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Interferon gamma (IFN-gamma)

 IFNG_FELCA              Reviewed;         167 AA.
P46402;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
18-SEP-2019, entry version 123.
RecName: Full=Interferon gamma;
Short=IFN-gamma;
Flags: Precursor;
Name=IFNG;
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymph node;
PubMed=7612928; DOI=10.3109/10425179509029357;
Argyle D.J., Smith K., McBride K., Fulton R., Onions D.E.;
"Nucleotide and predicted peptide sequence of feline interferon-gamma
(IFN-gamma).";
DNA Seq. 5:169-171(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=7590986; DOI=10.1007/bf00179414;
Schijns V.E.C.J., Wierda C.M.H., Vahlenkamp T.W., Horzinek M.C.,
de Groot R.J.;
"Molecular cloning and expression of cat interferon-gamma.";
Immunogenetics 42:440-441(1995).
-!- FUNCTION: Produced by lymphocytes activated by specific antigens
or mitogens. IFN-gamma, in addition to having antiviral activity,
has important immunoregulatory functions. It is a potent activator
of macrophages, it has antiproliferative effects on transformed
cells and it can potentiate the antiviral and antitumor effects of
the type I interferons.
-!- SUBUNIT: Homodimer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Released primarily from activated T
lymphocytes.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
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EMBL; D30619; BAA06309.1; -; mRNA.
EMBL; X86972; CAA60535.1; -; Genomic_DNA.
PIR; S57644; S57644.
RefSeq; NP_001009873.1; NM_001009873.1.
SMR; P46402; -.
STRING; 9685.ENSFCAP00000008355; -.
Ensembl; ENSFCAT00000009016; ENSFCAP00000008355; ENSFCAG00000009014.
GeneID; 493965; -.
KEGG; fca:493965; -.
CTD; 3458; -.
VGNC; VGNC:67703; IFNG.
eggNOG; ENOG410IWSY; Eukaryota.
eggNOG; ENOG410Z8I5; LUCA.
GeneTree; ENSGT00390000007831; -.
HOGENOM; HOG000254784; -.
InParanoid; P46402; -.
KO; K04687; -.
OMA; WKEESDK; -.
OrthoDB; 1382686at2759; -.
TreeFam; TF336308; -.
Proteomes; UP000011712; Chromosome B4.
Bgee; ENSFCAG00000009014; Expressed in 1 organ(s), highest expression level in liver.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
GO; GO:0048143; P:astrocyte activation; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:1902948; P:negative regulation of tau-protein kinase activity; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
GO; GO:0032834; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:1904798; P:positive regulation of core promoter binding; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0060550; P:positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; IEA:Ensembl.
GO; GO:0060552; P:positive regulation of fructose 1,6-bisphosphate metabolic process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0051712; P:positive regulation of killing of cells of other organism; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein complex assembly; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:2000309; P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
GO; GO:0010835; P:regulation of protein ADP-ribosylation; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense; Complete proteome; Cytokine; Glycoprotein;
Growth regulation; Pyrrolidone carboxylic acid; Reference proteome;
Secreted; Signal.
SIGNAL 1 23 {ECO:0000250}.
CHAIN 24 167 Interferon gamma.
/FTId=PRO_0000016442.
MOD_RES 24 24 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:P01579}.
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 107 107 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 167 AA; 19623 MW; CF60183F0609DD12 CRC64;
MNYTSFIFAF QLCIILCSSG YYCQAMFFKE IEELKGYFNA SNPDVADGGS LFVDILKNWK
EESDKTIIQS QIVSFYLKMF ENLKDDDQRI QRSMDTIKED MLDKLLNTSS SKRDDFLKLI
QIPVNDLQVQ RKAINELFKV MNDLSPRSNL RKRKRSQNLF RGRRASK


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WP32: Translation Factors
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WP760: estrogen signalling
WP2006: Squamous cell TarBase
WP868: estrogen signalling
WP2152: BDNF
WP1224: EBV LMP1 signaling
WP262: EBV LMP1 signaling
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WP1654: gamma-Hexachlorocyclohexane degradation
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WP786: Type II interferon signaling (IFNG)
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Related Genes :
[psbX] Photosystem II reaction center X protein
[ndhA] NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit 1) (NDH subunit 1) (NADH-plastoquinone oxidoreductase subunit 1)
[KK1_045969] 40S ribosomal protein SA
[KK1_006657] Uncharacterized protein
[ndhF] NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic (EC 7.1.1.-) (NADH-plastoquinone oxidoreductase subunit 5) (Fragment)
[KK1_031928] Tyrosine N-monooxygenase
[] UDP-glycosyltransferase homolog (Fragment)
[ndhA] NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit 1) (NDH subunit 1) (NADH-plastoquinone oxidoreductase subunit 1)
[KK1_005898] Secologanin synthase
[ndhD] NAD(P)H-quinone oxidoreductase chain 4, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase, chain 4) (NADH-plastoquinone oxidoreductase chain 4)
[psbH] Photosystem II reaction center protein H (PSII-H)
[KK1_044146] Uncharacterized protein
[petB] Cytochrome b6
[ARD1] 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54) (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD) (Fe-ARD)
[COB] Cytochrome b (Fragment)
[ndhF] NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic (EC 7.1.1.-) (NADH-plastoquinone oxidoreductase subunit 5)
[ndhF] NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic (EC 7.1.1.-) (NADH-plastoquinone oxidoreductase subunit 5) (Fragment)
[atpF] ATP synthase subunit b, chloroplastic (ATP synthase F(0) sector subunit b) (ATPase subunit I)
[malate dehydrogenase] Malate dehydrogenase
[ndhE] NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit 4L) (NADH-plastoquinone oxidoreductase subunit 4L)
[g.33360] 4-alpha-glucanotransferase (EC 2.4.1.25) (Amylomaltase) (Disproportionating enzyme) (Fragment)
[ndhI] NAD(P)H-quinone oxidoreductase subunit I, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit I) (NDH subunit I) (NADH-plastoquinone oxidoreductase subunit I)
[ndhK] NAD(P)H-quinone oxidoreductase subunit K, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit K) (NADH-plastoquinone oxidoreductase subunit K)
[psbA] Photosystem II protein D1 (PSII D1 protein) (EC 1.10.3.9) (Photosystem II Q(B) protein)
[LOC101502735] Lipoxygenase (EC 1.13.11.-)
[AM588_10001736] Uncharacterized protein
[ndhF] NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic (EC 7.1.1.-) (NADH-plastoquinone oxidoreductase subunit 5) (Fragment)
[LOC101491357] cytochrome P450 734A1-like isoform X1
[psbI] Photosystem II reaction center protein I (PSII-I) (PSII 4.8 kDa protein)
[petB] Cytochrome b6

Bibliography :
[31532399] Viral Inhibitory Activity of CD8+ T Cells in HIV Infection.
[31532346] Increase of Plasma TNF- Is Associated with Decreased Levels of Blood Platelets in Clinical Dengue Infection.
[31531832] Reduction of Immune Activation and Partial Recovery of Staphylococcal Enterotoxin B-Induced Cytokine Production After Switching to an Integrase Strand Transfer Inhibitor-Containing Regimen: Results from an Observational Cohort Study.
[31530731] Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4 T cells.
[31530556] Safety and immune response of a live-attenuated herpes zoster vaccine in patients with systemic lupus erythematosus: a randomised placebo-controlled trial.
[31526800] Association of peripheral cytokine levels with cerebral structural abnormalities in schizophrenia.
[31525445] Significance of peripheral mononuclear cells producing interferon-γ in response to insulin B:9-23-related peptides in subtypes of type 1 diabetes.
[31522446] In Vitro Evaluation of CMV Specific CD8+T Cells Function in CMV+ Colorectal Cancer Patients Compared to Healthy Controls.
[31522433] Alteration of Serum Levels of Cytokines in Schizophrenic Patients before and after Treatment with Risperidone.
[31522092] An interferon-gamma release assay for the diagnosis of the Mycobacterium bovis infection in white rhinoceros (Ceratotherium simum).