GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Interferon gamma (IFN-gamma)

 IFNG_VULVU              Reviewed;         166 AA.
Q25BC0;
16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
18-APR-2006, sequence version 1.
02-JUN-2021, entry version 54.
RecName: Full=Interferon gamma;
Short=IFN-gamma;
Flags: Precursor;
Name=IFNG;
Vulpes vulpes (Red fox).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
NCBI_TaxID=9627;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=16321447; DOI=10.1016/j.vetimm.2005.10.006;
Rolland-Turner M., Farre G., Boue F.;
"Cloning of fox (Vulpes vulpes) IL2, IL6, IL10 and IFNgamma and analysis of
their expression by quantitative RT-PCR in fox PBMC after in vitro
stimulation by concanavalin A.";
Vet. Immunol. Immunopathol. 110:369-375(2006).
-!- FUNCTION: Type II interferon produced by immune cells such as T-cells
and NK cells that plays crucial roles in antimicrobial, antiviral, and
antitumor responses by activating effector immune cells and enhancing
antigen presentation. Primarily signals through the JAK-STAT pathway
after interaction with its receptor IFNGR1 to affect gene regulation.
Upon IFNG binding, IFNGR1 intracellular domain opens out to allow
association of downstream signaling components JAK2, JAK1 and STAT1,
leading to STAT1 activation, nuclear translocation and transcription of
IFNG-regulated genes. Many of the induced genes are transcription
factors such as IRF1 that are able to further drive regulation of a
next wave of transcription. Plays a role in class I antigen
presentation pathway by inducing a replacement of catalytic proteasome
subunits with immunoproteasome subunits. In turn, increases the
quantity, quality, and repertoire of peptides for class I MHC loading.
Increases the efficiency of peptide generation also by inducing the
expression of activator PA28 that associates with the proteasome and
alters its proteolytic cleavage preference. Up-regulates as well MHC II
complexes on the cell surface by promoting expression of several key
molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By
similarity). Participates in the regulation of hematopoietic stem cells
during development and under homeostatic conditions by affecting their
development, quiescence, and differentiation (By similarity).
{ECO:0000250|UniProtKB:P01579, ECO:0000250|UniProtKB:P01580}.
-!- SUBUNIT: Homodimer. Interacts with IFNGR1 (via extracellular domain);
this interaction promotes IFNGR1 dimerization.
{ECO:0000250|UniProtKB:P01579}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01579}.
-!- TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AJ621191; CAF18415.1; -; mRNA.
SMR; Q25BC0; -.
OMA; WKEESDK; -.
Proteomes; UP000286640; Genome assembly.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0048143; P:astrocyte activation; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:1902948; P:negative regulation of tau-protein kinase activity; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
GO; GO:0032834; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
GO; GO:1904798; P:positive regulation of core promoter binding; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0060550; P:positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; IEA:Ensembl.
GO; GO:0060552; P:positive regulation of fructose 1,6-bisphosphate metabolic process; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0051712; P:positive regulation of killing of cells of other organism; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:2000309; P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0060557; P:positive regulation of vitamin D biosynthetic process; IEA:Ensembl.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
GO; GO:0010835; P:regulation of protein ADP-ribosylation; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense; Cytokine; Glycoprotein; Growth regulation;
Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
SIGNAL 1..23
/evidence="ECO:0000250"
CHAIN 24..166
/note="Interferon gamma"
/id="PRO_0000235174"
MOD_RES 24
/note="Pyrrolidone carboxylic acid"
/evidence="ECO:0000250|UniProtKB:P01579"
CARBOHYD 39
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 106
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
SEQUENCE 166 AA; 19395 MW; 72179B0B637402DB CRC64;
MNYTSYILAF QLCVILCSSG CNCQAMFFKE IENLKEYFNA SNPDVSDGGS LFVDILKKWR
EESDKTIIQS QIVSFYLKLF DNFKDNQIIQ RSMDTIKEDM LGKFLNSSTS KREDFLKLIQ
IPVNDLQVQR KAINELIKVM NDLSPRSNLR KRKRSQNLFR GRRASK


Related products :

Catalog number Product name Quantity
18-783-78408 RABBIT ANTI HUMAN INTERFERON GAMMA Biotin - INTERFERON GAMMA; IFN-gamma Polyclonal 0.05 mg
20-663-48022 Interferon-gamma (mAHuIFNg) - Mouse Anti Human Interferon-gamma (mAHuIFNg); IFN-gamma; Immune interferon Monoclonal 1 mg
20-663-48022 Interferon-gamma (mAHuIFNg) - Mouse Anti Human Interferon-gamma (mAHuIFNg); IFN-gamma; Immune interferon Monoclonal 0.5 mg
20-271-80026 Interferon-gamma - Mouse Anti Human Interferon-gamma; IFN-gamma Monoclonal 1 mg
20-271-80026 Interferon-gamma - Mouse Anti Human Interferon-gamma; IFN-gamma Monoclonal 0.5 mg
18-783-78407 RABBIT ANTI HUMAN INTERFERON GAMMA - INTERFERON GAMMA; IFN-gamma Polyclonal 0.1 mg
20-271-80063 Interferon-gamma - Rat Anti Mouse Interferon-gamma; IFN-gamma Monoclonal 1 mg
20-663-48058 Interferon-gamma - Rat Anti-Mouse Interferon-gamma; IFN-gamma Monoclonal 0.5 mg
20-663-48058 Interferon-gamma - Rat Anti-Mouse Interferon-gamma; IFN-gamma Monoclonal 1 mg
20-271-80063 Interferon-gamma - Rat Anti Mouse Interferon-gamma; IFN-gamma Monoclonal 0.5 mg
orb82062 Human Interferon-gamma, recombinant protein Interferon gamma (IFN-gamma) Recombinant is a purified cytokine_growth factor. For research use only. 20
E0371m ELISA kit 10 kDa interferon gamma-induced protein,C7,Crg2,C-X-C motif chemokine 10,Cxcl10,Gamma-IP10,Ifi10,Inp10,Interferon-gamma induced protein CRG-2,IP-10,Mouse,Mus musculus,Scyb10,Small-inducible 96T
U0371m CLIA 10 kDa interferon gamma-induced protein,C7,Crg2,C-X-C motif chemokine 10,Cxcl10,Gamma-IP10,Ifi10,Inp10,Interferon-gamma induced protein CRG-2,IP-10,Mouse,Mus musculus,Scyb10,Small-inducible cytok 96T
E0371m ELISA 10 kDa interferon gamma-induced protein,C7,Crg2,C-X-C motif chemokine 10,Cxcl10,Gamma-IP10,Ifi10,Inp10,Interferon-gamma induced protein CRG-2,IP-10,Mouse,Mus musculus,Scyb10,Small-inducible cyto 96T
20-321-175081 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO HUMAN GAMMA INTERFERON (IFN-gamma) Monoclonal 0.1 mg
20-321-175082 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO HUMAN GAMMA INTERFERON (IFN-gamma) Monoclonal 0.3 mg
20-321-175083 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO HUMAN GAMMA INTERFERON (IFN-gamma) Monoclonal 0.1 mg
20-321-175084 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO HUMAN GAMMA INTERFERON (IFN-gamma) Monoclonal 0.3 mg
20-321-175004 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO MOUSE GAMMA INTERFERON (IFN-gamma) Monoclonal 0.1 mg
20-321-175005 GAMMA INTERFERON (IFN-gamma) - MONOCLONAL ANTIBODY TO MOUSE GAMMA INTERFERON (IFN-gamma) Monoclonal 0.5 mg
10-663-45229 Interferon-gamma (IFN-gamma) Porcine - IFN-gamma; Immune interferon N_A 0.05 mg
10-663-45229 Interferon-gamma (IFN-gamma) Porcine - IFN-gamma; Immune interferon N_A 1 mg
10-663-45229 Interferon-gamma (IFN-gamma) Porcine - IFN-gamma; Immune interferon N_A 0.01 mg
GS-1053a interferon gamma receptor 2 (interferon gamma transducer 1) primary antibody, Host: Rabbit 200ul
E0049h ELISA Homo sapiens,Human,IFNG,IFN-gamma,Immune interferon,Interferon gamma 96T
Pathways :
WP1836: Interferon gamma signaling
WP2199: Seed Development
WP1225: estrogen signalling
WP32: Translation Factors
WP1722: Th1/Th2
WP760: estrogen signalling
WP868: estrogen signalling
WP2006: Squamous cell TarBase
WP2152: BDNF
WP1224: EBV LMP1 signaling
WP262: EBV LMP1 signaling
WP542: Electron Transport Chain
WP1654: gamma-Hexachlorocyclohexane degradation
WP758: EBV LMP1 signaling
WP866: EBV LMP1 signaling
WP1993: angiogenesis overview
WP2292: Chemokine signaling pathway
WP537: Translation Factors
WP152: FGF signaling pathway
WP1886: Post-translational modification: gamma carboxylation and hypusine formation
WP2113: Type III interferon signaling
WP1017: Type II interferon signaling (IFNG)
WP900: Type II interferon signaling (IFNG)
WP1350: Type II interferon signaling (IFNG)
WP585: Interferon type I

Related Genes :
[IFNGR1] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (BoIFNG) (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFN-g IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma IF2F] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNg IF2F IFNG] Interferon gamma (IFN-gamma)
[Cadr_000017035] Interferon gamma (IFN-gamma)
[IF2F IFNG] Interferon gamma (IFN-gamma)

Bibliography :
[34651048] A Bioinformatics Approach for the Prediction of Immunogenic Properties and Structure of the SARS-COV-2 B.1.617.1 Variant Spike Protein.
[34650972] Tumor Immune Microenvironment Landscape in Glioma Identifies a Prognostic and Immunotherapeutic Signature.
[34650558] Human Wharton's Jelly-Derived Mesenchymal Stromal Cells Primed by Tumor Necrosis Factor-α and Interferon-γ Modulate the Innate and Adaptive Immune Cells of Type 1 Diabetic Patients.
[34647607] PEDF relieves kidney injury in type 2 diabetic nephropathy mice by reducing macrophage infiltration.
[34647015] Interferon-gamma impairs phagocytosis of by primary murine peritoneal macrophages stimulated with LPS and differentially modulates proinflammatory cytokine release.
[34646805] Long-Term Course of Humoral and Cellular Immune Responses in Outpatients After SARS-CoV-2 Infection.
[34644992] The cytokine response of afferent lymph following orf virus reinfection of sheep.
[34644571] The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
[34644290] Schistosoma mansoni egg-derived extracellular vesicles: A promising vaccine candidate against murine schistosomiasis.
[34641798] Immunogenicity of a new enhanced tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccine against Bordetella pertussis in a murine model.