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Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)

 I12R2_MOUSE             Reviewed;         874 AA.
P97378; B9EHD9;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
17-JUN-2020, entry version 166.
RecName: Full=Interleukin-12 receptor subunit beta-2;
Short=IL-12 receptor subunit beta-2;
Short=IL-12R subunit beta-2;
Short=IL-12R-beta-2;
Short=IL-12RB2;
Flags: Precursor;
Name=Il12rb2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8943050; DOI=10.1073/pnas.93.24.14002;
Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.-Y.,
Gately M.K., Gubler U.;
"A functional interleukin 12 receptor complex is composed of two beta-type
cytokine receptor subunits.";
Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Thymus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 692-699, AND IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=C57BL/6J; TISSUE=Brain;
Lubec G., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
[4]
FUNCTION IN STAT3/STAT4 ACTIVATION, AND MUTAGENESIS OF TYR-677; TYR-693;
TYR-727; TYR-737; TYR-748; TYR-757; TYR-778; TYR-804; TYR-811 AND TYR-866.
PubMed=12370372; DOI=10.4049/jimmunol.169.8.4388;
Nishikomori R., Usui T., Wu C.-Y., Morinobu A., O'Shea J.J., Strober W.;
"Activated STAT4 has an essential role in Th1 differentiation and
proliferation that is independent of its role in the maintenance of IL-12R
beta 2 chain expression and signaling.";
J. Immunol. 169:4388-4398(2002).
[5]
DEVELOPMENTAL STAGE.
PubMed=9120387; DOI=10.1084/jem.185.5.817;
Szabo S.J., Dighe A.S., Gubler U., Murphy K.M.;
"Regulation of the interleukin (IL)-12R beta 2 subunit expression in
developing T helper 1 (Th1) and Th2 cells.";
J. Exp. Med. 185:817-824(1997).
[6]
IL12 UNRESPONSIVENESS IN CR MUTANT MICE.
PubMed=11489994; DOI=10.4049/jimmunol.167.4.2106;
Poltorak A., Merlin T., Nielsen P.J., Sandra O., Smirnova I., Schupp I.,
Boehm T., Galanos C., Freudenberg M.A.;
"A point mutation in the IL-12R beta 2 gene underlies the IL-12
unresponsiveness of Lps-defective C57BL/10ScCr mice.";
J. Immunol. 167:2106-2111(2001).
-!- FUNCTION: Receptor for interleukin-12. This subunit is the signaling
component coupling to the JAK2/STAT4 pathway. Promotes the
proliferation of T-cells as well as NK cells. Induces the promotion of
T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma
production. Can also activate STAT3. {ECO:0000269|PubMed:12370372}.
-!- SUBUNIT: Heterodimer/heterooligomer; disulfide-linked. The functional
high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2
binds JAK2 (via its N-terminal) through a membrane-proximal region of
the cytoplasmic domain (By similarity). {ECO:0000250}.
-!- INTERACTION:
P97378; Q99KY4: Gak; NbExp=7; IntAct=EBI-6253448, EBI-7652906;
P97378; Q60837: Il12rb1; NbExp=2; IntAct=EBI-6253448, EBI-2481455;
P97378; Q00560: Il6st; NbExp=2; IntAct=EBI-6253448, EBI-3862992;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
-!- TISSUE SPECIFICITY: Expressed in developing T-helper (TH) cells.
-!- DEVELOPMENTAL STAGE: Expressed at high levels in Th1 cells on day 3, 5
and 7 after primary activation. Very low expression in Th2 cells on day
3 and not detectable on day 5 nor day 7 after activation.
{ECO:0000269|PubMed:9120387}.
-!- INDUCTION: Following T-cell activation, expression inhibited by IL4 and
induced by IFN gamma.
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-surface
receptor binding.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation.
-!- PTM: On IL12 stimulation, phosphorylated on C-terminal tyrosine
residues. Phosphorylation of any one of Tyr-757, Tyr-804 or Tyr-811 can
activate STAT4, IFN-gamma production, and T-cell proliferation. Tyr-811
is the dominant site of cell proliferation.
-!- MISCELLANEOUS: Lps-defective mice C57BL/10ScCr (Cr) mice carry a
mutation in the IL12RB2 gene leading to the production of a truncated
IL12 receptor beta 2 chain resulting in malfunction of the IL12-
mediated IFN-gamma response.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; U64199; AAB36676.1; -; mRNA.
EMBL; BC137745; AAI37746.1; -; mRNA.
CCDS; CCDS20220.1; -.
RefSeq; NP_001298070.1; NM_001311141.1.
RefSeq; NP_032380.1; NM_008354.3.
RefSeq; XP_006505680.1; XM_006505617.3.
BioGRID; 200612; 1.
ComplexPortal; CPX-388; Interleukin-12-receptor complex.
IntAct; P97378; 3.
MINT; P97378; -.
STRING; 10090.ENSMUSP00000010605; -.
PhosphoSitePlus; P97378; -.
EPD; P97378; -.
PaxDb; P97378; -.
PRIDE; P97378; -.
Antibodypedia; 19617; 331 antibodies.
Ensembl; ENSMUST00000018485; ENSMUSP00000010605; ENSMUSG00000018341.
GeneID; 16162; -.
KEGG; mmu:16162; -.
UCSC; uc009cfo.1; mouse.
CTD; 3595; -.
MGI; MGI:1270861; Il12rb2.
eggNOG; ENOG410IHXG; Eukaryota.
eggNOG; ENOG41116V2; LUCA.
GeneTree; ENSGT00940000159829; -.
HOGENOM; CLU_016653_0_0_1; -.
InParanoid; P97378; -.
KO; K05064; -.
OMA; SKWAKEC; -.
OrthoDB; 144839at2759; -.
PhylomeDB; P97378; -.
TreeFam; TF338122; -.
Reactome; R-MMU-8984722; Interleukin-35 Signalling.
Reactome; R-MMU-9020591; Interleukin-12 signaling.
BioGRID-ORCS; 16162; 1 hit in 12 CRISPR screens.
ChiTaRS; Il12rb2; mouse.
PRO; PR:P97378; -.
Proteomes; UP000000589; Chromosome 6.
RNAct; P97378; protein.
Bgee; ENSMUSG00000018341; Expressed in cortex of kidney and 34 other tissues.
ExpressionAtlas; P97378; baseline and differential.
Genevisible; P97378; MM.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
GO; GO:0019901; F:protein kinase binding; IPI:MGI.
GO; GO:0032609; P:interferon-gamma production; IGI:MGI.
GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; IMP:MGI.
GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:MGI.
GO; GO:0034097; P:response to cytokine; IMP:MGI.
GO; GO:0032496; P:response to lipopolysaccharide; IGI:MGI.
CDD; cd00063; FN3; 3.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR010457; IgC2-like_lig-bd.
Pfam; PF00041; fn3; 3.
Pfam; PF06328; Lep_receptor_Ig; 1.
SMART; SM00060; FN3; 4.
SUPFAM; SSF49265; SSF49265; 4.
PROSITE; PS50853; FN3; 4.
PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
1: Evidence at protein level;
Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane;
Phosphoprotein; Receptor; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1..23
/evidence="ECO:0000255"
CHAIN 24..874
/note="Interleukin-12 receptor subunit beta-2"
/id="PRO_0000010921"
TOPO_DOM 24..637
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 638..658
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 659..874
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 139..237
/note="Fibronectin type-III 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
DOMAIN 242..335
/note="Fibronectin type-III 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
DOMAIN 336..430
/note="Fibronectin type-III 3"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
DOMAIN 438..530
/note="Fibronectin type-III 4"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
DOMAIN 536..635
/note="Fibronectin type-III 5"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
MOTIF 321..325
/note="WSXWS motif"
MOTIF 677..685
/note="Box 1 motif"
MOD_RES 757
/note="Phosphotyrosine"
/evidence="ECO:0000305"
MOD_RES 804
/note="Phosphotyrosine"
/evidence="ECO:0000305"
MOD_RES 811
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:Q99665, ECO:0000305"
CARBOHYD 48
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 101
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 114
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 142
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 151
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 169
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 179
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 224
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 252
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 279
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 287
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 323
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 391
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 495
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
MUTAGEN 677
/note="Y->F: No loss of IL12-induced STAT4 activation nor
T-cell proliferation. No effect on IFN-gamma production."
/evidence="ECO:0000269|PubMed:12370372"
MUTAGEN 693
/note="Y->F: No loss of IL12-induced STAT4 activation nor
T-cell proliferation. No effect on IFN-gamma production."
/evidence="ECO:0000269|PubMed:12370372"
MUTAGEN 727
/note="Y->F: No loss of IL12-induced STAT4 activation nor
T-cell proliferation. No effect on IFN-gamma production."
/evidence="ECO:0000269|PubMed:12370372"
MUTAGEN 737
/note="Y->F: No loss of IL12-induced STAT4 activation nor
T-cell proliferation. No effect on IFN-gamma production."
/evidence="ECO:0000269|PubMed:12370372"
MUTAGEN 748
/note="Y->F: No loss of IL12-induced STAT4 activation nor
T-cell proliferation. No effect on IFN-gamma production."
/evidence="ECO:0000269|PubMed:12370372"
MUTAGEN 757
/note="Y->F: No loss of IL12-induced STAT4 activation nor
T-cell proliferation. No effect on IFN-gamma production."
/evidence="ECO:0000269|PubMed:12370372"
MUTAGEN 778
/note="Y->F: No loss of IL12-induced STAT4 activation nor
T-cell proliferation. No effect on IFN-gamma production."
/evidence="ECO:0000269|PubMed:12370372"
MUTAGEN 804
/note="Y->F: No loss of IL12-induced STAT4 activation nor
T-cell proliferation. No effect on IFN-gamma production."
/evidence="ECO:0000269|PubMed:12370372"
MUTAGEN 811
/note="Y->F: No loss of IL12-induced STAT4 activation.
Greatly reduced IL12-induced T-cell proliferation and IFN-
gamma production."
/evidence="ECO:0000269|PubMed:12370372"
MUTAGEN 866
/note="Y->F: No loss of IL12-induced STAT4 activation nor
T-cell proliferation. No effect on IFN-gamma production."
/evidence="ECO:0000269|PubMed:12370372"
SEQUENCE 874 AA; 98197 MW; 582E4D21BF1FBD67 CRC64;
MAQTVRECSL ALLFLFMWLL IKANIDVCKL GTVTVQPAPV IPLGSAANIS CSLNPKQGCS
HYPSSNELIL LKFVNDVLVE NLHGKKVHDH TGHSSTFQVT NLSLGMTLFV CKLNCSNSQK
KPPVPVCGVE ISVGVAPEPP QNISCVQEGE NGTVACSWNS GKVTYLKTNY TLQLSGPNNL
TCQKQCFSDN RQNCNRLDLG INLSPDLAES RFIVRVTAIN DLGNSSSLPH TFTFLDIVIP
LPPWDIRINF LNASGSRGTL QWEDEGQVVL NQLRYQPLNS TSWNMVNATN AKGKYDLRDL
RPFTEYEFQI SSKLHLSGGS WSNWSESLRT RTPEEEPVGI LDIWYMKQDI DYDRQQISLF
WKSLNPSEAR GKILHYQVTL QEVTKKTTLQ NTTRHTSWTR VIPRTGAWTA SVSAANSKGA
SAPTHINIVD LCGTGLLAPH QVSAKSENMD NILVTWQPPK KADSAVREYI VEWRALQPGS
ITKFPPHWLR IPPDNMSALI SENIKPYICY EIRVHALSES QGGCSSIRGD SKHKAPVSGP
HITAITEKKE RLFISWTHIP FPEQRGCILH YRIYWKERDS TAQPELCEIQ YRRSQNSHPI
SSLQPRVTYV LWMTAVTAAG ESPQGNEREF CPQGKANWKA FVISSICIAI ITVGTFSIRY
FRQKAFTLLS TLKPQWYSRT IPDPANSTWV KKYPILEEKI QLPTDNLLMA WPTPEEPEPL
IIHEVLYHMI PVVRQPYYFK RGQGFQGYST SKQDAMYIAN PQATGTLTAE TRQLVNLYKV
LESRDPDSKL ANLTSPLTVT PVNYLPSHEG YLPSNIEDLS PHEADPTDSF DLEHQHISLS
IFASSSLRPL IFGGERLTLD RLKMGYDSLM SNEA


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Related Genes :
[Il12rb2] Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
[IL12RB2] Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
[IL12RB1 IL12R IL12RB] Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12RB1) (IL-12 receptor beta component) (CD antigen CD212)
[Il12rb1 Il12rb] Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12 receptor beta component) (CD antigen CD212)
[IL12RB2] Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
[IL12RB2] Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
[IL2RB IL15RB] Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
[IL10RB CRFB4 D21S58 D21S66] Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
[Il6st] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
[IL6ST] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[IL18RAP IL1R7] Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)
[Il6st] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[OSMR OSMRB] Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB)
[CSF2RB IL3RB IL5RB] Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
[Osmr Osmrb] Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB)
[Il1rap] Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-33 receptot beta chain)
[Il2rb] Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (p70-75) (CD antigen CD122)
[Csf2rb Aic2b Csf2rb1 Il3rb1] Cytokine receptor common subunit beta (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[IL2RG] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[Il2rb] Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (p70-75) (CD antigen CD122)
[Il2rg] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[IL13RA2 IL13R] Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)
[Il3ra Sut-1] Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (Interleukin-3 receptor class II alpha chain) (CD antigen CD123)
[Csf2rb2 Ai2ca Il3r Il3rb2] Interleukin-3 receptor class 2 subunit beta (IL-3 receptor class 2 subunit beta) (IL-3R class 2 subunit beta) (Colony-stimulating factor 2 receptor subunit beta-2) (Interleukin-3 receptor class II beta chain)
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Il1b] Interleukin-1 beta (IL-1 beta)
[IL10RA IL10R] Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)

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