA.
Q9DF49; Q6GQH6;
10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
10-JAN-2006, sequence version 2.
02-DEC-2020, entry version 85.
RecName: Full=Insulin receptor substrate 2-A;
Short=IRS-2-A;
AltName: Full=Insulin receptor substrate-undetermined designation;
AltName: Full=Insulin receptor substrate-unique;
Short=xIRS-u;
Name=irs2-a; Synonyms=irsu;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
NCBI_TaxID=8355;
[1] {ECO:0000312|EMBL:AAH72768.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo {ECO:0000312|EMBL:AAH72768.1};
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000305, ECO:0000312|EMBL:AAG18441.1}
NUCLEOTIDE SEQUENCE [MRNA] OF 1-1071, AND FUNCTION.
TISSUE=Ovary {ECO:0000269|PubMed:9717835};
PubMed=9717835; DOI=10.1210/mend.12.8.0147;
Ohan N., Bayaa M., Kumar P., Zhu L., Liu X.J.;
"A novel insulin receptor substrate protein, xIRS-u, potentiates insulin
signaling: functional importance of its pleckstrin homology domain.";
Mol. Endocrinol. 12:1086-1098(1998).
-!- FUNCTION: Potentiates insulin signaling. {ECO:0000269|PubMed:9717835}.
-!- PTM: Phosphorylated by INSR. {ECO:0000250}.
-!- SEQUENCE CAUTION:
Sequence=AAG18441.1; Type=Frameshift; Evidence={ECO:0000305};
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EMBL; BC072768; AAH72768.1; -; mRNA.
EMBL; AF297960; AAG18441.1; ALT_FRAME; mRNA.
RefSeq; NP_001084242.1; NM_001090773.1.
SMR; Q9DF49; -.
GeneID; 399388; -.
KEGG; xla:399388; -.
CTD; 399388; -.
Xenbase; XB-GENE-865320; irs4.S.
OrthoDB; 298675at2759; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
GO; GO:0042169; F:SH2 domain binding; ISS:UniProtKB.
GO; GO:0008286; P:insulin receptor signaling pathway; IDA:UniProtKB.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
CDD; cd01204; PTB_IRS; 1.
Gene3D; 2.30.29.30; -; 2.
InterPro; IPR039011; IRS.
InterPro; IPR002404; IRS_PTB.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
PANTHER; PTHR10614; PTHR10614; 1.
Pfam; PF02174; IRS; 1.
Pfam; PF00169; PH; 1.
PRINTS; PR00628; INSULINRSI.
SMART; SM00233; PH; 1.
SMART; SM00310; PTBI; 1.
PROSITE; PS51064; IRS_PTB; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
2: Evidence at transcript level;
Phosphoprotein; Repeat; Transducer.
CHAIN 1..1074
/note="Insulin receptor substrate 2-A"
/id="PRO_0000076225"
DOMAIN 63..168
/note="PH"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
DOMAIN 193..297
/note="IRS-type PTB"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00389"
MOTIF 33..36
/note="YXXM motif 1"
/evidence="ECO:0000255"
MOTIF 145..148
/note="YXXM motif 2"
/evidence="ECO:0000255"
MOTIF 496..499
/note="YXXM motif 3"
/evidence="ECO:0000255"
MOTIF 592..595
/note="YXXM motif 4"
/evidence="ECO:0000255"
MOTIF 605..608
/note="YXXM motif 5"
/evidence="ECO:0000255"
MOTIF 631..634
/note="YXXM motif 6"
/evidence="ECO:0000255"
MOTIF 663..666
/note="YXXM motif 7"
/evidence="ECO:0000255"
MOTIF 710..713
/note="YXXM motif 8"
/evidence="ECO:0000255"
MOTIF 888..891
/note="YXXM motif 9"
/evidence="ECO:0000255"
COMPBIAS 402..464
/note="Ser-rich"
/evidence="ECO:0000255"
CONFLICT 398
/note="A -> P (in Ref. 2; AAG18441)"
/evidence="ECO:0000305"
CONFLICT 475
/note="S -> I (in Ref. 2; AAG18441)"
/evidence="ECO:0000305"
CONFLICT 785
/note="S -> N (in Ref. 2; AAG18441)"
/evidence="ECO:0000305"
CONFLICT 1027
/note="S -> Y (in Ref. 2)"
/evidence="ECO:0000305"
CONFLICT 1047
/note="S -> I (in Ref. 2)"
/evidence="ECO:0000305"
CONFLICT 1052..1053
/note="SG -> NW (in Ref. 2)"
/evidence="ECO:0000305"
CONFLICT 1062..1064
/note="RCD -> SVN (in Ref. 2)"
/evidence="ECO:0000305"
SEQUENCE 1074 AA; 117910 MW; 9262B6ECB6E7BF2C CRC64;
MAGVLCPTEE DRSSRAALRM LPPQPCPDES GAYRRMSGPT LSQVQEEPAA EPPQPPASAA
EDDVRKRGYL RKQKHGHKRY FVLRSQSHLG PARLEYYDNE KKFRSGQRSG CHPKRVIPLY
LCFTVSRRAD AKNKHLVALY TKDEYFAMAA ENEQEQDGWY QALSELINES KGACLDTEEL
EENYGTLRPG TVFKEVWQVN VKPRGLGQAK NLSGVYRLCL SSKAVHLVKL NSDVACVHLL
LMNIRRCGHS ENYFFIEVGR SSSTGAGELW MQVDDCVVAQ HMHETFLDTM KALKAYSEFR
PRSKSQSSCT NPISFITTRR YLGNLPPSQT GLQRRARTES MVGTPPSAKN NSFRFRTSSE
GEGTMTRPFR SVTGSLSHLN TARINLGKQE GAGRYVRAPF NSGYQSRSAS LPVSHFPSAT
SPISVCSSSG HGSASETLTR PSSSSVCGSP SDGGFISSDE YGSSPGDLRY FRVRSNTPDS
LGNTPPIQEE NTLSDYMSMS THSQPDSRDD YMEADKCFRK RTYSLTKHTN SASKQKSQTA
ISLGEDSEEI NKQFAFAESP KLKDSSLVDD YSNGVIDSVC NQSRSKASDD GYMPMMPSNL
YDSDYLPMAP KTVSAPKQIN RCPSQADSKG YMMMFPINSS PVKNVFGGAA TKSNLEKLSN
GGYMDMSYGN STKQIHDSNL NNNSRGLSSY FSLPRSFKSL TKQTTDQNEY VPMSSPGKLL
HLGAENGVDV CKDGAVHDIA KIELKSSSSI LDQQVKRPNK LTLGIRGSNT IPRMFDHSAP
AEPTSPGEYI NIDFSDKASS TPYSLSADGS PSSLGSSCDH RQSPLSDYMS VDIDVQSPKA
TAEQSNSLTD ISLYACTVVS RMQPNAEYAK LPCGTACVSK TDNIMDDYTT MTFNMAMTPP
RSFASETENG TKVDSPSSIV NRLCIGELTS LNSGFSLPNP LPEPIAGPKV IRADSQGRRR
HSSETFASSS TVTTSSSCFT ESGKRHSSAS FDNVWLKPDE NSCEQENKMS RHCSTGFQNG
LNYISLSMHN GVCEPTSPDC HQHQNGSRNL ESGGYVSIDF TRCDCLKCPT SRKD


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Related Genes :
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[IRS1] Insulin receptor substrate 1 (IRS-1)
[IRS4] Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)
[Baiap2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)
[InR dinr Dir-a Inr-a CG18402] Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC 2.7.10.1) (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[INSR] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Irs4] Insulin receptor substrate 4 (IRS-4) (Phosphoprotein of 160 kDa) (pp160)
[irs1-a] Insulin receptor substrate 1-A (IRS1-A) (xIRS-1-A) (XIRS-L)
[IGF2R MPRI] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[Igf2r] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
[DOK4] Docking protein 4 (Downstream of tyrosine kinase 4) (Insulin receptor substrate 5) (IRS-5) (IRS5)
[IGF2R M6P] Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (CD antigen CD222)
[Znf106 H3a Sh3bp3 Sirm Zfp106 Znf474] Zinc finger protein 106 (Zfp-106) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant) (Zinc finger protein 474)
[DOK5 C20orf180] Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)
[IGF2 PP1446] Insulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]
[SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
[BAIAP2] Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate) (p58/p53)
[Sirpa Bit Mfr Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (Macrophage membrane protein MFP150) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (CD antigen CD172a)
[INS] Insulin [Cleaved into: Insulin B chain; Insulin A chain]
[Sirpa Bit Myd1 Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)

Bibliography :