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Interferon gamma (IFN-gamma)

 IFNG_TURTR              Reviewed;         166 AA.
Q9TV67;
02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
31-JUL-2019, entry version 112.
RecName: Full=Interferon gamma;
Short=IFN-gamma;
Flags: Precursor;
Name=IFNG;
Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus
truncatus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Cetacea;
Odontoceti; Delphinidae; Tursiops.
NCBI_TaxID=9739;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10487235; DOI=10.1292/jvms.61.939;
Inoue Y., Itou T., Oike T., Sakai T.;
"Cloning and sequencing of the bottle-nosed dolphin (Tursiops
truncatus) interferon-gamma gene.";
J. Vet. Med. Sci. 61:939-942(1999).
-!- FUNCTION: Produced by lymphocytes activated by specific antigens
or mitogens. IFN-gamma, in addition to having antiviral activity,
has important immunoregulatory functions. It is a potent activator
of macrophages, it has antiproliferative effects on transformed
cells and it can potentiate the antiviral and antitumor effects of
the type I interferons (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- TISSUE SPECIFICITY: Released primarily from activated T
lymphocytes.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
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EMBL; AB022044; BAA82042.2; -; mRNA.
RefSeq; NP_001267561.1; NM_001280632.1.
SMR; Q9TV67; -.
GeneID; 101337436; -.
CTD; 3458; -.
eggNOG; ENOG410IWSY; Eukaryota.
eggNOG; ENOG410Z8I5; LUCA.
HOGENOM; HOG000254784; -.
OMA; WKEESDK; -.
OrthoDB; 1382686at2759; -.
Proteomes; UP000245320; Genome assembly.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0048143; P:astrocyte activation; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:1902948; P:negative regulation of tau-protein kinase activity; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
GO; GO:0032834; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:1904798; P:positive regulation of core promoter binding; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0060550; P:positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; IEA:Ensembl.
GO; GO:0060552; P:positive regulation of fructose 1,6-bisphosphate metabolic process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0051712; P:positive regulation of killing of cells of other organism; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein complex assembly; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:2000309; P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
GO; GO:0010835; P:regulation of protein ADP-ribosylation; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense; Complete proteome; Cytokine; Glycoprotein;
Growth regulation; Pyrrolidone carboxylic acid; Reference proteome;
Secreted; Signal.
SIGNAL 1 23 {ECO:0000250}.
CHAIN 24 166 Interferon gamma.
/FTId=PRO_0000016461.
MOD_RES 24 24 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:P01579}.
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 106 106 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 166 AA; 19389 MW; 8749BC98803A0D0D CRC64;
MKYTSYFLAF QLCVILGSSG SYCQAPFFKE IQNLKEYFNA SNPDVAGGGP LFLEILENWK
DESDKKIIQS QIVSFYFKLF ENLKGNQIIQ RSMDIIKQDM FQKFLNGSSE KLDDFKKLIQ
IPVDDLQIQR KAISELIRVM KDLSPRSNLR KRRRSQNLFR GQRASK


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Pathways :
WP1836: Interferon gamma signaling
WP2199: Seed Development
WP1225: estrogen signalling
WP32: Translation Factors
WP1722: Th1/Th2
WP760: estrogen signalling
WP868: estrogen signalling
WP2006: Squamous cell TarBase
WP2152: BDNF
WP1224: EBV LMP1 signaling
WP262: EBV LMP1 signaling
WP542: Electron Transport Chain
WP1654: gamma-Hexachlorocyclohexane degradation
WP758: EBV LMP1 signaling
WP866: EBV LMP1 signaling
WP1993: angiogenesis overview
WP2292: Chemokine signaling pathway
WP537: Translation Factors
WP152: FGF signaling pathway
WP1886: Post-translational modification: gamma carboxylation and hypusine formation
WP1017: Type II interferon signaling (IFNG)
WP900: Type II interferon signaling (IFNG)
WP2113: Type III interferon signaling
WP1350: Type II interferon signaling (IFNG)
WP585: Interferon type I

Related Genes :
[IFNGR1] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (BoIFNG) (IFN-gamma)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFN-g IFNG] Interferon gamma (IFN-gamma)
[IFNG IFN-gamma] Interferon gamma (IFN-gamma)
[IFN-gamma] Interferon gamma (IFN-gamma)
[IFNg IFNG] Interferon gamma (IFN-gamma)
[IFNG PANDA_006820] Interferon gamma (IFN-gamma)

Bibliography :
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[31626125] Serial analysis of cytokine and chemokine profiles and viral load in severe fever with thrombocytopenia syndrome: Case report and review of literature.
[31625070] The therapeutic and protective effects of bee pollen against prenatal methylmercury induced neurotoxicity in rat pups.
[31624262] Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation.
[31622780] Adaptive in vivo device for theranostics of inflammation: real-time monitoring of interferon-γ and aspirin.
[31621209] Effects of pentoxifylline on whole blood IL-2 and IFN-gamma gene expression in normal dogs.
[31620869] Predominant role of innate pro-inflammatory cytokines in vitiligo disease.
[31620662] Altered metabolism for neuroprotection provided by mesenchymal stem cells.
[31620037] Reduced Expression of Immune Mediators by T-Cell Subpopulations of Combat-Exposed Veterans With Post-Traumatic Stress Disorder.
[31619524] The predominance of Th1 Immune Response in Pleural Effusion of Patients with Tuberculosis Among Other Exudative Etiologies.