GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Interferon regulatory factor 7

 F1QNG2_DANRE            Unreviewed;       422 AA.
F1QNG2;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
03-MAY-2011, sequence version 1.
11-DEC-2019, entry version 64.
SubName: Full=Interferon regulatory factor 7 {ECO:0000313|Ensembl:ENSDARP00000094398};
Name=irf7 {ECO:0000313|Ensembl:ENSDARP00000094398,
ECO:0000313|ZFIN:ZDB-GENE-040426-1518};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000094398, ECO:0000313|Proteomes:UP000000437};
[1] {ECO:0000313|Ensembl:ENSDARP00000094398}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000094398};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[2] {ECO:0000313|Ensembl:ENSDARP00000094398, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000094398,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the human
genome.";
Nature 496:498-503(2013).
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AL928892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; NP_956971.2; NM_200677.2.
STRING; 7955.ENSDARP00000094398; -.
PaxDb; F1QNG2; -.
Ensembl; ENSDART00000103622; ENSDARP00000094398; ENSDARG00000045661.
GeneID; 393650; -.
CTD; 3665; -.
ZFIN; ZDB-GENE-040426-1518; irf7.
eggNOG; ENOG410IWNR; Eukaryota.
eggNOG; ENOG4111G85; LUCA.
GeneTree; ENSGT00940000160931; -.
InParanoid; F1QNG2; -.
OMA; IPWKHNS; -.
OrthoDB; 648909at2759; -.
TreeFam; TF328512; -.
Reactome; R-DRE-3134963; DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
Reactome; R-DRE-9013973; TICAM1-dependent activation of IRF3/IRF7.
Reactome; R-DRE-918233; TRAF3-dependent IRF activation pathway.
Reactome; R-DRE-933541; TRAF6 mediated IRF7 activation.
Reactome; R-DRE-936964; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
Reactome; R-DRE-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
Proteomes; UP000000437; Chromosome 25.
Bgee; ENSDARG00000045661; Expressed in 29 organ(s), highest expression level in caudal fin.
ExpressionAtlas; F1QNG2; baseline and differential.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
GO; GO:0044212; F:transcription regulatory region DNA binding; IGI:ZFIN.
GO; GO:0030097; P:hemopoiesis; IMP:ZFIN.
GO; GO:0002376; P:immune system process; IBA:GO_Central.
GO; GO:1902037; P:negative regulation of hematopoietic stem cell differentiation; IGI:ZFIN.
GO; GO:0045580; P:regulation of T cell differentiation; IGI:ZFIN.
GO; GO:0009615; P:response to virus; IDA:ZFIN.
CDD; cd00103; IRF; 1.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 2.60.200.10; -; 1.
InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
InterPro; IPR019471; Interferon_reg_factor-3.
InterPro; IPR017855; SMAD-like_dom_sf.
InterPro; IPR008984; SMAD_FHA_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
PANTHER; PTHR11949; PTHR11949; 2.
Pfam; PF00605; IRF; 1.
Pfam; PF10401; IRF-3; 1.
PRINTS; PR00267; INTFRNREGFCT.
SMART; SM00348; IRF; 1.
SMART; SM01243; IRF-3; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF49879; SSF49879; 1.
PROSITE; PS51507; IRF_2; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000000437}.
DOMAIN 7..109
/note="IRF tryptophan pentad repeat"
/evidence="ECO:0000259|PROSITE:PS51507"
SEQUENCE 422 AA; 48871 MW; B23AD9F63BA1DB73 CRC64;
MQSTNAKPQF GPWLIEQVES GQYEGLSMIG HDIFRIPWKH NARRDLGDAD VKIFKEWAIV
SGKINEYPND KAKWKTNFRC ALHSLKSFEM LEDHSKDPDD QHKIYRIIRP QNHQEIKSAI
QSAEAVQRQL PFIAEVYNAS NHMSQDMELE LLNLVETMDL NLHAVSQSLK TYSQPNIQTT
SSNYFETTYS DDPCMQNNIP ASVQQSHTTV DQWNLDLEIS ISYRRTEVLK TRLCSSLIHF
FYQCDPSELR GEQIRFPTTD CLIDVKQIQY TKRILDSIQR GLQLEVNQYG IYGFRQDKCK
VFVSTSDPCE IQKPEPRKLQ QNSKEQLLSF DKYIRDLLDF KENRGGSPDY TIYLCFGEKL
HDGKPLEKKL ITVKVVPLIC RELHERAQME GASSLRNDNV SLQISHNSLY DLINSLGLPS
VE


Related products :

Catalog number Product name Quantity
31-202 Interferon regulatory factor 8 (IRF8, interferon consensus sequence-binding protein, Ion ChannelSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this 0.05 mg
18-003-42263 Interferon regulatory factor 4 - IRF-4; Lymphocyte-specific interferon regulatory factor; LSIRF; NF-EM5; Multiple myeloma oncogene 1 Polyclonal 0.1 mg Protein A
orb80393 Human Interferon Regulatory Factor-1 protein Interferon Regulatory Factor-1 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 134 amino acids (1-114) wit 5
orb80394 Human Interferon Regulatory Factor-2 protein Interferon Regulatory Factor-2 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 133 amino acids (1-113) wit 10
31-154 IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interf 0.05 mg
27-469 IRF3 is interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine_threonine phosphorylatio 0.05 mg
28-780 IRF3 is interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine_threonine phosphorylatio 0.1 mg
LF-PA41488 anti-Interferon Regulatory Factor 4, Rabbit polyclonal to Interferon Regulatory Factor 4, Isotype IgG, Host Rabbit 50 ug
LF-PA41805 anti-Interferon Regulatory Factor 3, Rabbit polyclonal to Interferon Regulatory Factor 3, Isotype IgG, Host Rabbit 50 ul
28-794 IRF1 is interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse i 0.05 mg
31-203 Interferon consensus sequence-binding protein (Ion ChannelSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA 0.1 mg
18-003-43029 Interferon regulatory factor 8 - IRF-8; Interferon consensus sequence-binding protein; ICSBP Polyclonal 0.05 mg Aff Pur
18-661-15212 Interferon regulatory factor 8 - IRF-8; Interferon consensus sequence-binding protein; ICSBP Polyclonal 0.1 mg
18-003-43028 Interferon regulatory factor 8 - IRF-8; Interferon consensus sequence-binding protein; ICSBP Polyclonal 0.05 mg Aff Pur
18-003-43029 Interferon regulatory factor 8 - IRF-8; Interferon consensus sequence-binding protein; ICSBP Polyclonal 0.1 mg Protein A
18-003-43028 Interferon regulatory factor 8 - IRF-8; Interferon consensus sequence-binding protein; ICSBP Polyclonal 0.1 mg Protein A
28-795 IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth 0.1 mg
18-003-42030 Transcriptional regulator ISGF3 subunit gamma - Interferon regulatory factor 9; IRF-9; IFN-alpha-responsive transcription factor subunit; Interferon-stimulated gene factor 3 gamma; ISGF3 p48 subunit; 0.05 mg Aff Pur
U1776m CLIA ICSBP,Icsbp,Icsbp1,Interferon consensus sequence-binding protein,Interferon regulatory factor 8,Irf8,IRF-8,Mouse,Mus musculus 96T
E1776m ELISA ICSBP,Icsbp,Icsbp1,Interferon consensus sequence-binding protein,Interferon regulatory factor 8,Irf8,IRF-8,Mouse,Mus musculus 96T
E1776m ELISA kit ICSBP,Icsbp,Icsbp1,Interferon consensus sequence-binding protein,Interferon regulatory factor 8,Irf8,IRF-8,Mouse,Mus musculus 96T
E1776h ELISA kit H-ICSBP,Homo sapiens,Human,ICSBP,ICSBP1,Interferon consensus sequence-binding protein,Interferon regulatory factor 8,IRF8,IRF-8 96T
U1776h CLIA H-ICSBP,Homo sapiens,Human,ICSBP,ICSBP1,Interferon consensus sequence-binding protein,Interferon regulatory factor 8,IRF8,IRF-8 96T
E1776h ELISA H-ICSBP,Homo sapiens,Human,ICSBP,ICSBP1,Interferon consensus sequence-binding protein,Interferon regulatory factor 8,IRF8,IRF-8 96T
EIAAB32304 Beta-interferon gene positive regulatory domain I-binding factor,BLIMP1,BLIMP-1,Homo sapiens,Human,Positive regulatory domain I-binding factor 1,PR domain zinc finger protein 1,PR domain-containing pr
Pathways :
WP1017: Type II interferon signaling (IFNG)
WP2226: Cell engulfment
WP1901: Regulatory RNA pathways
WP1983: Splicing factor NOVA regulated synpatic proteins
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP786: Type II interferon signaling (IFNG)
WP1253: Type II interferon signaling (IFNG)
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP2119: Interferon induced apoptosis
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1380: Regulation of Actin Cytoskeleton
WP1835: Interferon alpha/beta signaling
WP619: Type II interferon signaling (IFNG)
WP1345: T Cell Receptor Signaling Pathway
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1136: Type II interferon signaling (IFNG)
WP731: Sterol regulatory element binding protein related
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP900: Type II interferon signaling (IFNG)
WP2113: Type III interferon signaling
WP272: Blood Clotting Cascade
WP1350: Type II interferon signaling (IFNG)
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP585: Interferon type I

Related Genes :
[IRF7] Interferon regulatory factor 7 (IRF-7)
[Irf7] Interferon regulatory factor 7 (IRF-7)
[Irf4 Spip] Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (NF-EM5) (PU.1 interaction partner) (Transcriptional activator PIP)
[IRF4 MUM1] Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5)
[IRF9 ISGF3G] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
[IRF3] Interferon regulatory factor 3 (IRF-3)
[IRF1] Interferon regulatory factor 1 (IRF-1)
[IRF5] Interferon regulatory factor 5 (IRF-5)
[IRF2] Interferon regulatory factor 2 (IRF-2)
[Irf1] Interferon regulatory factor 1 (IRF-1)
[Irf3] Interferon regulatory factor 3 (IRF-3)
[Irf1] Interferon regulatory factor 1 (IRF-1)
[IRF8 ICSBP1] Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP)
[Irf8 Icsbp Icsbp1] Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (ICSBP)
[IRF2BP2] Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)
[PRDM1 BLIMP1] PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1)
[Irf6] Interferon regulatory factor 6 (IRF-6)
[IRF2BP1] Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1)
[EIF2AK2 PKR PRKR] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[IRF6] Interferon regulatory factor 6 (IRF-6)
[Prdm1 Blimp1] PR domain zinc finger protein 1 (EC 2.1.1.-) (B lymphocyte-induced maturation protein 1) (Blimp-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1)
[Eif2ak2 Pkr Prkr Tik] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[IRF2BPL C14orf4 EAP1 KIAA1865 My039] Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like)
[IRF3] Interferon regulatory factor 3 (IRF-3)
[Irf3 rCG_54412] Interferon regulatory factor 3 (Interferon regulatory factor 3, isoform CRA_c)
[IRF1] Interferon regulatory factor 1 (IRF-1)
[Irf5] Interferon regulatory factor 5 (IRF-5)
[Eif2ak2 Prkr] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2)
[IFNGR2 IFNGT1] Interferon gamma receptor 2 (IFN-gamma receptor 2) (IFN-gamma-R2) (Interferon gamma receptor accessory factor 1) (AF-1) (Interferon gamma receptor beta-chain) (IFN-gamma-R-beta) (Interferon gamma transducer 1)
[Irf9 Isgf3g] Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)

Bibliography :
[32032764] Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7.
[31993305] Xenobiotic receptors in mediating the effect of sepsis on drug metabolism.
[31960143] Activation of interferon regulatory factor 7 in plasmacytoid dendritic cells promotes experimental autoimmune pancreatitis.
[31941042] Autophagy Promotes Duck Tembusu Virus Replication by Suppressing p62/SQSTM1-Mediated Innate Immune Responses In Vitro.
[31863665] Gene Expression Microarray Data Meta-Analysis Identifies Candidate Genes and Molecular Mechanism Associated with Clear Cell Renal Cell Carcinoma.
[31814207] Development and characterization of a continuous cell line (EL) from the liver of European eel Anguilla anguilla.
[31788050] Identification of the lncRNA-miRNA-mRNA network associated with gastric cancer via integrated bioinformatics analysis.
[31779082] miR29a and miR378b Influence CpG-Stimulated Dendritic Cells and Regulate cGAS/STING Pathway.
[31775040] IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation.
[31697956] Duck karyopherin α4 (duKPNA4) is involved in type I interferon expression and the antiviral response against Japanese encephalitis virus.