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Interleukin-1 receptor-associated kinase 1 (IRAK) (IRAK-1) (EC 2.7.11.1) (Pelle-like protein kinase) (mPLK)

 IRAK1_MOUSE             Reviewed;         710 AA.
Q62406; B1AUW4; Q6Y3Z5; Q6Y3Z6;
11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
14-AUG-2001, sequence version 3.
17-JUN-2020, entry version 189.
RecName: Full=Interleukin-1 receptor-associated kinase 1;
Short=IRAK;
Short=IRAK-1;
EC=2.7.11.1;
AltName: Full=Pelle-like protein kinase;
Short=mPLK;
Name=Irak1; Synonyms=Il1rak;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Kopp E.B., Ghosh S.;
"Cloning of mouse IRAK.";
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
PubMed=10723722; DOI=10.1007/s003350010035;
Reichwald K., Thiesen J., Wiehe T., Weitzel J., Poustka W.A., Rosenthal A.,
Platzer M., Stratling W.H., Kioschis P.;
"Comparative sequence analysis of the MECP2-locus in human and mouse
reveals new transcribed regions.";
Mamm. Genome 11:182-190(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 34-710 (ISOFORM 1), FUNCTION, DEVELOPMENTAL
STAGE, TISSUE SPECIFICITY, AND AUTOPHOSPHORYLATION.
TISSUE=Embryo;
PubMed=8663605; DOI=10.1074/jbc.271.30.17609;
Trofimova M., Sprenkle A.B., Green M., Sturgill T.W., Goebl M.G.,
Harrington M.A.;
"Developmental and tissue-specific expression of mouse pelle-like protein
kinase.";
J. Biol. Chem. 271:17609-17612(1996).
[5]
INTERACTION WITH IRAK1BP1.
PubMed=11096118; DOI=10.1074/jbc.m010399200;
Vig E., Green M., Liu Y., Yu K.-Y., Kwon H.-J., Tian J., Goebl M.G.,
Harrington M.A.;
"SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-
kappaB activity.";
J. Biol. Chem. 276:7859-7866(2001).
[6]
DIMERIZATION, AND MUTAGENESIS OF THR-66.
PubMed=12138165; DOI=10.1074/jbc.m205160200;
Ross K., Yang L., Dower S., Volpe F., Guesdon F.;
"Identification of threonine 66 as a functionally critical residue of the
interleukin-1 receptor-associated kinase.";
J. Biol. Chem. 277:37414-37421(2002).
[7]
INTERACTION WITH PELI2.
PubMed=12370331; DOI=10.4049/jimmunol.169.8.4075;
Yu K.-Y., Kwon H.-J., Norman D.A.M., Vig E., Goebl M.G., Harrington M.A.;
"Mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling.";
J. Immunol. 169:4075-4078(2002).
[8]
DISRUPTION PHENOTYPE.
PubMed=15767370; DOI=10.1084/jem.20042372;
Uematsu S., Sato S., Yamamoto M., Hirotani T., Kato H., Takeshita F.,
Matsuda M., Coban C., Ishii K.J., Kawai T., Takeuchi O., Akira S.;
"Interleukin-1 receptor-associated kinase-1 plays an essential role for
Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha}
induction.";
J. Exp. Med. 201:915-923(2005).
[9]
IDENTIFICATION IN COMPLEX WITH IRAK4; MYD88; PELI1 AND TRAF6.
PubMed=16951688; DOI=10.1038/ni1383;
Choi K.C., Lee Y.S., Lim S., Choi H.K., Lee C.H., Lee E.K., Hong S.,
Kim I.H., Kim S.J., Park S.H.;
"Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor
signaling through direct interaction with the adaptor Pellino-1.";
Nat. Immunol. 7:1057-1065(2006).
[10]
INTERACTION WITH RSAD2, AND SUBCELLULAR LOCATION.
PubMed=21435586; DOI=10.1016/j.immuni.2011.03.010;
Saitoh T., Satoh T., Yamamoto N., Uematsu S., Takeuchi O., Kawai T.,
Akira S.;
"Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like
receptor 9-mediated type I interferon production in plasmacytoid dendritic
cells.";
Immunity 34:352-363(2011).
[11]
INTERACTION WITH ZC3H12A.
PubMed=22037600; DOI=10.1038/ni.2137;
Iwasaki H., Takeuchi O., Teraguchi S., Matsushita K., Uehata T.,
Kuniyoshi K., Satoh T., Saitoh T., Matsushita M., Standley D.M., Akira S.;
"The IkappaB kinase complex regulates the stability of cytokine-encoding
mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.";
Nat. Immunol. 12:1167-1175(2011).
-!- FUNCTION: Serine/threonine-protein kinase that plays a critical role in
initiating innate immune response against foreign pathogens. Involved
in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly
recruited by MYD88 to the receptor-signaling complex upon TLR
activation. Association with MYD88 leads to IRAK1 phosphorylation by
IRAK4 and subsequent autophosphorylation and kinase activation.
Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and
PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then,
the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated
IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the
NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA
and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and
activation. Alternatively, phosphorylates TIRAP to promote its
ubiquitination and subsequent degradation. Phosphorylates the
interferon regulatory factor 7 (IRF7) to induce its activation and
translocation to the nucleus, resulting in transcriptional activation
of type I IFN genes, which drive the cell in an antiviral state. When
sumoylated, translocates to the nucleus and phosphorylates STAT3 (By
similarity). {ECO:0000250, ECO:0000269|PubMed:8663605}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
-!- SUBUNIT: Homodimer (By similarity). Forms a complex with TRAF6, PELI1,
IRAK4 and MYD88 (PubMed:16951688). Direct binding of SMAD6 to PELI1
prevents complex formation and hence negatively regulates IL1R-TLR
signaling and eventually NF-kappa-B-mediated gene expression (By
similarity). The TRAF6-PELI1-IRAK4-MYD88 complex recruits MAP3K7/TAK1,
TAB1 and TAB2 to mediate NF-kappa-B activation (By similarity).
Interaction with MYD88 recruits IRAK1 to the stimulated receptor
complex (By similarity). Interacts with TOLLIP; this interaction occurs
in the cytosol prior to receptor activation (By similarity). Interacts
with IL1RL1 (By similarity). Interacts (when polyubiquitinated) with
IKBKG/NEMO (By similarity). Interacts with RSAD2/viperin
(PubMed:21435586). Interacts with IRAK1BP1 (PubMed:11096118). Interacts
with PELI2 (PubMed:12370331). Interacts with ZC3H12A; this interaction
increases the interaction between ZC3H12A and IKBKB/IKKB
(PubMed:22037600). Interacts with IRAK4 (By similarity). Interacts with
PELI3 (By similarity). Interacts with PELI1 and TRAF6 (By similarity).
Interacts with INAVA; the interaction takes place upon PRR stimulation
(By similarity). Interacts (via C-terminus) with NFATC4 (via N-
terminus) (By similarity). {ECO:0000250|UniProtKB:P51617,
ECO:0000269|PubMed:11096118, ECO:0000269|PubMed:12370331,
ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:21435586,
ECO:0000269|PubMed:22037600}.
-!- INTERACTION:
Q62406; P22366: Myd88; NbExp=3; IntAct=EBI-448533, EBI-525108;
Q62406; Q8BST6: Peli2; NbExp=2; IntAct=EBI-448533, EBI-448554;
Q62406; Q793I8: Tifa; NbExp=2; IntAct=EBI-448533, EBI-524817;
Q62406; Q9QZ06: Tollip; NbExp=2; IntAct=EBI-448533, EBI-74272;
Q62406; P39429: Traf2; NbExp=2; IntAct=EBI-448533, EBI-520016;
Q62406-1; Q3THG9: Aarsd1; NbExp=4; IntAct=EBI-488313, EBI-646572;
Q62406-1; P37889-1: Fbln2; NbExp=10; IntAct=EBI-488313, EBI-645953;
Q62406-1; P70196: Traf6; NbExp=4; IntAct=EBI-488313, EBI-448028;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Lipid droplet {ECO:0000269|PubMed:21435586}. Note=Translocates to the
nucleus when sumoylated (By similarity). RSAD2/viperin recruits it to
the lipid droplet. {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q62406-1; Sequence=Displayed;
Name=2;
IsoId=Q62406-2; Sequence=VSP_011852;
-!- TISSUE SPECIFICITY: Highly expressed in liver, followed by kidney and
skeletal muscle. {ECO:0000269|PubMed:8663605}.
-!- DEVELOPMENTAL STAGE: Expressed from 11 dpc to 18 dpc.
{ECO:0000269|PubMed:8663605}.
-!- DOMAIN: The ProST region is composed of many proline and serine
residues (more than 20 of each) and some threonines. This region is the
site of IRAK-1 hyperphosphorylation (By similarity). {ECO:0000250}.
-!- PTM: Following recruitment on the activated receptor complex,
phosphorylated on Thr-209, probably by IRAK4, resulting in a
conformational change of the kinase domain, allowing further
phosphorylations to take place. Thr-387 phosphorylation in the
activation loop is required to achieve full enzymatic activity (By
similarity). {ECO:0000250}.
-!- PTM: Polyubiquitinated by TRAF6 after cell stimulation with IL-1-beta
by PELI1, PELI2 and PELI3. Polyubiquitination occurs with polyubiquitin
chains linked through 'Lys-63'. Ubiquitination promotes interaction
with NEMO/IKBKG. Also sumoylated; leading to nuclear translocation (By
similarity). {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Mice show a loss in TLR7- and TLR9-mediated IFN-
alpha production in plasmacytoid dendritic cells demonstrating an
important role in innate immune response.
{ECO:0000269|PubMed:15767370}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
protein kinase family. Pelle subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAD13224.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AF103876; AAD13224.1; ALT_INIT; mRNA.
EMBL; AY184363; AAO63013.1; -; mRNA.
EMBL; AY184364; AAO63014.1; -; mRNA.
EMBL; AL672002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; U56773; AAC52694.2; -; mRNA.
CCDS; CCDS30219.2; -. [Q62406-1]
CCDS; CCDS53103.1; -. [Q62406-2]
RefSeq; NP_001171445.1; NM_001177974.1. [Q62406-1]
RefSeq; NP_001171447.1; NM_001177976.1. [Q62406-2]
RefSeq; NP_032389.2; NM_008363.2. [Q62406-1]
SMR; Q62406; -.
BioGRID; 200627; 24.
DIP; DIP-31491N; -.
ELM; Q62406; -.
IntAct; Q62406; 28.
STRING; 10090.ENSMUSP00000033769; -.
iPTMnet; Q62406; -.
PhosphoSitePlus; Q62406; -.
PRIDE; Q62406; -.
Antibodypedia; 3845; 983 antibodies.
Ensembl; ENSMUST00000068286; ENSMUSP00000064448; ENSMUSG00000031392. [Q62406-1]
Ensembl; ENSMUST00000114352; ENSMUSP00000109992; ENSMUSG00000031392. [Q62406-1]
Ensembl; ENSMUST00000114360; ENSMUSP00000110000; ENSMUSG00000031392. [Q62406-2]
GeneID; 16179; -.
KEGG; mmu:16179; -.
UCSC; uc009tnn.2; mouse. [Q62406-1]
UCSC; uc012hkn.1; mouse. [Q62406-2]
CTD; 3654; -.
MGI; MGI:107420; Irak1.
GeneTree; ENSGT00940000160502; -.
InParanoid; Q62406; -.
KO; K04730; -.
BRENDA; 2.7.10.2; 3474.
Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
Reactome; R-MMU-168638; NOD1/2 Signaling Pathway.
Reactome; R-MMU-209543; p75NTR recruits signalling complexes.
Reactome; R-MMU-209560; NF-kB is activated and signals survival.
Reactome; R-MMU-445989; TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
Reactome; R-MMU-450302; activated TAK1 mediates p38 MAPK activation.
Reactome; R-MMU-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-MMU-9020702; Interleukin-1 signaling.
Reactome; R-MMU-937039; IRAK1 recruits IKK complex.
Reactome; R-MMU-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
Reactome; R-MMU-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
Reactome; R-MMU-975144; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
Reactome; R-MMU-975155; MyD88 dependent cascade initiated on endosome.
BioGRID-ORCS; 16179; 0 hits in 12 CRISPR screens.
ChiTaRS; Irak1; mouse.
PRO; PR:Q62406; -.
Proteomes; UP000000589; Chromosome X.
RNAct; Q62406; protein.
Bgee; ENSMUSG00000031392; Expressed in pancreas and 284 other tissues.
ExpressionAtlas; Q62406; baseline and differential.
Genevisible; Q62406; MM.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005811; C:lipid droplet; IDA:UniProtKB.
GO; GO:0016020; C:membrane; IDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0031072; F:heat shock protein binding; ISO:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0005149; F:interleukin-1 receptor binding; IPI:MGI.
GO; GO:0016301; F:kinase activity; ISO:MGI.
GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:0004672; F:protein kinase activity; IDA:MGI.
GO; GO:0004674; F:protein serine/threonine kinase activity; ISO:MGI.
GO; GO:0007250; P:activation of NF-kappaB-inducing kinase activity; ISO:MGI.
GO; GO:0034605; P:cellular response to heat; ISO:MGI.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IDA:MGI.
GO; GO:0045087; P:innate immune response; IEP:UniProtKB.
GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IDA:UniProtKB.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0007254; P:JNK cascade; ISO:MGI.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IDA:MGI.
GO; GO:0090370; P:negative regulation of cholesterol efflux; IMP:UniProtKB.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISO:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISO:MGI.
GO; GO:0043507; P:positive regulation of JUN kinase activity; IMP:BHF-UCL.
GO; GO:1904996; P:positive regulation of leukocyte adhesion to vascular endothelial cell; ISO:MGI.
GO; GO:0043406; P:positive regulation of MAP kinase activity; IMP:BHF-UCL.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:MGI.
GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISO:MGI.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISO:MGI.
GO; GO:0032481; P:positive regulation of type I interferon production; ISO:MGI.
GO; GO:0046777; P:protein autophosphorylation; IDA:MGI.
GO; GO:0006468; P:protein phosphorylation; ISO:MGI.
GO; GO:0001959; P:regulation of cytokine-mediated signaling pathway; ISO:MGI.
GO; GO:0070555; P:response to interleukin-1; ISO:MGI.
GO; GO:0032496; P:response to lipopolysaccharide; IDA:MGI.
GO; GO:0032494; P:response to peptidoglycan; IDA:MGI.
GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IDA:MGI.
GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IDA:MGI.
GO; GO:0060337; P:type I interferon signaling pathway; ISO:MGI.
CDD; cd08794; Death_IRAK1; 1.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR000488; Death_domain.
InterPro; IPR035533; Death_IRAK1.
InterPro; IPR035536; IRAK1.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR24419:SF1; PTHR24419:SF1; 1.
Pfam; PF00531; Death; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF47986; SSF47986; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
Alternative splicing; ATP-binding; Cytoplasm; Immunity; Innate immunity;
Isopeptide bond; Kinase; Lipid droplet; Magnesium; Nucleotide-binding;
Nucleus; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Transferase; Ubl conjugation.
CHAIN 1..710
/note="Interleukin-1 receptor-associated kinase 1"
/id="PRO_0000086031"
DOMAIN 27..106
/note="Death"
DOMAIN 212..521
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 218..226
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 342..345
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
REGION 110..211
/note="ProST region"
/evidence="ECO:0000250"
ACT_SITE 340
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 239
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
BINDING 358
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 66
/note="Phosphothreonine; by PKC/PRKCI"
/evidence="ECO:0000250|UniProtKB:P51617"
MOD_RES 131
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P51617"
MOD_RES 209
/note="Phosphothreonine; by IRAK4"
/evidence="ECO:0000250|UniProtKB:P51617"
MOD_RES 375
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P51617"
MOD_RES 387
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P51617"
MOD_RES 553
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P51617"
CROSSLNK 134
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:P51617"
CROSSLNK 180
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:P51617"
VAR_SEQ 691..710
/note="GLDLEPEKSQGPEESDEFQS -> DFVDIDAIGIEAFMSELFINHI (in
isoform 2)"
/evidence="ECO:0000303|PubMed:10723722"
/id="VSP_011852"
MUTAGEN 66
/note="T->A: Abolishes dimerization."
/evidence="ECO:0000269|PubMed:12138165"
MUTAGEN 66
/note="T->E: Abolishes dimerization."
/evidence="ECO:0000269|PubMed:12138165"
CONFLICT 702
/note="P -> L (in Ref. 2; AAO63013)"
/evidence="ECO:0000305"
SEQUENCE 710 AA; 77269 MW; 8A501F002CD3EBD2 CRC64;
MAGGPGPGEP VVPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE
RSEQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPVVP PSTAAPRPSS
ISAGSEAGDW SPRKLQSSAS TFLSPAFPGS QTHSESELLQ VPLPVSLGPP LPSSAPSSTK
SSPESPVSGL QRAHPSPFCW PFCEISQGTC NFSEELRIGE GGFGCVYRAV MRNTTYAVKR
LKEEADLEWT MVKQSFLTEV EQLSRFRHPN IVDFAGYCAE SGLYCLVYGF LPNGSLEDQL
HLQTQACSPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE RLMPKLGDFG
LARFSRFAGA KASQSSTVAR TSTVRGTLAY LPEEYIKTGR LAVDTDTFSF GVVILETLAG
QRAVRTQGAK TKYLKDLIED EAEEAGVTLK STQPTLWVGV ATDAWAAPIA AQIYKKHLDS
RPGPCPPQLG LALAQLACCC MHRRAKKRPP MTQVYKRLEG LQAGPPWELE VAGHGSPSPQ
ENSYMSTTGS AQSGDEPWQP LVVTTRAPAQ AAQQLQRSPN QPVESDESVP GLSATLHSWH
LTPGSHPSPA SFREASCTQG GTTRESSVRS SPGFQPTTME GSPTGSSSLL SSEPPQIIIN
PARQKMVQKL ALYEEGVLDS LQLLSSGFFP GLDLEPEKSQ GPEESDEFQS


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Catalog number Product name Quantity
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Pathways :
WP88: Toll Like Receptor signaling
WP1493: Carbon assimilation C4 pathway
WP1701: Starch and sucrose metabolism
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1653: Galactose metabolism
WP2292: Chemokine signaling pathway
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1681: Pantothenate and CoA biosynthesis
WP1844: MAP kinase cascade
WP2272: Pathogenic Escherichia coli infection
WP1946: Cori Cycle
WP32: Translation Factors
WP1703: Streptomycin biosynthesis
WP1567: Glycolysis and Gluconeogenesis
WP1619: Amino sugar and nucleotide sugar metabolism
WP253: Glycolysis
WP1693: Purine metabolism
WP2218: sGC
WP581: EPO Receptor Signaling
WP1183: Toll-like receptor signaling pathway
WP1654: gamma-Hexachlorocyclohexane degradation
WP1913: Signaling by Insulin receptor
WP274: B Cell Receptor Signaling Pathway
WP813: G Protein Signaling Pathways
WP1004: Kit Receptor Signaling Pathway

Related Genes :
[Irak1 Il1rak] Interleukin-1 receptor-associated kinase 1 (IRAK) (IRAK-1) (EC 2.7.11.1) (Pelle-like protein kinase) (mPLK)
[IRAK3] Interleukin-1 receptor-associated kinase 3 (IRAK-3) (EC 2.7.11.1) (IL-1 receptor-associated kinase M) (IRAK-M)
[Irak3] Interleukin-1 receptor-associated kinase 3 (IRAK-3) (EC 2.7.11.1) (IL-1 receptor-associated kinase M) (IRAK-M)
[IRAK1 IRAK] Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
[IRAK4] Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)
[Irak4] Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1)
[Irak1bp1 Aip70 Simpl] Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1-binding protein 1) (ActA-binding protein 70) (PLK-interacting protein) (Signaling molecule that associates with the mouse pelle-like kinase) (SIMPL)
[IRAK2] Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)
[Irak2] Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) (mu-IRAK-2)
[Irak1 Irak1_predicted rCG_43846] Interleukin-1 receptor-associated kinase 1 (Interleukin-1 receptor-associated kinase 1 (Predicted)) (Irak1 protein)
[IRAK4] Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1)
[pll CG5974] Serine/threonine-protein kinase pelle (EC 2.7.11.1)
[Irak2] Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)
[TRAF6 RNF85] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
[IRAK2] Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)
[RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092] Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Il1rap] Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-33 receptot beta chain)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Map3k7 Tak1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[IRAK1BP1] Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1-binding protein 1)
[Il1rl1 Ly84 St2 Ste2] Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1)
[CHUK IKKA TCF16] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[ERECTA ER QRP1 QRS1 TE1 At2g26330 T1D16.3] LRR receptor-like serine/threonine-protein kinase ERECTA (EC 2.7.11.1) (Protein QUANTITATIVE RESISTANCE TO PLECTOSPHAERELLA 1) (Protein QUANTITATIVE RESISTANCE TO RALSTONIA SOLANACEARUM 1) (Protein TRANSPIRATION EFFICIENCY 1)
[Chuk Ikka] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[AHK4 CRE1 RAW1 WOL At2g01830 T23K3.2] Histidine kinase 4 (EC 2.7.13.3) (Arabidopsis histidine kinase 4) (AtHK4) (Cytokinin receptor CYTOKININ RESPONSE 1) (AtCRE1) (Cytokinin receptor CRE1) (Phosphoprotein phosphatase AHK4) (EC 3.1.3.16) (Protein AUTHENTIC HIS-KINASE 4) (Protein ROOT AS IN WOL 1) (Protein WOODEN LEG)
[hchA A8C65_13880 A9R57_25255 AMK83_16550 AWB10_10580 AWG90_013200 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BON65_01250 BON66_15955 BON86_06490 BON95_14610 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP047_03567 BvCmsSINP011_04162 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 C9Z23_21970 C9Z37_00915 C9Z43_06360 C9Z78_05610 CDC27_10055 CDL37_00765 CI693_17820 CI694_25210 CIG45_02340 COD46_23180 CQP61_17160 CRD98_26150 D2188_01360 D4628_09465 D6T98_10515 D6X36_17295 D9D20_21030 D9D43_06110 D9G29_20785 D9G69_01560 D9H68_20750 D9H70_25730 D9I87_15275 D9J58_04360 D9S45_22925 DEN89_24995 DEO04_05510 DL705_18425 DL800_09215 DLU50_17670 DLW88_16170 DLY44_04800 DND16_20085 DNR35_16895 DQE83_22775 DQP61_11280 DTL43_21780 DTZ20_09315 DU321_04440 DXT73_20690 E2134_24005 E2135_17195 E2855_02503 E2863_02392 E4K55_17625 E4K61_03800 E5P22_21380 E5S46_06650 EA213_19000 EA225_13320 EAX79_27320 EC95NR1_00961 ED648_25045 EG796_17135 EHD79_18540 EI028_00085 ELT20_21515 ELV08_24970 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 ExPECSC019_03873 ExPECSC038_01920 EXX71_02385 EXX78_21815 EYD11_09165 F7F11_20115 F7F18_11615 F7F29_22635 FNJ83_13175 FQ915_04255 FQR64_09390 FQZ46_21375 FWK02_18105 FZ043_14730 GIY13_02485 GNZ00_15670 GNZ02_11235 GNZ03_00440 GP712_09450 GQE64_12165 GQL64_10635 GQM17_02800 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC10974_02300 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13216_04667 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[Il1rl1 Fit1] Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Fit-1) (Fos-responsive gene 1 protein)

Bibliography :