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Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)

 I10R2_HUMAN             Reviewed;         325 AA.
Q08334; Q9BUU4;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 2.
16-OCT-2019, entry version 181.
RecName: Full=Interleukin-10 receptor subunit beta;
Short=IL-10 receptor subunit beta;
Short=IL-10R subunit beta;
Short=IL-10RB;
AltName: Full=Cytokine receptor class-II member 4;
AltName: Full=Cytokine receptor family 2 member 4;
Short=CRF2-4;
AltName: Full=Interleukin-10 receptor subunit 2;
Short=IL-10R subunit 2;
Short=IL-10R2;
AltName: CD_antigen=CDw210b;
Flags: Precursor;
Name=IL10RB; Synonyms=CRFB4, D21S58, D21S66;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fetal brain;
PubMed=8314576; DOI=10.1006/geno.1993.1199;
Lutfalla G., Gardiner K., Uze G.;
"A new member of the cytokine receptor gene family maps on chromosome
21 at less than 35 kb from IFNAR.";
Genomics 16:366-373(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=7563119; DOI=10.1007/bf00186545;
Lutfalla G., McInnis M.G., Antonarakis S.E., Uze G.;
"Structure of the human CRFB4 gene: comparison with its IFNAR
neighbor.";
J. Mol. Evol. 41:338-344(1995).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLU-47.
SeattleSNPs variation discovery resource;
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PROTEIN SEQUENCE OF 20-34.
PubMed=15340161; DOI=10.1110/ps.04682504;
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally
verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[7]
CHARACTERIZATION.
PubMed=9312047; DOI=10.1093/emboj/16.19.5894;
Kotenko S.V., Krause C.D., Izotova L.S., Pollack B.P., Wu W.,
Pestka S.;
"Identification and functional characterization of a second chain of
the interleukin-10 receptor complex.";
EMBO J. 16:5894-5903(1997).
[8]
CHARACTERIZATION.
PubMed=10875937; DOI=10.1074/jbc.m005304200;
Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J.,
Wood W.I., Goddard A.D., Gurney A.L.;
"Interleukin (IL)-22, a novel human cytokine that signals through the
interferon receptor-related proteins CRF2-4 and IL-22R.";
J. Biol. Chem. 275:31335-31339(2000).
[9]
FUNCTION, AND SUBUNIT.
PubMed=12469119; DOI=10.1038/ni873;
Sheppard P., Kindsvogel W., Xu W., Henderson K., Schlutsmeyer S.,
Whitmore T.E., Kuestner R., Garrigues U., Birks C., Roraback J.,
Ostrander C., Dong D., Shin J., Presnell S., Fox B., Haldeman B.,
Cooper E., Taft D., Gilbert T., Grant F.J., Tackett M., Krivan W.,
McKnight G., Clegg C., Foster D., Klucher K.M.;
"IL-28, IL-29 and their class II cytokine receptor IL-28R.";
Nat. Immunol. 4:63-68(2003).
[10]
FUNCTION.
PubMed=15123776; DOI=10.1189/jlb.0204117;
Donnelly R.P., Sheikh F., Kotenko S.V., Dickensheets H.;
"The expanded family of class II cytokines that share the IL-10
receptor-2 (IL-10R2) chain.";
J. Leukoc. Biol. 76:314-321(2004).
[11]
INVOLVEMENT IN SUSCEPTIBILITY TO HBV INFECTION, VARIANT GLU-47, AND
CHARACTERIZATION OF VARIANT GLU-47.
PubMed=16757563; DOI=10.1073/pnas.0602800103;
Frodsham A.J., Zhang L., Dumpis U., Taib N.A.M., Best S., Durham A.,
Hennig B.J.W., Hellier S., Knapp S., Wright M., Chiaramonte M.,
Bell J.I., Graves M., Whittle H.C., Thomas H.C., Thursz M.R.,
Hill A.V.S.;
"Class II cytokine receptor gene cluster is a major locus for
hepatitis B persistence.";
Proc. Natl. Acad. Sci. U.S.A. 103:9148-9153(2006).
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19413330; DOI=10.1021/ac9004309;
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
Mohammed S.;
"Lys-N and trypsin cover complementary parts of the phosphoproteome in
a refined SCX-based approach.";
Anal. Chem. 81:4493-4501(2009).
[13]
INVOLVEMENT IN IBD25.
PubMed=19890111; DOI=10.1056/nejmoa0907206;
Glocker E.O., Kotlarz D., Boztug K., Gertz E.M., Schaffer A.A.,
Noyan F., Perro M., Diestelhorst J., Allroth A., Murugan D.,
Hatscher N., Pfeifer D., Sykora K.W., Sauer M., Kreipe H., Lacher M.,
Nustede R., Woellner C., Baumann U., Salzer U., Koletzko S., Shah N.,
Segal A.W., Sauerbrey A., Buderus S., Snapper S.B., Grimbacher B.,
Klein C.;
"Inflammatory bowel disease and mutations affecting the interleukin-10
receptor.";
N. Engl. J. Med. 361:2033-2045(2009).
[14]
X-RAY CRYSTALLOGRAPHY (2.14 ANGSTROMS) OF 20-220, AND DISULFIDE BONDS.
PubMed=20462497; DOI=10.1016/j.str.2010.02.009;
Yoon S.I., Jones B.C., Logsdon N.J., Harris B.D., Deshpande A.,
Radaeva S., Halloran B.A., Gao B., Walter M.R.;
"Structure and mechanism of receptor sharing by the IL-10R2 common
chain.";
Structure 18:638-648(2010).
-!- FUNCTION: Shared cell surface receptor required for the activation
of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The
IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2
and IFNL3 and mediates their antiviral activity. The
ligand/receptor complex stimulate the activation of the JAK/STAT
signaling pathway leading to the expression of IFN-stimulated
genes (ISG), which contribute to the antiviral state.
{ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:15123776}.
-!- SUBUNIT: Heterodimer with IFNLR1. {ECO:0000269|PubMed:12469119}.
-!- INTERACTION:
P22301:IL10; NbExp=2; IntAct=EBI-11175900, EBI-1031632;
Q9GZX6:IL22; NbExp=2; IntAct=EBI-11175900, EBI-8040250;
Q8N6P7:IL22RA1; NbExp=5; IntAct=EBI-11175900, EBI-3940749;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- POLYMORPHISM: Genetic variations in IL10RB influence
susceptibility to hepatitis B virus (HBV) infection [MIM:610424].
-!- DISEASE: Inflammatory bowel disease 25 (IBD25) [MIM:612567]: A
chronic, relapsing inflammation of the gastrointestinal tract with
a complex etiology. It is subdivided into Crohn disease and
ulcerative colitis phenotypes. Crohn disease may affect any part
of the gastrointestinal tract from the mouth to the anus, but most
frequently it involves the terminal ileum and colon. Bowel
inflammation is transmural and discontinuous; it may contain
granulomas or be associated with intestinal or perianal fistulas.
In contrast, in ulcerative colitis, the inflammation is continuous
and limited to rectal and colonic mucosal layers; fistulas and
granulomas are not observed. Both diseases include extraintestinal
inflammation of the skin, eyes, or joints.
{ECO:0000269|PubMed:19890111}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the type II cytokine receptor family.
{ECO:0000305}.
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/il10rb/";
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EMBL; Z17227; CAA78933.1; -; mRNA.
EMBL; U08988; AAA86872.1; -; Genomic_DNA.
EMBL; BT009777; AAP88779.1; -; mRNA.
EMBL; AY323826; AAP72016.1; -; Genomic_DNA.
EMBL; BC001903; AAH01903.1; -; mRNA.
CCDS; CCDS13623.1; -.
PIR; A47003; A47003.
RefSeq; NP_000619.3; NM_000628.4.
PDB; 3LQM; X-ray; 2.14 A; A/B=20-220.
PDB; 5T5W; X-ray; 2.85 A; A=19-220.
PDBsum; 3LQM; -.
PDBsum; 5T5W; -.
SMR; Q08334; -.
BioGrid; 109802; 3.
CORUM; Q08334; -.
DIP; DIP-6016N; -.
IntAct; Q08334; 5.
STRING; 9606.ENSP00000290200; -.
ChEMBL; CHEMBL3831284; -.
iPTMnet; Q08334; -.
PhosphoSitePlus; Q08334; -.
SwissPalm; Q08334; -.
BioMuta; IL10RB; -.
DMDM; 56757647; -.
EPD; Q08334; -.
jPOST; Q08334; -.
MassIVE; Q08334; -.
MaxQB; Q08334; -.
PaxDb; Q08334; -.
PeptideAtlas; Q08334; -.
PRIDE; Q08334; -.
ProteomicsDB; 58594; -.
DNASU; 3588; -.
Ensembl; ENST00000290200; ENSP00000290200; ENSG00000243646.
GeneID; 3588; -.
KEGG; hsa:3588; -.
UCSC; uc002yrk.3; human.
CTD; 3588; -.
DisGeNET; 3588; -.
GeneCards; IL10RB; -.
HGNC; HGNC:5965; IL10RB.
HPA; CAB020670; -.
HPA; HPA047550; -.
MalaCards; IL10RB; -.
MIM; 123889; gene.
MIM; 610424; phenotype.
MIM; 612567; phenotype.
neXtProt; NX_Q08334; -.
OpenTargets; ENSG00000243646; -.
Orphanet; 238569; Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome.
PharmGKB; PA29780; -.
eggNOG; ENOG410IER7; Eukaryota.
eggNOG; ENOG410YTBJ; LUCA.
GeneTree; ENSGT00940000158231; -.
InParanoid; Q08334; -.
KO; K05135; -.
OMA; PETWTMK; -.
OrthoDB; 892736at2759; -.
PhylomeDB; Q08334; -.
TreeFam; TF332537; -.
Reactome; R-HSA-449836; Other interleukin signaling.
Reactome; R-HSA-6783783; Interleukin-10 signaling.
Reactome; R-HSA-8854691; Interleukin-20 family signaling.
SignaLink; Q08334; -.
SIGNOR; Q08334; -.
ChiTaRS; IL10RB; human.
EvolutionaryTrace; Q08334; -.
GeneWiki; Interleukin_10_receptor,_beta_subunit; -.
GenomeRNAi; 3588; -.
Pharos; Q08334; -.
PRO; PR:Q08334; -.
Proteomes; UP000005640; Chromosome 21.
Bgee; ENSG00000243646; Expressed in 224 organ(s), highest expression level in sigmoid colon.
ExpressionAtlas; Q08334; baseline and differential.
Genevisible; Q08334; HS.
GO; GO:0016021