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Insulin-like growth factor I (IGF-I) (Somatomedin)

 IGF1_CAPHI              Reviewed;         154 AA.
P51457;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
14-AUG-2001, sequence version 2.
13-FEB-2019, entry version 104.
RecName: Full=Insulin-like growth factor I;
Short=IGF-I;
AltName: Full=Somatomedin;
Flags: Precursor;
Name=IGF1;
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=7765981; DOI=10.1271/bbb.59.87;
Mikawa S., Yoshikawa G., Aoki H., Yamano Y., Sakai H., Komano T.;
"Dynamic aspects in the expression of the goat insulin-like growth
factor-I (IGF-I) gene: diversity in transcription and post-
transcription.";
Biosci. Biotechnol. Biochem. 59:87-92(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=Shiba; TISSUE=Liver;
PubMed=7772848; DOI=10.1271/bbb.59.759;
Mikawa S., Yoshikawa G., Yamano Y., Sakai H., Komano T., Hosoi Y.,
Utsumi K.;
"Tissue- and development-specific expression of goat insulin-like
growth factor-I (IGF-I) mRNAs.";
Biosci. Biotechnol. Biochem. 59:759-761(1995).
-!- FUNCTION: The insulin-like growth factors, isolated from plasma,
are structurally and functionally related to insulin but have a
much higher growth-promoting activity. May be a physiological
regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and
glycogen synthesis in osteoblasts. Stimulates glucose transport in
bone-derived osteoblastic (PyMS) cells and is effective at much
lower concentrations than insulin, not only regarding glycogen and
DNA synthesis but also with regard to enhancing glucose uptake.
May play a role in synapse maturation. Ca(2+)-dependent exocytosis
of IGF1 is required for sensory perception of smell in the
olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha
subunit of IGF1R, leading to the activation of the intrinsic
tyrosine kinase activity which autophosphorylates tyrosine
residues in the beta subunit thus initiatiating a cascade of down-
stream signaling events leading to activation of the PI3K-AKT/PKB
and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and
ITGA6:ITGB4. Its binding to integrins and subsequent ternary
complex formation with integrins and IGFR1 are essential for IGF1
signaling. Induces the phosphorylation and activation of IGFR1,
MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).
{ECO:0000250|UniProtKB:P05017, ECO:0000250|UniProtKB:P05019}.
-!- SUBUNIT: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms
a ternary complex with IGFR1 and ITGA6:ITGB4.
{ECO:0000250|UniProtKB:P05019}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05017}.
-!- TISSUE SPECIFICITY: Expressed in all tissues examined: brain,
lung, liver, spleen, uterus, ovary, testis, heart and skeletal
muscle. {ECO:0000269|PubMed:7772848}.
-!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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EMBL; D26119; BAB77524.1; ALT_SEQ; Genomic_DNA.
EMBL; D11378; BAA01976.1; -; mRNA.
PIR; JC2483; JC2483.
RefSeq; NP_001272626.1; NM_001285697.1.
UniGene; Chi.6376; -.
ProteinModelPortal; P51457; -.
SMR; P51457; -.
GeneID; 100860838; -.
KEGG; chx:100860838; -.
CTD; 3479; -.
HOVERGEN; HBG006137; -.
KO; K05459; -.
OrthoDB; 1644517at2759; -.
GO; GO:0035867; C:alphav-beta3 integrin-IGF-1-IGF1R complex; ISS:UniProtKB.
GO; GO:0070382; C:exocytic vesicle; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005179; F:hormone activity; IEA:InterPro.
GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.
InterPro; IPR022341; IGF-I.
InterPro; IPR016179; Insulin-like.
InterPro; IPR022350; Insulin-like_growth_factor.
InterPro; IPR036438; Insulin-like_sf.
InterPro; IPR022353; Insulin_CS.
InterPro; IPR022352; Insulin_family.
Pfam; PF00049; Insulin; 1.
PRINTS; PR02002; INSLNLIKEGF.
PRINTS; PR02005; INSLNLIKEGF1.
PRINTS; PR00276; INSULINFAMLY.
SMART; SM00078; IlGF; 1.
SUPFAM; SSF56994; SSF56994; 1.
PROSITE; PS00262; INSULIN; 1.
2: Evidence at transcript level;
Disulfide bond; Growth factor; Secreted; Signal.
SIGNAL 1 ? {ECO:0000255}.
PROPEP ? 49 {ECO:0000250}.
/FTId=PRO_0000015652.
CHAIN 50 119 Insulin-like growth factor I.
/FTId=PRO_0000015653.
PROPEP 120 154 E peptide.
/FTId=PRO_0000015654.
REGION 50 78 B.
REGION 79 90 C.
REGION 91 111 A.
REGION 112 119 D.
DISULFID 55 97 {ECO:0000250}.
DISULFID 67 110 {ECO:0000250}.
DISULFID 96 101 {ECO:0000250}.
SEQUENCE 154 AA; 17082 MW; 07238B6AF3068422 CRC64;
MGKISSLPTQ LFKCCFCDFL KQVKMPVTSS SHLFYLALCL LAFTSSATAG PETLCGAELV
DALQFVCGDR GFYFNKPTGY GSSSRRAPQT GIVDECCFRS CDLRRLEMYC APLKPTKSAR
SVRAQRHTDM PKAQKEVHLK NTSRGSAGNK NYRM


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1065: Endochondral Ossification
WP1085: Insulin Signaling
WP1181: Endochondral Ossification
WP1270: Endochondral Ossification
WP1308: Endochondral Ossification
WP1313: Insulin Signaling
WP1383: Endochondral Ossification
WP1403: AMPK signaling
WP17: daf-2 or insulin signaling pathway
WP1830: Insulin Synthesis and Processing
WP1866: NCAM signaling for neurite out-growth
WP1913: Signaling by Insulin receptor
WP1983: Splicing factor NOVA regulated synpatic proteins

Related Genes :
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF2 PP1446] Insulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Igf1 Igf-1] Insulin-like growth factor I (IGF-I) (Somatomedin)
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment)
[IGF2BP1 CRDBP VICKZ1 ZBP1] Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1)
[Igf2bp1 Vickz1] Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1)
[IGFBP1 IBP1] Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12)
[Igf2bp1 Imp1 Vickz1] Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (B-actin zipcode-binding protein 1) (ZBP1) (rZBP-1) (IGF-II mRNA-binding protein 1) (VICKZ family member 1)
[IGF2BP1 VICKZ1 ZBP1] Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zip-code binding polypeptide) (Zipcode-binding protein 1) (ZBP-1)
[IGF2BP3 IMP3 KOC1 VICKZ3] Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
[PAPPA] Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A)
[igf2bp3-a vera-a vickz3-a] Insulin-like growth factor 2 mRNA-binding protein 3-A (IGF2 mRNA-binding protein 3-A) (IMP-3-A) (69 kDa RNA-binding protein A) (IGF-II mRNA-binding protein 3-A) (KH domain-containing transcription factor B3-A) (RNA-binding protein Vera-A) (Trans-acting factor B3-A) (VICKZ family member 3-A) (VLE-binding protein A) (Vg1 RNA-binding protein A) (Vg1 RBP-A) (Vg1 localization element binding protein A) (VgLE-binding and ER association protein A)
[IGF2BP2 IMP2 VICKZ2] Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)
[Pappa] Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A)
[IGFBP3 IBP3] Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)
[IGFBP3] Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)
[IGFBP2 BP2 IBP2] Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2)
[IGFBP4 IBP4] Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4)
[Igfbp3 Igfbp-3] Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)
[Igfbp3 Igfbp-3] Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)
[IGFBP6 IBP6] Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6)
[Igfbp2 Igfbp-2] Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) (BRL-BP)
[IGFBP5 IBP5] Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5)
[Igfbp2 Igfbp-2] Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) (mIGFBP-2)
[Igfbp4 Igfbp-4] Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4)
[igfbp2a igfbp2 igfbp2b] Insulin-like growth factor-binding protein 2-A (IGF-binding protein 2-A) (IGFBP-2-A) (IGFBP-2a)
[igf2bp3-b vickz3-b] Insulin-like growth factor 2 mRNA-binding protein 3-B (IGF2 mRNA-binding protein 3-B) (IMP-3-B) (69 kDa RNA-binding protein B) (B3.65 protein B) (IGF-II mRNA-binding protein 3-B) (KH domain-containing transcription factor B3-B) (RNA-binding protein Vera-B) (Trans-acting factor B3-B) (VICKZ family member 3-B) (VLE-binding protein B) (Vg1 RNA-binding protein B) (Vg1 RBP-B) (Vg1 localization element binding protein B) (VgLE-binding and ER association protein B)
[Igfbp5 Igfbp-5] Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5)

Bibliography :
[30795479] Distribution, metabolism and hepatotoxicity of neonicotinoids in small farmland lizard and their effects on GH/IGF axis.
[30785508] Ramipril can alleviate the accumulation of renal mesangial matrix in rats with diabetic nephropathy by inhibiting insulin-like growth factor-11.
[30716059] Expression and Mechanism of Interleukin 1 (IL-1), Interleukin 2 (IL-2), Interleukin 8 (IL-8), BMP, Fibroblast Growth Factor 1 (FGF1), and Insulin-Like Growth Factor (IGF-1) in Lumbar Disc Herniation.
[30683825] The influence of orlistat, metformin and diet on serum levels of insulin-like growth factor-1 in obeses women with and without insulin resistance.
[30653179] Elastography detected solid organ stiffness increased in patients with acromegaly.
[30627944] AcroVoice: eliciting the patients' perspective on acromegaly disease activity.
[30620709] Pregnancy in acromegaly is safe and is associated with improvements in IGF-1 concentrations.
[30611815] Evaluation of growth status using endocrine growth indices, insulin-like growth factor (IGF)-I and IGF-binding protein-1b, in out-migrating juvenile chum salmon.
[30587647] Growth Patterns in Small for Gestational Age Babies and Correlation with Insulin-like Growth Factor-1 Levels.
[30579142] Seasonal expression of insulin-like growth factor 1 (IGF-1), its receptor IGF-1R and klotho in testis and epididymis of the European bison (Bison bonasus, Linnaeus 1758).