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Interferon gamma (IFN-gamma)

 IFNG_RAT                Reviewed;         156 AA.
P01581;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
18-SEP-2019, entry version 149.
RecName: Full=Interferon gamma;
Short=IFN-gamma;
Flags: Precursor;
Name=Ifng;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3924594; DOI=10.1002/j.1460-2075.1985.tb03694.x;
Dijkema R., van der Meide P.H., Pouwels P.H., Caspers M., Dubbeld M.,
Schellekens H.;
"Cloning and expression of the chromosomal immune interferon gene of
the rat.";
EMBO J. 4:761-767(1985).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3093809; DOI=10.1016/0076-6879(86)19065-3;
Dijkema R., der Meide P.H., Dubbeld M., Caspers M., Wubben J.,
Schellekens H.;
"Cloning, expression, and purification of rat IFN-gamma.";
Methods Enzymol. 119:453-463(1986).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Fischer;
Widegren B., Visse E., Sjogren H.O.;
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Produced by lymphocytes activated by specific antigens
or mitogens. IFN-gamma, in addition to having antiviral activity,
has important immunoregulatory functions. It is a potent activator
of macrophages, it has antiproliferative effects on transformed
cells and it can potentiate the antiviral and antitumor effects of
the type I interferons.
-!- SUBUNIT: Homodimer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Released primarily from activated T
lymphocytes.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
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EMBL; X02325; CAA26185.1; -; Genomic_DNA.
EMBL; X02326; CAA26186.1; -; Genomic_DNA.
EMBL; X02326; CAA26187.1; -; Genomic_DNA.
EMBL; X02327; CAA26188.1; -; Genomic_DNA.
EMBL; M29317; AAA41362.1; -; Genomic_DNA.
EMBL; M29315; AAA41362.1; JOINED; Genomic_DNA.
EMBL; M29316; AAA41362.1; JOINED; Genomic_DNA.
EMBL; AF010466; AAB66352.1; -; mRNA.
PIR; A01845; IVRTG.
RefSeq; NP_620235.1; NM_138880.2.
SMR; P01581; -.
STRING; 10116.ENSRNOP00000009917; -.
PaxDb; P01581; -.
PRIDE; P01581; -.
Ensembl; ENSRNOT00000009919; ENSRNOP00000009917; ENSRNOG00000007468.
GeneID; 25712; -.
KEGG; rno:25712; -.
UCSC; RGD:2866; rat.
CTD; 3458; -.
RGD; 2866; Ifng.
eggNOG; ENOG410IWSY; Eukaryota.
eggNOG; ENOG410Z8I5; LUCA.
GeneTree; ENSGT00390000007831; -.
HOGENOM; HOG000254784; -.
InParanoid; P01581; -.
KO; K04687; -.
OMA; WKEESDK; -.
OrthoDB; 1382686at2759; -.
PhylomeDB; P01581; -.
TreeFam; TF336308; -.
Reactome; R-RNO-877300; Interferon gamma signaling.
Reactome; R-RNO-877312; Regulation of IFNG signaling.
PRO; PR:P01581; -.
Proteomes; UP000002494; Chromosome 7.
Bgee; ENSRNOG00000007468; Expressed in 5 organ(s), highest expression level in testis.
Genevisible; P01581; RN.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0043005; C:neuron projection; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
GO; GO:0048143; P:astrocyte activation; IEA:Ensembl.
GO; GO:0002302; P:CD8-positive, alpha-beta T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0071351; P:cellular response to interleukin-18; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IGI:ARUK-UCL.
GO; GO:1900222; P:negative regulation of amyloid-beta clearance; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:RGD.
GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IDA:BHF-UCL.
GO; GO:0048147; P:negative regulation of fibroblast proliferation; IDA:RGD.
GO; GO:0072125; P:negative regulation of glomerular mesangial cell proliferation; IMP:RGD.
GO; GO:0031642; P:negative regulation of myelination; IEA:Ensembl.
GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0150076; P:neuroinflammatory response; IDA:ARUK-UCL.
GO; GO:0001781; P:neutrophil apoptotic process; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0044794; P:positive regulation by host of viral process; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IDA:RGD.
GO; GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
GO; GO:0045785; P:positive regulation of cell adhesion; IDA:RGD.
GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:BHF-UCL.
GO; GO:1901857; P:positive regulation of cellular respiration; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IDA:ARUK-UCL.
GO; GO:0045821; P:positive regulation of glycolytic process; IEA:Ensembl.
GO; GO:0050725; P:positive regulation of interleukin-1 beta biosynthetic process; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; IEA:Ensembl.
GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
GO; GO:1904440; P:positive regulation of iron ion import across plasma membrane; IEA:Ensembl.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEP:RGD.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:RGD.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IEA:Ensembl.
GO; GO:1904783; P:positive regulation of NMDA glutamate receptor activity; IGI:ARUK-UCL.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IDA:BHF-UCL.
GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0010870; P:positive regulation of receptor biosynthetic process; IEA:Ensembl.
GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IDA:RGD.
GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; IEA:Ensembl.
GO; GO:1904469; P:positive regulation of tumor necrosis factor secretion; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:BHF-UCL.
GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0050691; P:regulation of defense response to virus by host; IEA:Ensembl.
GO; GO:0060251; P:regulation of glial cell proliferation; IDA:RGD.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:2000345; P:regulation of hepatocyte proliferation; IDA:RGD.
GO; GO:0098908; P:regulation of neuronal action potential; IDA:RGD.
GO; GO:0002026; P:regulation of the force of heart contraction; IDA:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0050954; P:sensory perception of mechanical stimulus; IDA:RGD.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense; Complete proteome; Cytokine; Glycoprotein;
Growth regulation; Pyrrolidone carboxylic acid; Reference proteome;
Secreted; Signal.
SIGNAL 1 22 {ECO:0000250}.
CHAIN 23 156 Interferon gamma.
/FTId=PRO_0000016457.
MOD_RES 23 23 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:P01579}.
CARBOHYD 38 38 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
CARBOHYD 91 91 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
SEQUENCE 156 AA; 17918 MW; BC0B433D2CE1E3F2 CRC64;
MSATRRVLVL QLCLMALSGC YCQGTLIESL ESLKNYFNSS SMDAMEGKSL LLDIWRNWQK
DGNTKILESQ IISFYLRLFE VLKDNQAISN NISVIESHLI TNFFSNSKAK KDAFMSIAKF
EVNNPQIQHK AVNELIRVIH QLSPESSLRK RKRSRC


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Pathways :
WP1836: Interferon gamma signaling
WP2199: Seed Development
WP1225: estrogen signalling
WP32: Translation Factors
WP1722: Th1/Th2
WP760: estrogen signalling
WP868: estrogen signalling
WP2006: Squamous cell TarBase
WP2152: BDNF
WP1224: EBV LMP1 signaling
WP262: EBV LMP1 signaling
WP542: Electron Transport Chain
WP1654: gamma-Hexachlorocyclohexane degradation
WP758: EBV LMP1 signaling
WP866: EBV LMP1 signaling
WP1993: angiogenesis overview
WP2292: Chemokine signaling pathway
WP537: Translation Factors
WP152: FGF signaling pathway
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WP900: Type II interferon signaling (IFNG)
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Related Genes :
[IFNGR1] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (BoIFNG) (IFN-gamma)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFN-g IFNG] Interferon gamma (IFN-gamma)
[IFNG IFN-gamma] Interferon gamma (IFN-gamma)
[IFN-gamma] Interferon gamma (IFN-gamma)
[IFNg IFNG] Interferon gamma (IFN-gamma)
[IFNG PANDA_006820] Interferon gamma (IFN-gamma)

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[31620037] Reduced Expression of Immune Mediators by T-Cell Subpopulations of Combat-Exposed Veterans With Post-Traumatic Stress Disorder.
[31619524] The predominance of Th1 Immune Response in Pleural Effusion of Patients with Tuberculosis Among Other Exudative Etiologies.