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Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (CD antigen CD11b)

 ITAM_MOUSE              Reviewed;        1153 AA.
P05555; Q8CA73;
01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 2.
13-FEB-2019, entry version 169.
RecName: Full=Integrin alpha-M;
AltName: Full=CD11 antigen-like family member B;
AltName: Full=CR-3 alpha chain;
AltName: Full=Cell surface glycoprotein MAC-1 subunit alpha;
AltName: Full=Leukocyte adhesion receptor MO1;
AltName: CD_antigen=CD11b;
Flags: Precursor;
Name=Itgam;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=3044779;
Pytela R.;
"Amino acid sequence of the murine Mac-1 alpha chain reveals homology
with the integrin family and an additional domain related to von
Willebrand factor.";
EMBO J. 7:1371-1378(1988).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=C57BL/6J; TISSUE=Spinal cord;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-45.
STRAIN=BALB/cJ; TISSUE=Spleen;
PubMed=2942940; DOI=10.1073/pnas.83.15.5644;
Sastre L., Roman J.M., Teplow D.B., Dreyer W.J., Gee C.E.,
Larson R.S., Roberts T.M., Springer T.A.;
"A partial genomic DNA clone for the alpha subunit of the mouse
complement receptor type 3 and cellular adhesion molecule Mac-1.";
Proc. Natl. Acad. Sci. U.S.A. 83:5644-5648(1986).
[4]
PROTEIN SEQUENCE OF 17-28, AND TISSUE SPECIFICITY.
PubMed=3887182; DOI=10.1038/314540a0;
Springer T.A., Teplow D.B., Dreyer W.J.;
"Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion
glycoproteins and unexpected relation to leukocyte interferon.";
Nature 314:540-542(1985).
[5]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
PHENOTYPE.
PubMed=8986723;
Coxon A., Rieu P., Barkalow F.J., Askari S., Sharpe A.H.,
von Andrian U.H., Arnaout M.A., Mayadas T.N.;
"A novel role for the beta 2 integrin CD11b/CD18 in neutrophil
apoptosis: a homeostatic mechanism in inflammation.";
Immunity 5:653-666(1996).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=9382884;
Tang T., Rosenkranz A., Assmann K.J., Goodman M.J.,
Gutierrez-Ramos J.C., Carroll M.C., Cotran R.S., Mayadas T.N.;
"A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil
function in vivo: Mac-1 deficiency abrogates sustained Fcgamma
receptor-dependent neutrophil adhesion and complement-dependent
proteinuria in acute glomerulonephritis.";
J. Exp. Med. 186:1853-1863(1997).
[7]
DISRUPTION PHENOTYPE.
PubMed=9207125;
Dong Z.M., Gutierrez-Ramos J.C., Coxon A., Mayadas T.N., Wagner D.D.;
"A new class of obesity genes encodes leukocyte adhesion receptors.";
Proc. Natl. Acad. Sci. U.S.A. 94:7526-7530(1997).
[8]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
PHENOTYPE.
PubMed=9862668;
Rosenkranz A.R., Coxon A., Maurer M., Gurish M.F., Austen K.F.,
Friend D.S., Galli S.J., Mayadas T.N.;
"Impaired mast cell development and innate immunity in Mac-1
(CD11b/CD18, CR3)-deficient mice.";
J. Immunol. 161:6463-6467(1998).
[9]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Lung, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Integrin ITGAM/ITGB2 is implicated in various adhesive
interactions of monocytes, macrophages and granulocytes as well as
in mediating the uptake of complement-coated particles and
pathogens (By similarity). It is identical with CR-3, the receptor
for the iC3b fragment of the third complement component. It
probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2
is also a receptor for fibrinogen, factor X and ICAM1. It
recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates
neutrophil migration. In association with beta subunit ITGB2/CD18,
required for CD177-PRTN3-mediated activation of TNF primed
neutrophils (By similarity). May regulate phagocytosis-induced
apoptosis in extravasated neutrophils (By similarity). May play a
role in mast cell development (By similarity).
{ECO:0000250|UniProtKB:P11215, ECO:0000269|PubMed:8986723,
ECO:0000269|PubMed:9382884, ECO:0000269|PubMed:9862668}.
-!- SUBUNIT: Heterodimer of an alpha and a beta subunit. ITGAM
associates with ITGB2. Found in a complex with CD177 and
ITGB2/CD18. Interacts with JAM3. Interacts with THBD. Interacts
with complement factor H/CFH; this interaction mediates adhesion
of neutrophils to pathogens leading to pathogen clearance.
{ECO:0000250|UniProtKB:P11215}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8986723,
ECO:0000269|PubMed:9862668}; Single-pass type I membrane protein
{ECO:0000250|UniProtKB:P11215}. Membrane raft
{ECO:0000250|UniProtKB:P11215}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P11215}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P05555-1; Sequence=Displayed;
Name=2;
IsoId=P05555-2; Sequence=VSP_010473;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Predominantly expressed in monocytes and
granulocytes (PubMed:3887182, PubMed:8986723). Expressed in a
subset of peritoneal mast cells (PubMed:9862668).
{ECO:0000269|PubMed:3887182, ECO:0000269|PubMed:8986723,
ECO:0000269|PubMed:9862668}.
-!- INDUCTION: Induced by lipopolysaccharide (LPS) in mast cells.
{ECO:0000269|PubMed:9862668}.
-!- DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins
with I-domains do not undergo protease cleavage.
-!- DISRUPTION PHENOTYPE: Mice are born at the expected Mendelian rate
(PubMed:8986723). The numbers of blood leukocytes are normal and
neutrophils rolling on blood vessels is not affected
(PubMed:8986723). Impaired LTB4-induced neutrophil adhesion to
venules (PubMed:8986723). Numbers of mast cells in the peritoneal
cavity, peritoneal wall and in the dorsal skin are reduced
(PubMed:9862668). In an experimental model of thioglycolate-
induced peritonitis, abnormal accumulation of recruited
neutrophils due to impaired apoptosis (PubMed:8986723). In an
experimental model of acute septic peritonitis, 5-fold increase in
mortality rate, reduced neutrophil recruitment in the peritoneum,
reduced histamine production and impaired bacterial clearence
(PubMed:9862668). In experimental model of immune complex-mediated
glomerulonephritis, reduced neutrophil accumulation without
affecting their initial recruitment and reduced proteinuria
(PubMed:9382884). Enhanced susceptibility to high fat diet-induced
obesity characterized by a weight increase and higher levels of
white and brown fat (PubMed:9207125). {ECO:0000269|PubMed:8986723,
ECO:0000269|PubMed:9207125, ECO:0000269|PubMed:9382884,
ECO:0000269|PubMed:9862668}.
-!- SIMILARITY: Belongs to the integrin alpha chain family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X07640; CAA30479.1; -; mRNA.
EMBL; AK039444; BAC30350.1; -; mRNA.
EMBL; M14293; AAA39484.1; -; Genomic_DNA.
CCDS; CCDS21889.1; -. [P05555-1]
PIR; S00551; S00551.
UniGene; Mm.262106; -.
ProteinModelPortal; P05555; -.
SMR; P05555; -.
ComplexPortal; CPX-3129; Integrin alphaM-beta2 complex.
IntAct; P05555; 2.
MINT; P05555; -.
STRING; 10090.ENSMUSP00000101849; -.
ChEMBL; CHEMBL3603; -.
PhosphoSitePlus; P05555; -.
MaxQB; P05555; -.
PaxDb; P05555; -.
PeptideAtlas; P05555; -.
PRIDE; P05555; -.
MGI; MGI:96607; Itgam.
eggNOG; ENOG410IPBA; Eukaryota.
eggNOG; ENOG410ZFBE; LUCA.
HOGENOM; HOG000113114; -.
HOVERGEN; HBG100530; -.
InParanoid; P05555; -.
PhylomeDB; P05555; -.
ChiTaRS; Itgam; mouse.
PRO; PR:P05555; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0009986; C:cell surface; IDA:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IDA:MGI.
GO; GO:0008305; C:integrin complex; IEA:InterPro.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0044853; C:plasma membrane raft; ISO:MGI.
GO; GO:0038024; F:cargo receptor activity; IGI:ARUK-UCL.
GO; GO:0001851; F:complement component C3b binding; IGI:ARUK-UCL.
GO; GO:0031072; F:heat shock protein binding; ISO:MGI.
GO; GO:0043395; F:heparan sulfate proteoglycan binding; IDA:MGI.
GO; GO:0008201; F:heparin binding; IDA:MGI.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0001846; F:opsonin binding; IDA:MGI.
GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
GO; GO:0050798; P:activated T cell proliferation; IMP:MGI.
GO; GO:0097242; P:amyloid-beta clearance; IMP:ARUK-UCL.
GO; GO:0097190; P:apoptotic signaling pathway; IDA:ARUK-UCL.
GO; GO:0007155; P:cell adhesion; IMP:MGI.
GO; GO:1905114; P:cell surface receptor signaling pathway involved in cell-cell signaling; IMP:ARUK-UCL.
GO; GO:0098609; P:cell-cell adhesion; IGI:MGI.
GO; GO:0045123; P:cellular extravasation; IMP:MGI.
GO; GO:0150062; P:complement-mediated synapse pruning; IMP:ARUK-UCL.
GO; GO:0030900; P:forebrain development; IDA:ARUK-UCL.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
GO; GO:0061756; P:leukocyte adhesion to vascular endothelial cell; IMP:UniProtKB.
GO; GO:0007159; P:leukocyte cell-cell adhesion; IMP:MGI.
GO; GO:0002523; P:leukocyte migration involved in inflammatory response; IMP:MGI.
GO; GO:0014005; P:microglia development; IDA:MGI.
GO; GO:0001774; P:microglial cell activation; IMP:ARUK-UCL.
GO; GO:0045963; P:negative regulation of dopamine metabolic process; IDA:ARUK-UCL.
GO; GO:0001781; P:neutrophil apoptotic process; IMP:UniProtKB.
GO; GO:0030593; P:neutrophil chemotaxis; IMP:MGI.
GO; GO:0006909; P:phagocytosis; IMP:UniProtKB.
GO; GO:0006911; P:phagocytosis, engulfment; IMP:ARUK-UCL.
GO; GO:0110090; P:positive regulation of hippocampal neuron apoptotic process; IDA:ARUK-UCL.
GO; GO:0060376; P:positive regulation of mast cell differentiation; IMP:UniProtKB.
GO; GO:1903980; P:positive regulation of microglial cell activation; IMP:ARUK-UCL.
GO; GO:1904151; P:positive regulation of microglial cell mediated cytotoxicity; IMP:UniProtKB.
GO; GO:1901216; P:positive regulation of neuron death; IMP:ARUK-UCL.
GO; GO:0043315; P:positive regulation of neutrophil degranulation; ISO:MGI.
GO; GO:1903223; P:positive regulation of oxidative stress-induced neuron death; IMP:ARUK-UCL.
GO; GO:2000363; P:positive regulation of prostaglandin-E synthase activity; IMP:ARUK-UCL.
GO; GO:0090314; P:positive regulation of protein targeting to membrane; IMP:ARUK-UCL.
GO; GO:0032930; P:positive regulation of superoxide anion generation; IDA:ARUK-UCL.
GO; GO:0006898; P:receptor-mediated endocytosis; IMP:ARUK-UCL.
GO; GO:0150064; P:vertebrate eye-specific patterning; IMP:ARUK-UCL.
Gene3D; 2.130.10.130; -; 1.
Gene3D; 3.40.50.410; -; 1.
InterPro; IPR013517; FG-GAP.
InterPro; IPR013519; Int_alpha_beta-p.
InterPro; IPR000413; Integrin_alpha.
InterPro; IPR013649; Integrin_alpha-2.
InterPro; IPR018184; Integrin_alpha_C_CS.
InterPro; IPR028994; Integrin_alpha_N.
InterPro; IPR032695; Integrin_dom_sf.
InterPro; IPR002035; VWF_A.
InterPro; IPR036465; vWFA_dom_sf.
Pfam; PF01839; FG-GAP; 1.
Pfam; PF00357; Integrin_alpha; 1.
Pfam; PF08441; Integrin_alpha2; 1.
Pfam; PF00092; VWA; 1.
PRINTS; PR01185; INTEGRINA.
SMART; SM00191; Int_alpha; 5.
SMART; SM00327; VWA; 1.
SUPFAM; SSF53300; SSF53300; 1.
SUPFAM; SSF69179; SSF69179; 3.
PROSITE; PS51470; FG_GAP; 7.
PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PROSITE; PS50234; VWFA; 1.
1: Evidence at protein level;
Alternative splicing; Calcium; Cell adhesion; Cell membrane;
Complete proteome; Direct protein sequencing; Disulfide bond;
Glycoprotein; Integrin; Membrane; Metal-binding; Receptor;
Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 16 {ECO:0000269|PubMed:3887182}.
CHAIN 17 1153 Integrin alpha-M.
/FTId=PRO_0000016290.
TOPO_DOM 17 1105 Extracellular. {ECO:0000255}.
TRANSMEM 1106 1129 Helical. {ECO:0000255}.
TOPO_DOM 1130 1153 Cytoplasmic. {ECO:0000255}.
REPEAT 18 75 FG-GAP 1. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
REPEAT 76 135 FG-GAP 2. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
DOMAIN 164 338 VWFA. {ECO:0000255|PROSITE-
ProRule:PRU00219}.
REPEAT 339 390 FG-GAP 3. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
REPEAT 391 442 FG-GAP 4. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
REPEAT 443 503 FG-GAP 5. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
REPEAT 506 564 FG-GAP 6. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
REPEAT 569 629 FG-GAP 7. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
CA_BIND 465 473 {ECO:0000255}.
CA_BIND 529 537 {ECO:0000255}.
CA_BIND 592 600 {ECO:0000255}.
MOTIF 1132 1136 GFFKR motif.
CARBOHYD 58 58 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 86 86 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 391 391 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 696 696 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 734 734 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 772 772 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 801 801 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 881 881 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 907 907 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 941 941 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 980 980 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 994 994 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1022 1022 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1045 1045 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1051 1051 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1076 1076 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 66 73 {ECO:0000250}.
DISULFID 105 123 {ECO:0000250}.
DISULFID 654 711 {ECO:0000250}.
DISULFID 770 776 {ECO:0000250}.
DISULFID 999 1023 {ECO:0000250}.
DISULFID 1028 1033 {ECO:0000250}.
VAR_SEQ 453 569 Missing (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_010473.
CONFLICT 37 37 N -> S (in Ref. 2; BAC30350).
{ECO:0000305}.
CONFLICT 683 683 V -> G (in Ref. 2; BAC30350).
{ECO:0000305}.
SEQUENCE 1153 AA; 127481 MW; 178DB988AECB0343 CRC64;
MTLKALLVTA LALCHGFNLD TEHPMTFQEN AKGFGQNVVQ LGGTSVVVAA PQEAKAVNQT
GALYQCDYST SRCHPIPLQV PPEAVNMSLG LSLAVSTVPQ QLLACGPTVH QNCKENTYVN
GLCYLFGSNL LRPPQQFPEA LRECPQQESD IVFLIDGSGS INNIDFQKMK EFVSTVMEQF
KKSKTLFSLM QYSDEFRIHF TFNDFKRNPS PRSHVSPIKQ LNGRTKTASG IRKVVRELFH
KTNGARENAA KILVVITDGE KFGDPLDYKD VIPEADRAGV IRYVIGVGNA FNKPQSRREL
DTIASKPAGE HVFQVDNFEA LNTIQNQLQE KIFAIEGTQT GSTSSFEHEM SQEGFSASIT
SNGPLLGSVG SFDWAGGAFL YTSKDKVTFI NTTRVDSDMN DAYLGYASAV ILRNRVQSLV
LGAPRYQHIG LVVMFRENFG TWEPHTSIKG SQIGSYFGAS LCSVDMDADG NTNLILIGAP
HYYEKTRGGQ VSVCPLPRGR ARWQCEALLH GDQGHPWGRF GAALTVLGDV NGDKLTDVAI
GAPGEQENQG AVYIFYGASI ASLSASHSHR IIGAHFSPGL QYFGQSLSGG KDLTMDGLMD
LAVGAQGHLL LLRAQPVLRL EATMEFSPKK VARSVFACQE QVLKNKDAGE VRVCLRVRKN
TKDRLREGDI QSTVTYDLAL DPVRSRIRAF FDETKNNTRR RTQVFGLMQK CETLKLILPD
CVDDSVSPII LRLNYTLVGE PLRSFGNLRP VLAMDAQRFF TAMFPFEKNC GNDSICQDDL
SITMSAMGLD TLVVGGPQDF NMSVTLRNDG EDSYGTQVTV YYPSGLSYRK DSASQNPLTK
KPWFVKPAES SSSSEGHGAL KSTTWNINHP IFPANSEVTF NVTFDVDSHA SFGNKLLLKA
IVASENNMSR THKTKFQLEL PVKYAIYMIV TSDESSIRYL NFTASEMTSK VIQHQYQFNN
LGQRSLPVSV VFWIPVQINN VTVWDHPQVI FSQNLSSACH TEQKSPPHSN FRDQLERTPV
LNCSVAVCKR IQCDLPSFNT QEIFNVTLKG NLSFDWYIKT SHGHLLLVSS TEILFNDSAF
ALLPGQESYV RSKTETKVEP YEVHNPVPLI VGSSIGGLVL LALITAGLYK LGFFKRQYKD
MMNEAAPQDA PPQ


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E1685m ELISA kit CD11 antigen-like family member B,Cell surface glycoprotein MAC-1 subunit alpha,CR-3 alpha chain,Integrin alpha-M,Itgam,Leukocyte adhesion receptor MO1,Mouse,Mus musculus 96T
E1685m ELISA CD11 antigen-like family member B,Cell surface glycoprotein MAC-1 subunit alpha,CR-3 alpha chain,Integrin alpha-M,Itgam,Leukocyte adhesion receptor MO1,Mouse,Mus musculus 96T
U1685m CLIA CD11 antigen-like family member B,Cell surface glycoprotein MAC-1 subunit alpha,CR-3 alpha chain,Integrin alpha-M,Itgam,Leukocyte adhesion receptor MO1,Mouse,Mus musculus 96T
20-272-190815 CD11 _ 18 - Mouse monoclonal [24] to CD11 _ 18; Cell surface glycoprotein MAC-1 alpha subunit; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b antigen Monoclona 0.1 mg
20-783-72304 MOUSE ANTI HUMAN CD11b Azide Free - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11 1 mg
20-783-72303 MOUSE ANTI HUMAN CD11b - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b antigen M 0.02 mg
20-783-72301 MOUSE ANTI HUMAN CD11b - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b antigen M 0.1 mg
20-783-72298 MOUSE ANTI HUMAN CD11b - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b antigen M 0.2 mg
20-272-191997 Integrin alpha M - Mouse monoclonal [ICRF 44] to Integrin alpha M; Cell surface glycoprotein MAC-1 alpha subunit; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11 0.2 mg
E1572m ELISA kit CD11 antigen-like family member A,Integrin alpha-L,Itgal,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,Lfa-1,LFA-1A,Ly-15,Ly-15,Lymp 96T
U1572m CLIA CD11 antigen-like family member A,Integrin alpha-L,Itgal,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,Lfa-1,LFA-1A,Ly-15,Ly-15,Lymphocyte 96T
E1572m ELISA CD11 antigen-like family member A,Integrin alpha-L,Itgal,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,Lfa-1,LFA-1A,Ly-15,Ly-15,Lymphocyt 96T
E1572b ELISA Bos taurus,Bovine,CD11 antigen-like family member A,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA-1A 96T
E1572b ELISA kit Bos taurus,Bovine,CD11 antigen-like family member A,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA-1A 96T
U1572b CLIA Bos taurus,Bovine,CD11 antigen-like family member A,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA-1A 96T
E1572h ELISA CD11 antigen-like family member A,CD11A,Homo sapiens,Human,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA-1A 96T
E1572h ELISA kit CD11 antigen-like family member A,CD11A,Homo sapiens,Human,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA- 96T
U1572h CLIA CD11 antigen-like family member A,CD11A,Homo sapiens,Human,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA-1A 96T
20-783-72299 MOUSE ANTI HUMAN CD11b Biotin - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b an 0.1 mg
20-783-72302 MOUSE ANTI HUMAN CD11b RPE - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b antig 100 TESTS
20-783-72300 MOUSE ANTI HUMAN CD11b FITC - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b anti 0.1 mg
20-272-190178 CD11b - Mouse monoclonal [LT11] to CD11b; Cell surface glycoprotein MAC-1 alpha subunit; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b antigen Monoclonal 0.1 mg

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Gentaur; yes we can

Pathways :
WP1614: 1- and 2-Methylnaphthalene degradation
WP1963: The effect of Glucocorticoids on target gene expression
WP2328: Allograft rejection
WP1566: Citrate cycle (TCA cycle)
WP1655: Geraniol degradation
WP566: canonical wnt - zebrafish
WP1003: Ovarian Infertility Genes
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1069: Integrin-mediated cell adhesion
WP1120: Ovarian Infertility Genes
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1185: Integrin-mediated cell adhesion
WP1209: EBV LMP1 signaling
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP1340: Ovarian Infertility Genes
WP1369: TNF-alpha NF-kB Signaling Pathway
WP1386: Integrin-mediated cell adhesion
WP1434: Osteopontin Signaling
WP1487: TNF-alpha and mucus production in lung epythelium
WP1531: Vitamin D synthesis
WP1571: EBV LMP1 signaling
WP1584: Type II diabetes mellitus
WP1618: alpha-Linolenic acid metabolism
WP1772: Apoptosis Modulation and Signaling

Related Genes :
[ITGAM CD11B CR3A] Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
[ITGAL CD11A] Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)
[TIF1 TIF41A YKR059W; TIF2 TIF41B YJL138C J0660] ATP-dependent RNA helicase eIF4A (EC 3.6.4.13) (Eukaryotic initiation factor 4A) (eIF-4A) (Stimulator factor I 37 kDa component) (Translation initiation factor 1/2) (p37)
[Itgb2] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[ITGB2 CD18 MFI7] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[CD177 NB1 PRV1 UNQ595/PRO1181] CD177 antigen (Human neutrophil alloantigen 2a) (HNA-2a) (NB1 glycoprotein) (NB1 GP) (Polycythemia rubra vera protein 1) (PRV-1) (CD antigen CD177)
[Itga4] Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (Lymphocyte Peyer patch adhesion molecules subunit alpha) (LPAM subunit alpha) (VLA-4 subunit alpha) (CD antigen CD49d)
[ITGA4 CD49D] Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[SELL LNHR LYAM1] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
[EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1] Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
[POL RR33_52434gpPOL] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[ITGA2 CD49B] Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)
[ITGAV MSK8 VNRA VTNR] Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
[ITGA6] Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)]
[ITGB2 CD18] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[ITGB2 CD18] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[Sell Lnhr Ly-22 Ly22] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (CD antigen CD62L)
[CD84 SLAMF5] SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
[ITGB2 CD18] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
[Itga6] Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain]
[CD44 LHR MDU2 MDU3 MIC4] CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Cd79a Iga Mb-1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[Sirpa Bit Myd1 Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)
[ITGA2B GP2B ITGAB] Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]
[CD79A IGA MB1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[Itgav] Integrin alpha-V (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
[CLEC4M CD209L CD209L1 CD299] C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299)

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