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Interferon gamma (BoIFNG) (IFN-gamma)

 IFNG_BOVIN              Reviewed;         166 AA.
P07353; A7L687; A9QWQ4;
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
01-APR-1988, sequence version 1.
02-JUN-2021, entry version 167.
RecName: Full=Interferon gamma;
Short=BoIFNG;
Short=IFN-gamma;
Flags: Precursor;
Name=IFNG;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3086437;
Cerretti D.P., McKereghan K., Larsen A., Cosman D., Gillis S., Baker P.E.;
"Cloning, sequence, and expression of bovine interferon-gamma.";
J. Immunol. 136:4561-4564(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-14.
STRAIN=Deutsche Schwarzbunte;
PubMed=12396714; DOI=10.1089/10799900260286632;
Schmidt P., Kuehn C., Maillard J.-C., Pitra C., Tiemann U., Weikard R.,
Schwerin M.;
"A comprehensive survey for polymorphisms in the bovine IFN-gamma gene
reveals a highly polymorphic intronic DNA sequence allowing improved
genotyping of Bovinae.";
J. Interferon Cytokine Res. 22:923-934(2002).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-166.
Li G., Hu Y., Ren X., Ma D., Gai R.;
"Cloning and sequence analysis of cattle interferon gamma.";
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Belted Galloway; TISSUE=Peripheral blood;
U.S. Veterinary Immune Reagent Network;
Hudgens T., Tompkins D., Baldwin C.L.;
"U.S. veterinary immune reagent network: expressed bovine gene sequences.";
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
[5]
X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
PubMed=15299487; DOI=10.1107/s0907444993006924;
Samudzi C.T., Rubin J.R.;
"Structure of recombinant bovine interferon-gamma at 3.0-A resolution.";
Acta Crystallogr. D 49:513-521(1993).
[6]
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
PubMed=10666622; DOI=10.1107/s0907444999014304;
Randal M., Kossiakoff A.A.;
"The 2.0-A structure of bovine interferon-gamma; assessment of the
structural differences between species.";
Acta Crystallogr. D 56:14-24(2000).
-!- FUNCTION: Type II interferon produced by immune cells such as T-cells
and NK cells that plays crucial roles in antimicrobial, antiviral, and
antitumor responses by activating effector immune cells and enhancing
antigen presentation. Primarily signals through the JAK-STAT pathway
after interaction with its receptor IFNGR1 to affect gene regulation.
Upon IFNG binding, IFNGR1 intracellular domain opens out to allow
association of downstream signaling components JAK2, JAK1 and STAT1,
leading to STAT1 activation, nuclear translocation and transcription of
IFNG-regulated genes. Many of the induced genes are transcription
factors such as IRF1 that are able to further drive regulation of a
next wave of transcription. Plays a role in class I antigen
presentation pathway by inducing a replacement of catalytic proteasome
subunits with immunoproteasome subunits. In turn, increases the
quantity, quality, and repertoire of peptides for class I MHC loading.
Increases the efficiency of peptide generation also by inducing the
expression of activator PA28 that associates with the proteasome and
alters its proteolytic cleavage preference. Up-regulates as well MHC II
complexes on the cell surface by promoting expression of several key
molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By
similarity). Participates in the regulation of hematopoietic stem cells
during development and under homeostatic conditions by affecting their
development, quiescence, and differentiation (By similarity).
{ECO:0000250|UniProtKB:P01579, ECO:0000250|UniProtKB:P01580}.
-!- SUBUNIT: Homodimer. Interacts with IFNGR1 (via extracellular domain);
this interaction promotes IFNGR1 dimerization.
{ECO:0000250|UniProtKB:P01579}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01579}.
-!- TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
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EMBL; M29867; AAB64477.1; -; mRNA.
EMBL; Z54144; CAA90859.1; -; Genomic_DNA.
EMBL; EF675629; ABS11696.1; -; mRNA.
EMBL; EU276066; ABX72064.1; -; mRNA.
PIR; A24390; IVBOG.
RefSeq; NP_776511.1; NM_174086.1.
PDB; 1D9C; X-ray; 2.00 A; A/B=24-144.
PDB; 1D9G; X-ray; 2.90 A; A/B=24-144.
PDB; 1RFB; X-ray; 3.00 A; A/B=24-142.
PDBsum; 1D9C; -.
PDBsum; 1D9G; -.
PDBsum; 1RFB; -.
SMR; P07353; -.
STRING; 9913.ENSBTAP00000016634; -.
PaxDb; P07353; -.
PRIDE; P07353; -.
Ensembl; ENSBTAT00000016634; ENSBTAP00000016634; ENSBTAG00000012529.
GeneID; 281237; -.
KEGG; bta:281237; -.
CTD; 3458; -.
VGNC; VGNC:30057; IFNG.
eggNOG; ENOG502SBGW; Eukaryota.
GeneTree; ENSGT00390000007831; -.
HOGENOM; CLU_135106_0_0_1; -.
InParanoid; P07353; -.
OMA; WKEESDK; -.
OrthoDB; 1382686at2759; -.
TreeFam; TF336308; -.
Reactome; R-BTA-877300; Interferon gamma signaling.
Reactome; R-BTA-877312; Regulation of IFNG signaling.
EvolutionaryTrace; P07353; -.
Proteomes; UP000009136; Chromosome 5.
Bgee; ENSBTAG00000012529; Expressed in leukocyte and 38 other tissues.
GO; GO:0005615; C:extracellular space; IDA:AgBase.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
GO; GO:0048143; P:astrocyte activation; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:1902948; P:negative regulation of tau-protein kinase activity; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IMP:AgBase.
GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
GO; GO:0032834; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
GO; GO:1904798; P:positive regulation of core promoter binding; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0060550; P:positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; IEA:Ensembl.
GO; GO:0060552; P:positive regulation of fructose 1,6-bisphosphate metabolic process; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0051712; P:positive regulation of killing of cells of other organism; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:AgBase.
GO; GO:2000309; P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0060557; P:positive regulation of vitamin D biosynthetic process; IEA:Ensembl.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
GO; GO:0010835; P:regulation of protein ADP-ribosylation; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
1: Evidence at protein level;
3D-structure; Antiviral defense; Cytokine; Glycoprotein; Growth regulation;
Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
SIGNAL 1..23
/evidence="ECO:0000250"
CHAIN 24..166
/note="Interferon gamma"
/id="PRO_0000016433"
MOD_RES 24
/note="Pyrrolidone carboxylic acid"
/evidence="ECO:0000250|UniProtKB:P01579"
CARBOHYD 39
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000250"
CARBOHYD 106
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000250"
VARIANT 14
/note="G -> V"
/evidence="ECO:0000269|PubMed:12396714"
VARIANT 166
/note="M -> T (may represent an allelic difference or a
cloning artifact)"
/evidence="ECO:0000269|Ref.3"
HELIX 25..38
/evidence="ECO:0007829|PDB:1D9C"
TURN 39..41
/evidence="ECO:0007829|PDB:1D9G"
HELIX 43..46
/evidence="ECO:0007829|PDB:1D9G"
HELIX 53..58
/evidence="ECO:0007829|PDB:1D9C"
TURN 59..61
/evidence="ECO:0007829|PDB:1D9C"
TURN 63..65
/evidence="ECO:0007829|PDB:1D9C"
HELIX 66..81
/evidence="ECO:0007829|PDB:1D9C"
TURN 82..85
/evidence="ECO:0007829|PDB:1D9C"
TURN 87..89
/evidence="ECO:0007829|PDB:1D9C"
HELIX 90..104
/evidence="ECO:0007829|PDB:1D9C"
HELIX 109..119
/evidence="ECO:0007829|PDB:1D9C"
HELIX 126..134
/evidence="ECO:0007829|PDB:1D9C"
HELIX 136..143
/evidence="ECO:0007829|PDB:1D9C"
SEQUENCE 166 AA; 19393 MW; 27B268B950BB3B1F CRC64;
MKYTSYFLAL LLCGLLGFSG SYGQGQFFRE IENLKEYFNA SSPDVAKGGP LFSEILKNWK
DESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM FQKFLNGSSE KLEDFKKLIQ
IPVDDLQIQR KAINELIKVM NDLSPKSNLR KRKRSQNLFR GRRASM


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WP2006: Squamous cell TarBase
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WP262: EBV LMP1 signaling
WP542: Electron Transport Chain
WP1654: gamma-Hexachlorocyclohexane degradation
WP758: EBV LMP1 signaling
WP866: EBV LMP1 signaling
WP1993: angiogenesis overview
WP2292: Chemokine signaling pathway
WP537: Translation Factors
WP152: FGF signaling pathway
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WP1017: Type II interferon signaling (IFNG)
WP900: Type II interferon signaling (IFNG)
WP2113: Type III interferon signaling
WP1350: Type II interferon signaling (IFNG)
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Related Genes :
[IFNG] Interferon gamma (BoIFNG) (IFN-gamma)
[IFNGR1] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFN-g IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma IF2F] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNg IF2F IFNG] Interferon gamma (IFN-gamma)
[Cadr_000017035] Interferon gamma (IFN-gamma)
[IF2F IFNG] Interferon gamma (IFN-gamma)

Bibliography :
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