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Interleukin-11 receptor subunit alpha-1 (IL-11 receptor subunit alpha-1) (IL-11R subunit alpha-1) (IL-11R-alpha-1) (IL-11RA1) (Enhancer trap locus homolog 2) (Etl-2) (Novel cytokine receptor 1) (NR-1) (NR1)

 I11RA_MOUSE             Reviewed;         432 AA.
Q64385; A2AMS4; Q6NSQ0;
23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
12-AUG-2020, entry version 148.
RecName: Full=Interleukin-11 receptor subunit alpha-1 {ECO:0000305};
Short=IL-11 receptor subunit alpha-1;
Short=IL-11R subunit alpha-1;
Short=IL-11R-alpha-1;
Short=IL-11RA1;
AltName: Full=Enhancer trap locus homolog 2;
Short=Etl-2;
AltName: Full=Novel cytokine receptor 1;
Short=NR-1;
Short=NR1;
Contains:
RecName: Full=Soluble interleukin-11 receptor subunit alpha {ECO:0000305};
Short=sIL-11R {ECO:0000303|PubMed:26876177};
Short=sIL-11RA;
Short=sIL11RA {ECO:0000305};
Flags: Precursor;
Name=Il11ra1 {ECO:0000312|MGI:MGI:107426}; Synonyms=Etl2, Il11ra;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
STRAIN=BALB/cJ;
PubMed=7813775; DOI=10.1006/dbio.1994.1335;
Neuhaus H., Bettenhausen B., Bilinski P., Simon-Chazottes D., Guenet J.-L.,
Gossler A.;
"etl2, a novel putative type-1 cytokine receptor expressed during mouse
embryogenesis at high levels in skin and cells with skeletogenic
potential.";
Dev. Biol. 166:531-542(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6 X CBA; TISSUE=Liver;
PubMed=7957045; DOI=10.1002/j.1460-2075.1994.tb06802.x;
Hilton D.J., Hilton A.A., Raicevic A., Rakar S., Harrison-Smith M.,
Gough N.M., Begley C.G., Metcalf D., Nicola N.A., Willson T.A.;
"Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for
high affinity binding and signal transduction.";
EMBO J. 13:4765-4775(1994).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=8973540; DOI=10.1042/bj3200359;
Bilinski P., Hall M.A., Neuhaus H., Gissel C., Heath J.K., Gossler A.;
"Two differentially expressed interleukin-11 receptor genes in the mouse
genome.";
Biochem. J. 320:359-363(1996).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
STRAIN=129/Sv; TISSUE=Testis;
PubMed=8662802; DOI=10.1074/jbc.271.23.13754;
Robb L., Hilton D.J., Willson T.A., Begley C.G.;
"Structural analysis of the gene encoding the murine interleukin-11
receptor alpha-chain and a related locus.";
J. Biol. Chem. 271:13754-13761(1996).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Limb, and Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
PROTEIN SEQUENCE OF 24-38, AND FUNCTION OF SOLUBLE FORM.
PubMed=9373251;
Curtis D.J., Hilton D.J., Roberts B., Murray L., Nicola N., Begley C.G.;
"Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as
an IL-11 antagonist.";
Blood 90:4403-4412(1997).
[8]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=21741611; DOI=10.1016/j.ajhg.2011.05.024;
Nieminen P., Morgan N.V., Fenwick A.L., Parmanen S., Veistinen L.,
Mikkola M.L., van der Spek P.J., Giraud A., Judd L., Arte S., Brueton L.A.,
Wall S.A., Mathijssen I.M., Maher E.R., Wilkie A.O., Kreiborg S.,
Thesleff I.;
"Inactivation of IL11 signaling causes craniosynostosis, delayed tooth
eruption, and supernumerary teeth.";
Am. J. Hum. Genet. 89:67-81(2011).
[9]
FUNCTION, PROTEOLYTIC CLEAVAGE, AND SUBCELLULAR LOCATION.
PubMed=26876177; DOI=10.1016/j.celrep.2016.01.053;
Lokau J., Nitz R., Agthe M., Monhasery N., Aparicio-Siegmund S.,
Schumacher N., Wolf J., Moeller-Hackbarth K., Waetzig G.H., Groetzinger J.,
Mueller-Newen G., Rose-John S., Scheller J., Garbers C.;
"Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.";
Cell Rep. 14:1761-1773(2016).
-!- FUNCTION: Receptor for interleukin-11. The receptor systems for IL6,
LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal
transmission. The IL11/IL11RA/IL6ST complex may be involved in the
control of proliferation and/or differentiation of skeletogenic
progenitor or other mesenchymal cells. Essential for the normal
development of craniofacial bones and teeth.
-!- FUNCTION: [Soluble interleukin-11 receptor subunit alpha]: Soluble form
of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity.
The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and
induces signaling also on cells that do not express membrane-bound
IL11RA in a process called IL11 trans-signaling.
{ECO:0000250|UniProtKB:Q14626}.
-!- SUBUNIT: On IL11 binding, forms a multimer complex with IL6ST/gp130.
{ECO:0000250|UniProtKB:Q14626}.
-!- SUBCELLULAR LOCATION: [Interleukin-11 receptor subunit alpha-1]:
Membrane {ECO:0000269|PubMed:26876177}; Single-pass type I membrane
protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:Q14626}.
-!- SUBCELLULAR LOCATION: [Soluble interleukin-11 receptor subunit alpha]:
Secreted {ECO:0000269|PubMed:26876177}.
-!- TISSUE SPECIFICITY: Widely expressed in all adult tissues and in
embryos. Highest levels in kidney, skeletal muscle and embryo.
{ECO:0000269|PubMed:8662802}.
-!- DEVELOPMENTAL STAGE: First detected at low levels at 10.5 dpc in
cranofacial mesenchyme and in parts of the nervous system. At 12.5 dpc,
high expression found in heart, diaphragm, bronchi and in the
mesenchyme surrounding precartilage condensations. At later stages,
expressed in dental papilla, dermis, hair follicles and in the
perichondrium and in regions containing chondro and osteo progenitor
cells. {ECO:0000269|PubMed:7813775}.
-!- PTM: A short soluble form is also released from the membrane by
proteolysis (PubMed:26876177). The sIL11RA is formed either by limited
proteolysis of membrane-bound receptors, a process referred to as
ectodomain shedding, or directly secreted from the cells after
alternative mRNA splicing (PubMed:26876177). mIL11RA is cleaved by the
proteases ADAM10, ELANE and PRTN3 (PubMed:26876177).
{ECO:0000269|PubMed:26876177}.
-!- DISRUPTION PHENOTYPE: Mice have disturbed cranial growth and suture
activity. {ECO:0000269|PubMed:21741611}.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; X74953; CAA52908.1; -; mRNA.
EMBL; U14412; AAA53248.1; -; mRNA.
EMBL; X94162; CAA63873.1; -; Genomic_DNA.
EMBL; X94163; CAA63873.1; JOINED; Genomic_DNA.
EMBL; AL807796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC004619; AAH04619.1; -; mRNA.
EMBL; BC057664; AAH57664.1; -; mRNA.
EMBL; BC069984; AAH69984.1; -; mRNA.
CCDS; CCDS18071.1; -.
PIR; I48343; I48343.
RefSeq; NP_001156873.1; NM_001163401.1.
RefSeq; NP_001165525.1; NM_001172054.1.
RefSeq; NP_034679.1; NM_010549.3.
SMR; Q64385; -.
DIP; DIP-5781N; -.
IntAct; Q64385; 2.
STRING; 10090.ENSMUSP00000095736; -.
GlyGen; Q64385; 2 sites.
PhosphoSitePlus; Q64385; -.
PaxDb; Q64385; -.
PRIDE; Q64385; -.
Ensembl; ENSMUST00000098132; ENSMUSP00000095736; ENSMUSG00000073889.
Ensembl; ENSMUST00000108040; ENSMUSP00000103675; ENSMUSG00000073889.
Ensembl; ENSMUST00000108041; ENSMUSP00000103676; ENSMUSG00000073889.
Ensembl; ENSMUST00000108042; ENSMUSP00000103677; ENSMUSG00000073889.
GeneID; 16157; -.
KEGG; mmu:16157; -.
UCSC; uc008sjr.2; mouse.
CTD; 16157; -.
MGI; MGI:107426; Il11ra1.
eggNOG; ENOG502R7G6; Eukaryota.
GeneTree; ENSGT00940000160904; -.
HOGENOM; CLU_047259_0_1_1; -.
InParanoid; Q64385; -.
KO; K05056; -.
OMA; RDPLEQM; -.
OrthoDB; 741136at2759; -.
PhylomeDB; Q64385; -.
TreeFam; TF331210; -.
Reactome; R-MMU-6788467; IL-6-type cytokine receptor ligand interactions.
BioGRID-ORCS; 16157; 0 hits in 18 CRISPR screens.
ChiTaRS; Il11ra1; mouse.
PRO; PR:Q64385; -.
Proteomes; UP000000589; Chromosome 4.
RNAct; Q64385; protein.
Bgee; ENSMUSG00000073889; Expressed in limb and 73 other tissues.
Genevisible; Q64385; MM.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
GO; GO:0019970; F:interleukin-11 binding; IPI:MGI.
GO; GO:0004921; F:interleukin-11 receptor activity; IDA:MGI.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IDA:MGI.
GO; GO:0046697; P:decidualization; IMP:MGI.
GO; GO:0032502; P:developmental process; ISS:UniProtKB.
GO; GO:0060322; P:head development; ISS:UniProtKB.
GO; GO:0060135; P:maternal process involved in female pregnancy; IMP:MGI.
GO; GO:0001779; P:natural killer cell differentiation; IMP:MGI.
GO; GO:0001890; P:placenta development; IMP:MGI.
GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:MGI.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
SMART; SM00060; FN3; 2.
SMART; SM00409; IG; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 2.
PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
PROSITE; PS50835; IG_LIKE; 1.
1: Evidence at protein level;
Direct protein sequencing; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat;
Secreted; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1..23
/evidence="ECO:0000269|PubMed:9373251"
CHAIN 24..432
/note="Interleukin-11 receptor subunit alpha-1"
/id="PRO_0000010914"
CHAIN 24..?
/note="Soluble interleukin-11 receptor subunit alpha"
/id="PRO_0000450689"
TOPO_DOM 24..372
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 373..393
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 394..432
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 27..110
/note="Ig-like C2-type"
DOMAIN 112..219
/note="Fibronectin type-III 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
DOMAIN 220..317
/note="Fibronectin type-III 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
MOTIF 304..308
/note="WSXWS motif"
CARBOHYD 127
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 194
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 48..94
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 120..130
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 170..180
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
CONFLICT 93
/note="V -> I (in Ref. 6; AAH57664/AAH69984)"
/evidence="ECO:0000305"
CONFLICT 332
/note="G -> R (in Ref. 6; AAH57664/AAH69984)"
/evidence="ECO:0000305"
CONFLICT 368
/note="V -> I (in Ref. 6; AAH57664/AAH69984)"
/evidence="ECO:0000305"
SEQUENCE 432 AA; 46655 MW; 068389943502BBFC CRC64;
MSSSCSGLTR VLVAVATALV SSSSPCPQAW GPPGVQYGQP GRPVMLCCPG VSAGTPVSWF
RDGDSRLLQG PDSGLGHRLV LAQVDSPDEG TYVCQTLDGV SGGMVTLKLG FPPARPEVSC
QAVDYENFSC TWSPGQVSGL PTRYLTSYRK KTLPGAESQR ESPSTGPWPC PQDPLEASRC
VVHGAEFWSE YRINVTEVNP LGASTCLLDV RLQSILRPDP PQGLRVESVP GYPRRLHASW
TYPASWRRQP HFLLKFRLQY RPAQHPAWST VEPIGLEEVI TDAVAGLPHA VRVSARDFLD
AGTWSAWSPE AWGTPSTGPL QDEIPDWSQG HGQQLEAVVA QEDSPAPARP SLQPDPRPLD
HRDPLEQVAV LASLGIFSCL GLAVGALALG LWLRLRRSGK DGPQKPGLLA PMIPVEKLPG
IPNLQRTPEN FS


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[Il11ra1 Etl2 Il11ra] Interleukin-11 receptor subunit alpha-1 (IL-11 receptor subunit alpha-1) (IL-11R subunit alpha-1) (IL-11R-alpha-1) (IL-11RA1) (Enhancer trap locus homolog 2) (Etl-2) (Novel cytokine receptor 1) (NR-1) (NR1) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
[IL11RA] Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
[Il11ra1] Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
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[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[IL6R] Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)]
[IL6ST] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[Il3ra Sut-1] Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (Interleukin-3 receptor class II alpha chain) (CD antigen CD123)
[IL10RA IL10R] Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
[IL13RA1 IL13R IL13RA] Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1)
[IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384] Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL18R1 IL1RRP] Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Il18r1] Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[RORA NR1F1 RZRA] Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha)
[IL13RA2 IL13R] Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)
[IL17RB CRL4 EVI27 IL17BR UNQ2501/PRO19612] Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor)
[IL10RB CRFB4 D21S58 D21S66] Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
[IL15RA] Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]
[Rora Nr1f1 Rzra] Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha)
[IL3RA IL3R] Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)
[IL5RA IL5R] Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)
[IL7R] Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)

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