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Interferon gamma (IFN-gamma)

 IFNG_TURTR              Reviewed;         166 AA.
Q9TV67;
02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
22-APR-2020, entry version 115.
RecName: Full=Interferon gamma;
Short=IFN-gamma;
Flags: Precursor;
Name=IFNG;
Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
Delphinidae; Tursiops.
NCBI_TaxID=9739;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10487235; DOI=10.1292/jvms.61.939;
Inoue Y., Itou T., Oike T., Sakai T.;
"Cloning and sequencing of the bottle-nosed dolphin (Tursiops truncatus)
interferon-gamma gene.";
J. Vet. Med. Sci. 61:939-942(1999).
-!- FUNCTION: Produced by lymphocytes activated by specific antigens or
mitogens. IFN-gamma, in addition to having antiviral activity, has
important immunoregulatory functions. It is a potent activator of
macrophages, it has antiproliferative effects on transformed cells and
it can potentiate the antiviral and antitumor effects of the type I
interferons (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
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EMBL; AB022044; BAA82042.2; -; mRNA.
RefSeq; NP_001267561.1; NM_001280632.1.
SMR; Q9TV67; -.
Ensembl; ENSTTRT00000006485; ENSTTRP00000006137; ENSTTRG00000006482.
GeneID; 101337436; -.
CTD; 3458; -.
eggNOG; ENOG410IWSY; Eukaryota.
eggNOG; ENOG410Z8I5; LUCA.
HOGENOM; CLU_135106_0_0_1; -.
OMA; WKEESDK; -.
OrthoDB; 1382686at2759; -.
Proteomes; UP000245320; Genome assembly.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0048143; P:astrocyte activation; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:1902948; P:negative regulation of tau-protein kinase activity; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
GO; GO:0032834; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:1904798; P:positive regulation of core promoter binding; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0060550; P:positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; IEA:Ensembl.
GO; GO:0060552; P:positive regulation of fructose 1,6-bisphosphate metabolic process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0051712; P:positive regulation of killing of cells of other organism; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:2000309; P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
GO; GO:0010835; P:regulation of protein ADP-ribosylation; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense; Cytokine; Glycoprotein; Growth regulation;
Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
SIGNAL 1..23
/evidence="ECO:0000250"
CHAIN 24..166
/note="Interferon gamma"
/id="PRO_0000016461"
MOD_RES 24
/note="Pyrrolidone carboxylic acid"
/evidence="ECO:0000250|UniProtKB:P01579"
CARBOHYD 39
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 106
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
SEQUENCE 166 AA; 19389 MW; 8749BC98803A0D0D CRC64;
MKYTSYFLAF QLCVILGSSG SYCQAPFFKE IQNLKEYFNA SNPDVAGGGP LFLEILENWK
DESDKKIIQS QIVSFYFKLF ENLKGNQIIQ RSMDIIKQDM FQKFLNGSSE KLDDFKKLIQ
IPVDDLQIQR KAISELIRVM KDLSPRSNLR KRRRSQNLFR GQRASK


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Pathways :
WP1836: Interferon gamma signaling
WP1225: estrogen signalling
WP2199: Seed Development
WP32: Translation Factors
WP1722: Th1/Th2
WP760: estrogen signalling
WP2006: Squamous cell TarBase
WP868: estrogen signalling
WP1224: EBV LMP1 signaling
WP2152: BDNF
WP262: EBV LMP1 signaling
WP1654: gamma-Hexachlorocyclohexane degradation
WP542: Electron Transport Chain
WP758: EBV LMP1 signaling
WP866: EBV LMP1 signaling
WP1993: angiogenesis overview
WP2292: Chemokine signaling pathway
WP537: Translation Factors
WP152: FGF signaling pathway
WP1886: Post-translational modification: gamma carboxylation and hypusine formation
WP2113: Type III interferon signaling
WP1017: Type II interferon signaling (IFNG)
WP900: Type II interferon signaling (IFNG)
WP1350: Type II interferon signaling (IFNG)
WP585: Interferon type I

Related Genes :
[IFNGR1] Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (BoIFNG) (IFN-gamma)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNG] Interferon gamma (IFN-gamma)
[Ifng] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFN-g IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma] Interferon gamma (IFN-gamma)
[Cadr_000017035] Interferon gamma (IFN-gamma)
[IFNg IFNG] Interferon gamma (IFN-gamma)
[IFNG PANDA_006820] Interferon gamma (IFN-gamma)
[IFNG] Interferon gamma (IFN-gamma)
[IFN-gamma] Interferon gamma (IFN-gamma)

Bibliography :
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[32483462] imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy.
[32478954] Bronchoalveolar lavage T cell cytokine profiles and their association with lung function in children with M.pneumoniae-associated bronchiolitis obliterans.
[32478427] Lactobacillus rhamnosus 2016SWU.05.0601 regulates immune balance in ovalbumin-sensitized mice by modulating the immune-related transcription factors expression and gut microbiota.
[32477152] Neuroprotective Effects of Fluoxetine Against Chronic Stress-Induced Neural Inflammation and Apoptosis: Involvement of the p38 Activity.
[32475915] Ziyuglycoside II Inhibits Rotavirus Induced Diarrhea Possibly via TLR4/NF-κB Pathways.
[32475437] Research Note: The immune enhancement ability of inulin on ptfA gene DNA vaccine of avian Pasteurella multocida.
[32474541] Plasma levels of tumor necrosis factor-alpha, interferon-gamma, inducible nitric oxide synthase, and 3-nitrotyrosine in drug-resistant and drug-sensitive pulmonary tuberculosis patients, Ibadan, Nigeria.
[32474490] Evaluation of extracellular vesicles role in BALB/c mice immune modulatory.
[32472615] Interferon-gamma (IFN-γ) Serum Level and Immunohistochemical expression of CD8 cells in tissue biopsies in patients with Alopecia areata in correlation with the trichoscopic findings.