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Intercellular adhesion molecule 1 (ICAM-1) (CD antigen CD54) (Fragment)

 ICAM1_CANLF             Reviewed;         528 AA.
P33729; Q28291;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
11-DEC-2019, entry version 122.
RecName: Full=Intercellular adhesion molecule 1;
Short=ICAM-1;
AltName: CD_antigen=CD54;
Flags: Precursor; Fragment;
Name=ICAM1;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7758971; DOI=10.1016/0378-1119(95)00045-8;
Manning A.M., Lu H.F., Kukielka G.L., Oliver M.G., Ty T., Toman C.A.,
Drong R.F., Slightom J.L., Ballantyne C.M., Entman M.L.;
"Cloning and comparative sequence analysis of the gene encoding canine
intercellular adhesion molecule-1 (ICAM-1).";
Gene 156:291-295(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 184-413.
TISSUE=Cardiac myocyte;
PubMed=1680878; DOI=10.1172/jci115424;
Smith C.W., Entman M.L., Lane C.L., Beaudet A.L., Ty T.I., Youker K.,
Hawkins H.K., Anderson D.C.;
"Adherence of neutrophils to canine cardiac myocytes in vitro is dependent
on intercellular adhesion molecule-1.";
J. Clin. Invest. 88:1216-1223(1991).
-!- FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein
LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial
migration, ICAM1 engagement promotes the assembly of endothelial apical
cups through ARHGEF26/SGEF and RHOG activation (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Homodimer. Interacts with MUC1 and promotes cell aggregation
in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell
side) with CD81, CD247 and CD9 at immunological synapses between
antigen-presenting cells and T cells. {ECO:0000250|UniProtKB:P05362}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
-!- PTM: Monoubiquitinated, which is promoted by MARCH9 and leads to
endocytosis. {ECO:0000250}.
-!- SIMILARITY: Belongs to the immunoglobulin superfamily. ICAM family.
{ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; L31625; AAA92551.1; -; mRNA.
EMBL; M68524; -; NOT_ANNOTATED_CDS; mRNA.
PIR; PC4025; PC4025.
SMR; P33729; -.
STRING; 9612.ENSCAFP00000026375; -.
PaxDb; P33729; -.
PRIDE; P33729; -.
eggNOG; ENOG410IPHM; Eukaryota.
eggNOG; ENOG410YQ1Q; LUCA.
InParanoid; P33729; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005178; F:integrin binding; IBA:GO_Central.
GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR003988; ICAM.
InterPro; IPR013768; ICAM_N.
InterPro; IPR003987; ICAM_VCAM_N.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
Pfam; PF03921; ICAM_N; 1.
PRINTS; PR01473; ICAM.
PRINTS; PR01472; ICAMVCAM1.
SMART; SM00409; IG; 3.
SUPFAM; SSF48726; SSF48726; 5.
2: Evidence at transcript level;
Cell adhesion; Disulfide bond; Glycoprotein; Immunoglobulin domain;
Membrane; Phosphoprotein; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix; Ubl conjugation.
SIGNAL <1..24
/evidence="ECO:0000255"
CHAIN 25..528
/note="Intercellular adhesion molecule 1"
/id="PRO_0000014781"
TOPO_DOM 25..476
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 477..499
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 500..528
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 38..99
/note="Ig-like C2-type 1"
DOMAIN 123..188
/note="Ig-like C2-type 2"
DOMAIN 225..292
/note="Ig-like C2-type 3"
DOMAIN 320..373
/note="Ig-like C2-type 4"
DOMAIN 407..460
/note="Ig-like C2-type 5"
MOTIF 147..149
/note="Cell attachment site; atypical"
/evidence="ECO:0000255"
MOD_RES 526
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P05362"
CARBOHYD 44
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 50
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 125
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 140
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 178
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 197
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 299
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 309
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 354
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 380
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 401
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 45..88
/evidence="ECO:0000250|UniProtKB:P05362"
DISULFID 49..92
/evidence="ECO:0000250|UniProtKB:P05362"
DISULFID 130..181
/evidence="ECO:0000250|UniProtKB:P05362"
DISULFID 232..285
/evidence="ECO:0000250|UniProtKB:P05362"
DISULFID 327..366
/evidence="ECO:0000250|UniProtKB:P05362"
DISULFID 398..414
/evidence="ECO:0000250|UniProtKB:P05362"
DISULFID 414..453
/evidence="ECO:0000250"
DISULFID 426..453
/evidence="ECO:0000250|UniProtKB:P05362"
CONFLICT 225
/note="G -> D (in Ref. 2; M68524)"
/evidence="ECO:0000305"
CONFLICT 233..235
/note="TMD -> RHE (in Ref. 2; M68524)"
/evidence="ECO:0000305"
CONFLICT 292
/note="E -> V (in Ref. 2; M68524)"
/evidence="ECO:0000305"
CONFLICT 340
/note="L -> P (in Ref. 2; M68524)"
/evidence="ECO:0000305"
CONFLICT 408
/note="F -> S (in Ref. 2; M68524)"
/evidence="ECO:0000305"
NON_TER 1
SEQUENCE 528 AA; 57952 MW; 36BEDC1AF0FD6904 CRC64;
APALPRLPAL LALLGALLPG LGGAQTSVDP AEAIILRGGS VQVNCSTSCN QTSIFGLETL
LTKTEVTSGD NWVLFELTDV QEDSKLICFS NCHDETMAPI DLTVYWFPER VELAPLPRWQ
PVGENLTMTC QVAGGAPRTN LTVVLLRGEE ELSRQPAVGE PAEVTFTVAV GREDHLANFS
CRTDLDLRHR GLGLFQNSSA PRQLQTFVLP ETPPRLATPP IVEVGTQWSV DCTMDGVFPA
SEAQVHLALA EERLHSTVLY KKDSLLATAN VKANPEDEGT QQLWCEVTLG DENRRWQENV
TFYSFPAPNL TLSEPEVSEW TTVTVECEAP AGVVVSLSGL PSGLAVPRAQ FQLNASAADN
RRSFSCSAAL EVAGHMLQKN QTRELHVLYG PRLDQRDCPG NWTWEEGFHQ TLKCQAWGNP
VPELKCHRKG DDALLPIGDL RPVKREVAGT YLCQARSPRG EITREVVINV IYHQNNILII
ILVTTIVILG TVSVAAYLYN RQRKIQKYKL QKAQEAAAMK LNTPATPP


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Related Genes :
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[CLEC4M CD209L CD209L1 CD299] C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299)
[ITGAL CD11A] Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)
[CD209 CLEC4L] CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209)
[Ceacam1] Carcinoembryonic antigen-related cell adhesion molecule 1 (ATP-dependent taurocolate-carrier protein) (Cell-CAM 105) (C-CAM 105) (Ecto-ATPase) (GP110) (pp120) (CD antigen CD66a)
[EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1] Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
[Cd44 Ly-24] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen 24) (Ly-24) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Sell Lnhr Ly-22] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (CD antigen CD62L)
[SELL LNHR LYAM1] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
[CEACAM1 BGP BGP1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)
[Sell Lnhr Ly-22 Ly22] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (CD antigen CD62L)
[SELE ELAM1] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[Sele Elam-1] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[Sele Elam-1] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[PECAM1] Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)
[Alcam] CD166 antigen (Activated leukocyte cell adhesion molecule) (BEN) (Protein DM-GRASP) (CD antigen CD166)
[BCAM LU MSK19] Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239)
[ALCAM MEMD] CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
[SELE] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[Alcam] CD166 antigen (Activated leukocyte cell adhesion molecule) (HB2) (KG-CAM) (Protein MEMD) (SB-10 antigen) (CD antigen CD166)
[ITGAM CD11B CR3A] Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
[Pecam1 Pecam Pecam-1] Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31)
[CD44] CD44 antigen (Extracellular matrix receptor-III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) (Fragment)
[CD44 LHR MDU2 MDU3 MIC4] CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Sirpa Bit Myd1 Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)
[CD44] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HAM1 antigen) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Cd44] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
[CD44] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[CD44] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)

Bibliography :
[16351797] [Impact of CPP-Id on expression of co-stimulating molecules on dendritic cells in mice].
[9539702] A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1.
[9476917] CD49d expression and function on allergen-stimulated T cells from blood and airway.
[7608563] Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18.
[7538431] A recombinant amino-terminal fragment of bactericidal/permeability increasing protein (rBPI23) inhibits soluble CD14-mediated lipopolysaccharide-induced endothelial adherence for human neutrophils.