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Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Fragilis protein) (Interferon-inducible protein 15) (Mouse ifitm-like protein 1) (Mil-1)

 IFM3_MOUSE              Reviewed;         137 AA.
Q9CQW9; Q9D8L6;
05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
08-MAY-2019, entry version 124.
RecName: Full=Interferon-induced transmembrane protein 3;
AltName: Full=Dispanin subfamily A member 2b;
Short=DSPA2b;
AltName: Full=Fragilis protein;
AltName: Full=Interferon-inducible protein 15;
AltName: Full=Mouse ifitm-like protein 1;
Short=Mil-1;
Name=Ifitm3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
PubMed=14516695; DOI=10.1016/S0925-4773(03)00126-6;
Tanaka S.S., Matsui Y.;
"Developmentally regulated expression of mil-1 and mil-2, mouse
interferon-induced transmembrane protein like genes, during formation
and differentiation of primordial germ cells.";
Mech. Dev. 119:S261-S267(2002).
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
DEVELOPMENTAL STAGE.
STRAIN=129/SvEv;
PubMed=12124616; DOI=10.1038/nature00927;
Saitou M., Barton S.C., Surani M.A.;
"A molecular programme for the specification of germ cell fate in
mice.";
Nature 418:293-300(2002).
[3]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
STRAIN=BALB/cJ;
PubMed=15184081; DOI=10.1016/j.bbrc.2004.05.085;
Ropolo A., Tomasini R., Grasso D., Dusetti N.J., Cerquetti M.C.,
Iovanna J.L., Vaccaro M.I.;
"Cloning of IP15, a pancreatitis-induced gene whose expression
inhibits cell growth.";
Biochem. Biophys. Res. Commun. 319:1001-1009(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Bone marrow, Embryo, and Pancreas;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N-3; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
TISSUE SPECIFICITY.
PubMed=12659663; DOI=10.1186/1471-213X-3-1;
Lange U.C., Saitou M., Western P.S., Barton S.C., Surani M.A.;
"The fragilis interferon-inducible gene family of transmembrane
proteins is associated with germ cell specification in mice.";
BMC Dev. Biol. 3:1-1(2003).
[8]
SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
PubMed=16326387; DOI=10.1016/j.devcel.2005.10.010;
Tanaka S.S., Yamaguchi Y.L., Tsoi B., Lickert H., Tam P.P.;
"IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct
roles in mouse primordial germ cell homing and repulsion.";
Dev. Cell 9:745-756(2005).
[9]
INTERACTION WITH CD81.
PubMed=16395393; DOI=10.1038/sj.gene.6364278;
Smith R.A., Young J., Weis J.J., Weis J.H.;
"Expression of the mouse fragilis gene products in immune cells and
association with receptor signaling complexes.";
Genes Immun. 7:113-121(2006).
[10]
FUNCTION.
PubMed=18505827; DOI=10.1128/MCB.00272-08;
Lange U.C., Adams D.J., Lee C., Barton S., Schneider R., Bradley A.,
Surani M.A.;
"Normal germ line establishment in mice carrying a deletion of the
Ifitm/Fragilis gene family cluster.";
Mol. Cell. Biol. 28:4688-4696(2008).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-27, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[13]
REVIEW.
PubMed=21166591; DOI=10.1089/jir.2010.0112;
Siegrist F., Ebeling M., Certa U.;
"The small interferon-induced transmembrane genes and proteins.";
J. Interferon Cytokine Res. 31:183-197(2011).
[14]
FUNCTION.
PubMed=21253575; DOI=10.1371/journal.ppat.1001258;
Huang I.C., Bailey C.C., Weyer J.L., Radoshitzky S.R., Becker M.M.,
Chiang J.J., Brass A.L., Ahmed A.A., Chi X., Dong L., Longobardi L.E.,
Boltz D., Kuhn J.H., Elledge S.J., Bavari S., Denison M.R., Choe H.,
Farzan M.;
"Distinct patterns of IFITM-mediated restriction of filoviruses, SARS
coronavirus, and influenza A virus.";
PLoS Pathog. 7:E1001258-E1001258(2011).
[15]
FUNCTION, AND INTERACTION WITH ATP6V0B.
PubMed=22467717; DOI=10.1177/1753425912443392;
Wee Y.S., Roundy K.M., Weis J.J., Weis J.H.;
"Interferon-inducible transmembrane proteins of the innate immune
response act as membrane organizers by influencing clathrin and v-
ATPase localization and function.";
Inn. Immun. 18:834-845(2012).
[16]
INVOLVEMENT IN SUSCEPTIBILITY TO SEVERE INFLUENZA INFECTION.
PubMed=22446628; DOI=10.1038/nature10921;
Everitt A.R., Clare S., Pertel T., John S.P., Wash R.S., Smith S.E.,
Chin C.R., Feeley E.M., Sims J.S., Adams D.J., Wise H.M., Kane L.,
Goulding D., Digard P., Anttila V., Baillie J.K., Walsh T.S.,
Hume D.A., Palotie A., Xue Y., Colonna V., Tyler-Smith C., Dunning J.,
Gordon S.B., Smyth R.L., Openshaw P.J., Dougan G., Brass A.L.,
Kellam P.;
"IFITM3 restricts the morbidity and mortality associated with
influenza.";
Nature 484:519-523(2012).
[17]
GENE FAMILY.
PubMed=22363774; DOI=10.1371/journal.pone.0031961;
Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
"The dispanins: a novel gene family of ancient origin that contains 14
human members.";
PLoS ONE 7:E31961-E31961(2012).
-!- FUNCTION: IFN-induced antiviral protein which inhibits the entry
of viruses to the host cell cytoplasm, permitting endocytosis, but
preventing subsequent viral fusion and release of viral contents
into the cytosol. Active against multiple viruses, including
influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus
(MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus
(WNV) and human immunodeficiency virus type 1 (HIV-1). Can
inhibit: influenza virus hemagglutinin protein-mediated viral
entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S
protein-mediated viral entry. Plays a critical role in the
structural stability and function of vacuolar ATPase (v-ATPase).
Establishes physical contact with the v-ATPase of endosomes which
is critical for proper clathrin localization and is also required
for the function of the v-ATPase to lower the pH in phagocytic
endosomes thus establishing an antiviral state. Involved in
initiating germ cell competence and specification, and in the
demarcation of PGCs from their somatic neighbors.
{ECO:0000269|PubMed:12124616, ECO:0000269|PubMed:18505827,
ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22467717}.
-!- SUBUN