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Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Fragilis protein 2) (Mouse ifitm-like protein 2) (Mil-2)

 IFM1_MOUSE              Reviewed;         106 AA.
Q9D103; Q8R2S7;
05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
08-MAY-2019, entry version 123.
RecName: Full=Interferon-induced transmembrane protein 1;
AltName: Full=Dispanin subfamily A member 2a;
Short=DSPA2a;
AltName: Full=Fragilis protein 2;
AltName: Full=Mouse ifitm-like protein 2;
Short=Mil-2;
Name=Ifitm1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
PubMed=14516695; DOI=10.1016/S0925-4773(03)00126-6;
Tanaka S.S., Matsui Y.;
"Developmentally regulated expression of mil-1 and mil-2, mouse
interferon-induced transmembrane protein like genes, during formation
and differentiation of primordial germ cells.";
Mech. Dev. 119:S261-S267(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and NOD; TISSUE=Embryo;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II, and FVB/N;
TISSUE=Colon, Heart, Lung, and Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION, AND TISSUE SPECIFICITY.
PubMed=12659663; DOI=10.1186/1471-213X-3-1;
Lange U.C., Saitou M., Western P.S., Barton S.C., Surani M.A.;
"The fragilis interferon-inducible gene family of transmembrane
proteins is associated with germ cell specification in mice.";
BMC Dev. Biol. 3:1-1(2003).
[6]
SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
PubMed=16326387; DOI=10.1016/j.devcel.2005.10.010;
Tanaka S.S., Yamaguchi Y.L., Tsoi B., Lickert H., Tam P.P.;
"IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct
roles in mouse primordial germ cell homing and repulsion.";
Dev. Cell 9:745-756(2005).
[7]
FUNCTION.
PubMed=18505827; DOI=10.1128/MCB.00272-08;
Lange U.C., Adams D.J., Lee C., Barton S., Schneider R., Bradley A.,
Surani M.A.;
"Normal germ line establishment in mice carrying a deletion of the
Ifitm/Fragilis gene family cluster.";
Mol. Cell. Biol. 28:4688-4696(2008).
[8]
REVIEW.
PubMed=21166591; DOI=10.1089/jir.2010.0112;
Siegrist F., Ebeling M., Certa U.;
"The small interferon-induced transmembrane genes and proteins.";
J. Interferon Cytokine Res. 31:183-197(2011).
[9]
FUNCTION.
PubMed=21253575; DOI=10.1371/journal.ppat.1001258;
Huang I.C., Bailey C.C., Weyer J.L., Radoshitzky S.R., Becker M.M.,
Chiang J.J., Brass A.L., Ahmed A.A., Chi X., Dong L., Longobardi L.E.,
Boltz D., Kuhn J.H., Elledge S.J., Bavari S., Denison M.R., Choe H.,
Farzan M.;
"Distinct patterns of IFITM-mediated restriction of filoviruses, SARS
coronavirus, and influenza A virus.";
PLoS Pathog. 7:E1001258-E1001258(2011).
[10]
GENE FAMILY.
PubMed=22363774; DOI=10.1371/journal.pone.0031961;
Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
"The dispanins: a novel gene family of ancient origin that contains 14
human members.";
PLoS ONE 7:E31961-E31961(2012).
-!- FUNCTION: IFN-induced antiviral protein which inhibits the entry
of viruses to the host cell cytoplasm, permitting endocytosis, but
preventing subsequent viral fusion and release of viral contents
into the cytosol. Active against multiple viruses, including
influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus
(MARV), Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus
(WNV). Can inhibit: influenza virus hemagglutinin protein-mediated
viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV
S protein-mediated viral entry. Also implicated in cell adhesion
and control of cell growth and migration. Plays a key role in the
antiproliferative action of IFN-gamma either by inhibiting the ERK
activation or by arresting cell growth in G1 phase in a p53-
dependent manner. Acts as a positive regulator of osteoblast
differentiation. {ECO:0000269|PubMed:18505827,
ECO:0000269|PubMed:21253575}.
-!- SUBUNIT: Interacts with CD81. Part of a complex composed of CD19,
CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B-cells.
Interacts with CAV1; this interaction enhances the ability of CAV1
in inhibiting ERK activation. {ECO:0000250|UniProtKB:P13164}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16326387};
Single-pass membrane protein {ECO:0000269|PubMed:16326387}.
-!- TISSUE SPECIFICITY: Predominantly expressed in nascent primordial
germ cells, as well as in gonadal germ cells.
{ECO:0000269|PubMed:12659663}.
-!- DEVELOPMENTAL STAGE: In migrating PGCs, expression is first
detected during germ cell differentiation.
{ECO:0000269|PubMed:14516695, ECO:0000269|PubMed:16326387}.
-!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
-!- CAUTION: It has been previously shown that mediates migration of
early primordial germ cells (PGCs) (PubMed:16326387). But
according to PubMed:16326387, have no detectable effects on
development of the germ line or on the generation of live young,
hence, is not essential for PGC migration.
{ECO:0000305|PubMed:16326387}.
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EMBL; AK004121; BAB23181.1; -; mRNA.
EMBL; AK169960; BAE41483.1; -; mRNA.
EMBL; CH466531; EDL17976.1; -; Genomic_DNA.
EMBL; BC027285; AAH27285.1; -; mRNA.
EMBL; BC090258; AAH90258.1; -; mRNA.
EMBL; BC090972; AAH90972.1; -; mRNA.
EMBL; BK001123; DAA01238.1; -; mRNA.
CCDS; CCDS21995.1; -.
RefSeq; NP_001106186.1; NM_001112715.1.
RefSeq; NP_081096.3; NM_026820.3.
RefSeq; XP_006536301.1; XM_006536238.1.
DIP; DIP-60824N; -.
IntAct; Q9D103; 1.
STRING; 10090.ENSMUSP00000026564; -.
PhosphoSitePlus; Q9D103; -.
SwissPalm; Q9D103; -.
EPD; Q9D103; -.
MaxQB; Q9D103; -.
PaxDb; Q9D103; -.
PRIDE; Q9D103; -.
Ensembl; ENSMUST00000026564; ENSMUSP00000026564; ENSMUSG00000025491.
Ensembl; ENSMUST00000106040; ENSMUSP00000101655; ENSMUSG00000025491.
Ensembl; ENSMUST00000106042; ENSMUSP00000101657; ENSMUSG00000025491.
GeneID; 68713; -.
KEGG; mmu:68713; -.
UCSC; uc009kja.2; mouse.
CTD; 8519; -.
MGI; MGI:1915963; Ifitm1.
eggNOG; ENOG410J2DU; Eukaryota.
eggNOG; ENOG4112C1U; LUCA.
GeneTree; ENSGT00950000182857; -.
HOGENOM; HOG000115781; -.
InParanoid; Q9D103; -.
KO; K19831; -.
OMA; MIIFQAI; -.
OrthoDB; 1555189at2759; -.
PhylomeDB; Q9D103; -.
TreeFam; TF334894; -.
Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
PRO; PR:Q9D103; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000025491; Expressed in 244 organ(s), highest expression level in conjunctival fornix.
Genevisible; Q9D103; MM.
GO; GO:0005769; C:early endosome; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0032991; C:protein-containing complex; ISO:MGI.
GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
GO; GO:0051607; P:defense response to virus; IDA:MGI.
GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
GO; GO:0046597; P:negative regulation of viral entry into host cell; IDA:UniProtKB.
GO; GO:0045071; P:negative regulation of viral genome replication; ISS:UniProtKB.
GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
GO; GO:0035455; P:response to interferon-alpha; ISS:UniProtKB.
GO; GO:0035456; P:response to interferon-beta; ISS:UniProtKB.
GO; GO:0034341; P:response to interferon-gamma; ISS:UniProtKB.
GO; GO:0009615; P:response to virus; IDA:UniProtKB.
GO; GO:0001756; P:somitogenesis; IMP:MGI.
GO; GO:0060337; P:type I interferon signaling pathway; IBA:GO_Central.
InterPro; IPR007593; CD225/Dispanin_fam.
Pfam; PF04505; CD225; 1.
2: Evidence at transcript level;
Antiviral defense; Cell membrane; Complete proteome; Immunity;
Innate immunity; Lipoprotein; Membrane; Osteogenesis; Palmitate;
Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 106 Interferon-induced transmembrane protein
1.
/FTId=PRO_0000398565.
TOPO_DOM 1 35 Cytoplasmic. {ECO:0000255}.
INTRAMEM 36 56 Helical. {ECO:0000250|UniProtKB:P13164}.
TOPO_DOM 57 84 Cytoplasmic. {ECO:0000255}.
TRANSMEM 85 105 Helical. {ECO:0000255}.
TOPO_DOM 106 106 Extracellular. {ECO:0000255}.
LIPID 49 49 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 50 50 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 83 83 S-palmitoyl cysteine. {ECO:0000250}.
CONFLICT 37 37 V -> I (in Ref. 3; AAH27285).
{ECO:0000305}.
CONFLICT 54 54 V -> I (in Ref. 3; AAH27285).
{ECO:0000305}.
SEQUENCE 106 AA; 11524 MW; 7B0E7D8200D36631 CRC64;
MPKEQQEVVV LGSPHISTSA TATTINMPEI STPDHVVWSL FNTLFMNFCC LGFVAYAYSV
KSRDRKMVGD TTGAQAFAST AKCLNISSLF FTILTAIVVI VVCAIR


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Related Genes :
[Ifitm1] Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Fragilis protein 2) (Mouse ifitm-like protein 2) (Mil-2)
[Ifitm3] Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Fragilis protein) (Interferon-inducible protein 15) (Mouse ifitm-like protein 1) (Mil-1)
[IFITM1 CD225 IFI17] Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225)
[Eif2ak2 Pkr Prkr Tik] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[EIF2AK2 PKR PRKR] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Protein VP0 (VP4-VP2); Protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Protein VP1-2A (VPX); Capsid protein VP1 (P1D) (Virion protein 1); Assembly signal 2A (pX); Protein 2BC; Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3ABCD (P3); Protein 3ABC; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD; Protease 3C (P3C) (EC 3.4.22.28) (Picornain 3C); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48)]
[Kmt2a All1 Hrx Mll Mll1] Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
[Ppp2ca] Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16)
[Cdkn2a] Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p19ARF)
[Set] Protein SET (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I)
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[Prrt2] Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3)
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[Slc2a1 Glut1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (GT1)
[] Genome polyprotein [Cleaved into: Protein VP0 (VP4-VP2); Protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Protein VP1-2A (VPX); Capsid protein VP1 (P1D) (Virion protein 1); Assembly signal 2A (pX); Protein 2BC; Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3ABCD (P3); Protein 3ABC; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD; Protease 3C (P3C) (EC 3.4.22.28) (Picornain 3C); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[Bcl2l1 Bcl2l Bclx] Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Kdm3a Jhdm2a Jmjd1a Kiaa0742] Lysine-specific demethylase 3A (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A)
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Ppp2r2b] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta)
[Cdkn2a P16ink4a] Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4a) (p16-INK4)
[Ppp2cb] Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)
[GP1 MZ11_60484gpGP1 MZ11_60553gpGP1] Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (NS5)]

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