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Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA)

 I11RA_HUMAN             Reviewed;         422 AA.
Q14626; Q16542; Q5VZ80; Q7KYJ7;
23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
23-NOV-2004, sequence version 2.
12-AUG-2020, entry version 152.
RecName: Full=Interleukin-11 receptor subunit alpha {ECO:0000305};
Short=IL-11 receptor subunit alpha;
Short=IL-11R subunit alpha;
Short=IL-11R-alpha;
Short=IL-11RA;
Contains:
RecName: Full=Soluble interleukin-11 receptor subunit alpha {ECO:0000305};
Short=sIL-11R {ECO:0000303|PubMed:26876177};
Short=sIL-11RA;
Short=sIL11RA {ECO:0000305};
Flags: Precursor;
Name=IL11RA {ECO:0000312|HGNC:HGNC:5967};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HCR1 AND HCR2), AND TISSUE
SPECIFICITY.
TISSUE=Muscle;
PubMed=7670098;
Cherel M., Sorel M., Lebeau B., Dubois S., Moreau J.-F., Bataille R.,
Minvielle S., Jacques Y.;
"Molecular cloning of two isoforms of a receptor for the human
hematopoietic cytokine interleukin-11.";
Blood 86:2534-2540(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM HCR1).
PubMed=8808281; DOI=10.1006/geno.1996.0010;
Van Leuven F., Stas L., Hilliker C., Miyake Y., Bilinski P., Gossler A.;
"Molecular cloning and characterization of the human interleukin-11
receptor alpha-chain gene, IL11RA, located on chromosome 9p13.";
Genomics 31:65-70(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HCR1).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-65 AND TRP-395.
SeattleSNPs variation discovery resource;
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164053; DOI=10.1038/nature02465;
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HCR1).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
TISSUE SPECIFICITY.
PubMed=11141475; DOI=10.1016/s0002-9440(10)63940-5;
Campbell C.L., Jiang Z., Savarese D.M., Savarese T.M.;
"Increased expression of the interleukin-11 receptor and evidence of STAT3
activation in prostate carcinoma.";
Am. J. Pathol. 158:25-32(2001).
[9]
FUNCTION (ISOFORM HCR2), PROTEOLYTIC CLEAVAGE, MUTAGENESIS OF ARG-355, AND
SUBCELLULAR LOCATION.
PubMed=26876177; DOI=10.1016/j.celrep.2016.01.053;
Lokau J., Nitz R., Agthe M., Monhasery N., Aparicio-Siegmund S.,
Schumacher N., Wolf J., Moeller-Hackbarth K., Waetzig G.H., Groetzinger J.,
Mueller-Newen G., Rose-John S., Scheller J., Garbers C.;
"Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.";
Cell Rep. 14:1761-1773(2016).
[10]
FUNCTION (ISOFORM HCR2).
PubMed=30279168; DOI=10.1126/scisignal.aar7388;
Lamertz L., Rummel F., Polz R., Baran P., Hansen S., Waetzig G.H.,
Moll J.M., Floss D.M., Scheller J.;
"Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling
but not intracellular autocrine responses.";
Sci. Signal. 11:0-0(2018).
[11]
VARIANTS CRSDA ARG-221; CYS-245; TRP-296 AND THR-TRP-SER-308 INS,
CHARACTERIZATION OF VARIANT CRSDA TRP-296, AND FUNCTION.
PubMed=21741611; DOI=10.1016/j.ajhg.2011.05.024;
Nieminen P., Morgan N.V., Fenwick A.L., Parmanen S., Veistinen L.,
Mikkola M.L., van der Spek P.J., Giraud A., Judd L., Arte S., Brueton L.A.,
Wall S.A., Mathijssen I.M., Maher E.R., Wilkie A.O., Kreiborg S.,
Thesleff I.;
"Inactivation of IL11 signaling causes craniosynostosis, delayed tooth
eruption, and supernumerary teeth.";
Am. J. Hum. Genet. 89:67-81(2011).
-!- FUNCTION: Receptor for interleukin-11 (IL11). The receptor systems for
IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating
signal transmission. The IL11/IL11RA/IL6ST complex may be involved in
the control of proliferation and/or differentiation of skeletogenic
progenitor or other mesenchymal cells (Probable). Essential for the
normal development of craniofacial bones and teeth. Restricts suture
fusion and tooth number. {ECO:0000269|PubMed:21741611, ECO:0000305}.
-!- FUNCTION: [Soluble interleukin-11 receptor subunit alpha]: Soluble form
of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity
(PubMed:30279168, PubMed:26876177). The IL11:sIL11RA complex binds to
IL6ST/gp130 on cell surfaces and induces signaling also on cells that
do not express membrane-bound IL11RA in a process called IL11 trans-
signaling (PubMed:30279168, PubMed:26876177).
{ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:30279168}.
-!- FUNCTION: [Isoform HCR2]: Soluble form of IL11 receptor (sIL11RA) that
acts as an agonist of IL11 activity (PubMed:30279168, PubMed:26876177).
The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and
induces signaling also on cells that do not express membrane-bound
IL11RA in a process called IL11 trans-signaling (PubMed:30279168,
PubMed:26876177). {ECO:0000269|PubMed:26876177,
ECO:0000269|PubMed:30279168}.
-!- SUBUNIT: On IL11 binding, forms a multimer complex with IL6ST/gp130.
{ECO:0000305|PubMed:26876177, ECO:0000305|PubMed:30279168}.
-!- INTERACTION:
Q14626; Q6UX06: OLFM4; NbExp=3; IntAct=EBI-13638581, EBI-2804156;
-!- SUBCELLULAR LOCATION: [Interleukin-11 receptor subunit alpha]: Membrane
{ECO:0000269|PubMed:26876177}; Single-pass type I membrane protein
{ECO:0000255}.
-!- SUBCELLULAR LOCATION: [Soluble interleukin-11 receptor subunit alpha]:
Secreted {ECO:0000269|PubMed:26876177}.
-!- SUBCELLULAR LOCATION: [Isoform HCR2]: Secreted
{ECO:0000269|PubMed:26876177}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=HCR1 {ECO:0000303|PubMed:7670098}; Synonyms=Membrane form, mIL11RA
{ECO:0000303|PubMed:26876177};
IsoId=Q14626-1; Sequence=Displayed;
Name=HCR2 {ECO:0000303|PubMed:7670098}; Synonyms=Soluble form, sIL11RA
{ECO:0000303|PubMed:26876177};
IsoId=Q14626-2; Sequence=VSP_011879;
-!- TISSUE SPECIFICITY: Expressed in a number of cell lines, including the
myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell
line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma
cell lines, MG-63 and SaOS-2 (PubMed:7670098). Also expressed in normal
and malignant prostate epithelial cell lines. Expression levels are
increased in prostate carcinoma. {ECO:0000269|PubMed:11141475,
ECO:0000269|PubMed:7670098}.
-!- PTM: A short soluble form is also released from the membrane by
proteolysis (PubMed:26876177). The sIL11RA is formed either by limited
proteolysis of membrane-bound receptors, a process referred to as
ectodomain shedding, or directly secreted from the cells after
alternative mRNA splicing (PubMed:26876177). mIL11RA is cleaved by the
proteases ADAM10, ELANE and PRTN3 (PubMed:26876177).
{ECO:0000269|PubMed:26876177}.
-!- DISEASE: Craniosynostosis and dental anomalies (CRSDA) [MIM:614188]: A
disorder characterized by craniosynostosis, maxillary hypoplasia, and
dental anomalies, including malocclusion, delayed and ectopic tooth
eruption, and/or supernumerary teeth. Some patients also display minor
digit anomalies, such as syndactyly and/or clinodactyly.
{ECO:0000269|PubMed:21741611}. Note=The disease is caused by mutations
affecting the gene represented in this entry.
-!- MISCELLANEOUS: [Isoform HCR2]: Lacks the entire cytoplasmic domain.
{ECO:0000305}.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
subfamily. {ECO:0000305}.
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/il11ra/";
---------------------------------------------------------------------------
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EMBL; Z38102; CAA86224.1; -; mRNA.
EMBL; Z46595; CAA86570.1; -; mRNA.
EMBL; U32323; AAB36491.1; -; Genomic_DNA.
EMBL; U32324; AAB36492.1; -; mRNA.
EMBL; BT009864; AAP88866.1; -; mRNA.
EMBL; AY532110; AAS00093.1; -; Genomic_DNA.
EMBL; AL162231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471071; EAW58423.1; -; Genomic_DNA.
EMBL; BC003110; AAH03110.1; -; mRNA.
CCDS; CCDS6567.1; -. [Q14626-1]
PIR; I37891; I37891.
RefSeq; NP_001136256.1; NM_001142784.2. [Q14626-1]
PDB; 6O4P; X-ray; 3.43 A; A/B=23-363.
PDBsum; 6O4P; -.
SMR; Q14626; -.
DIP; DIP-3776N; -.
IntAct; Q14626; 2.
STRING; 9606.ENSP00000450565; -.
ChEMBL; CHEMBL2050; -.
DrugBank; DB00038; Oprelvekin.
DrugCentral; Q14626; -.
GlyGen; Q14626; 2 sites.
iPTMnet; Q14626; -.
PhosphoSitePlus; Q14626; -.
BioMuta; IL11RA; -.
DMDM; 55976300; -.
MassIVE; Q14626; -.
PaxDb; Q14626; -.
PeptideAtlas; Q14626; -.
PRIDE; Q14626; -.
ProteomicsDB; 60076; -. [Q14626-1]
ProteomicsDB; 60077; -. [Q14626-2]
Antibodypedia; 25597; 311 antibodies.
DNASU; 3590; -.
Ensembl; ENST00000318041; ENSP00000326500; ENSG00000137070. [Q14626-1]
Ensembl; ENST00000441545; ENSP00000394391; ENSG00000137070. [Q14626-1]
Ensembl; ENST00000555003; ENSP00000450565; ENSG00000137070. [Q14626-1]
Ensembl; ENST00000602473; ENSP00000473647; ENSG00000137070. [Q14626-2]
GeneID; 3590; -.
KEGG; hsa:3590; -.
UCSC; uc031tdp.2; human. [Q14626-1]
CTD; 3590; -.
DisGeNET; 3590; -.
EuPathDB; HostDB:ENSG00000137070.17; -.
GeneCards; IL11RA; -.
HGNC; HGNC:5967; IL11RA.
HPA; ENSG00000137070; Low tissue specificity.
MalaCards; IL11RA; -.
MIM; 600939; gene.
MIM; 614188; phenotype.
neXtProt; NX_Q14626; -.
OpenTargets; ENSG00000137070; -.
Orphanet; 284149; Craniosynostosis-dental anomalies.
PharmGKB; PA29782; -.
eggNOG; ENOG502R7G6; Eukaryota.
GeneTree; ENSGT00940000160904; -.
HOGENOM; CLU_047259_0_1_1; -.
InParanoid; Q14626; -.
KO; K05056; -.
OMA; RDPLEQM; -.
PhylomeDB; Q14626; -.
TreeFam; TF331210; -.
PathwayCommons; Q14626; -.
Reactome; R-HSA-6788467; IL-6-type cytokine receptor ligand interactions.
SignaLink; Q14626; -.
SIGNOR; Q14626; -.
BioGRID-ORCS; 3590; 2 hits in 874 CRISPR screens.
GeneWiki; Interleukin_11_receptor_alpha_subunit; -.
GenomeRNAi; 3590; -.
Pharos; Q14626; Tclin.
PRO; PR:Q14626; -.
Proteomes; UP000005640; Chromosome 9.
RNAct; Q14626; protein.
Bgee; ENSG00000137070; Expressed in stomach and 208 other tissues.
ExpressionAtlas; Q14626; baseline and differential.
Genevisible; Q14626; HS.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
GO; GO:0019970; F:interleukin-11 binding; IBA:GO_Central.
GO; GO:0004921; F:interleukin-11 receptor activity; IBA:GO_Central.
GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0032502; P:developmental process; IMP:UniProtKB.
GO; GO:0060322; P:head development; IMP:UniProtKB.
GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
SMART; SM00060; FN3; 2.
SMART; SM00409; IG; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 2.
PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
PROSITE; PS50835; IG_LIKE; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Craniosynostosis; Disease mutation;
Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1..22
/evidence="ECO:0000255"
CHAIN 23..422
/note="Interleukin-11 receptor subunit alpha"
/id="PRO_0000010913"
CHAIN 23..?
/note="Soluble interleukin-11 receptor subunit alpha"
/id="PRO_0000450688"
TOPO_DOM 24..370
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 371..391
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 392..422
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 27..110
/note="Ig-like C2-type"
DOMAIN 112..219
/note="Fibronectin type-III 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
DOMAIN 220..317
/note="Fibronectin type-III 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
MOTIF 304..308
/note="WSXWS motif"
CARBOHYD 127
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 194
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 48..94
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 120..130
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 170..180
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
VAR_SEQ 391..422
/note="Missing (in isoform HCR2)"
/evidence="ECO:0000303|PubMed:7670098"
/id="VSP_011879"
VARIANT 65
/note="P -> T (in dbSNP:rs11575589)"
/evidence="ECO:0000269|Ref.4"
/id="VAR_019821"
VARIANT 221
/note="P -> R (in CRSDA; dbSNP:rs387906785)"
/evidence="ECO:0000269|PubMed:21741611"
/id="VAR_066666"
VARIANT 245
/note="S -> C (in CRSDA; dbSNP:rs387906786)"
/evidence="ECO:0000269|PubMed:21741611"
/id="VAR_066667"
VARIANT 296
/note="R -> W (in CRSDA; renders the receptor unable to
mediate the IL11 signal; dbSNP:rs387906784)"
/evidence="ECO:0000269|PubMed:21741611"
/id="VAR_066668"
VARIANT 308
/note="S -> STWS (in CRSDA)"
/id="VAR_066669"
VARIANT 395
/note="R -> W (in dbSNP:rs11575580)"
/evidence="ECO:0000269|Ref.4"
/id="VAR_019822"
MUTAGEN 355
/note="R->E: Decreases proteolyisis by ADAM10."
/evidence="ECO:0000269|PubMed:26876177"
SEQUENCE 422 AA; 45222 MW; 1F8BC05C139FC326 CRC64;
MSSSCSGLSR VLVAVATALV SASSPCPQAW GPPGVQYGQP GRSVKLCCPG VTAGDPVSWF
RDGEPKLLQG PDSGLGHELV LAQADSTDEG TYICQTLDGA LGGTVTLQLG YPPARPVVSC
QAADYENFSC TWSPSQISGL PTRYLTSYRK KTVLGADSQR RSPSTGPWPC PQDPLGAARC
VVHGAEFWSQ YRINVTEVNP LGASTRLLDV SLQSILRPDP PQGLRVESVP GYPRRLRASW
TYPASWPCQP HFLLKFRLQY RPAQHPAWST VEPAGLEEVI TDAVAGLPHA VRVSARDFLD
AGTWSTWSPE AWGTPSTGTI PKEIPAWGQL HTQPEVEPQV DSPAPPRPSL QPHPRLLDHR
DSVEQVAVLA SLGILSFLGL VAGALALGLW LRLRRGGKDG SPKPGFLASV IPVDRRPGAP
NL


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U1815m CLIA kit IL-6 receptor subunit alpha,Il6r,IL-6R 1,IL-6R subunit alpha,Il6ra,IL-6RA,IL-6R-alpha,Interleukin-6 receptor subunit alpha,Mouse,Mus musculus 96T
E2031m ELISA IL-4 receptor subunit alpha,Il4r,IL-4R subunit alpha,Il4ra,IL-4RA,IL-4R-alpha,Interleukin-4 receptor subunit alpha,Mouse,Mus musculus 96T
E1815m ELISA kit IL-6 receptor subunit alpha,Il6r,IL-6R 1,IL-6R subunit alpha,Il6ra,IL-6RA,IL-6R-alpha,Interleukin-6 receptor subunit alpha,Mouse,Mus musculus 96T
E1815r ELISA kit IL-6 receptor subunit alpha,Il6r,IL-6R 1,IL-6R subunit alpha,Il6ra,IL-6RA,IL-6R-alpha,Interleukin-6 receptor subunit alpha,Rat,Rattus norvegicus 96T
U2031r CLIA kit IL-4 receptor subunit alpha,Il4r,IL-4R subunit alpha,Il4ra,IL-4RA,IL-4R-alpha,Interleukin-4 receptor subunit alpha,Rat,Rattus norvegicus 96T
U2031m CLIA kit IL-4 receptor subunit alpha,Il4r,IL-4R subunit alpha,Il4ra,IL-4RA,IL-4R-alpha,Interleukin-4 receptor subunit alpha,Mouse,Mus musculus 96T
U1815r CLIA IL-6 receptor subunit alpha,Il6r,IL-6R 1,IL-6R subunit alpha,Il6ra,IL-6RA,IL-6R-alpha,Interleukin-6 receptor subunit alpha,Rat,Rattus norvegicus 96T
U2031r CLIA IL-4 receptor subunit alpha,Il4r,IL-4R subunit alpha,Il4ra,IL-4RA,IL-4R-alpha,Interleukin-4 receptor subunit alpha,Rat,Rattus norvegicus 96T
U1815m CLIA IL-6 receptor subunit alpha,Il6r,IL-6R 1,IL-6R subunit alpha,Il6ra,IL-6RA,IL-6R-alpha,Interleukin-6 receptor subunit alpha,Mouse,Mus musculus 96T
E2031r ELISA kit IL-4 receptor subunit alpha,Il4r,IL-4R subunit alpha,Il4ra,IL-4RA,IL-4R-alpha,Interleukin-4 receptor subunit alpha,Rat,Rattus norvegicus 96T
U2031m CLIA IL-4 receptor subunit alpha,Il4r,IL-4R subunit alpha,Il4ra,IL-4RA,IL-4R-alpha,Interleukin-4 receptor subunit alpha,Mouse,Mus musculus 96T
E2031m ELISA kit IL-4 receptor subunit alpha,Il4r,IL-4R subunit alpha,Il4ra,IL-4RA,IL-4R-alpha,Interleukin-4 receptor subunit alpha,Mouse,Mus musculus 96T
E1815m ELISA IL-6 receptor subunit alpha,Il6r,IL-6R 1,IL-6R subunit alpha,Il6ra,IL-6RA,IL-6R-alpha,Interleukin-6 receptor subunit alpha,Mouse,Mus musculus 96T
E1815r ELISA IL-6 receptor subunit alpha,Il6r,IL-6R 1,IL-6R subunit alpha,Il6ra,IL-6RA,IL-6R-alpha,Interleukin-6 receptor subunit alpha,Rat,Rattus norvegicus 96T
EIAAB08300 Chicken,Ciliary neurotrophic factor receptor subunit alpha,CNTF receptor subunit alpha,CNTFR,CNTFR-alpha,Gallus gallus,GPA receptor subunit alpha,GPAR-alpha,Growth-promoting activity receptor subunit
Pathways :
WP1655: Geraniol degradation
WP1566: Citrate cycle (TCA cycle)
WP1614: 1- and 2-Methylnaphthalene degradation
WP566: canonical wnt - zebrafish
WP1963: The effect of Glucocorticoids on target gene expression
WP2292: Chemokine signaling pathway
WP2272: Pathogenic Escherichia coli infection
WP929: TNF-alpha NF-kB Signaling Pathway
WP1003: Ovarian Infertility Genes
WP263: Ovarian Infertility Genes
WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP1369: TNF-alpha NF-kB Signaling Pathway
WP1434: Osteopontin Signaling
WP1225: estrogen signalling
WP885: Ovarian Infertility Genes
WP2359: Parkin-Ubiquitin Proteasomal System pathway
WP1487: TNF-alpha and mucus production in lung epythelium
WP1571: EBV LMP1 signaling
WP1772: Apoptosis Modulation and Signaling
WP457: TNF-alpha NF-kB Signaling Pathway
WP262: EBV LMP1 signaling
WP1618: alpha-Linolenic acid metabolism
WP219: Cytoplasmic tRNA Synthetases
WP537: Translation Factors
WP811: TNF-alpha NF-kB Signaling Pathway

Related Genes :
[IL11RA] Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
[Il11ra1 Etl2 Il11ra] Interleukin-11 receptor subunit alpha-1 (IL-11 receptor subunit alpha-1) (IL-11R subunit alpha-1) (IL-11R-alpha-1) (IL-11RA1) (Enhancer trap locus homolog 2) (Etl-2) (Novel cytokine receptor 1) (NR-1) (NR1) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
[Il11ra1] Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
[Il11ra2] Interleukin-11 receptor subunit alpha-2 (IL-11 receptor subunit alpha-2) (IL-11R subunit alpha-2) (IL-11R-alpha-2) (IL-11RA2) (Interleukin-11 receptor subunit beta) (IL-11 receptor subunit beta) (IL-11R subunit beta) (IL-11R-beta) (IL-11RB)
[IL6ST] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[Ccl27 Ilc Scya27] C-C motif chemokine 27 (CC chemokine ILC) (Cutaneous T-cell-attracting chemokine) (CTACK) (ESkine) (IL-11 R-alpha-locus chemokine) (ALP) (mILC) (Skinkine) (Small-inducible cytokine A27)
[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
[IL6R] Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)]
[IL10RA IL10R] Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
[IL15RA] Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]
[Il3ra Sut-1] Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (Interleukin-3 receptor class II alpha chain) (CD antigen CD123)
[IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384] Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)
[IL13RA1 IL13R IL13RA] Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1)
[IL13RA2 IL13R] Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)
[IL5RA IL5R] Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)
[IL7R] Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)
[IL27RA CRL1 TCCR WSX1 UNQ296/PRO336] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
[IL3RA IL3R] Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124)
[Il7r] Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CD antigen CD127)
[Il6st] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[Il27ra Tccr Wsx1] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Type I T-cell cytokine receptor) (TCCR) (WSX-1)
[Il6st] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[IL11RA] Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL18R1 IL1RRP] Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]

Bibliography :
[19734214] IL-11 regulates autoimmune demyelination.