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Interferon gamma (IFN-gamma)

 A9LN08_PIG              Unreviewed;       166 AA.
A9LN08;
05-FEB-2008, integrated into UniProtKB/TrEMBL.
05-FEB-2008, sequence version 1.
16-OCT-2019, entry version 80.
RecName: Full=Interferon gamma {ECO:0000256|PIRNR:PIRNR001936};
Short=IFN-gamma {ECO:0000256|PIRNR:PIRNR001936};
Name=IFNG {ECO:0000313|EMBL:QBB84828.1};
Synonyms=IFN-gamma {ECO:0000313|EMBL:ADU85977.1};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823 {ECO:0000313|EMBL:ABX38909.1};
[1] {ECO:0000313|EMBL:ABX38909.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Peripheral blood lymphocytes {ECO:0000313|EMBL:ABX38909.1};
Li C.H., Zou Y., Wei X.F., Zhang C.L., Wang Y., He X.Z.;
"Cloning and expression of interferon gamma gene from Fengjing pig.";
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:ADU85977.1}
NUCLEOTIDE SEQUENCE.
Liu Y., Zhang Q.;
"Polymorphism identification and association of IFN-gamma gene with
immune traits in pigs.";
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:AEQ59454.1}
NUCLEOTIDE SEQUENCE.
Zeng Z.Y., Zhou L., Liu Z.J.;
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:QBB84828.1}
NUCLEOTIDE SEQUENCE.
Wen G., Zhang S., Li C., Xu L., Tian L., Wen M., Wang K., Chen Z.,
Zhao D.;
"Cloning and sequence analysis of interferon gamma (IFNG) gene from
Congjiang Xiang pigs.";
Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Produced by lymphocytes activated by specific antigens
or mitogens. IFN-gamma, in addition to having antiviral activity,
has important immunoregulatory functions. It is a potent activator
of macrophages, it has antiproliferative effects on transformed
cells and it can potentiate the antiviral and antitumor effects of
the type I interferons. {ECO:0000256|PIRNR:PIRNR001936}.
-!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR001936}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR001936}.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000256|PIRNR:PIRNR001936}.
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EMBL; EU249804; ABX38909.1; -; mRNA.
EMBL; HQ026021; ADU85977.1; -; Genomic_DNA.
EMBL; JF906510; AEQ59454.1; -; mRNA.
EMBL; MH538101; QBB84828.1; -; mRNA.
RefSeq; NP_999113.1; NM_213948.1.
SMR; A9LN08; -.
GeneID; 396991; -.
KEGG; ssc:396991; -.
CTD; 3458; -.
eggNOG; ENOG410IWSY; Eukaryota.
eggNOG; ENOG410Z8I5; LUCA.
KO; K04687; -.
OMA; WKEESDK; -.
OrthoDB; 1382686at2759; -.
Bgee; ENSSSCG00000000481; Expressed in 2 organ(s), highest expression level in heart.
ExpressionAtlas; A9LN08; baseline and differential.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0048143; P:astrocyte activation; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:1902948; P:negative regulation of tau-protein kinase activity; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
GO; GO:0032834; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:1904798; P:positive regulation of core promoter binding; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0060550; P:positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; IEA:Ensembl.
GO; GO:0060552; P:positive regulation of fructose 1,6-bisphosphate metabolic process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0051712; P:positive regulation of killing of cells of other organism; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein complex assembly; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:2000309; P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
GO; GO:0010835; P:regulation of protein ADP-ribosylation; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense {ECO:0000256|PIRNR:PIRNR001936};
Cytokine {ECO:0000256|PIRNR:PIRNR001936};
Growth regulation {ECO:0000256|PIRNR:PIRNR001936};
Secreted {ECO:0000256|PIRNR:PIRNR001936};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 23 {ECO:0000256|SAM:SignalP}.
CHAIN 24 166 Interferon gamma.
{ECO:0000256|SAM:SignalP}.
/FTId=PRO_5010104277.
SEQUENCE 166 AA; 19419 MW; 19B51CC05D5ED276 CRC64;
MSYTTYFLAF QLCVTLCFSG SYCQAPFFKE ITILKDYFNA STSDVPNGGP LFLEILKNWK
EESDKKIIQS QIVSFYFKFF EIFKDNQAIQ RSMDVIKQDM FQRFLNGSSG KLNDFEKLIK
IPVDNLQIQR KAISELIKVM NDLSPRSNLR KRKRSQTMFQ GQRASK


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WP1993: angiogenesis overview
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WP2292: Chemokine signaling pathway
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Related Genes :
[IFNGR1] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (BoIFNG) (IFN-gamma)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFN-g IFNG] Interferon gamma (IFN-gamma)
[IFNG IFN-gamma] Interferon gamma (IFN-gamma)
[IFN-gamma] Interferon gamma (IFN-gamma)
[IFNg IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)

Bibliography :
No related Items