Insulin receptor substrate 2-A (IRS-2-A) (Insulin receptor substrate-undetermined designation) (Insulin receptor substrate-unique) (xIRS-u)

 IRS2A_XENLA             Reviewed;        1074 AA.
 Q9DF49; Q6GQH6;
 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
 10-JAN-2006, sequence version 2.
 02-DEC-2020, entry version 85.
 RecName: Full=Insulin receptor substrate 2-A;
          Short=IRS-2-A;
 AltName: Full=Insulin receptor substrate-undetermined designation;
 AltName: Full=Insulin receptor substrate-unique;
          Short=xIRS-u;
 Name=irs2-a; Synonyms=irsu;
 Xenopus laevis (African clawed frog).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
 Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
 NCBI_TaxID=8355;
 [1] {ECO:0000312|EMBL:AAH72768.1}
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 TISSUE=Embryo {ECO:0000312|EMBL:AAH72768.1};
 NIH - Xenopus Gene Collection (XGC) project;
 Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
 [2] {ECO:0000305, ECO:0000312|EMBL:AAG18441.1}
 NUCLEOTIDE SEQUENCE [MRNA] OF 1-1071, AND FUNCTION.
 TISSUE=Ovary {ECO:0000269|PubMed:9717835};
 PubMed=9717835; DOI=10.1210/mend.12.8.0147;
 Ohan N., Bayaa M., Kumar P., Zhu L., Liu X.J.;
 "A novel insulin receptor substrate protein, xIRS-u, potentiates insulin
 signaling: functional importance of its pleckstrin homology domain.";
 Mol. Endocrinol. 12:1086-1098(1998).
 -!- FUNCTION: Potentiates insulin signaling. {ECO:0000269|PubMed:9717835}.
 -!- PTM: Phosphorylated by INSR. {ECO:0000250}.
 -!- SEQUENCE CAUTION:
     Sequence=AAG18441.1; Type=Frameshift; Evidence={ECO:0000305};
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 EMBL; BC072768; AAH72768.1; -; mRNA.
 EMBL; AF297960; AAG18441.1; ALT_FRAME; mRNA.
 RefSeq; NP_001084242.1; NM_001090773.1.
 SMR; Q9DF49; -.
 GeneID; 399388; -.
 KEGG; xla:399388; -.
 CTD; 399388; -.
 Xenbase; XB-GENE-865320; irs4.S.
 OrthoDB; 298675at2759; -.
 GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO; GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
 GO; GO:0005634; C:nucleus; ISS:UniProtKB.
 GO; GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
 GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
 GO; GO:0042169; F:SH2 domain binding; ISS:UniProtKB.
 GO; GO:0008286; P:insulin receptor signaling pathway; IDA:UniProtKB.
 GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
 CDD; cd01204; PTB_IRS; 1.
 Gene3D; 2.30.29.30; -; 2.
 InterPro; IPR039011; IRS.
 InterPro; IPR002404; IRS_PTB.
 InterPro; IPR011993; PH-like_dom_sf.
 InterPro; IPR001849; PH_domain.
 PANTHER; PTHR10614; PTHR10614; 1.
 Pfam; PF02174; IRS; 1.
 Pfam; PF00169; PH; 1.
 PRINTS; PR00628; INSULINRSI.
 SMART; SM00233; PH; 1.
 SMART; SM00310; PTBI; 1.
 PROSITE; PS51064; IRS_PTB; 1.
 PROSITE; PS50003; PH_DOMAIN; 1.
 2: Evidence at transcript level;
 Phosphoprotein; Repeat; Transducer.
 CHAIN           1..1074
                 /note="Insulin receptor substrate 2-A"
                 /id="PRO_0000076225"
 DOMAIN          63..168
                 /note="PH"
                 /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
 DOMAIN          193..297
                 /note="IRS-type PTB"
                 /evidence="ECO:0000255|PROSITE-ProRule:PRU00389"
 MOTIF           33..36
                 /note="YXXM motif 1"
                 /evidence="ECO:0000255"
 MOTIF           145..148
                 /note="YXXM motif 2"
                 /evidence="ECO:0000255"
 MOTIF           496..499
                 /note="YXXM motif 3"
                 /evidence="ECO:0000255"
 MOTIF           592..595
                 /note="YXXM motif 4"
                 /evidence="ECO:0000255"
 MOTIF           605..608
                 /note="YXXM motif 5"
                 /evidence="ECO:0000255"
 MOTIF           631..634
                 /note="YXXM motif 6"
                 /evidence="ECO:0000255"
 MOTIF           663..666
                 /note="YXXM motif 7"
                 /evidence="ECO:0000255"
 MOTIF           710..713
                 /note="YXXM motif 8"
                 /evidence="ECO:0000255"
 MOTIF           888..891
                 /note="YXXM motif 9"
                 /evidence="ECO:0000255"
 COMPBIAS        402..464
                 /note="Ser-rich"
                 /evidence="ECO:0000255"
 CONFLICT        398
                 /note="A -> P (in Ref. 2; AAG18441)"
                 /evidence="ECO:0000305"
 CONFLICT        475
                 /note="S -> I (in Ref. 2; AAG18441)"
                 /evidence="ECO:0000305"
 CONFLICT        785
                 /note="S -> N (in Ref. 2; AAG18441)"
                 /evidence="ECO:0000305"
 CONFLICT        1027
                 /note="S -> Y (in Ref. 2)"
                 /evidence="ECO:0000305"
 CONFLICT        1047
                 /note="S -> I (in Ref. 2)"
                 /evidence="ECO:0000305"
 CONFLICT        1052..1053
                 /note="SG -> NW (in Ref. 2)"
                 /evidence="ECO:0000305"
 CONFLICT        1062..1064
                 /note="RCD -> SVN (in Ref. 2)"
                 /evidence="ECO:0000305"
 SEQUENCE   1074 AA;  117910 MW;  9262B6ECB6E7BF2C CRC64;
 MAGVLCPTEE DRSSRAALRM LPPQPCPDES GAYRRMSGPT LSQVQEEPAA EPPQPPASAA
 EDDVRKRGYL RKQKHGHKRY FVLRSQSHLG PARLEYYDNE KKFRSGQRSG CHPKRVIPLY
 LCFTVSRRAD AKNKHLVALY TKDEYFAMAA ENEQEQDGWY QALSELINES KGACLDTEEL
 EENYGTLRPG TVFKEVWQVN VKPRGLGQAK NLSGVYRLCL SSKAVHLVKL NSDVACVHLL
 LMNIRRCGHS ENYFFIEVGR SSSTGAGELW MQVDDCVVAQ HMHETFLDTM KALKAYSEFR
 PRSKSQSSCT NPISFITTRR YLGNLPPSQT GLQRRARTES MVGTPPSAKN NSFRFRTSSE
 GEGTMTRPFR SVTGSLSHLN TARINLGKQE GAGRYVRAPF NSGYQSRSAS LPVSHFPSAT
 SPISVCSSSG HGSASETLTR PSSSSVCGSP SDGGFISSDE YGSSPGDLRY FRVRSNTPDS
 LGNTPPIQEE NTLSDYMSMS THSQPDSRDD YMEADKCFRK RTYSLTKHTN SASKQKSQTA
 ISLGEDSEEI NKQFAFAESP KLKDSSLVDD YSNGVIDSVC NQSRSKASDD GYMPMMPSNL
 YDSDYLPMAP KTVSAPKQIN RCPSQADSKG YMMMFPINSS PVKNVFGGAA TKSNLEKLSN
 GGYMDMSYGN STKQIHDSNL NNNSRGLSSY FSLPRSFKSL TKQTTDQNEY VPMSSPGKLL
 HLGAENGVDV CKDGAVHDIA KIELKSSSSI LDQQVKRPNK LTLGIRGSNT IPRMFDHSAP
 AEPTSPGEYI NIDFSDKASS TPYSLSADGS PSSLGSSCDH RQSPLSDYMS VDIDVQSPKA
 TAEQSNSLTD ISLYACTVVS RMQPNAEYAK LPCGTACVSK TDNIMDDYTT MTFNMAMTPP
 RSFASETENG TKVDSPSSIV NRLCIGELTS LNSGFSLPNP LPEPIAGPKV IRADSQGRRR
 HSSETFASSS TVTTSSSCFT ESGKRHSSAS FDNVWLKPDE NSCEQENKMS RHCSTGFQNG
 LNYISLSMHN GVCEPTSPDC HQHQNGSRNL ESGGYVSIDF TRCDCLKCPT SRKD

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