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Interferon-alpha1

 L0N195_HUMAN            Unreviewed;       189 AA.
L0N195;
06-MAR-2013, integrated into UniProtKB/TrEMBL.
06-MAR-2013, sequence version 1.
17-JUN-2020, entry version 45.
SubName: Full=Interferon-alpha1 {ECO:0000313|EMBL:BAM72353.1};
Name=IFNA1 {ECO:0000313|EMBL:BAM72353.1};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606 {ECO:0000313|EMBL:BAM72353.1};
[1] {ECO:0000313|EMBL:BAM72353.1}
NUCLEOTIDE SEQUENCE.
PubMed=23224365; DOI=10.1007/s00018-012-1216-x;
Kimura T., Jiang S., Nishizawa M., Yoshigai E., Hashimoto I., Nishikawa M.,
Okumura T., Yamada H.;
"Stabilization of human interferon-?1 mRNA by its antisense RNA.";
Cell. Mol. Life Sci. 70:1451-1467(2013).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00135286}.
-!- SIMILARITY: Belongs to the alpha/beta interferon family.
{ECO:0000256|RuleBase:RU000436, ECO:0000256|SAAS:SAAS00562792}.
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EMBL; AB578886; BAM72353.1; -; mRNA.
RefSeq; NP_076918.1; NM_024013.2.
SMR; L0N195; -.
PRIDE; L0N195; -.
Antibodypedia; 10448; 857 antibodies.
GeneID; 3439; -.
KEGG; hsa:3439; -.
CTD; 3439; -.
EuPathDB; HostDB:ENSG00000197919.4; -.
eggNOG; ENOG410IR8X; Eukaryota.
eggNOG; ENOG4110Q1A; LUCA.
KO; K05414; -.
OMA; DSYAAWD; -.
OrthoDB; 1358010at2759; -.
PhylomeDB; L0N195; -.
BioGRID-ORCS; 3439; 23 hits in 732 CRISPR screens.
GenomeRNAi; 3439; -.
Bgee; ENSG00000197919; Expressed in hypothalamus and 17 other tissues.
ExpressionAtlas; L0N195; baseline and differential.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
CDD; cd00095; IFab; 1.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000471; Interferon_alpha/beta/delta.
PANTHER; PTHR11691; PTHR11691; 1.
Pfam; PF00143; Interferon; 1.
PRINTS; PR00266; INTERFERONAB.
SMART; SM00076; IFabd; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00252; INTERFERON_A_B_D; 1.
2: Evidence at transcript level;
Antiviral defense {ECO:0000256|RuleBase:RU000436,
ECO:0000256|SAAS:SAAS00135290};
Cytokine {ECO:0000256|RuleBase:RU000436, ECO:0000256|SAAS:SAAS00135284};
Disulfide bond {ECO:0000256|SAAS:SAAS00487274};
Secreted {ECO:0000256|SAAS:SAAS00487273}; Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1..23
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 24..189
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5003946419"
SEQUENCE 189 AA; 21725 MW; F32F9CB969606B69 CRC64;
MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS SCLMDRHDFG
FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW DEDLLDKFCT ELYQQLNDLE
ACVMQEERVG ETPLMNADSI LAVKKYFRRI TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN
LQERLRRKE


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Related Genes :
[IFNA1; IFNA13] Interferon alpha-1/13 (IFN-alpha-1/13) (Interferon alpha-D) (LeIF D)
[Ifna1] Interferon alpha-1 (IFN-alpha-1)
[Sirpa Bit Myd1 Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)
[IL22RA1 IL22R] Interleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Cytokine receptor class-II member 9) (Cytokine receptor family 2 member 9) (CRF2-9) (ZcytoR11)
[S] Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) (Major surface antigen)
[EEF1A1 EEF1A EF1A LENG7] Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)
[Fut2 Ftb Sec1] Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha 1,2-fucosyltransferase) (Alpha 1,2-fucosyltransferase B) (Alpha 1-2 fucosyltransferase) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor blood group alpha-2-fucosyltransferase) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
[Fut2 Sec2] Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase) (MFUT-II) (Secretory blood group protein 2) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
[Prkaa1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
[Rps6ka1 Mapkapk1a Rsk1] Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
[Runx2 Aml3 Cbfa1 Osf2 Pebp2a] Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)
[Eef1a1 Eef1a] Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1)
[ADRA1A ADRA1C] Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c)
[FUT8] Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)
[Adra1a Adra1c] Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor)
[Fut1] Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Fucosyltransferase 1) (MFUT-1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344)
[ADRA1D ADRA1A] Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a)
[FUT2] Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
[FUT2 SEC2] Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
[Serpina1c Dom3 Dom6 Spi1-3 Spi1-6] Alpha-1-antitrypsin 1-3 (Alpha-1 protease inhibitor 3) (Alpha-1 protease inhibitor 6) (Alpha-1-antitrypsin 1-6) (Serine protease inhibitor 1-3) (Serine protease inhibitor 1-6) (Serine protease inhibitor A1c) (Serpin A1c)
[Adra1d Adra1a] Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (RA42)
[Adra1a Adra1c] Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor)
[IGHA1] Immunoglobulin heavy constant alpha 1 (Ig alpha-1 chain C region) (Ig alpha-1 chain C region BUR) (Ig alpha-1 chain C region TRO)
[Fut8] Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)
[FUT2] Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
[FUT2] Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
[FUT2 RFT-II SEC1] Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor blood group alpha-2-fucosyltransferase) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
[fut-8 C10F3.6] Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)
[FUT2] Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
[FUT1 H HSC] Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Blood group H alpha 2-fucosyltransferase) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344)

Bibliography :
[32378673] [Non-coding Natural Antisense RNA: Mechanisms of Action in the Regulation of Target Gene Expression and Its Clinical Implications].
[32101556] A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis.
[30844714] IFN-Alpha1 antisense RNA represses human influenza A virus growth in a guinea pig system.
[30844713] A guinea pig gene with antiviral activity against human influenza virus infection.
[25821968] Structural and immunological effects of skin cryoablation in a mouse model.
[25746225] Interferon-alpha competing endogenous RNA network antagonizes microRNA-1270.
[25343404] Characterization of bovine interferon α1: expression in yeast Pichia pastoris, biological activities, and physicochemical characteristics.
[25310498] Recombinant rabies virus expressing IFNα1 enhanced immune responses resulting in its attenuation and stronger immunogenicity.
[23748141] Construction and characterization of a potent, long-lasting recombinant human serum albumin-interferon α1 fusion protein expressed in Pichia pastoris.
[23224365] Stabilization of human interferon-α1 mRNA by its antisense RNA.