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Interferon gamma (IFN-gamma)

 IFNG_MERUN              Reviewed;         173 AA.
Q62574;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
22-APR-2020, entry version 78.
RecName: Full=Interferon gamma;
Short=IFN-gamma;
Flags: Precursor;
Name=IFNG;
Meriones unguiculatus (Mongolian jird) (Mongolian gerbil).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Gerbillinae; Meriones.
NCBI_TaxID=10047;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Spleen;
Mai Z., Klei T.R.;
"Full length cDNA isolation of gerbil (Meriones unguiculatus) Th1 and Th2
cell cytokines by PCR method as well as their characterization.";
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Produced by lymphocytes activated by specific antigens or
mitogens. IFN-gamma, in addition to having antiviral activity, has
important immunoregulatory functions. It is a potent activator of
macrophages, it has antiproliferative effects on transformed cells and
it can potentiate the antiviral and antitumor effects of the type I
interferons (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
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EMBL; L37782; AAA65674.1; -; mRNA.
SMR; Q62574; -.
OrthoDB; 1382686at2759; -.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense; Cytokine; Glycoprotein; Growth regulation;
Pyrrolidone carboxylic acid; Secreted; Signal.
SIGNAL 1..22
/evidence="ECO:0000250"
CHAIN 23..173
/note="Interferon gamma"
/id="PRO_0000016451"
MOD_RES 23
/note="Pyrrolidone carboxylic acid"
/evidence="ECO:0000250|UniProtKB:P01579"
CARBOHYD 38
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 105
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
SEQUENCE 173 AA; 19363 MW; D587282DD49B4C79 CRC64;
MNATHCILAL QLCLLAISGC SSQVPIIEEI ENLKRYFNSS NSAVGDSKDV VLHVLRNWQE
DGDTKVIDVQ IVSFYFKLFE ALKGNQAIEK SINAIRADLI ANFFNNSEAK YDGFMSIMKI
EVNDPQIQSK AINELVKVMG HLSPRVTLRK RKRSRCCFGG GNRLNKNNPA STI


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Pathways :
WP1836: Interferon gamma signaling
WP2199: Seed Development
WP1225: estrogen signalling
WP32: Translation Factors
WP1722: Th1/Th2
WP760: estrogen signalling
WP868: estrogen signalling
WP2006: Squamous cell TarBase
WP2152: BDNF
WP1224: EBV LMP1 signaling
WP262: EBV LMP1 signaling
WP542: Electron Transport Chain
WP1654: gamma-Hexachlorocyclohexane degradation
WP758: EBV LMP1 signaling
WP866: EBV LMP1 signaling
WP1993: angiogenesis overview
WP2292: Chemokine signaling pathway
WP152: FGF signaling pathway
WP537: Translation Factors
WP1886: Post-translational modification: gamma carboxylation and hypusine formation
WP1017: Type II interferon signaling (IFNG)
WP900: Type II interferon signaling (IFNG)
WP2113: Type III interferon signaling
WP1350: Type II interferon signaling (IFNG)
WP585: Interferon type I

Related Genes :
[IFNGR1] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (BoIFNG) (IFN-gamma)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFN-g IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma] Interferon gamma (IFN-gamma)
[Cadr_000017035] Interferon gamma (IFN-gamma)
[IFNg IFNG] Interferon gamma (IFN-gamma)
[IFNG PANDA_006820] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma] Interferon gamma (IFN-gamma)

Bibliography :
[32441280] Characterization of regulatory T cell expansion for manufacturing cellular immunotherapies.
[32441185] A New Method for Screening Natural Products to Stimulate IFN-γ Production in Jurkat Human T Lymphocytes.
[32439799] PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations.
[32439430] NK cells as a possible new player in atopic dermatitis.
[32439226] Induction of inducible nitric oxide synthase expression in activated microglia and astrocytes following pre- and postnatal immune challenge in an animal model of schizophrenia.
[32436879] Immune response during influenza virus infection among the population of Assam, Northeast India.
[32436176] Changes in the severity of gastric mucosal inflammation associated with Helicobacter pylori in humans coinfected with  intestinal helminths.
[32434847] A double-blind, placebo-controlled phase 1/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1.
[32430872] Depletion but Activation of CD56CD16 NK Cells in Acute Infection with Severe Fever with Thrombocytopenia Syndrome Virus.
[32428799] Decreased T-cell mediated hepatic injury in concanavalin A-treated PLRP2-deficient mice.