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Interferon alpha 10

 A0A6C0QL32_CAMDR        Unreviewed;       187 AA.
A0A6C0QL32;
17-JUN-2020, integrated into UniProtKB/TrEMBL.
17-JUN-2020, sequence version 1.
12-AUG-2020, entry version 2.
SubName: Full=Interferon alpha 10 {ECO:0000313|EMBL:QHZ32116.1};
Name=IFNA10 {ECO:0000313|EMBL:QHZ32116.1};
Camelus dromedarius (Dromedary) (Arabian camel).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
NCBI_TaxID=9838 {ECO:0000313|EMBL:QHZ32116.1};
[1] {ECO:0000313|EMBL:QHZ32116.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Blood {ECO:0000313|EMBL:QHZ32116.1};
PubMed=32014632;
Premraj A., Aleyas A.G., Nautiyal B., Rasool T.J.;
"Camelid type I interferons: Identification and functional characterization
of interferon alpha from the dromedary camel (Camelus dromedarius).";
Mol. Immunol. 119:132-143(2020).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
-!- SIMILARITY: Belongs to the alpha/beta interferon family.
{ECO:0000256|RuleBase:RU000436}.
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EMBL; MN883363; QHZ32116.1; -; Genomic_DNA.
CDD; cd00095; IFab; 1.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000471; Interferon_alpha/beta/delta.
PANTHER; PTHR11691; PTHR11691; 1.
Pfam; PF00143; Interferon; 1.
PRINTS; PR00266; INTERFERONAB.
SMART; SM00076; IFabd; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00252; INTERFERON_A_B_D; 1.
3: Inferred from homology;
Antiviral defense {ECO:0000256|ARBA:ARBA00023118,
ECO:0000256|RuleBase:RU000436}; Cytokine {ECO:0000256|RuleBase:RU000436};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1..26
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 27..187
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5025411688"
SEQUENCE 187 AA; 21238 MW; 527B59993EC18BC2 CRC64;
MSPVARPLSV LMALVALSFD SICSLGCDLP QTHSLATRRT LVLLGQMRRI SPSSCLKDRQ
DFGFPQEVLG GHRLQKAQAI SVFHELVQQL FLLFSTEGSS AAWEDSLLHR LCTGLDQQLT
ELEACPKQEA ELQGRLLLNE DPILAVRRYF HRITLYLQEK KYSPCAWEIV RAEVMRSFSS
ARHLQER


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Related Genes :
[Ifngr1 Ifngr] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[EIF2AK2 PKR PRKR] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[Eif2ak2 Pkr Prkr Tik] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[Eif2ak2 Prkr] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2)
[IFNA10] Interferon alpha-10 (IFN-alpha-10) (Interferon alpha-6L) (Interferon alpha-C) (LeIF C)
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[IFNA14] Interferon alpha-14 (IFN-alpha-14) (Interferon alpha-H) (LeIF H) (Interferon lambda-2-H)
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[IFNA2 IFNA2A IFNA2B IFNA2C] Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A)
[IFNGR1] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[IFNAR1 IFNAR] Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
[Ifnar1 Ifar Ifnar] Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Type I interferon receptor 1)
[Ifnar2] Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha/beta receptor 2) (Type I interferon receptor 2)
[Cxcl10 Inp10 Mob1 Scyb10] C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Interferon-inducible protein 10) (Protein Mob-1) (Small-inducible cytokine B10)
[IFNA8] Interferon alpha-8 (IFN-alpha-8) (Interferon alpha-B) (LeIF B) (Interferon alpha-B2)
[IFNA17] Interferon alpha-17 (IFN-alpha-17) (Interferon alpha-88) (Interferon alpha-I') (LeIF I) (Interferon alpha-T)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[IFI6 G1P3] Interferon alpha-inducible protein 6 (Interferon-induced protein 6-16) (Ifi-6-16)
[IFIT2 CIG-42 G10P2 IFI54 ISG54] Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54)
[IFIT1 G10P1 IFI56 IFNAI1 ISG56] Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56)
[CXCL10 INP10 SCYB10] C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)]
[CXCL11 ITAC SCYB11 SCYB9B] C-X-C motif chemokine 11 (Beta-R1) (H174) (Interferon gamma-inducible protein 9) (IP-9) (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11)
[IFNA7] Interferon alpha-7 (IFN-alpha-7) (Interferon alpha-J) (LeIF J) (Interferon alpha-J1) (IFN-alpha-J1)
[rep 1a-1b] Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-alpha); Nsp1-beta papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-beta); Nsp2 cysteine proteinase (EC 3.4.19.12) (EC 3.4.22.-) (CP2) (CP); Non-structural protein 3 (Nsp3); Serine protease nsp4 (3CLSP) (EC 3.4.21.-) (3C-like serine proteinase) (Nsp4); Non-structural protein 5-6-7 (Nsp5-6-7); Non-structural protein 5 (Nsp5); Non-structural protein 6 (Nsp6); Non-structural protein 7-alpha (Nsp7-alpha); Non-structural protein 7-beta (Nsp7-beta); Non-structural protein 8 (Nsp8); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (Nsp9); Helicase nsp10 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Nsp10); Non-structural protein 11 (Nsp11); Non-structural protein 12 (Nsp12)]
[IFNAR1 IFNAR] Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Type I interferon receptor 1)
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
[IFNA21] Interferon alpha-21 (IFN-alpha-21) (Interferon alpha-F) (LeIF F)

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[32779429] Intralesional Injection of Mouse Mesenchymal Stem Cells Reduces IL-10 Production and Parasite Burden in Infected BALB/c Mice.
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