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Interferon alpha-1

 IFNA1_BOVIN             Reviewed;         189 AA.
P07348;
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
01-APR-1988, sequence version 1.
26-FEB-2020, entry version 120.
RecName: Full=Interferon alpha-1;
Flags: Precursor;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Pancreas;
PubMed=2985969; DOI=10.1128/mcb.5.4.768;
Capon D.J., Shepard H.M., Goeddel D.V.;
"Two distinct families of human and bovine interferon-alpha genes are
coordinately expressed and encode functional polypeptides.";
Mol. Cell. Biol. 5:768-779(1985).
-!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
Interferon stimulates the production of two enzymes: a protein kinase
and an oligoadenylate synthetase.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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EMBL; M11001; AAA30577.1; -; Genomic_DNA.
PIR; A23285; IVBOI1.
SMR; P07348; -.
STRING; 9913.ENSBTAP00000055837; -.
PaxDb; P07348; -.
eggNOG; ENOG410J735; Eukaryota.
eggNOG; ENOG410ZH91; LUCA.
Proteomes; UP000009136; Unplaced.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
CDD; cd00095; IFab; 1.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000471; Interferon_alpha/beta/delta.
PANTHER; PTHR11691; PTHR11691; 1.
Pfam; PF00143; Interferon; 1.
PRINTS; PR00266; INTERFERONAB.
SMART; SM00076; IFabd; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00252; INTERFERON_A_B_D; 1.
3: Inferred from homology;
Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
Signal.
SIGNAL 1..23
CHAIN 24..189
/note="Interferon alpha-1"
/id="PRO_0000016384"
DISULFID 24..122
/evidence="ECO:0000250"
DISULFID 52..162
/evidence="ECO:0000250"
SEQUENCE 189 AA; 21406 MW; 58FB5FD9485A2E12 CRC64;
MAPAWSLLLA LLLLSCNAIC SLGCHLPHSH SLAKRRVLTL LRQLRRVSPS SCLQDRNDFA
FPQEALGGSQ LQKAQAISVL HEVTQHTFQL FSTEGSAAVW DESLLDRLRT ALDQQLTDLQ
ACLRQEEGLP GAPLLKEDSS LAVRKYFHRL TLYLQEKRHS PCAWEVVRAQ VMRAFSSSTN
LQERFRRKD


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Pathways :
WP2199: Seed Development
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WP1835: Interferon alpha/beta signaling
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WP469: Glutathione metabolism
WP310: mRNA processing
WP1003: Ovarian Infertility Genes
WP2085: miRNAs involved in DDR
WP820: Complement and Coagulation Cascades
WP1315: IL-5 Signaling Pathway
WP1330: estrogen signalling
WP1487: TNF-alpha and mucus production in lung epythelium
WP929: TNF-alpha NF-kB Signaling Pathway
WP1359: IL-3 Signaling Pathway
WP1347: Triacylglyceride Synthesis
WP1530: miRNA regulation of DNA Damage Response
WP34: Ovarian Infertility Genes
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP1358: Selenium metabolism Selenoproteins
WP1120: Ovarian Infertility Genes
WP210: Cytoplasmic Ribosomal Proteins
WP2184: Purine metabolism
WP2313: Aging
WP1209: EBV LMP1 signaling
WP2119: Interferon induced apoptosis

Related Genes :

Bibliography :
[32624702] The efficacy of addition of Tenofovir Disoproxil Fumarate to Peg-IFNα-2b is superior to the addition of Entecavir in HBeAg positive CHB patients with a poor response after 12 weeks of Peg-IFNα-2b treatment alone.
[32619290] Associations between Smoking and Systemic Lupus Erythematosus (SLE)-Related Cytokines and Chemokines among US Female Nurses.
[32614974] A rare form of diabetes and a rare complication of treatment.
[32611267] Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine.
[32607773] Epidemiology, Natural History, and Treatment of Hepatitis Delta Virus Infection in HIV/Hepatitis B Virus Coinfection.
[32604862] Immunotherapy in Myeloproliferative Diseases.
[32595767] Anticancer Drug-induced Thyroid Dysfunction.
[32592408] Illuminating novel biological aspects and potential new therapeutic approaches for chronic myeloproliferative malignancies.
[32591646] Erdheim-Chester disease: a rapidly evolving disease model.
[32590991] Effects of interferon-alpha on hippocampal neurogenesis and behavior in common marmosets.