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Interferon gamma (IFN-gamma)

 A3FG73_CAPHI            Unreviewed;       166 AA.
A3FG73;
20-MAR-2007, integrated into UniProtKB/TrEMBL.
20-MAR-2007, sequence version 1.
22-APR-2020, entry version 39.
RecName: Full=Interferon gamma {ECO:0000256|PIRNR:PIRNR001936};
Short=IFN-gamma {ECO:0000256|PIRNR:PIRNR001936};
Name=IFNG {ECO:0000313|EMBL:ABN51232.1,
ECO:0000313|Ensembl:ENSCHIP00000016152};
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Caprinae; Capra.
NCBI_TaxID=9925 {ECO:0000313|EMBL:ABN51232.1};
[1] {ECO:0000313|EMBL:ABN51232.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Blood {ECO:0000313|EMBL:ABN51232.1};
Jin B., Liu S., Chen H.;
"Cloning and prokaryotic expression of caprine interferon-gamma and
preparation of its antiserum.";
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSCHIP00000016152, ECO:0000313|Proteomes:UP000291000}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
Phillippy A.M., Van Tassell C.P., Smith T.P.;
"Polished mammalian reference genomes with single-molecule sequencing and
chromosome conformation capture applied to the Capra hircus genome.";
Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSCHIP00000016152}
IDENTIFICATION.
Ensembl;
Submitted (MAR-2019) to UniProtKB.
-!- FUNCTION: Produced by lymphocytes activated by specific antigens or
mitogens. IFN-gamma, in addition to having antiviral activity, has
important immunoregulatory functions. It is a potent activator of
macrophages, it has antiproliferative effects on transformed cells and
it can potentiate the antiviral and antitumor effects of the type I
interferons. {ECO:0000256|PIRNR:PIRNR001936}.
-!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR001936}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR001936}.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000256|PIRNR:PIRNR001936}.
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EMBL; LWLT01000005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; EF375708; ABN51232.1; -; mRNA.
Ensembl; ENSCHIT00000023958; ENSCHIP00000016152; ENSCHIG00000016504.
GeneTree; ENSGT00390000007831; -.
Proteomes; UP000291000; Chromosome 5.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0048143; P:astrocyte activation; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:1902948; P:negative regulation of tau-protein kinase activity; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
GO; GO:0032834; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:1904798; P:positive regulation of core promoter binding; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0060550; P:positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; IEA:Ensembl.
GO; GO:0060552; P:positive regulation of fructose 1,6-bisphosphate metabolic process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0051712; P:positive regulation of killing of cells of other organism; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:2000309; P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
GO; GO:0010835; P:regulation of protein ADP-ribosylation; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense {ECO:0000256|PIRNR:PIRNR001936};
Cytokine {ECO:0000256|PIRNR:PIRNR001936};
Growth regulation {ECO:0000256|PIRNR:PIRNR001936};
Reference proteome {ECO:0000313|Proteomes:UP000291000};
Secreted {ECO:0000256|PIRNR:PIRNR001936}; Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1..23
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 24..166
/note="Interferon gamma"
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5022527424"
SEQUENCE 166 AA; 19312 MW; 1181FE1252694F0E CRC64;
MKYTSSFLAL LLSVLLGFSG SYGQGPFFKE IETLKEYFNA SNPDVAKGGP LFSEILKNWK
EESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM FQKFLNGSSE KLEDFKKLIQ
IPVDDLQIQR KAINELIKVM NDLSPKSNLR KRKRSQNLFR GRRASM


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WP868: estrogen signalling
WP1224: EBV LMP1 signaling
WP2152: BDNF
WP262: EBV LMP1 signaling
WP1654: gamma-Hexachlorocyclohexane degradation
WP542: Electron Transport Chain
WP758: EBV LMP1 signaling
WP1993: angiogenesis overview
WP866: EBV LMP1 signaling
WP2292: Chemokine signaling pathway
WP152: FGF signaling pathway
WP537: Translation Factors
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WP2113: Type III interferon signaling
WP1017: Type II interferon signaling (IFNG)
WP1350: Type II interferon signaling (IFNG)
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Related Genes :
[IFNGR1] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (BoIFNG) (IFN-gamma)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFN-g IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma] Interferon gamma (IFN-gamma)
[Cadr_000017035] Interferon gamma (IFN-gamma)
[IFNg IFNG] Interferon gamma (IFN-gamma)
[IFNG PANDA_006820] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma] Interferon gamma (IFN-gamma)

Bibliography :
[32474541] Plasma levels of tumor necrosis factor-alpha, interferon-gamma, inducible nitric oxide synthase, and 3-nitrotyrosine in drug-resistant and drug-sensitive pulmonary tuberculosis patients, Ibadan, Nigeria.
[32474490] Evaluation of extracellular vesicles role in BALB/c mice immune modulatory.
[32472615] Interferon-gamma (IFN-γ) Serum Level and Immunohistochemical expression of CD8 cells in tissue biopsies in patients with Alopecia areata in correlation with the trichoscopic findings.
[32471216] High Expression of Cannabinoid Receptor 2 on Cytokine-Induced Killer Cells and Multiple Myeloma Cells.
[32469149] Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization.
[32469071] Retinoic Acid Is Elevated in the Mucosa of Patients With Active Ulcerative Colitis and Displays a Proinflammatory Role by Augmenting IL-17 and IFNγ Production.
[32466031] High Dimensional Flow Cytometry Characterization of Cardiac Allograft Vasculopathy Highlights Monocyte Activation Pathways.
[32465046] Natural Killer (NK) Cells: The Missing Link between Antibody-Mediated Rejection (ABMR) and Chronic Lung Allograft Dysfunction (CLAD)?
[32461350] Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes.
[32461349] Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10.