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Interferon alpha-1

 A0A2H4P4F5_DESRO        Unreviewed;       188 AA.
A0A2H4P4F5;
28-FEB-2018, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 1.
11-DEC-2019, entry version 6.
SubName: Full=Interferon alpha-1 {ECO:0000313|EMBL:ATW00985.1};
Name=IFNa1 {ECO:0000313|EMBL:ATW00985.1};
Desmodus rotundus (Vampire bat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Phyllostomidae;
Desmodontinae; Desmodus.
NCBI_TaxID=9430 {ECO:0000313|EMBL:ATW00985.1};
[1] {ECO:0000313|EMBL:ATW00985.1}
NUCLEOTIDE SEQUENCE.
PubMed=29122634; DOI=10.1016/j.dci.2017.10.023;
Sarkis S., Lise M.C., Darcissac E., Dabo S., Falk M., Chaulet L.,
Neuveut C., Meurs E.F., Lavergne A., Lacoste V.;
"Development of molecular and cellular tools to decipher the type I IFN
pathway of the common vampire bat.";
Dev. Comp. Immunol. 81:1-7(2017).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00135286}.
-!- SIMILARITY: Belongs to the alpha/beta interferon family.
{ECO:0000256|RuleBase:RU000436, ECO:0000256|SAAS:SAAS00562792}.
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EMBL; MF121913; ATW00985.1; -; mRNA.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
CDD; cd00095; IFab; 1.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000471; Interferon_alpha/beta/delta.
PANTHER; PTHR11691; PTHR11691; 1.
Pfam; PF00143; Interferon; 1.
PRINTS; PR00266; INTERFERONAB.
SMART; SM00076; IFabd; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00252; INTERFERON_A_B_D; 1.
2: Evidence at transcript level;
Antiviral defense {ECO:0000256|RuleBase:RU000436,
ECO:0000256|SAAS:SAAS00135290};
Cytokine {ECO:0000256|RuleBase:RU000436, ECO:0000256|SAAS:SAAS00135284};
Disulfide bond {ECO:0000256|SAAS:SAAS00487274};
Secreted {ECO:0000256|SAAS:SAAS00487273}; Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1..23
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 24..188
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5014126006"
SEQUENCE 188 AA; 21452 MW; D01E02897788627B CRC64;
MALRFSFLVA LVALSCNSIY SLGCDLPQTH SLVNRRSLML LGQMRRISPF FCLKDRKDFG
FPQEVFSGNQ FQKAQATSAI HEMVGQTFHL FSTEGAFAAW DKTLLDQLCN GLYQQLSDLE
ACLTQEVGME EAPLMSEDSI LAVRKYFQRI TLYLQEKQHS PCAWEIVRAE IRRSLSLSAN
LEEEEIEQ


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Bibliography :
[32624702] The efficacy of addition of Tenofovir Disoproxil Fumarate to Peg-IFNα-2b is superior to the addition of Entecavir in HBeAg positive CHB patients with a poor response after 12 weeks of Peg-IFNα-2b treatment alone.
[32619290] Associations between Smoking and Systemic Lupus Erythematosus (SLE)-Related Cytokines and Chemokines among US Female Nurses.
[32614974] A rare form of diabetes and a rare complication of treatment.
[32611267] Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine.
[32607773] Epidemiology, Natural History, and Treatment of Hepatitis Delta Virus Infection in HIV/Hepatitis B Virus Coinfection.
[32604862] Immunotherapy in Myeloproliferative Diseases.
[32595767] Anticancer Drug-induced Thyroid Dysfunction.
[32592408] Illuminating novel biological aspects and potential new therapeutic approaches for chronic myeloproliferative malignancies.
[32591646] Erdheim-Chester disease: a rapidly evolving disease model.
[32590991] Effects of interferon-alpha on hippocampal neurogenesis and behavior in common marmosets.