GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Interferon gamma (IFN-gamma)

 IFNG_RABIT              Reviewed;         167 AA.
P30123; P79215; Q0PW35;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
12-AUG-2020, entry version 134.
RecName: Full=Interferon gamma;
Short=IFN-gamma;
Flags: Precursor;
Name=IFNG;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=B/Jas;
Yuasa T., Isono T., Tambe Y.;
"Rabbit interferon gamma.";
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymph node;
Perkins H.D., Lei S., van Leeuwen B., Kerr P.J.;
"Oryctolagus cuniculus gamma interferon mRNA, complete cds.";
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Chinese white;
Qiao J., Meng Q., Cai X.;
"Cloning and expression of IFN gamma gene of Chinese white rabbit.";
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA].
Huang D., Yang G.;
"Cloning and sequence analysis of IFN-gamma gene in rabbit.";
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 81-136.
STRAIN=B/Jas;
PubMed=8753862; DOI=10.1007/bf02602561;
Isono T., Nagano Y., Seto A.;
"Expression of the interferon-gamma and interleukin-10 genes in rabbit
HTLV-I-transformed T-cell lines.";
Immunogenetics 44:306-308(1996).
[6]
X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
PubMed=1939201;
Samudzi C.T., Burton L.E., Rubin J.R.;
"Crystal structure of recombinant rabbit interferon-gamma at 2.7-A
resolution.";
J. Biol. Chem. 266:21791-21797(1991).
-!- FUNCTION: Produced by lymphocytes activated by specific antigens or
mitogens. IFN-gamma, in addition to having antiviral activity, has
important immunoregulatory functions. It is a potent activator of
macrophages, it has antiproliferative effects on transformed cells and
it can potentiate the antiviral and antitumor effects of the type I
interferons.
-!- SUBUNIT: Homodimer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AB010386; BAA24439.1; -; mRNA.
EMBL; AF244933; AAF64188.1; -; mRNA.
EMBL; DQ680162; ABG73601.1; -; mRNA.
EMBL; DQ852341; ABH10826.1; -; mRNA.
EMBL; D84216; BAA20884.1; -; mRNA.
RefSeq; NP_001075460.1; NM_001081991.1.
PDB; 2RIG; X-ray; 2.30 A; A=24-167.
PDBsum; 2RIG; -.
SMR; P30123; -.
STRING; 9986.ENSOCUP00000021866; -.
Ensembl; ENSOCUT00000030109; ENSOCUP00000021866; ENSOCUG00000024937.
GeneID; 100008602; -.
KEGG; ocu:100008602; -.
CTD; 3458; -.
eggNOG; ENOG502SBGW; Eukaryota.
GeneTree; ENSGT00390000007831; -.
HOGENOM; CLU_135106_0_0_1; -.
InParanoid; P30123; -.
KO; K04687; -.
OMA; WKEESDK; -.
OrthoDB; 1382686at2759; -.
TreeFam; TF336308; -.
EvolutionaryTrace; P30123; -.
Proteomes; UP000001811; Chromosome 4.
Bgee; ENSOCUG00000024937; Expressed in blood and 5 other tissues.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
1: Evidence at protein level;
3D-structure; Antiviral defense; Cytokine; Glycoprotein; Growth regulation;
Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
SIGNAL 1..23
/evidence="ECO:0000250"
CHAIN 24..167
/note="Interferon gamma"
/id="PRO_0000016456"
MOD_RES 24
/note="Pyrrolidone carboxylic acid"
/evidence="ECO:0000250|UniProtKB:P01579"
CARBOHYD 41
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 108
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 117
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CONFLICT 123
/note="Missing (in Ref. 5; BAA20884)"
/evidence="ECO:0000305"
SEQUENCE 167 AA; 19516 MW; 96D1CAD2A5163850 CRC64;
MSYTSYILAF QLCLILGSYG CYCQDTLTRE TEHLKAYLKA NTSDVANGGP LFLNILRNWK
EESDNKIIQS QIVSFYFKLF DNLKDHEVIK KSMESIKEDI FVKFFNSNLT KMDDFQNLTR
ISVDDRLVQR KAVSELSNVL NFLSPKSNLK KRKRSQTLFR GRRASKY


Related products :

Catalog number Product name Quantity
18-783-78408 RABBIT ANTI HUMAN INTERFERON GAMMA Biotin - INTERFERON GAMMA; IFN-gamma Polyclonal 0.05 mg
20-663-48022 Interferon-gamma (mAHuIFNg) - Mouse Anti Human Interferon-gamma (mAHuIFNg); IFN-gamma; Immune interferon Monoclonal 1 mg
20-663-48022 Interferon-gamma (mAHuIFNg) - Mouse Anti Human Interferon-gamma (mAHuIFNg); IFN-gamma; Immune interferon Monoclonal 0.5 mg
20-271-80026 Interferon-gamma - Mouse Anti Human Interferon-gamma; IFN-gamma Monoclonal 1 mg
20-271-80026 Interferon-gamma - Mouse Anti Human Interferon-gamma; IFN-gamma Monoclonal 0.5 mg
18-783-78407 RABBIT ANTI HUMAN INTERFERON GAMMA - INTERFERON GAMMA; IFN-gamma Polyclonal 0.1 mg
20-271-80063 Interferon-gamma - Rat Anti Mouse Interferon-gamma; IFN-gamma Monoclonal 1 mg
20-663-48058 Interferon-gamma - Rat Anti-Mouse Interferon-gamma; IFN-gamma Monoclonal 0.5 mg
20-663-48058 Interferon-gamma - Rat Anti-Mouse Interferon-gamma; IFN-gamma Monoclonal 1 mg
20-271-80063 Interferon-gamma - Rat Anti Mouse Interferon-gamma; IFN-gamma Monoclonal 0.5 mg
orb82062 Human Interferon-gamma, recombinant protein Interferon gamma (IFN-gamma) Recombinant is a purified cytokine_growth factor. For research use only. 20
E0371m ELISA kit 10 kDa interferon gamma-induced protein,C7,Crg2,C-X-C motif chemokine 10,Cxcl10,Gamma-IP10,Ifi10,Inp10,Interferon-gamma induced protein CRG-2,IP-10,Mouse,Mus musculus,Scyb10,Small-inducible 96T
U0371m CLIA 10 kDa interferon gamma-induced protein,C7,Crg2,C-X-C motif chemokine 10,Cxcl10,Gamma-IP10,Ifi10,Inp10,Interferon-gamma induced protein CRG-2,IP-10,Mouse,Mus musculus,Scyb10,Small-inducible cytok 96T
E0371m ELISA 10 kDa interferon gamma-induced protein,C7,Crg2,C-X-C motif chemokine 10,Cxcl10,Gamma-IP10,Ifi10,Inp10,Interferon-gamma induced protein CRG-2,IP-10,Mouse,Mus musculus,Scyb10,Small-inducible cyto 96T
20-321-175081 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO HUMAN GAMMA INTERFERON (IFN-gamma) Monoclonal 0.1 mg
20-321-175082 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO HUMAN GAMMA INTERFERON (IFN-gamma) Monoclonal 0.3 mg
20-321-175083 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO HUMAN GAMMA INTERFERON (IFN-gamma) Monoclonal 0.1 mg
20-321-175084 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO HUMAN GAMMA INTERFERON (IFN-gamma) Monoclonal 0.3 mg
20-321-175004 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO MOUSE GAMMA INTERFERON (IFN-gamma) Monoclonal 0.1 mg
20-321-175005 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO MOUSE GAMMA INTERFERON (IFN-gamma) Monoclonal 0.5 mg
10-663-45229 Interferon-gamma (IFN-gamma) Porcine - IFN-gamma; Immune interferon N_A 0.05 mg
10-663-45229 Interferon-gamma (IFN-gamma) Porcine - IFN-gamma; Immune interferon N_A 1 mg
10-663-45229 Interferon-gamma (IFN-gamma) Porcine - IFN-gamma; Immune interferon N_A 0.01 mg
GS-1053a interferon gamma receptor 2 (interferon gamma transducer 1) primary antibody, Host: Rabbit 200ul
E0049h ELISA Homo sapiens,Human,IFNG,IFN-gamma,Immune interferon,Interferon gamma 96T
Pathways :
WP1836: Interferon gamma signaling
WP2199: Seed Development
WP1225: estrogen signalling
WP32: Translation Factors
WP1722: Th1/Th2
WP760: estrogen signalling
WP2006: Squamous cell TarBase
WP868: estrogen signalling
WP1224: EBV LMP1 signaling
WP2152: BDNF
WP262: EBV LMP1 signaling
WP1654: gamma-Hexachlorocyclohexane degradation
WP542: Electron Transport Chain
WP758: EBV LMP1 signaling
WP1993: angiogenesis overview
WP866: EBV LMP1 signaling
WP2292: Chemokine signaling pathway
WP152: FGF signaling pathway
WP537: Translation Factors
WP1886: Post-translational modification: gamma carboxylation and hypusine formation
WP1017: Type II interferon signaling (IFNG)
WP900: Type II interferon signaling (IFNG)
WP2113: Type III interferon signaling
WP1350: Type II interferon signaling (IFNG)
WP585: Interferon type I

Related Genes :
[IFNGR1] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (BoIFNG) (IFN-gamma)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFN-g IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma] Interferon gamma (IFN-gamma)
[Cadr_000017035] Interferon gamma (IFN-gamma)
[IFNg IFNG] Interferon gamma (IFN-gamma)
[IFNG PANDA_006820] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)

Bibliography :
[32777584] Diagnostic Utility of Pleural Fluid T-SPOT and Interferon-gamma for Tuberculous Pleurisy: A Two-Center Prospective Cohort Study in China.
[32776792] Inflammatory risk factors for hypertriglyceridemia in patients with severe influenza.
[32776009] Interferon-Gamma and Interleukin-1Beta Enhance the Secretion of Brain-Derived Neurotrophic Factor and Promotes the Survival of Cortical Neurons in Brain Injury.
[32775129] Oral administration of the probiotic bacterium strain L-55 modulates the immunological parameters of the laying hen inoculated with a Newcastle disease virus-based live attenuated vaccine.
[32774769] Th1 cytokines in conjunction with pharmacological Akt inhibition potentiate apoptosis of breast cancer cells and suppress tumor growth .
[32774332] T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis.
[32773969] Biomarkers in biological fluids in adults with periodontitis and/or obesity: A meta-analysis.
[32772240] Inhibition of JAK-STAT Signaling by Baricitinib Reduces Interferon-γ-Induced CXCL10 Production in Human Salivary Gland Ductal Cells.
[32771878] CARD9 mediates T cell inflammatory response in Coxsackievirus B3-induced acute myocarditis.
[32770644] Risk factors for recurrence of Helicobacter pylori infection after successful eradication in Chinese children: A prospective, nested case-control study.