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Interferon lambda-1 (IFN-lambda-1) (Cytokine Zcyto21) (Interleukin-29) (IL-29)

 IFNL1_HUMAN             Reviewed;         200 AA.
Q8IU54; A0AV25; Q17R34;
23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
02-JUN-2021, entry version 144.
RecName: Full=Interferon lambda-1;
Short=IFN-lambda-1;
AltName: Full=Cytokine Zcyto21;
AltName: Full=Interleukin-29;
Short=IL-29;
Flags: Precursor;
Name=IFNL1; Synonyms=IL29, ZCYTO21;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=12469119; DOI=10.1038/ni873;
Sheppard P., Kindsvogel W., Xu W., Henderson K., Schlutsmeyer S.,
Whitmore T.E., Kuestner R., Garrigues U., Birks C., Roraback J.,
Ostrander C., Dong D., Shin J., Presnell S., Fox B., Haldeman B.,
Cooper E., Taft D., Gilbert T., Grant F.J., Tackett M., Krivan W.,
McKnight G., Clegg C., Foster D., Klucher K.M.;
"IL-28, IL-29 and their class II cytokine receptor IL-28R.";
Nat. Immunol. 4:63-68(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=12483210; DOI=10.1038/ni875;
Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M.,
Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.;
"IFN-lambdas mediate antiviral protection through a distinct class II
cytokine receptor complex.";
Nat. Immunol. 4:69-77(2003).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Li M., He S.;
"Construction of mammalian cell expression vector of human interleukin
(IL)-28A, IL-28B and IL-29 gene from activated peripheral blood mononuclear
cell and analysis of its sequence.";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-188.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
REVIEW.
PubMed=20712453; DOI=10.1089/jir.2010.0078;
Donnelly R.P., Kotenko S.V.;
"Interferon-lambda: a new addition to an old family.";
J. Interferon Cytokine Res. 30:555-564(2010).
[7]
REVIEW.
PubMed=24751921; DOI=10.1159/000360084;
Hermant P., Michiels T.;
"Interferon-lambda in the context of viral infections: production, response
and therapeutic implications.";
J. Innate Immun. 6:563-574(2014).
[8]
X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-200 IN COMPLEX WITH IFNLR1, AND
DISULFIDE BOND.
PubMed=20934432; DOI=10.1016/j.jmb.2010.09.068;
Miknis Z.J., Magracheva E., Li W., Zdanov A., Kotenko S.V., Wlodawer A.;
"Crystal structure of human interferon-lambda1 in complex with its high-
affinity receptor interferon-lambdaR1.";
J. Mol. Biol. 404:650-664(2010).
-!- FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory
activities. Plays a critical role in the antiviral host defense,
predominantly in the epithelial tissues. Acts as a ligand for the
heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1,
and receptor engagement leads to the activation of the JAK/STAT
signaling pathway resulting in the expression of IFN-stimulated genes
(ISG), which mediate the antiviral state. Has a restricted receptor
distribution and therefore restricted targets: is primarily active in
epithelial cells and this cell type-selective action is because of the
epithelial cell-specific expression of its receptor IFNLR1. Exerts an
immunomodulatory effect by up-regulating MHC class I antigen
expression.
-!- SUBCELLULAR LOCATION: Secreted.
-!- INDUCTION: By viral infections or double-stranded RNA.
-!- SIMILARITY: Belongs to the lambda interferon family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-29 entry;
URL="https://en.wikipedia.org/wiki/Interleukin_29";
---------------------------------------------------------------------------
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EMBL; AY129150; AAN28265.1; -; mRNA.
EMBL; AY184372; AAN86125.1; -; mRNA.
EMBL; AY336716; AAR24511.1; -; mRNA.
EMBL; AC011445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC074985; AAH74985.1; -; mRNA.
EMBL; BC126183; AAI26184.1; -; mRNA.
EMBL; BC117482; AAI17483.1; -; mRNA.
CCDS; CCDS12531.1; -.
RefSeq; NP_742152.1; NM_172140.1.
PDB; 3OG4; X-ray; 2.16 A; A=23-200.
PDB; 3OG6; X-ray; 2.10 A; A=20-200.
PDBsum; 3OG4; -.
PDBsum; 3OG6; -.
SMR; Q8IU54; -.
BioGRID; 129396; 6.
ComplexPortal; CPX-6011; Interferon lambda receptor-ligand complex, IFNL1 variant.
IntAct; Q8IU54; 3.
STRING; 9606.ENSP00000329991; -.
GlyGen; Q8IU54; 1 site.
iPTMnet; Q8IU54; -.
PhosphoSitePlus; Q8IU54; -.
BioMuta; IFNL1; -.
MassIVE; Q8IU54; -.
PaxDb; Q8IU54; -.
PeptideAtlas; Q8IU54; -.
PRIDE; Q8IU54; -.
ProteomicsDB; 70504; -.
Antibodypedia; 30288; 284 antibodies.
DNASU; 282618; -.
Ensembl; ENST00000333625; ENSP00000329991; ENSG00000182393.
GeneID; 282618; -.
KEGG; hsa:282618; -.
UCSC; uc002okv.4; human.
CTD; 282618; -.
DisGeNET; 282618; -.
GeneCards; IFNL1; -.
HGNC; HGNC:18363; IFNL1.
HPA; ENSG00000182393; Tissue enhanced (blood).
MIM; 607403; gene.
neXtProt; NX_Q8IU54; -.
OpenTargets; ENSG00000182393; -.
PharmGKB; PA134899000; -.
VEuPathDB; HostDB:ENSG00000182393.2; -.
eggNOG; ENOG502SSDC; Eukaryota.
GeneTree; ENSGT00390000014310; -.
HOGENOM; CLU_120266_0_0_1; -.
InParanoid; Q8IU54; -.
OMA; CNTRLFH; -.
OrthoDB; 1429532at2759; -.
PhylomeDB; Q8IU54; -.
TreeFam; TF336172; -.
PathwayCommons; Q8IU54; -.
Reactome; R-HSA-449836; Other interleukin signaling.
Reactome; R-HSA-8854691; Interleukin-20 family signaling.
SignaLink; Q8IU54; -.
SIGNOR; Q8IU54; -.
BioGRID-ORCS; 282618; 10 hits in 979 CRISPR screens.
GeneWiki; Interleukin_29; -.
GenomeRNAi; 282618; -.
Pharos; Q8IU54; Tbio.
PRO; PR:Q8IU54; -.
Proteomes; UP000005640; Chromosome 19.
RNAct; Q8IU54; protein.
Bgee; ENSG00000182393; Expressed in granulocyte and 15 other tissues.
Genevisible; Q8IU54; HS.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0032002; C:interleukin-28 receptor complex; IDA:UniProtKB.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0032003; F:interleukin-28 receptor binding; IPI:UniProtKB.
GO; GO:0005102; F:signaling receptor binding; IDA:UniProtKB.
GO; GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
GO; GO:0051607; P:defense response to virus; IDA:UniProtKB.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
GO; GO:0032696; P:negative regulation of interleukin-13 production; IDA:UniProtKB.
GO; GO:0032714; P:negative regulation of interleukin-5 production; IDA:UniProtKB.
GO; GO:0043381; P:negative regulation of memory T cell differentiation; IDA:UniProtKB.
GO; GO:0045581; P:negative regulation of T cell differentiation; IDA:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0002829; P:negative regulation of type 2 immune response; IDA:UniProtKB.
GO; GO:0050778; P:positive regulation of immune response; TAS:UniProtKB.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:UniProtKB.
GO; GO:0045345; P:positive regulation of MHC class I biosynthetic process; IDA:UniProtKB.
GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IDA:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:UniProtKB.
GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:InterPro.
Gene3D; 1.20.1250.60; -; 1.
InterPro; IPR038326; IFN-lambda_sf.
InterPro; IPR029177; INF_lambda.
PANTHER; PTHR31943; PTHR31943; 1.
Pfam; PF15177; IL28A; 1.
1: Evidence at protein level;
3D-structure; Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
Reference proteome; Secreted; Signal.
SIGNAL 1..19
/evidence="ECO:0000255"
CHAIN 20..200
/note="Interferon lambda-1"
/id="PRO_0000015511"
CARBOHYD 65
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 68..164
/evidence="ECO:0000269|PubMed:20934432"
VARIANT 188
/note="N -> D (in dbSNP:rs30461)"
/evidence="ECO:0000269|PubMed:15489334"
/id="VAR_024506"
HELIX 44..61
/evidence="ECO:0007829|PDB:3OG6"
HELIX 79..81
/evidence="ECO:0007829|PDB:3OG6"
HELIX 84..86
/evidence="ECO:0007829|PDB:3OG6"
HELIX 87..105
/evidence="ECO:0007829|PDB:3OG6"
TURN 108..110
/evidence="ECO:0007829|PDB:3OG6"
HELIX 111..129
/evidence="ECO:0007829|PDB:3OG6"
HELIX 145..159
/evidence="ECO:0007829|PDB:3OG6"
HELIX 162..178
/evidence="ECO:0007829|PDB:3OG6"
HELIX 180..186
/evidence="ECO:0007829|PDB:3OG6"
SEQUENCE 200 AA; 21898 MW; D4433B9462DCB4A1 CRC64;
MAAAWTVVLV TLVLGLAVAG PVPTSKPTTT GKGCHIGRFK SLSPQELASF KKARDALEES
LKLKNWSCSS PVFPGNWDLR LLQVRERPVA LEAELALTLK VLEAAAGPAL EDVLDQPLHT
LHHILSQLQA CIQPQPTAGP RPRGRLHHWL HRLQEAPKKE SAGCLEASVT FNLFRLLTRD
LKYVADGNLC LRTSTHPEST


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Pathways :
WP1017: Type II interferon signaling (IFNG)
WP619: Type II interferon signaling (IFNG)
WP1289: Type II interferon signaling (IFNG)
WP1836: Interferon gamma signaling
WP1839: Interleukin-1 signaling
WP2119: Interferon induced apoptosis
WP585: Interferon type I
WP900: Type II interferon signaling (IFNG)
WP1253: Type II interferon signaling (IFNG)
WP1835: Interferon alpha/beta signaling
WP1838: Interleukin-1 processing
WP2113: Type III interferon signaling
WP2332: Interleukin-11 Signaling Pathway
WP786: Type II interferon signaling (IFNG)
WP1136: Type II interferon signaling (IFNG)
WP1350: Type II interferon signaling (IFNG)
WP1837: Interferon Signaling
WP1840: Interleukin-3, 5 and GM-CSF signaling
WP2292: Chemokine signaling pathway

Related Genes :
[IFNL1 IL29 ZCYTO21] Interferon lambda-1 (IFN-lambda-1) (Cytokine Zcyto21) (Interleukin-29) (IL-29)
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
[IFNL3 IL28B IL28C ZCYTO22] Interferon lambda-3 (IFN-lambda-3) (Cytokine Zcyto22) (Interleukin-28B) (IL-28B) (Interleukin-28C) (IL-28C)
[IFNL2 IL28A ZCYTO20] Interferon lambda-2 (IFN-lambda-2) (Cytokine Zcyto20) (Interleukin-28A) (IL-28A)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL10RB CRFB4 D21S58 D21S66] Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL6 IFNB2] Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
[IFNAR1 IFNAR] Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
[Ticam1 Trif] TIR domain-containing adapter molecule 1 (TICAM-1) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (TIR domain-containing adapter protein inducing IFN-beta)
[IL27RA CRL1 TCCR WSX1 UNQ296/PRO336] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
[TICAM1 PRVTIRB TRIF] TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
[Il27ra Tccr Wsx1] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Type I T-cell cytokine receptor) (TCCR) (WSX-1)
[IL18R1 IL1RRP] Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
[IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384] Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IL1B IL1F2] Interleukin-1 beta (IL-1 beta) (Catabolin)
[Il11ra1 Etl2 Il11ra] Interleukin-11 receptor subunit alpha-1 (IL-11 receptor subunit alpha-1) (IL-11R subunit alpha-1) (IL-11R-alpha-1) (IL-11RA1) (Enhancer trap locus homolog 2) (Etl-2) (Novel cytokine receptor 1) (NR-1) (NR1) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL17RB CRL4 EVI27 IL17BR UNQ2501/PRO19612] Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor)
[IFNAR2 IFNABR IFNARB] Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)
[Irak1 Il1rak] Interleukin-1 receptor-associated kinase 1 (IRAK) (IRAK-1) (EC 2.7.11.1) (Pelle-like protein kinase) (mPLK)
[IL2RG] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[CXCL11 ITAC SCYB11 SCYB9B] C-X-C motif chemokine 11 (Beta-R1) (H174) (Interferon gamma-inducible protein 9) (IP-9) (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11)
[Ifnar1 Ifar Ifnar] Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Type I interferon receptor 1)
[ORF1ab ORF1a orf1ab] 3C-like proteinase (EC 3.4.19.12) (EC 3.4.22.69) (Growth factor-like peptide) (Leader protein) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (Papain-like proteinase) (p65 homolog)
[IL17F] Interleukin-17F (IL-17F) (Cytokine ML-1)

Bibliography :
[20872712] Toll-like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection.