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Intercellular adhesion molecule 1 (ICAM-1) (CD antigen CD54)

 ICAM1_PANTR             Reviewed;         532 AA.
Q28806; Q5NKW2;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
15-FEB-2005, sequence version 2.
26-FEB-2020, entry version 144.
RecName: Full=Intercellular adhesion molecule 1;
Short=ICAM-1;
AltName: CD_antigen=CD54;
Flags: Precursor;
Name=ICAM1;
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Pan.
NCBI_TaxID=9598;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Isolate Bonnie, Isolate Caesar, and Isolate Jenny; TISSUE=Blood;
Messier W., Walter N.A.R., Hink R.L.;
"The chimpanzee ICAM proteins have been positively selected.";
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 28-532.
PubMed=9105055; DOI=10.1164/ajrccm.155.4.9105055;
Huguenel E.D., Cohn D., Dockum D.P., Greve J.M., Fournel M.A., Hammond L.,
Irwin R., Mahoney J., McClelland A., Muchmore E., Ohlin A.C., Scuderi P.;
"Prevention of rhinovirus infection in chimpanzees by soluble intercellular
adhesion molecule-1.";
Am. J. Respir. Crit. Care Med. 155:1206-1210(1997).
-!- FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein
LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial
migration, ICAM1 engagement promotes the assembly of endothelial apical
cups through ARHGEF26/SGEF and RHOG activation (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Homodimer. Interacts with MUC1 and promotes cell aggregation
in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell
side) with CD81, CD247 and CD9 at immunological synapses between
antigen-presenting cells and T cells. {ECO:0000250|UniProtKB:P05362}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
membrane protein {ECO:0000250}.
-!- PTM: Monoubiquitinated, which is promoted by MARCH9 and leads to
endocytosis. {ECO:0000250}.
-!- SIMILARITY: Belongs to the immunoglobulin superfamily. ICAM family.
{ECO:0000305}.
---------------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AF340033; AAQ14896.1; -; mRNA.
EMBL; AF340034; AAQ14897.1; -; mRNA.
EMBL; AF340035; AAQ14898.1; -; mRNA.
EMBL; M86848; AAA35415.1; -; mRNA.
RefSeq; NP_001009946.1; NM_001009946.1.
SMR; Q28806; -.
STRING; 9598.ENSPTRP00000017827; -.
PaxDb; Q28806; -.
PRIDE; Q28806; -.
Ensembl; ENSPTRT00000019261; ENSPTRP00000017827; ENSPTRG00000010463.
GeneID; 450196; -.
KEGG; ptr:450196; -.
CTD; 3383; -.
VGNC; VGNC:2351; ICAM1.
eggNOG; ENOG410IPHM; Eukaryota.
eggNOG; ENOG410YQ1Q; LUCA.
GeneTree; ENSGT00940000162311; -.
HOGENOM; CLU_036160_1_1_1; -.
InParanoid; Q28806; -.
KO; K06490; -.
OMA; TFLTVYW; -.
OrthoDB; 731140at2759; -.
TreeFam; TF333745; -.
Proteomes; UP000002277; Chromosome 19.
Bgee; ENSPTRG00000010463; Expressed in liver and 5 other tissues.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005178; F:integrin binding; IBA:GO_Central.
GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR003988; ICAM.
InterPro; IPR013768; ICAM_N.
InterPro; IPR003987; ICAM_VCAM_N.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
Pfam; PF03921; ICAM_N; 1.
PRINTS; PR01473; ICAM.
PRINTS; PR01472; ICAMVCAM1.
SMART; SM00409; IG; 3.
SUPFAM; SSF48726; SSF48726; 5.
PROSITE; PS50835; IG_LIKE; 1.
2: Evidence at transcript level;
Cell adhesion; Disulfide bond; Glycoprotein; Immunoglobulin domain;
Membrane; Phosphoprotein; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix; Ubl conjugation.
SIGNAL 1..27
/evidence="ECO:0000250"
CHAIN 28..532
/note="Intercellular adhesion molecule 1"
/id="PRO_0000014787"
TOPO_DOM 28..480
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 481..503
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 504..532
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 41..103
/note="Ig-like C2-type 1"
DOMAIN 128..193
/note="Ig-like C2-type 2"
DOMAIN 230..297
/note="Ig-like C2-type 3"
DOMAIN 325..378
/note="Ig-like C2-type 4"
DOMAIN 412..464
/note="Ig-like C2-type 5"
MOTIF 152..154
/note="Cell attachment site; atypical"
/evidence="ECO:0000255"
MOD_RES 521
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P05362"
MOD_RES 530
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P05362"
CARBOHYD 145
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 183
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 202
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 267
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 296
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 385
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 406
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 48..92
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 52..96
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 135..186
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 237..290
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 332..371
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 403..419
/evidence="ECO:0000250|UniProtKB:P05362"
DISULFID 419..457
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 431..457
/evidence="ECO:0000250|UniProtKB:P05362"
SEQUENCE 532 AA; 57757 MW; 896DBC7E9C5A61E4 CRC64;
MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPPKVILPR GGSVQVTCST SCDQPDLLGI
ETPLPKKELL LGGNNWKVYE LSNVQEDSQP MCYSNCPDGQ STAKTFLTVY WTPERVELAP
LPSWQPVGKD LTLRCQVEGG APRANLTVVL LRGEKELKRE PAVGEPAEVT TTVLVERDHH
GANFSCRTEL DLRPQGLQLF ENTSAPHQLQ TFVLPATPPQ LVSPRVLEVD TQGTVVCSLD
GLFPVLEAQV HLALGDQRLN PTVTYGNDSF SAKASVSVTA EDEGTQRLTC AVILGNQSRE
TLQTVTIYSF PAPNVILTKP EVSEGTEVTV KCEAHPRAKV TLNGVPAQPV GPRVQLLLKA
TPEDNGRSFS CSATLEVAGQ LIHKNQTREL RVLYGPRLDE RDCPGNWTWP ENSQQTPMCQ
ASGNPLPELK CLKDGTFPLP VGESVTVTRD LEGTYLCRAR STQGEVTRKV TVNVLSPRYE
IVIITVVAAA VIMGTAGLST YLYNRQRKIR KYRLQQAQKG TPMKPNTQAT PP


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Related Genes :
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[CLEC4M CD209L CD209L1 CD299] C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299)
[ITGAL CD11A] Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)
[CD209 CLEC4L] CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209)
[Ceacam1] Carcinoembryonic antigen-related cell adhesion molecule 1 (ATP-dependent taurocolate-carrier protein) (Cell-CAM 105) (C-CAM 105) (Ecto-ATPase) (GP110) (pp120) (CD antigen CD66a)
[EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1] Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
[Sell Lnhr Ly-22] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (CD antigen CD62L)
[SELL LNHR LYAM1] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
[CEACAM1 BGP BGP1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)
[Sell Lnhr Ly-22 Ly22] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (CD antigen CD62L)
[Cd44 Ly-24] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen 24) (Ly-24) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[SELE ELAM1] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[Sele Elam-1] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[Sele Elam-1] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[PECAM1] Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)
[Alcam] CD166 antigen (Activated leukocyte cell adhesion molecule) (BEN) (Protein DM-GRASP) (CD antigen CD166)
[BCAM LU MSK19] Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239)
[ALCAM MEMD] CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
[SELE] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[Alcam] CD166 antigen (Activated leukocyte cell adhesion molecule) (HB2) (KG-CAM) (Protein MEMD) (SB-10 antigen) (CD antigen CD166)
[Pecam1 Pecam Pecam-1] Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31)
[ITGAM CD11B CR3A] Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
[CD44 LHR MDU2 MDU3 MIC4] CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Sirpa Bit Myd1 Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)
[CD44] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HAM1 antigen) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Cd44] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
[CD44] CD44 antigen (Extracellular matrix receptor-III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) (Fragment)
[CD44] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[CD44] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)

Bibliography :
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