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Intercellular adhesion molecule 1

 A0A2K6C429_MACNE        Unreviewed;       532 AA.
A0A2K6C429;
28-MAR-2018, integrated into UniProtKB/TrEMBL.
28-MAR-2018, sequence version 1.
17-JUN-2020, entry version 18.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMNEP00000018404};
Name=ICAM1 {ECO:0000313|Ensembl:ENSMNEP00000018404};
Macaca nemestrina (Pig-tailed macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000018404, ECO:0000313|Proteomes:UP000233120};
[1] {ECO:0000313|Ensembl:ENSMNEP00000018404, ECO:0000313|Proteomes:UP000233120}
NUCLEOTIDE SEQUENCE.
Hughes D.S., Liu Y., Murali S., Raveendran M., Korchina V., Wang M.,
Jhangiani S., Bandaranaike D., Bellair M., Blankenburg K., Chao H.,
Dahdouli M., Dinh H., Doddapaneni H., English A., Gnanaolivu R., Gross S.,
Jayaseelan J., Jones J., Khan Z., Kovar C., Kurapati P., Le B., Lee S.,
Matakis S., Mathew T., Narasimhan A., Ngo D., Okwuonu G., Ongeri F.,
Osuji N., Otenyo P., Patel E., Qu C., Quiroz J., Raj R., Rajbhandari K.,
Reid J.G., Santibanez J., Skinner E., Vee V., Wang Y., Weissenberger G.,
Xin Y., Zou X., Han Y., Muzny D.M., Richards S., Worley K.C., Rogers J.,
Gibbs R.A.;
"Pig-tailed Macaque reference genome and diversity panel.";
Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSMNEP00000018404}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
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RefSeq; XP_011730911.1; XM_011732609.1.
Ensembl; ENSMNET00000042639; ENSMNEP00000018404; ENSMNEG00000033129.
GeneID; 105476548; -.
CTD; 3383; -.
GeneTree; ENSGT00940000162311; -.
OMA; TFLTVYW; -.
OrthoDB; 731140at2759; -.
Proteomes; UP000233120; Whole Genome Shotgun Assembly.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0005178; F:integrin binding; IEA:Ensembl.
GO; GO:0033627; P:cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl.
GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
GO; GO:0061028; P:establishment of endothelial barrier; IEA:Ensembl.
GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
GO; GO:0022614; P:membrane to membrane docking; IEA:Ensembl.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0002693; P:positive regulation of cellular extravasation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0046813; P:receptor-mediated virion attachment to host cell; IEA:Ensembl.
GO; GO:1900027; P:regulation of ruffle assembly; IEA:Ensembl.
GO; GO:0002291; P:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; IEA:Ensembl.
GO; GO:0002457; P:T cell antigen processing and presentation; IEA:Ensembl.
GO; GO:0072683; P:T cell extravasation; IEA:Ensembl.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR003988; ICAM.
InterPro; IPR013768; ICAM_N.
InterPro; IPR003987; ICAM_VCAM_N.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
Pfam; PF03921; ICAM_N; 1.
PRINTS; PR01473; ICAM.
PRINTS; PR01472; ICAMVCAM1.
SMART; SM00409; IG; 3.
SUPFAM; SSF48726; SSF48726; 5.
4: Predicted;
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000233120};
Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1..27
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 28..532
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5014336152"
TRANSMEM 482..503
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 33..110
/note="IG"
/evidence="ECO:0000259|SMART:SM00409"
DOMAIN 317..393
/note="IG"
/evidence="ECO:0000259|SMART:SM00409"
DOMAIN 404..475
/note="IG"
/evidence="ECO:0000259|SMART:SM00409"
REGION 513..532
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 532 AA; 57627 MW; 995D7D451DA8367E CRC64;
MAPSGPQPAL PTLVVLLGAL LLGPGNAQTS VFPPEVILPR GGSVKVNCSA SCDQPISLGM
ETPLPKKEIL PGGNNWKMYE LSNVQEDSQP MCYSNCPDGQ SSAKTLLTVY WTPERVELAP
LPPWQPVGKN LTLRCQVEGG APRANLTVML LRGEKELSRQ SAVGEPAEVT TTVPVGRDDH
GANFSCRTEL DLRPYVLKLF ENTSAPHQLQ TFDLPATPPQ LVSPQVLEVD TQGTVVCSLD
GLFPVSEAQV SLALGDQKLN PTITYGNNSL SAKASVKVTA EKEGTQQLLC GVMLGNQTQE
TRQTVTIYSF PAPNVNLTKP EVSEGTEVIV ECEAHPRAKV MLNGVPAQPP GPRAQFLLKA
TPEDNGRSFS CSATLEVAGQ LVHKNQTREL RVLYGPRLDE KDCPGNWTWP ENSQQTPMCQ
AWGNPLPQLK CLKDGTFPLP IGQSVTVTRD LEGTYLCQAR STRGEVTREV TVNVLSPRYE
VVIIPVVAAA VILGTAGVAT YLYNRQRKIR KYRLQQAQNG TPMKPNTQAT PP


Related products :

Catalog number Product name Quantity
PAS9212 Polyclonal antibody: Adhesion Molecules : INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1), Host Animal: Sheep, Format: Ig Fraction - Liquid, Ig Concentration: >5mg_ml (U.V.abs @ 280nm) 1ml
E02I0329 Rat intercellular adhesion molecule 3 96 Tests/kit
E02I0325 Rat intercellular adhesion molecule 1 96 Tests/kit
E02I0326 Rat Intercellular adhesion molecule 2 96 Tests/kit
pro-383 Recombinant Human Intercellular Adhesion Molecule-1 2
C306 Intercellular Adhesion Molecule 2 ICAM-2 500
CD35 Intercellular Adhesion Molecule 1 ICAM-1 (C-Fc-His tag) 500
E02I0326 Rat Intercellular adhesion molecule 2 ELISA 96T/kit
EH163 Intercellular adhesion molecule 3 Elisa Kit 96T
ER028 Intercellular Adhesion Molecule-1 Elisa Kit 96T
E0534r Rat intercellular adhesion molecule 2 ELISA Kit 96T
E06I0326 Goat Intercellular adhesion molecule 2 96 Tests/kit
EM1142 intercellular adhesion molecule 3 Elisa Kit 96T
E01I0325 Human intercellular adhesion molecule 1 96 Tests/kit
EM1141 intercellular adhesion molecule 2 Elisa Kit 96T
E01I0326 Human Intercellular adhesion molecule 2 96 Tests/kit
E01I0329 Human intercellular adhesion molecule 3 96 Tests/kit
GWB-ABF7D6 Intercellular Adhesion Molecule 1 (ICAM1)
E06I0325 Goat intercellular adhesion molecule 1 96 Tests/kit
E02I0022 Rat Intercellular Adhesion Molecule 1 Elisa Kit 96 Tests/kit
pro-383 Recombinant Human Intercellular Adhesion Molecule-1 10
E02S0258 Rat Soluble Intercellular Adhesion Molecule-1 96 Tests/kit
U0048r Rat intercellular adhesion molecule 1 CLIA KIT 96T
U1846r Rat DC specific intercellular adhesion molecule 3_ 96T
ER1336 Intercellular Adhesion Molecule-1 Elisa Kit 96T
Pathways :
WP1386: Integrin-mediated cell adhesion
WP310: mRNA processing
WP211: BMP signaling pathway
WP6: Integrin-mediated cell adhesion
WP1313: Insulin Signaling
WP1373: GPCRs, Class C Metabotropic glutamate, pheromone
WP1069: Integrin-mediated cell adhesion
WP164: Glutathione metabolism
WP1380: Regulation of Actin Cytoskeleton
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP1358: Selenium metabolism Selenoproteins
WP832: Integrin-mediated cell adhesion
WP1354: B Cell Receptor Signaling Pathway
WP2313: Aging
WP2287: Male mating
WP2087: miRNA regulation of DNA Damage Response
WP2199: Seed Development
WP185: Integrin-mediated cell adhesion
WP1372: Oxidative Stress
WP1349: Wnt Signaling Pathway
WP1963: The effect of Glucocorticoids on target gene expression
WP106: Alanine and aspartate metabolism
WP265: Delta-Notch Signaling Pathway
WP1126: Tryptophan metabolism
WP1383: Endochondral Ossification

Related Genes :

Bibliography :
[32626783] Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease.
[32622596] Staphylococcal enterotoxin M induced inflammation and impairment of bovine mammary epithelial cells.
[32621784] Treatment with 17β-estradiol protects donor heart against brain death effects in female rat.
[32618701] Endothelial Activation, Acute Kidney Injury, and Cognitive Impairment in Pediatric Severe Malaria.
[32616310] CADM1 suppresses c-Src activation by binding with Cbp on membrane lipid rafts and intervenes colon carcinogenesis.
[32615777] Acute differences in blood lipids and inflammatory biomarkers following controlled exposures to cookstove air pollution in the STOVES study.
[32614754] Piperine from Black Pepper Decreased the Expression of Intercellular Adhesion Molecule-1 in Macrophages.
[32605862] Increased levels of cytokines in the aqueous humor correlate with the severity of diabetic retinopathy.
[32605748] Bovine Respiratory Syncytial Virus Decreased Pasteurella multocida Adherence by Downregulating the Expression of Intercellular Adhesion Molecule-1 on the Surface of Upper Respiratory Epithelial Cells.
[32598403] Which salivary components can differentiate metabolic obesity?