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Interferon gamma (IFN-gamma)

 IFNG_SHEEP              Reviewed;         166 AA.
P17773; Q204I9;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
01-AUG-1990, sequence version 1.
02-JUN-2021, entry version 119.
RecName: Full=Interferon gamma;
Short=IFN-gamma;
Flags: Precursor;
Name=IFNG;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2115673; DOI=10.1093/nar/18.13.4012;
McInnes C.J., Logan M., Redmond J., Entrican G., Baird G.D.;
"The molecular cloning of the ovine gamma-interferon cDNA using the
polymerase chain reaction.";
Nucleic Acids Res. 18:4012-4012(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Xia L.B., Lian H.J., Bo X.W., Wang X.H.;
"Cloning and expression of ovine IFN gamma and its biological function.";
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Type II interferon produced by immune cells such as T-cells
and NK cells that plays crucial roles in antimicrobial, antiviral, and
antitumor responses by activating effector immune cells and enhancing
antigen presentation. Primarily signals through the JAK-STAT pathway
after interaction with its receptor IFNGR1 to affect gene regulation.
Upon IFNG binding, IFNGR1 intracellular domain opens out to allow
association of downstream signaling components JAK2, JAK1 and STAT1,
leading to STAT1 activation, nuclear translocation and transcription of
IFNG-regulated genes. Many of the induced genes are transcription
factors such as IRF1 that are able to further drive regulation of a
next wave of transcription. Plays a role in class I antigen
presentation pathway by inducing a replacement of catalytic proteasome
subunits with immunoproteasome subunits. In turn, increases the
quantity, quality, and repertoire of peptides for class I MHC loading.
Increases the efficiency of peptide generation also by inducing the
expression of activator PA28 that associates with the proteasome and
alters its proteolytic cleavage preference. Up-regulates as well MHC II
complexes on the cell surface by promoting expression of several key
molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By
similarity). Participates in the regulation of hematopoietic stem cells
during development and under homeostatic conditions by affecting their
development, quiescence, and differentiation (By similarity).
{ECO:0000250|UniProtKB:P01579, ECO:0000250|UniProtKB:P01580}.
-!- SUBUNIT: Homodimer. Interacts with IFNGR1 (via extracellular domain);
this interaction promotes IFNGR1 dimerization.
{ECO:0000250|UniProtKB:P01579}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01579}.
-!- TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
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EMBL; X52640; CAA36862.1; -; mRNA.
EMBL; DQ410715; ABD64367.1; -; mRNA.
PIR; S12723; S12723.
RefSeq; NP_001009803.1; NM_001009803.1.
SMR; P17773; -.
STRING; 9940.ENSOARP00000002060; -.
Ensembl; ENSOART00000002109; ENSOARP00000002060; ENSOARG00000001958.
Ensembl; ENSOART00020008348; ENSOARP00020006907; ENSOARG00020005439.
GeneID; 443396; -.
KEGG; oas:443396; -.
CTD; 3458; -.
eggNOG; ENOG502SBGW; Eukaryota.
HOGENOM; CLU_135106_0_0_1; -.
OMA; WKEESDK; -.
OrthoDB; 1382686at2759; -.
Proteomes; UP000002356; Chromosome 3.
GO; GO:0005615; C:extracellular space; IDA:AgBase.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0048143; P:astrocyte activation; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:1902948; P:negative regulation of tau-protein kinase activity; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
GO; GO:0032834; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
GO; GO:1904798; P:positive regulation of core promoter binding; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0060550; P:positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; IEA:Ensembl.
GO; GO:0060552; P:positive regulation of fructose 1,6-bisphosphate metabolic process; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0051712; P:positive regulation of killing of cells of other organism; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:2000309; P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0060557; P:positive regulation of vitamin D biosynthetic process; IEA:Ensembl.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
GO; GO:0010835; P:regulation of protein ADP-ribosylation; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense; Cytokine; Glycoprotein; Growth regulation;
Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
SIGNAL 1..23
/evidence="ECO:0000250"
CHAIN 24..166
/note="Interferon gamma"
/id="PRO_0000016459"
MOD_RES 24
/note="Pyrrolidone carboxylic acid"
/evidence="ECO:0000250|UniProtKB:P01579"
CARBOHYD 39
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000250"
CARBOHYD 106
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000250"
SEQUENCE 166 AA; 19370 MW; 9232D31269805D0A CRC64;
MKYTSSFLAL LLCVLLGFSG SYGQGPFFKE IENLKEYFNA SNPDVAKGGP LFSEILKNWK
EESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM FQKFLNGSSE KLEDFKRLIQ
IPVDDLQIQR KAINELIKVM NDLSPKSNLR KRKRSQNLFR GRRASM


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Pathways :
WP1836: Interferon gamma signaling
WP1225: estrogen signalling
WP2199: Seed Development
WP32: Translation Factors
WP1722: Th1/Th2
WP760: estrogen signalling
WP2006: Squamous cell TarBase
WP868: estrogen signalling
WP1224: EBV LMP1 signaling
WP2152: BDNF
WP262: EBV LMP1 signaling
WP542: Electron Transport Chain
WP1654: gamma-Hexachlorocyclohexane degradation
WP758: EBV LMP1 signaling
WP866: EBV LMP1 signaling
WP1993: angiogenesis overview
WP2292: Chemokine signaling pathway
WP537: Translation Factors
WP152: FGF signaling pathway
WP1886: Post-translational modification: gamma carboxylation and hypusine formation
WP2113: Type III interferon signaling
WP1017: Type II interferon signaling (IFNG)
WP900: Type II interferon signaling (IFNG)
WP1350: Type II interferon signaling (IFNG)
WP585: Interferon type I

Related Genes :
[IFNGR1] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (BoIFNG) (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFN-g IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma IF2F] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNg IF2F IFNG] Interferon gamma (IFN-gamma)
[Cadr_000017035] Interferon gamma (IFN-gamma)
[IF2F IFNG] Interferon gamma (IFN-gamma)

Bibliography :
[34687172] A field efficacy trial of a trivalent vaccine containing porcine circovirus type 2a and 2b, and Mycoplasma hyopneumoniae in three herds.
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[34680246] Interferon-γ Produced by EBV-Positive Neoplastic NK-Cells Induces Differentiation into Macrophages and Procoagulant Activity of Monocytes, Which Leads to HLH.
[34679659] The Natural Products Targeting on Allergic Rhinitis: From Traditional Medicine to Modern Drug Discovery.
[34679555] Profile of Urinary Cytokines in Kawasaki Disease: Non-Invasive Markers.
[34679061] Effects of Transportation Stress on Complete Blood Count, Blood Chemistry, and Cytokine Gene Expression in Heifers.
[34678320] Benzo[a]pyrene Immunogenetics and Immune Archetype Reprogramming of Lung.
[34676541] Altered increase in STAT1 expression and phosphorylation in severe COVID-19.
[34675591] Preventive Effect of Flavonoid Extract from the Peel of Gonggan (Citrus reticulata Blanco Var. Gonggan) on CCl-Induced Acute Liver Injury in Mice.
[34674748] Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle.